Cited by 300Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Atypical mitogen-activated protein kinases: Structure, regulation and functions

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Coulombe, Phillipe, Meloche, Sylvain·2007·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2006.11.001

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Abstract

Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a central role in transducing extracellular cues into a variety of intracellular responses ranging from lineage specification to cell division and adaptation. Fourteen MAP kinase genes have been identified in the human genome, which define 7 distinct MAP kinase signaling pathways. MAP kinases can be classified into conventional or atypical enzymes, based on their ability to get phosphorylated and activated by members of the MAP kinase kinase (MAPKK)/MEK family. Conventional MAP kinases comprise ERK1/ERK2, p38s, JNKs, and ERK5, which are all substrates of MAPKKs. Atypical MAP kinases include ERK3/ERK4, NLK and ERK7. Much less is known about the regulation, substrate specificity and physiological functions of atypical MAP kinases.

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Authors: Coulombe, P., & Meloche, S.
Affiliations: Institute for Research in Immunology and Cancer (CA)
Corresponding author: Meloche, Sylvain
ORCID: Meloche, Sylvain
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2007-08
Volume: 1773
Issue: 8
Pages: 1376-1387
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2006.11.001
OpenAlex: W1973460380
Cited by: 298
References: 87
Citations by year: 2026: 6 · 2025: 13 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 28 · 2020: 21 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 13
FWCI: 0.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2178 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Canada Research Chairs
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: mitogen-activated protein kinase, Nemo-like kinase, MAPK signaling, MAP kinase kinase, kinase regulation, substrate specificity, serine/threonine kinase, signal transduction
MeSH terms: Amino Acid Sequence, Animals, Enzyme Activation, Humans, Models, Molecular, Molecular Sequence Data, Substrate Specificity, Sequence Homology, Amino Acid, MAP Kinase Signaling System, Extracellular Signal-Regulated MAP Kinases

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Atypical mitogen-activated protein kinases: Structure, regulation and functions

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