The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Glutathione and modulation of cell apoptosis
Open accessAbstract
Apoptosis is a highly organized form of cell death that is important for tissue homeostasis, organ development and senescence. To date, the extrinsic (death receptor mediated) and intrinsic (mitochondria derived) apoptotic pathways have been characterized in mammalian cells. Reduced glutathione, GSH, is the most prevalent cellular thiol that plays an essential role in preserving a reduced intracellular environment. GSH protection of cellular macromolecules like DNA, proteins and lipids against oxidizing, environmental and cytotoxic agents, underscores its central anti-apoptotic function. Reactive oxygen and nitrogen species (ROS/RNS) can oxidize cellular GSH or induce its extracellular export leading to the loss of intracellular redox homeostasis and activation of the apoptotic signaling cascade. Recent evidence uncovered a novel role for GSH involvement in apoptotic signaling pathways wherein post-translational S-glutathiolation of protein redox active cysteines is implicated in the potentiation of apoptosis. In the present review we focus on the key aspects of GSH redox mechanisms associated with apoptotic signaling that includes: (a) changes in cellular GSH redox homeostasis through GSH oxidation or GSH transport in relation to the initiation or propagation of the apoptotic cascade, and (b) evidence for S-glutathiolation in protein modulation and apoptotic initiation.
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Cites
Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
Self-citationOxidized Redox State of Glutathione in the Endoplasmic Reticulum
Hwang, C., Sinskey, A. J., & Lodish, H. F. (1992) · Science · doi:10.1126/science.1523409 · Cited by 1,968
Reynaert, N. L., van der Vliet, A., Guala, A. S., McGovern, T., Hristova, M., Pantano, C., Heintz, N. H., Heim, J., Ho, Y.-S., Matthews, D. E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603290103 · Cited by 442
Direct evidence for S-nitrosation of mitochondrial complex I
Burwell, L. S., Nadtochiy, S. M., Tompkins, A. J., Young, S., & Brookes, P. S. (2006) · Biochemical Journal · doi:10.1042/bj20051435 · Cited by 274
Hu, J., Dong, L., & Outten, C. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803028200 · Cited by 273
Hurd, T. R., Requejo, R., Filipovska, A., Brown, S., Prime, T. A., Robinson, A. J., Fearnley, I. M., & Murphy, M. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803432200 · Cited by 182
Cited by
Activation of apoptosis signalling pathways by reactive oxygen species
Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731
Extracellular Cysteine in Connexins: Role as Redox Sensors
Retamal, M. A., García, I. E., Pinto, B. I., Pupo, A., Báez, D., Stehberg, J., Del Rio, R., & González, C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00001 · Cited by 482
siRNA Delivery Strategies: A Comprehensive Review of Recent Developments
Tatiparti, K., Sau, S., Kashaw, S., & Iyer, A. (2017) · Nanomaterials · doi:10.3390/nano7040077 · Cited by 429
Glutathione: Antioxidant Properties Dedicated to Nanotechnologies
Gaucher, C., Boudier, A., Bonetti, J., Clarot, I., Leroy, P., & Parent, M. (2018) · Antioxidants · doi:10.3390/antiox7050062 · Cited by 332
Skene, D. J., Skornyakov, E., Chowdhury, N. R., Gajula, R. P., Middleton, B., Satterfield, B. C., Porter, K. I., Van Dongen, H. P. A., & Gaddameedhi, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801183115 · Cited by 176
Metadata
- Authors
- Circu, M. L., & Aw, T. Y.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 1823
- Issue
- 10
- Pages
- 1767-1777
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2080308960
- Cited by
- 331
- References
- 6
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Circu, M. L., & Aw, T. Y. (2012). Glutathione and modulation of cell apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2012.06.019
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