Cited by 759Barrier Structure and Function StudiesIon Transport and Channel RegulationCell Adhesion Molecules Research

Crosstalk of tight junction components with signaling pathways

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González-Mariscal, Lorenza, Tapia, Rocio, Chamorro, David·2008·Biochimica et Biophysica Acta (BBA) - Biomembranes

Abstract

Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree of sealing varies according to external stimuli, physiological and pathological conditions. In this review we analyze how the crosstalk of protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinases, phosphoinositide 3-kinase and Rho signaling pathways is involved in TJ regulation triggered by diverse stimuli. We also report how the phosphorylation of the main TJ components, claudins, occludin and ZO proteins, impacts epithelial and endothelial cell function.

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Crossref · 10.1016/j.bbamem.2007.08.018

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  • MAPK signaling pathways modulate expression of tight junction proteins and alter molecular composition within tight junction complexes.

    “MAPK signaling pathways modulate the expression of tight junction proteins and alter the molecular composition within tight junction complexes (49).”

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Research works printed but not linked: 2

  1. J.M. Anderson, M. Cereijido, Evolution of ideas on the tight junction, in: M. Cereijido, J.M. Anderson (Eds.), Tight Junctions, CRC Press, Boca Raton, 2001, pp. 1-18.
  2. E. Lopez-Bayghen, B.E. Jaramillo, M. Huerta, A. Betanzos, L. Gonzalez- Mariscal, Tight junction proteins that make round trips to the nucleus, in: L. Gonzalez-Mariscal (Ed.), Tight Junctions, Landes Bioscience and Springer Science, Georgetown and New York, 2006, pp. 76-100.

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Authors
González-Mariscal, L., Tapia, R., & Chamorro, D.
Affiliations
Instituto Politécnico Nacional (MX)
Venue
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier BV
Published
2008-03
Volume
1778
Issue
3
Pages
729-756
ISSN
0005-2736 (ISSN-L)
OpenAlex
W2004723568
Cited by
759
References
270
Citations by year
2026: 17 · 2025: 21 · 2024: 41 · 2023: 40 · 2022: 40 · 2021: 57 · 2020: 47 · 2019: 37 · 2018: 42 · 2017: 45 · 2016: 50 · 2015: 47 · 2014: 39 · 2013: 57 · 2012: 43
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consejo Nacional de Ciencia y Tecnología (166727)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
tight junctions, tight junction signaling, paracellular permeability, protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, Rho GTPase signaling, claudins, occludin, protein phosphorylation, epithelial cells, endothelial cells, tight junction regulation
MeSH terms
Amino Acid Sequence, Animals, Humans, Membrane Proteins, Models, Biological, Molecular Sequence Data, Myosin-Light-Chain Kinase, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinase C, Signal Transduction, Cell Polarity, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP-Dependent Protein Kinases, Tight Junctions, Phosphatidylinositol 3-Kinases, Paracrine Communication, rho GTP-Binding Proteins, MAP Kinase Signaling System, Occludin

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