Crosstalk of tight junction components with signaling pathways
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Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree of sealing varies according to external stimuli, physiological and pathological conditions. In this review we analyze how the crosstalk of protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinases, phosphoinositide 3-kinase and Rho signaling pathways is involved in TJ regulation triggered by diverse stimuli. We also report how the phosphorylation of the main TJ components, claudins, occludin and ZO proteins, impacts epithelial and endothelial cell function.
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MAPK signaling pathways modulate expression of tight junction proteins and alter molecular composition within tight junction complexes.
“MAPK signaling pathways modulate the expression of tight junction proteins and alter the molecular composition within tight junction complexes (49).”
From Bacterial induction of Snail1 contributes to blood-brain barrier disruption (2015) · cites this paper as [49]
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Research works printed but not linked: 2
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- Authors
- González-Mariscal, L., Tapia, R., & Chamorro, D.
- Affiliations
- Instituto Politécnico Nacional (MX)
- ORCID
- Chamorro, David
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 1778
- Issue
- 3
- Pages
- 729-756
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2004723568
- Cited by
- 759
- References
- 270
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 41 · 2023: 40 · 2022: 40 · 2021: 57 · 2020: 47 · 2019: 37 · 2018: 42 · 2017: 45 · 2016: 50 · 2015: 47 · 2014: 39 · 2013: 57 · 2012: 43
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología (166727)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- tight junctions, tight junction signaling, paracellular permeability, protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, Rho GTPase signaling, claudins, occludin, protein phosphorylation, epithelial cells, endothelial cells, tight junction regulation
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Membrane Proteins, Models, Biological, Molecular Sequence Data, Myosin-Light-Chain Kinase, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinase C, Signal Transduction, Cell Polarity, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP-Dependent Protein Kinases, Tight Junctions, Phosphatidylinositol 3-Kinases, Paracrine Communication, rho GTP-Binding Proteins, MAP Kinase Signaling System, Occludin
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