Signaling Mechanisms of HIV-1 Tat-Induced Alterations of Claudin-5 Expression in Brain Endothelial Cells

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100 · see citing works

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works

Endothelial Claudin

Morita, K., Sasaki, H., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.185 · Cited by 867 · see citing works

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

Huber, J. D., Egleton, R. D., & Davis, T. P. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02004-x · Cited by 790 · see citing works

Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

Ikenouchi, J., Matsuda, M., Furuse, M., & Tsukita, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00389 · Cited by 678 · see citing works

Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines

Peinado, H., Quintanilla, M., & Cano, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211304200 · Cited by 642 · see citing works

Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme

Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E.-H., Kalbacher, H., & Wolburg, H. (2000) · Acta Neuropathologica · doi:10.1007/s004010000180 · Cited by 490 · see citing works

HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

Chang, H. C., Samaniego, F., Nair, B. C., Buonaguro, L., & Ensoli, B. (1997) · AIDS · doi:10.1097/00002030-199712000-00006 · Cited by 441 · see citing works

Drug and Gene Delivery to the Brain

Pardridge, W. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01054-1 · Cited by 405 · see citing works

The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

Albini, A., Soldi, R., Giunciuclio, D., Giraudo, E., Benelli, R., Primo, L., Noonan, D. M., Salio, M., Camussi, G., Rock, W., et al. (1996) · Nature Medicine · doi:10.1038/nm1296-1371 · Cited by 380 · see citing works

Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

Dallasta, L. M., Pisarov, L. A., Esplen, J. E., Werley, J., Moses, A. V., Nelson, J. A., & Achim, C. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65511-3 · Cited by 372 · see citing works

Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1

Xiao, H., Neuveut, C., Tiffany, H. L., Benkirane, M., Rich, E. A., Murphy, P. M., & Jeang, K.-T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11466 · Cited by 369 · see citing works

Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrier

Power, C., Kong, P., Crawford, T. O., Wesselingh, S. L., Glass, J. D., McArthur, J. C., & Trapp, B. D. (1993) · Annals of Neurology · doi:10.1002/ana.410340307 · Cited by 335 · see citing works

HIV-1 Tat protein mimicry of chemokines

Albini, A., Ferrini, S., Benelli, R., Sforzini, S., Giunciuglio, D., Aluigi, M. G., Proudfoot, A. E. I., Alouani, S., Wells, T. N. C., Mariani, G., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13153 · Cited by 279 · see citing works

Blood‐brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in postmortem brain

Petito, C. K., & Cash, K. S. (1992) · Annals of Neurology · doi:10.1002/ana.410320509 · Cited by 276 · see citing works

Human immunodeficiency virus type 1 tat activates non—N‐methyl‐ D ‐aspartate excitatory amino acid receptors and causes neurotoxicity

Magnuson, D. S. K., Knudsen, B. E., Geiger, J. D., Brownstone, R. M., & Nath, A. (1995) · Annals of Neurology · doi:10.1002/ana.410370314 · Cited by 275 · see citing works

The Structure and Function of Claudins, Cell Adhesion Molecules at Tight Junctions

Tsukita, S., & Furuse, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05235.x · Cited by 247 · see citing works

Neurobiological aspects of human immunodeficiency virus infection:Neurotoxic mechanisms

Nath, A. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00053-1 · Cited by 226 · see citing works

TAT Peptide Internalization: Seeking the Mechanism of Entry

Vivès, É., Richard, J., Rispal, C., & Lebleu, B. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487306 · Cited by 225 · see citing works

Detection of the human immunodeficiency virus regulatory proteintatin CNS tissues

Hudson, L., Liu, J., Nath, A., Jones, M., Raghavan, R., Narayan, O., Male, D. K., & Everall, I. (2000) · Journal of NeuroVirology · doi:10.3109/13550280009013158 · Cited by 218 · see citing works

HIV‐Tat protein induces oxidative and inflammatory pathways in brain endothelium

Toborek, M. J., Lee, Y. W., Pu, H., Małecki, A., Flora, G., Garrido, R., Hennig, B., Bauer, H., & Nath, A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01543.x · Cited by 208 · see citing works

Calcium Dysregulation and Neuronal Apoptosis by the HIV-1 Proteins Tat and gp120

Haughey, N. J., & Mattson, M. P. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200210012-00005 · Cited by 208 · see citing works

Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells

Liebner, S., Kniesel, U., Kalbacher, H., & Wolburg, H. (2000) · European Journal of Cell Biology · doi:10.1078/0171-9335-00101 · Cited by 204 · see citing works

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells

Ma, M., & Nath, A. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.2495-2499.1997 · Cited by 198 · see citing works

HIV‐1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells

Andras, I. E., Pu, H., Deli, M. A., Nath, A., Hennig, B., & Toborek, M. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10762 · Cited by 189 · see citing works

HIV-1 tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain

Pu, H., Tian, J., Flora, G., Lee, Y. W., Nath, A., Hennig, B., & Toborek, M. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00171-4 · Cited by 179 · see citing works

Regulation of Human Immunodeficiency Virus Type 1 Infectivity by the ERK Mitogen-Activated Protein Kinase Signaling Pathway

Yang, X., & Gabuzda, D. H. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.3460-3466.1999 · Cited by 154 · see citing works

The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

Barillari, G., Sgadari, C., Valeria Fiorelli, A., Samaniego, F., Colombini, S., Manzari, V., Modesti, A., Nair, B. C., Cafaro, A., Stürzl, M., et al. (1999) · PubMed · Cited by 154 · see citing works

Respiratory Syncytial Virus Inhibits Apoptosis and Induces NF-κB Activity through a Phosphatidylinositol 3-Kinase-dependent Pathway

Thomas, K. W., Monick, M. M., Staber, J. M. R., Yarovinsky, T., Carter, A. B., & Hunninghake, G. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108107200 · Cited by 151 · see citing works

Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1–infected patients: competition by HIV-1 Tat

Poggi, A. D., Carosio, R., Fenoglio, D., Brenci, S., Murdaca, G., Setti, M., Indiveri, F., Scabini, S., Ferrero, E., & Zocchi, M. R. (2003) · Blood · doi:10.1182/blood-2003-08-2928 · Cited by 149 · see citing works

Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy

Valle, L. D., Croul, S. E., Morgello, S., Amini, S., Rappaport, J., & Khalili, K. (2000) · Journal of NeuroVirology · doi:10.3109/13550280009015824 · Cited by 146 · see citing works

The diagnostic utility of elevation in cerebrospinal fluid β 2 ‐microglobulin in HIV‐1 dementia

McArthur, J. C., Nance‐Sproson, T. E., Griffin, D. E., Hoover, D. R., Selnes, O. A., Miller, E. N., Margolick, J. B., Cohen, B. A., Farzadegan, H., & Saah, A. J. (1992) · Neurology · doi:10.1212/wnl.42.9.1707 · Cited by 131 · see citing works

Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV‐1‐associated dementia

Boven, L. A., Middel, J., Verhoef, J., Groot, C. J. A. D., & Nottet, H. S. L. M. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00255.x · Cited by 128 · see citing works

HIV-1 Tat Causes Apoptotic Death and Calcium Homeostasis Alterations in Rat Neurons

Bonavia, R., Bajetto, A., Barbero, S., Albini, A., Noonan, D. M., & Schettini, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5743 · Cited by 125 · see citing works

Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C

Lippoldt, A., Liebner, S., Andbjer, B., Kalbacher, H., Wolburg, H., Haller, H. G., & Fuxé, K. (2000) · Neuroreport · doi:10.1097/00001756-200005150-00015 · Cited by 123 · see citing works

Multiple Interactions of HIV-I Tat Protein with Size-defined Heparin Oligosaccharides

Rusnati, M., Tulipano, G., Spillmann, D., Tanghetti, E., Oreste, P., Zoppetti, G., Giacca, M., & Presta, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28198 · Cited by 120 · see citing works

Mechanisms of leukocyte trafficking into the CNS.

Wu, D. T., Woodman, S. E., Weiss, J. M., McManus, C. M., D’Aversa, T. G., Hesselgesser, J., Major, E. O., Nath, A., & Berman, J. W. (2000) · PubMed · Cited by 120 · see citing works

HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells

Kim, T., Avraham, H. K., Koh, Y.-H., Jiang, S., Park, I.-W., & Avraham, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2629 · Cited by 113 · see citing works

Tat–Human Immunodeficiency Virus-1 Induces Human Monocyte Chemotaxis by Activation of Vascular Endothelial Growth Factor Receptor-1

Mitola, S. M. F., Sozzani, S., Luini, W., Primo, L., Borsatti, A., Weich, H. A., & Bussolino, F. (1997) · Blood · doi:10.1182/blood.v90.4.1365 · Cited by 102 · see citing works

Down‐regulation of occludin expression in astrocytes by tumour necrosis factor (TNF) is mediated via TNF type‐1 receptor and nuclear factor‐κB activation

Wachtel, M., Bolliger, M. F., Ishihara, H., Frei, K., Bluethmann, H., & Gloor, S. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00399.x · Cited by 76 · see citing works

Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-d-aspartate receptor

Prendergast, M., Rogers, D. T., Mulholland, P. J., Littleton, J. M., Wilkins, L. H., Self, R. L., & Nath, A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03360-7 · Cited by 76 · see citing works

Extracellular Human Immunodeficiency Virus Type-1 Tat Protein Activates Phosphatidylinositol 3-Kinase in PC12 Neuronal Cells

Milani, D., Mazzoni, M., Borgatti, P., Zauli, G., Cantley, L. C., & Capitani, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.22961 · Cited by 73 · see citing works

HIV-I-associated central nervous system dysfunction

Krebs, F. C., Ross, H. L., McAllister, J., & Wigdahl, B. L. (2000) · Advances in pharmacology · doi:10.1016/s1054-3589(00)49031-9 · Cited by 70 · see citing works

β-Chemokines and human immunodeficiency virus type-1 proteins evoke intracellular calcium increases in human microglia

Hegg, C. C., Hu, S., Peterson, P. K., & Thayer, S. A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00101-9 · Cited by 66 · see citing works

Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells

LEE, Y., Eum, S. Y., Nath, A., & Toborek, M. J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.006 · Cited by 66 · see citing works

Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons

Speth, C., Schabetsberger, T., Mohsenipour, I., Stöckl, G., Würzner, R., Stoiber, H., Lass‐Flörl, C., & Dierich, M. P. (2002) · Journal of Virology · doi:10.1128/jvi.76.7.3179-3188.2002 · Cited by 66 · see citing works

Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction

Giovannoni, G., Miller, R. F., Heales, S., Land, J. M., Harrison, M. J., & Thompson, E. J. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00021-5 · Cited by 64 · see citing works

Identification of Specific Molecular Structures of Human Immunodeficiency Virus Type 1 Tat Relevant for Its Biological Effects on Vascular Endothelial Cells

Mitola, S. M. F., Soldi, R., Zanon, I., Barra, L., Gutiérrez, M. I., Berkhout, B., Giacca, M., & Bussolino, F. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.344-353.2000 · Cited by 64 · see citing works

Ethanol Strongly Potentiates Apoptosis Induced by HIV-1 Proteins in Primary Human Brain Microvascular Endothelial Cells

Acheampong, E. A., Mukhtār, M., Parveen, Z., Ngoubilly, N., Ahmad, N., Patel, C. A., & Pomerantz, R. J. (2002) · Virology · doi:10.1006/viro.2002.1666 · Cited by 63 · see citing works

Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance?

Avison, M. J., Nath, A., & Berger, J. R. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02234-8 · Cited by 59 · see citing works

HIV-1 Tat Protein Stimulates In Vivo Vascular Permeability and Lymphomononuclear Cell Recruitment

Arese, M., Ferrandi, C., Primo, L., Camussi, G., & Bussolino, F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1380 · Cited by 55 · see citing works

HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways

Oshima, T., Flores, S. C., Vaitaitis, G. M., Coe, L. L., Joh, T., Park, J. H., Zhu, Y., Alexander, B., & Alexander, J. S. (2000) · AIDS · doi:10.1097/00002030-200003310-00002 · Cited by 49 · see citing works

Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity

Ansari, S. A., Safak, M., Gallia, G. L., Sawaya, B. E., Amini, S., & Khalili, K. (1999) · Journal of General Virology · doi:10.1099/0022-1317-80-10-2629 · Cited by 46 · see citing works

Activation of Endothelial Cell Mitogen Activated Protein Kinase ERK1/2by Extracellular HIV-1 Tat Protein

Rusnati, M., Urbinati, C., Musulin, B., Ribatti, D., Albini, A., Noonan, D. M., Marchisone, C., Waltenberger, J. L., & Presta, M. (2001) · Endothelium · doi:10.3109/10623320109063158 · Cited by 40 · see citing works

Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurologic disease.

Singer, E. J., Syndulko, K., Fahy-Chandon, B., Schmid, P., Conrad, A. J., & Tourtellotte, W. W. (1994) · PubMed · Cited by 39 · see citing works

Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.

Khan, N. A., Cello, F. D., Nath, A., & Kim, K. S. (2003) · PubMed · doi:10.1080/13550280390218760 · Cited by 30 · see citing works

Human Immunodeficiency Virus Type 1 Tat-Mediated Cytotoxicity of Human Brain Microvascular Endothelial Cells

Khan, N. A., Cello, F. D., Nath, A., & Kim, K. S. (2003) · Journal of NeuroVirology · doi:10.1080/jnv.9.6.584.593 · Cited by 21 · see citing works

AIDS meningoencephalomyelitis. Pathogenesis and changing neuropathologic findings.

Rh, R., & Jm, W. (1991) · PubMed · Cited by 11 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT

Itallie, C. M. V., & Anderson, J. M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.131404 · Cited by 1,123 · see citing works

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922 · see citing works

Crosstalk of tight junction components with signaling pathways

González-Mariscal, L., Tapia, R., & Chamorro, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.018 · Cited by 759 · see citing works

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654 · see citing works

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Takata, F., Nakagawa, S., Matsumoto, J., & Dohgu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.661838 · Cited by 651 · see citing works

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

Cardoso, F. L., Brites, D. M. T. O., & Brito, M. A. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.05.003 · Cited by 573 · see citing works

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777210 · Cited by 516 · see citing works

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

Deli, M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.016 · Cited by 385 · see citing works

Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain Vasculature

Chen, L., Yokel, R. A., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9131-5 · Cited by 295 · see citing works

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 282 · see citing works

Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction

Haorah, J., Knipe, B., Leibhart, J., Ghorpade, A., & Persidsky, Y. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605340 · Cited by 275 · see citing works

Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

Liu, W., Wang, Z., Zhang, L., Wei, X., & Li, L. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00340.x · Cited by 258 · see citing works

HIV-1 gp120 Compromises Blood–Brain Barrier Integrity and Enhance Monocyte Migration across Blood–Brain Barrier: Implication for Viral Neuropathogenesis

Kanmogne, G. D., Schall, K. A., Leibhart, J., Knipe, B., Gendelman, H. E., & Persidsky, Y. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600330 · Cited by 230 · see citing works

Viral disruption of the blood–brain barrier

Spindler, K. R., & Hsu, T.-H. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.03.009 · Cited by 219 · see citing works

Tight Junctions in Brain Barriers During Central Nervous System Inflammation

Coisne, C., & Engelhardt, B. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3929 · Cited by 186 · see citing works

Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

Herkenne, S., Ek, O., Zamberlan, M., Pellattiero, A., Chergova, M., Chivite, Í., Novotná, E., Rigoni, G., Fonseca, T. B., Samardžić, D., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.007 · Cited by 183 · see citing works

Endothelial calcium dynamics, connexin channels and blood–brain barrier function

Bock, M. D., Wang, N., Decrock, E., Bol, M., Gadicherla, A. K., Culot, M., Cecchelli, R., Bultynck, G., & Leybaert, L. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.001 · Cited by 169 · see citing works

The role of claudin-5 in blood-brain barrier (BBB) and brain metastases (Review)

Jia, W., Lu, R., Martin, T. A., & Jiang, W. G. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1875 · Cited by 159 · see citing works

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

Kim, B. J., Hancock, B. M., Bermudez, A., Cid, N. D., Reyes, E., van Sorge, N. M., Lauth, X., Smurthwaite, C. A., Hilton, B. J., Stotland, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74159 · Cited by 145 · see citing works

Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse

Mahajan, S. D., Aalinkeel, R., Sykes, D. E., Reynolds, J. L., Bindukumar, B., Adal, A., Qi, M., Toh, J., Xu, G., Prasad, P. N., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.093 · Cited by 139 · see citing works

NF-κB regulation of endothelial cell function during LPS-induced toxemia and cancer

Kisseleva, T., Li, S., Vorontchikhina, M., Feirt, N. M., Kitajewski, J., & Schindler, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27392 · Cited by 137 · see citing works

TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells

Aslam, M., Ahmad, N., Srivastava, R., & Hemmer, B. (2011) · Cytokine · doi:10.1016/j.cyto.2011.10.016 · Cited by 135 · see citing works

Disruption of the blood brain barrier is vital property of neurotropic viral infection of the central nervous system

Al‐Obaidi, M. M. J., Bahadoran, A., Wang, S., Manikam, R., Raju, C. S., & Sekaran, S. D. (2018) · Acta Virologica · doi:10.4149/av_2018_102 · Cited by 134 · see citing works

Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes

Kiatsurayanon, C., Niyonsaba, F., Smithrithee, R., Akiyama, T., Ushio, H., Hara, M., Okumura, K., Ikeda, S., & Ogawa, H. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.143 · Cited by 126 · see citing works

HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus

Tugizov, S. M., Herrera, R., Chin-Hong, P. V., Veluppillai, P., Greenspan, D., Berry, J. M., Pilcher, C. D., Shiboski, C. H., Jay, N., Rubin, M. M., et al. (2013) · Virology · doi:10.1016/j.virol.2013.08.018 · Cited by 117 · see citing works

Dysfunction of brain pericytes in chronic neuroinflammation

Persidsky, Y., Hill, J., Zhang, M., Dykstra, H., Winfield, M., Reichenbach, N. L., Potula, R., Mukherjee, A., Ramirez, S. H., & Rom, S. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15606149 · Cited by 116 · see citing works

Acquired immunodeficiency syndrome and the blood-brain barrier

Ivey, N., MacLean, A. G., & Lackner, A. A. (2009) · Journal of NeuroVirology · doi:10.1080/13550280902769764 · Cited by 115 · see citing works

Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling

Zhong, Y., Smart, E. J., Weksler, B. B., Couraud, P., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0061-08.2008 · Cited by 111 · see citing works

Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability

Mahajan, S. D., Aalinkeel, R., Sykes, D. E., Reynolds, J. L., Bindukumar, B., Fernandez, S. F., Chawda, R., Shanahan, T., & Schwartz, S. A. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9208-1 · Cited by 109 · see citing works

PPARα and PPARγ attenuate HIV‐induced dysrégulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

Huang, W., Eum, S. Y., Andras, I. E., Hennig, B., & Toborek, M. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-121624 · Cited by 109 · see citing works

HIV-1 Tat: Role in Bystander Toxicity

Ajasin, D., & Eugenin, E. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00061 · Cited by 104 · see citing works

Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood–brain barrier’s tight junction proteins

Manthari, R. K., Tikka, C., Ommati, M. M., Niu, R., Sun, Z., Wang, J., Zhang, J., & Wang, J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2304-y · Cited by 98 · see citing works

Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics

Shah, A. B., Gangwani, M. R., Chaudhari, N. S., Glazyrin, A., Bhat, H. K., & Kumar, A. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9646-0 · Cited by 95 · see citing works

HIV-TAT Protein Upregulates Expression of Multidrug Resistance Protein 1 in the Blood–Brain Barrier

Hayashi, K., Pu, H., Andras, I. E., Eum, S. Y., Yamauchi, A., Hennig, B., & Toborek, M. J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600254 · Cited by 94 · see citing works

Polychlorinated Biphenyls Disrupt Blood–Brain Barrier Integrity and Promote Brain Metastasis Formation

Seelbach, M. J., Chen, L., Powell, A., Choi, Y. J., Zhang, B., Hennig, B., & Toborek, M. J. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901334 · Cited by 94 · see citing works

Central nervous system inflammation in disease related conditions: Mechanistic prospects

Fung, A., Vizcaychipi, M. P., Lloyd, D. G., Wan, Y., & Ma, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.061 · Cited by 93 · see citing works

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

Ellis, R. J., Marquine, M. J., Kaul, M., Fields, J. A., & Schlachetzki, J. C. M. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00879-y · Cited by 98 · see citing works

Transmissible gastroenteritis virus and porcine epidemic diarrhoea virus infection induces dramatic changes in the tight junctions and microfilaments of polarized IPEC-J2 cells

Zhao, S., Gao, J., Zhu, L., & Yang, Q. (2014) · Virus Research · doi:10.1016/j.virusres.2014.08.014 · Cited by 92 · see citing works

HIV-1 neuroimmunity in the era of antiretroviral therapy

Kraft-Terry, S. D., Stothert, A. R., Buch, S. J., & Gendelman, H. E. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.015 · Cited by 89 · see citing works

Adrenomedullin Improves the Blood–Brain Barrier Function Through the Expression of Claudin-5

Honda, M., Nakagawa, S., Hayashi, K., Kitagawa, N., Tsutsumi, K., Nagata, I., & Niwa, M. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9028-x · Cited by 87 · see citing works

Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND

Marino, J., Maubert, M. E., Mele, A. R., Spector, C., Wigdahl, B. L., & Nonnemacher, M. R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03561-4 · Cited by 79 · see citing works

Human immunodeficiency virus–associated neurocognitive disorder

Nath, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05277.x · Cited by 80 · see citing works

HIV-1 Tat Triggers Nuclear Localization of ZO-1 via Rho Signaling and cAMP Response Element-Binding Protein Activation

Zhong, Y., Zhang, B., Eum, S. Y., & Toborek, M. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4266-11.2012 · Cited by 79 · see citing works

Selective Disruption of the Blood–Brain Barrier by Zika Virus

Léda, A. R., Bertrand, L., Andras, I. E., El‐Hage, N., Nair, M., & Toborek, M. J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02158 · Cited by 74 · see citing works

HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells

Mishra, R., & Singh, S. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4796-12.2013 · Cited by 74 · see citing works

HIV and viral protein effects on the blood brain barrier

McRae, M. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1143543 · Cited by 71 · see citing works

Mouse Adenovirus Type 1-Induced Breakdown of the Blood-Brain Barrier

Gralinski, L. E., Ashley, S. L., Dixon, S. D., & Spindler, K. R. (2009) · Journal of Virology · doi:10.1128/jvi.00954-09 · Cited by 70 · see citing works

HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

Leibrand, C. R., Paris, J. J., Ghandour, M. S., Knapp, P. E., Kim, W., Hauser, K. F., & McRae, M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.073 · Cited by 68 · see citing works

Amyloid beta accumulation in HIV‐1‐infected brain: The role of the blood brain barrier

Andras, I. E., & Toborek, M. J. (2012) · IUBMB Life · doi:10.1002/iub.1106 · Cited by 65 · see citing works

Tight junction proteins expression and modulation in immune cells and multiple sclerosis

Mandel, I., Paperna, T., Glass‐Marmor, L., Volkowich, A., Badarny, S., Schwartz, I., Vardi, P., Koren, I., & Miller, A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01380.x · Cited by 63 · see citing works

Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes

Nookala, A. R., & Kumar, A. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0214-3 · Cited by 63 · see citing works

Autophagy is involved in nanoalumina-induced cerebrovascular toxicity

Chen, L., Zhang, B., & Toborek, M. J. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.05.017 · Cited by 63 · see citing works

HIV-Associated Disruption of Tight and Adherens Junctions of Oral Epithelial Cells Facilitates HSV-1 Infection and Spread

Sufiawati, I., & Tugizov, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088803 · Cited by 64 · see citing works

Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier

Yang, R., Liu, W.-T., Miao, L., Yang, X., Fu, J., Dou, B., Cai, A., Zong, X., Tan, C., Chen, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11696 · Cited by 62 · see citing works

Human immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease

Tugizov, S. M. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1159276 · Cited by 62 · see citing works

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF

Dohgu, S., Fleegal, M. A., & Banks, W. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-167 · Cited by 60 · see citing works

Intact Lipid Rafts Regulate HIV-1 Tat Protein-Induced Activation of the Rho Signaling and Upregulation of P-Glycoprotein in Brain Endothelial Cells

Zhong, Y., Hennig, B., & Toborek, M. J. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.214 · Cited by 59 · see citing works

Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway

Yu, L., Gan, X., Liu, X., & An, R. (2017) · Renal Failure · doi:10.1080/0886022x.2017.1305968 · Cited by 59 · see citing works

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction

Jones, L. D., Jackson, J. W., & Maggirwar, S. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151702 · Cited by 57 · see citing works

Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases

Salimi, H., & Klein, R. S. (2019) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-19515-1_7 · Cited by 54 · see citing works

HIV and Alzheimer’s disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein

Hategan, A. P., Masliah, E., & Nath, A. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00736-z · Cited by 52 · see citing works

Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network

Springler, A., Hessenberger, S., Schatzmayr, G., & Mayer, E. (2016) · Toxins · doi:10.3390/toxins8090264 · Cited by 51 · see citing works

Extracellular Vesicles: A Possible Link between HIV and Alzheimer’s Disease-Like Pathology in HIV Subjects?

Kodidela, S., Gerth, K. A., Haque, S., Gong, Y., Ismael, S., Singh, A. K., Ishrat, T., & Kumar, S. (2019) · Cells · doi:10.3390/cells8090968 · Cited by 50 · see citing works

HIV-1/Cocaine Induced Oxidative Stress Disrupts Tight Junction Protein-1 in Human Pulmonary Microvascular Endothelial Cells: Role of Ras/ERK1/2 Pathway

Dalvi, P., Wang, K., Mermis, J. D., Zeng, R., Sanderson, M., Johnson, S. H., Dai, Y., Sharma, G., O'Brien-Ladner, A. R., & Dhillon, N. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085246 · Cited by 47 · see citing works

Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood–brain barrier

Pu, H., Hayashi, K., Andras, I. E., Eum, S. Y., Hennig, B., & Toborek, M. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.063 · Cited by 48 · see citing works

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway

Dohgu, S., & Banks, W. A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.12.028 · Cited by 46 · see citing works

Methamphetamine Alters Blood Brain Barrier Protein Expression in Mice, Facilitating Central Nervous System Infection by Neurotropic Cryptococcus neoformans

Eugenin, E. A., Greco, J. M., Frases, S., Nosanchuk, J. D., & Martinez, L. R. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit117 · Cited by 45 · see citing works

Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen receptor alpha and beta

Burek, M., Steinberg, K., & Förster, C. Y. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.05.003 · Cited by 45 · see citing works

Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging

Zhao, X., Fan, Y., Vann, P. H., Wong Jessica, M., Sumien, N., & He, J. J. (2020) · Aging and Disease · doi:10.14336/ad.2019.0323 · Cited by 43 · see citing works

Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND

Marino, J., Wigdahl, B. L., & Nonnemacher, M. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00168 · Cited by 43 · see citing works

HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

Andras, I. E., & Toborek, M. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_26 · Cited by 41 · see citing works

Cross‐talk between STAT1 and PI3K/AKT signaling in HIV‐1‐induced blood–brain barrier dysfunction: Role of CCR5 and implications for viral neuropathogenesis

Yang, B. Y., Singh, S., Bressani, R., & Kanmogne, G. D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22458 · Cited by 39 · see citing works

Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke

Shin, J. A., Kim, Y. A., Jeong, S. I., Lee, K.-E., Kim, H.-S., & Park, E. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0632-5 · Cited by 38 · see citing works

Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy

Wang, N., Sun, P., Lv, M., Tong, G., Jin, X., & Zhu, X. (2017) · Biomaterials Science · doi:10.1039/c7bm00133a · Cited by 37 · see citing works

Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders

Omeragic, A., Kayode, O., Hoque, M. T., & Bendayan, R. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00204-5 · Cited by 37 · see citing works

HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity

Leibrand, C. R., Paris, J. J., Jones, A. M., Masuda, Q. N., Halquist, M. S., Kim, W., Knapp, P. E., Kashuba, A. D. M., Hauser, K. F., & McRae, M. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00757-8 · Cited by 35 · see citing works

A Protein Kinase A-Dependent Mechanism by Which Rotavirus Affects the Distribution and mRNA Level of the Functional Tight Junction-Associated Protein, Occludin, in Human Differentiated Intestinal Caco-2 Cells

Beau, I., Cotte-Laffitte, J., Amsellem, R., & Servin, A. L. (2007) · Journal of Virology · doi:10.1128/jvi.00263-07 · Cited by 33 · see citing works

Claudins in viral infection: from entry to spread

Colpitts, C. C., & Baumert, T. F. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1908-4 · Cited by 31 · see citing works

Claudin 5 Across the Vascular Landscape: From Blood–Tissue Barrier Regulation to Disease Mechanisms

Selim, M. S., Matani, B. R., Henry-Ojo, H. O., Narayanan, S. P., & Somanath, P. R. (2025) · Cells · doi:10.3390/cells14171346 · Cited by 33 · see citing works

An insight into the ligand–receptor interactions involved in the translocation of pathogens across blood–brain barrier

Bencúrová, E., Mlynárčik, P., & Bhide, M. R. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00867.x · Cited by 28 · see citing works

Treponema pallidum Tp0751 alters the expression of tight junction proteins by promoting bEnd3 cell apoptosis and IL-6 secretion

Lu, S., Wang, J., He, Z., He, S., Zheng, K., Xu, M., Yuan, S. S., & Wu, Y. (2022) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2022.151553 · Cited by 26 · see citing works

Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins

Cooper, I., Sasson, K., Teichberg, V. I., Beeri, M. S., Fridkin, M., & Shechter, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.395384 · Cited by 26 · see citing works

Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins

Luo, D., Zhao, J., & Rong, J. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.006 · Cited by 26 · see citing works

HIV-1 Establishes a Sanctuary Site in the Testis by Permeating the BTB Through Changes in Cytoskeletal Organization

Wu, S., Frank, I., Derby, N. R., Martinelli, E., & Cheng, C. Y. (2021) · Endocrinology · doi:10.1210/endocr/bqab156 · Cited by 25 · see citing works

Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins

Sun, Y., Cai, M., Liang, Y., & Zhang, Y. (2023) · Journal of NeuroVirology · doi:10.1007/s13365-023-01179-3 · Cited by 23 · see citing works

Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor‐2: Involvement in HIV‐Associated Pulmonary Vascular Remodeling

Chinnappan, M., Mohan, A., Agarwal, S., Dalvi, P., & Dhillon, N. K. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008472 · Cited by 22 · see citing works

Cenicriviroc prevents dysregulation of astrocyte/endothelial cross talk induced by ischemia and HIV-1 via inhibiting the NLRP3 inflammasome and pyroptosis

Fattakhov, N. S., Ngo, A., Torices, S., Joseph, J.-A., Okoro, A., Moore, C., Naranjo, O., Becker, S., & Toborek, M. J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00600.2023 · Cited by 22 · see citing works

Overcoming Blood-Brain Barrier Resistance: Implications for Extracellular Vesicle-Mediated Drug Brain Delivery

Dardet, J. P., Serrano, N., Andras, I. E., & Toborek, M. J. (2022) · Frontiers in Drug Delivery · doi:10.3389/fddev.2022.855017 · Cited by 20 · see citing works

HIV-1, HCV and Alcohol in the CNS: Potential Interactions and Effects on Neuroinflammation

Silverstein, P. S., Kumar, S., & Kumar, A. (2014) · Current HIV Research · doi:10.2174/1570162x12666140721122956 · Cited by 20 · see citing works

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits

Chen, L., Choi, J. J., Choi, Y. J., Hennig, B., & Toborek, M. J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.004 · Cited by 20 · see citing works

Virus replication and disease progression inversely correlate with SIV tat evolution in morphine-dependent and SIV/SHIV-infected Indian rhesus macaques

Noel, R. J., & Kumar, A. (2005) · Virology · doi:10.1016/j.virol.2005.10.026 · Cited by 18 · see citing works

The Breakdown of Neurovascular Barriers: Molecular Mechanisms of Tight Junction Dysfunction

Gopal, S. S., Kaur, M., Lanzkron, S., & Srivastava, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05592-z · Cited by 19 · see citing works

The protective effect of gastrodin against the synergistic effect of HIV-Tat protein and METH on the blood–brain barrier via glucose transporter 1 and glucose transporter 3

Li, J., Huang, J. A., He, Y., Wang, W., Leung, C., Zhang, D., Zhang, R., Wang, S., Li, Y., Liu, L., et al. (2020) · Toxicology Research · doi:10.1093/toxres/tfaa102 · Cited by 17 · see citing works

Construction of biomimetic long-circulation delivery platform encapsulated by zwitterionic polymers for enhanced penetration of blood–brain barrier

Wang, N., Jin, X., & Zhu, X. (2017) · RSC Advances · doi:10.1039/c7ra01532a · Cited by 18 · see citing works

Claudins and pathogenesis of viral infection

Tawar, R. G., Colpitts, C. C., Lupberger, J., Saghire, H. E., Zeisel, M. B., & Baumert, T. F. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.04.011 · Cited by 18 · see citing works

Human Immunodeficiency Virus (HIV) and Human Cytomegalovirus (HCMV) Coinfection of Infant Tonsil Epithelium May Synergistically Promote both HIV-1 and HCMV Spread and Infection

Sufiawati, I., Herrera, R., Wasima, M., Cai, X., Borkakoti, J., Lin, V., Rosbe, K. W., & Tugizov, S. M. (2021) · Journal of Virology · doi:10.1128/jvi.00921-21 · Cited by 18 · see citing works

The Rare Marine Bioactive Compounds in Neurological Disorders and Diseases: Is the Blood-Brain Barrier an Obstacle or a Target?

Diao, X., Han, H., Li, B., Guo, Z., Fu, J. F., & Wu, W. (2023) · Marine Drugs · doi:10.3390/md21070406 · Cited by 18 · see citing works

Absence of Tight Junctions between Microvascular Endothelial Cells in Human Cerebellar Hemangioblastomas

Chen, Y., Tachibana, O., Hasegawa, M., Xu, R., Hamada, J.-I., Yamashita, J., Hashimoto, N., & Takahashi, J. A. (2006) · Neurosurgery · doi:10.1227/01.neu.0000223372.18607.d7 · Cited by 16 · see citing works

Hippocampal blood–brain barrier of methamphetamine self‐administering HIV‐1 transgenic rats

Ohene‐Nyako, M., Persons, A. L., & Napier, T. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14925 · Cited by 16 · see citing works

HIV‐1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells

Andras, I. E., Pu, H., Deli, M. A., Nath, A., Hennig, B., & Toborek, M. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10762 · Cited by 189 · see citing works

Rho signaling is involved in HIV‐1 Tat‐induced dysfunction of brain endothelial cells and alterations of claudin‐5 expression

Zhong, Y., Couraud, P., Hennig, B., & Toborek, M. J. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.734.12

Rho signaling is involved in HIV‐1 Tat‐induced tight junction protein ZO‐1 translocation and alterations of claudin‐5 expression in brain endothelial cells

Zhong, Y., Hennig, B., & Toborek, M. J. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.867.6

HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

Andras, I. E., & Toborek, M. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_26 · Cited by 41 · see citing works

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

Xu, R., Feng, X., Xie, X., Zhang, J., Wu, D., & Xu, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.052 · Cited by 138 · see citing works