The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Control of cell selectivity of antimicrobial peptides
Open accessAbstract
Antimicrobial peptides (AMPs) are promising novel antibiotics, because they exhibit broad antimicrobial spectra and do not easily induce resistance. For clinical applications, it is important to develop potent AMPs with less toxicity against host cells. This review article summarizes the molecular basis for the cell selectivity (bacteria versus host cells) of AMPs and various attempts to control it, including the optimization of physicochemical parameters of peptides, the introduction of D-, fluorinated, and unusual amino acids into peptides, the constraining of peptide conformations, and the modification of peptides by polymers. Pros and cons of these approaches are discussed.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431
Melittin Interaction with Sulfated Cell Surface Sugars
Klocek, G., & Seelig, J. (2008) · Biochemistry · doi:10.1021/bi702258z · Cited by 60
Cited by
Jennings, M. C., Minbiole, K. P. C., & Wuest, W. M. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00047 · Cited by 651
Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, P. R., & Svenson, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69995-9 · Cited by 441
Antimicrobial Peptides: An Update on Classifications and Databases
Bin Hafeez, A., Jiang, X., Bergen, P. J., & Zhu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111691 · Cited by 341
Recurrent Neural Network Model for Constructive Peptide Design
Müller, A. T., Hiss, J. A., & Schneider, G. (2018) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.7b00414 · Cited by 270
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.016 · Cited by 267
Metadata
- Authors
- Matsuzaki, K.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 1788
- Issue
- 8
- Pages
- 1687-1692
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2009106357
- Cited by
- 713
- References
- 3
- FWCI
- 18.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsuzaki, K. (2009). Control of cell selectivity of antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes. https://doi.org/10.1016/j.bbamem.2008.09.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
