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The blood-brain barrier in brain homeostasis and neurological diseases
Open accessAbstract
Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally. They form the blood-brain-barrier (BBB) which strictly controls the exchanges between the blood and the brain compartments by limiting passive diffusion of blood-borne solutes while actively transporting nutrients to the brain. Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases with important social impacts, such as multiple sclerosis, stroke, brain tumors, epilepsy or Alzheimer's disease. This review will focus on the implication of brain endothelial tight junctions in BBB architecture and physiology, will discuss the consequences of BBB dysfunction in these CNS diseases and will present some therapeutic strategies for drug delivery to the brain across the BBB.
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“Integrity of the BBB can be compromised because of exposures to certain toxicants, such as pesticides, mixed vehicle emissions, and tobacco smoke, as well as certain health conditions including diabetes and neurological disorders reviewed in Neurotoxicity of PFAS in Sensitive Populations, through molecular alterations in barrier function (Gupta et al., 1999; Weiss et al., 2009; Mazzone et al., 201”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“PFAS exposure could be more hazardous for individuals with pre-existing neurological conditions or a predisposition for these diseases”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Many neurological conditions, including Alzheimer’s disease (AD), Parkinson’s Disease (PD), multiple sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Huntington’s disease, and brain tumors, confer heightened damage by PFAS and other toxicants by functionally compromising the BBB”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
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In the citing paper
“The experiment demonstrated the remarkably high capability of the tested phytocompounds in crossing the BBB, with asiaticoside showing the highest permeability, followed by madecassoside. Notably, the compounds also showed higher permeability coefficient values than donepezil, a drug commonly used for AD. 43”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [43]
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In the citing paper
“In the same study using primary porcine brain endothelial cells, asiaticoside and madecassoside were proved to be efficient in crossing the BBB at a high rate without exerting any toxic effects, and while preserving the BBB tight junction integrity, making them desirable neurotherapeutics.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [43]
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“In the aforementioned study by Hanapi et al., 43 madecassoside, in particular, was observed to protect PBECs against H2O2‐induced oxidative stress.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [43]
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Items 201–244 of 244
Interferon Beta Promotes Nerve Growth Factor Secretion Early in the Course of Multiple Sclerosis
Biernacki, K., Antel, J. P., Blain, M., Narayanan, S., Arnold, D. L., & Prat, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.4.563 · Cited by 91
Lou, J., Gasche, Y., Zheng, L., et al. (1999) · PubMed · Cited by 89
Doulet, N., Donnadieu, E., Laran‐Chich, M., Niedergang, F., Nassif, X., Couraud, P. O., & Bourdoulous, S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507128 · Cited by 89
Self-citationWashington, C. B., WILTSHIRE, H. R., Man, M., et al. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15186-0 · Cited by 89
Pharmacological Modification of Bradykinin Induced Breakdown of the Blood-brain Barrier
Raymond, J. J., Robertson, D. M., & Dinsdale, H. B. (1986) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100036301 · Cited by 87
The Blood-Brain Barrier and Brain Drug Delivery
Koziara, J. M., Lockman, P. R., Allen, D. D., & Mumper, R. J. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.441 · Cited by 86
Zloković, B. V., Mačkić, J. B., Djuričić, B., & Davson, H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb08522.x · Cited by 85
Magnetic Resonance Imaging of Human Brain Macrophage Infiltration
Petry, K. G., Boiziau, C., Dousset, V., & Brochet, B. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.005 · Cited by 84
Migration and Multipotentiality of PSA-NCAM+ Neural Precursors Transplanted in the Developing Brain
Vitry, S., Avellana‐Adalid, V., Lachapelle, F., et al. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.0987 · Cited by 77
Romero, I. A., Prévost, M., Perret, E., Adamson, P., Greenwood, J., Couraud, P., & Ozden, S. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6021-6030.2000 · Cited by 77
Self-citationLeukocyte trans-endothelial migration: JAMs add new pieces to the puzzle.
Chavakis, T., Preissner, K. T., & Santoso, S. (2003) · PubMed · doi:10.1267/thro03010013 · Cited by 77
Viegas, P., Chaverot, N., Enslen, H., Perrière, N., Couraud, P., & Cazaubon, S. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03222 · Cited by 73
Self-citationMinagar, A., Ostanin, D. V., Long, A. C., Jennings, M. H., Kelley, R. E., Sasaki, M., & Alexander, J. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms916oa · Cited by 73
Martel, C. L., Mackic, J. B., McComb, J. G., Ghiso, J., & Zlokovic, B. V. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12462-9 · Cited by 69
A new model of the blood–brain barrier
Stanness, K. A., Neumaier, J. F., Sexton, T. J., et al. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00001 · Cited by 69
Rampon, C., Weiss, N., Deboux, C., Chaverot, N., Miller, F., Buchet, D., Tricoire-Leignel, H., Cazaubon, S. M., Evercooren, A. B., & Couraud, P. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0122 · Cited by 66
Self-citationEstablishment of the Permanent Microvascular Endothelial Cell Line PBMEC/C1-2 from Porcine Brains
Teifel, M., & Friedl, P. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0298 · Cited by 65
Role of ABC Transporters in the Chemoresistance of Human Gliomas
Decleves, X., Amiel, A., Delattre, J.-Y., & Scherrmann, J.-M. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906777723930 · Cited by 65
The transcellular railway: insights into leukocyte diapedesis
Dejana, E. (2006) · Nature Cell Biology · doi:10.1038/ncb0206-105 · Cited by 61
López‐Atalaya, J. P., Roussel, B. D., Ali, C., et al. (2007) · Stroke · doi:10.1161/01.str.0000258100.04923.84 · Cited by 60
Central action sites of interleukin‐1 beta for inducing fever in rabbits.
Murakami, N., Sakata, Y., & Watanabe, T. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018213 · Cited by 60
Brain-metastatic melanoma: a neurotrophic perspective
Marchetti, D., Denkins, Y. M., Reiland, J., Greiter‐Wilke, A., Galjour, J., Murry, B. P., Blust, J., & Roy, M. (2003) · Pathology & Oncology Research · doi:10.1007/bf03033729 · Cited by 56
Dore-Duffy, P., Washington, R., & Dragovic, L. (1993) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-2920-0_38 · Cited by 52
Blasig, I. E., Giese, H., Schroeter, M. L., Sporbert, A., Utepbergenov, D., Buchwalow, I., Neubert, K., Schönfelder, G., Freyer, D., Schimke, I., et al. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2318 · Cited by 50
Buckwalter, M. S., Coleman, B. S., Buttini, M., Barbour, R., Schenk, D., Games, D., Seubert, P. A., & Wyss‐Coray, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2436-06.2006 · Cited by 48
Neutral amino acid uptake by the isolated perfused sheep choroid plexus.
Preston, J. E., Segal, M. B., WALLEY, G. J., et al. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017444 · Cited by 43
Mechanisms of tumor cell invasion and angiogenesis in the central nervous system
Bjerkvig, R. (2003) · Frontiers in bioscience · doi:10.2741/1026 · Cited by 42
Durieu-Trautmann, O., Chaverot, N., Perdomo, J. J., Gounon, P., Strosberg, A. D., & Couraud, P. (1991) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631242 · Cited by 42
Self-citationVerbeek, M. M., Otte‐Höller, I., Wesseling, P., Ruiter, D. J., & de Waal, R. M. W. (1996) · Acta Neuropathologica · doi:10.1007/s004010050474 · Cited by 38
Giraudon, P., Vernant, J. C., Confavreux, C., et al. (1998) · Neurology · doi:10.1212/wnl.50.6.1920 · Cited by 36
Glioblastoma multiforme: evidence-based approach to therapy
Nicholas, M. K. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.12s.s23 · Cited by 35
Implications of the blood–brain barrier in primary central nervous system lymphoma
Jahnke, K., Doolittle, N. D., Muldoon, L. L., & Neuwelt, E. A. (2006) · Neurosurgical FOCUS · doi:10.3171/foc.2006.21.5.12 · Cited by 31
The search for a curative cell therapy in Parkinson's disease
Goya, R. L., Tyers, P., & Barker, R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.09.006 · Cited by 31
Stuertz, K., Merx, I., Eiffert, H., et al. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.8.2346-2348.1998 · Cited by 26
Ichiyama, T., Hayashi, T., Nishikawa, M., et al. (1997) · Clinical Infectious Diseases · doi:10.1086/516909 · Cited by 25
Aschner, M., Fitsanakis, V. A., dos Santos, A. P. M., et al. (2006) · Humana Press eBooks · doi:10.1385/1-59745-113-4:1 · Cited by 24
Nonpermeable and Permeable Vessels of the Brain
Brightman, M., & Kadota, Y. (1992) · PsycEXTRA Dataset · doi:10.1037/e496142006-009 · Cited by 22
Xu, C. R., Yusuf‐Makagiansar, H., Hu, Y., et al. (2002) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2002.10506785 · Cited by 21
Erdlenbruch, B., Kugler, W., Schinkhof, C., Neurath, H., Eibl, H., & Lakomek, M. (2005) · Journal of drug targeting · doi:10.1080/10611860400029085 · Cited by 18
Trojano, M., Defazio, G., Avolio, C., et al. (2000) · PubMed · Cited by 18
Lassmann, H., Schwerer, B., Kitz, K., et al. (1983) · Progress in brain research · doi:10.1016/s0079-6123(08)63875-3 · Cited by 17
Stem cell transplantation in multiple sclerosis: multiple choices and multiple challengesy
Hintzen, R. Q. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms789oa · Cited by 17
Bone marrow transplantation: Does it stop MS progression?
Freedman, M. S. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.10.023 · Cited by 17
Kordower (1999) · doi:10.1002/1531-8249(199909)46:3
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Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962
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Pandit, R., Chen, L., & Götz, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.11.009 · Cited by 651
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Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496
Sankowski, R., Mader, S., & Valdés-Ferrer, S. I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00028 · Cited by 351
Schwartz, M., & Baruch, K. (2014) · The EMBO Journal · doi:10.1002/embj.201386609 · Cited by 349
Metadata
- Authors
- Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Couraud, Pierre-Olivier
- ORCID
- Weiss, Nicolas
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 1788
- Issue
- 4
- Pages
- 842-857
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W1992883702
- Cited by
- 731
- References
- 244
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 37 · 2023: 36 · 2022: 62 · 2021: 61 · 2020: 54 · 2019: 42 · 2018: 48 · 2017: 58 · 2016: 56 · 2015: 31 · 2014: 41 · 2013: 45 · 2012: 40
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- blood-brain barrier, brain endothelial cells, tight junctions, apical junctional complex, BBB dysfunction, brain homeostasis, multiple sclerosis, stroke, brain tumors, epilepsy, Alzheimer's disease, central nervous system disorders, brain drug delivery
- MeSH terms
- Blood-Brain Barrier, Brain, Cell Movement, Homeostasis, Humans, Leukocytes, Meningitis, Viral, Multiple Sclerosis, Nervous System Diseases, Permeability, Meningitis, Bacterial, Tight Junctions, Neurodegenerative Diseases, Stroke, Endothelial Cells
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