Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Abstract
It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut-brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Proinflammatory miRNA-34a is up regulated, causing downregulation of TREM-2, which can cause deposition of Aβ-42 peptide.
“As a result, proinflammatory miRNA-34a is up regulated, causing downregulation of TREM-2 (trigger receptor expressed in microglial/myeloid cell-2), which can cause deposition of Aβ-42 peptide [25].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [25]
Cites
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · see citing works
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40074j · Cited by 1,734 · see citing works
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Ehrnhoefer, D. E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Pastore, A., & Wanker, E. (2008) · Nature Structural &Molecular Biology · doi:10.1038/nsmb.1437 · Cited by 1,424 · see citing works
Microbes in Gastrointestinal Health and Disease
Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,388 · see citing works
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241 · see citing works
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083 · see citing works
Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076 · see citing works
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
Bieschke, J., Russ, J., Friedrich, R., Ehrnhoefer, D. E., Wobst, H. J., Neugebauer, K., & Wanker, E. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0910723107 · Cited by 986 · see citing works
Microbiota and diabetes: an evolving relationship
Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853 · see citing works
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828 · see citing works
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750 · see citing works
The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works
Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
Lee, H. C., Jenner, A. M., Low, C. S., & Lee, Y. K. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.07.004 · Cited by 697 · see citing works
Interactions of gut microbiota with functional food components and nutraceuticals
Laparra, J. M., & Sanz, Y. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.001 · Cited by 684 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Review article: dietary fibre-microbiota interactions
Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602 · see citing works
The gut microbiota, obesity and insulin resistance
Shen, J., Obin, M. S., & Zhao, L. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.11.001 · Cited by 599 · see citing works
Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592 · see citing works
Antibiotics, Pediatric Dysbiosis, and Disease
Vangay, P., Ward, T., Gerber, J. S., & Knights, D. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.006 · Cited by 531 · see citing works
Infant antibiotic exposures and early-life body mass
Trasande, L., Blustein, J., Liu, M., Corwin, E. J., Cox, L. M., & Blaser, M. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.132 · Cited by 503 · see citing works
A Unifying Role for Prions in Neurodegenerative Diseases
Prusiner, S. B. (2012) · Science · doi:10.1126/science.1222951 · Cited by 495 · see citing works
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · see citing works
Brain metabolic dysfunction at the core of Alzheimer's disease
de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 462 · see citing works
Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
Calder, P. C. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700289 · Cited by 457 · see citing works
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 377 · see citing works
Neurodegenerative Diseases: Expanding the Prion Concept
Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361 · see citing works
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 354 · see citing works
Park, J., Lee, B. K., Jeong, G. S., Hyun, J. K., Lee, C. J., & Lee, S. (2014) · Lab on a Chip · doi:10.1039/c4lc00962b · Cited by 351 · see citing works
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338 · see citing works
Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease
Pablo, J. P., Banack, S. A., Cox, P. A., Johnson, T. E., Papapetropoulos, S., Bradley, W. G., Buck, A., & Mash, D. C. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01150.x · Cited by 333 · see citing works
Diversity, biogenesis and function of microbial amyloids
Blanco, L. P., Evans, M. L., Smith, D. R., Badtke, M. P., & Chapman, M. R. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2011.11.005 · Cited by 320 · see citing works
Age-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320 · see citing works
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 314 · see citing works
The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages
Zhang, J., Wu, Y., Zhang, Y., LeRoith, D., Bernlohr, D., & Chen, X. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0420 · Cited by 302 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288 · see citing works
Bastianetto, S., Yao, Z., Papadopoulos, V., & Quirion, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04532.x · Cited by 283 · see citing works
Gut microbiota and gastrointestinal health: current concepts and future directions
Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12046 · Cited by 280 · see citing works
Blood–brain-barriers in aging and in Alzheimer’s disease
Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 273 · see citing works
Gut microorganisms as promising targets for the management of type 2 diabetes
Delzenne, N. M., Cani, P. D., Everard, A., Neyrinck, A. M., & Bindels, L. B. (2015) · Diabetologia · doi:10.1007/s00125-015-3712-7 · Cited by 264 · see citing works
Insulin resistance predicts brain amyloid deposition in late middle‐aged adults
Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J. M., Statz, E. H., Hermann, B. P., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.03.011 · Cited by 262 · see citing works
Abuznait, A. H., Qosa, H., Busnena, B. A., Sayed, K. A. E., & Kaddoumi, A. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400024q · Cited by 261 · see citing works
(2012) · PubMed Central · Cited by 248 · see citing works
Shoemark, D. K., & Allen, S. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141170 · Cited by 248 · see citing works
Alzheimer's disease and the microbiome
Bhattacharjee, S., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00153 · Cited by 248 · see citing works
U.S. Outpatient Antibiotic Prescribing, 2010
Hicks, L. A., Taylor, T. H., & Hunkler, R. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1212055 · Cited by 247 · see citing works
New Technologies for Studying Biofilms
Franklin, M. J., Chang, C. B., Akiyama, T., & Bothner, B. B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mb-0016-2014 · Cited by 238 · see citing works
Stecher, B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0008-2014 · Cited by 235 · see citing works
Microbiota and the gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv019 · Cited by 234 · see citing works
Zhang, J., Ke, K.-F., Liu, Z., Qiu, Y.-H., & Peng, Y.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075786 · Cited by 231 · see citing works
Delzenne, N. M., Neyrinck, A. M., & Cani, P. D. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s10 · Cited by 231 · see citing works
Microbiome disturbances and autism spectrum disorders
Rosenfeld, C. S. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063826 · Cited by 229 · see citing works
Wang, I. ‐., Wu, Y. Y., Yang, Y., Ting, I., Lin, C. C., Yen, T., Chen, J.-H., Wang, C., Huang, C.-F., & Lin, H. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0088 · Cited by 223 · see citing works
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220 · see citing works
Morales, R., Moreno‐González, I., & Soto, C. A. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003537 · Cited by 220 · see citing works
Urieli-Shoval, S., Cohen, P., Eisenberg, S., & Matzner, Y. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804601206 · Cited by 219 · see citing works
Transmissible Proteins: Expanding the Prion Heresy
Soto, C. A. (2012) · Cell · doi:10.1016/j.cell.2012.05.007 · Cited by 210 · see citing works
Fernando, W. M. A. D. B., Martins, I. J., Goozee, K. G., Brennan, C. S., Jayasena, V., & Martins, R. N. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001452 · Cited by 198 · see citing works
John, S., Luben, R., Shrestha, S. S., Welch, A. A., Khaw, K., & Hart, A. R. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283352d05 · Cited by 184 · see citing works
Hultman, K., Strickland, S., & Norris, E. H. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.76 · Cited by 183 · see citing works
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180 · see citing works
Daubioul, C., Rousseau, N., Taper, H. S., Declerck, B., Delzenne, N. M., Demeure, R., & Gallez, B. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.967 · Cited by 178 · see citing works
Microbial amyloids – functions and interactions within the host
Schwartz, K., & Boles, B. R. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.12.001 · Cited by 174 · see citing works
Microbial-generated amyloids and Alzheimer's disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00009 · Cited by 173 · see citing works
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease
Paula‐Lima, A. C., Brito‐Moreira, J., & Ferreira, S. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12304 · Cited by 170 · see citing works
Higher normal fasting plasma glucose is associated with hippocampal atrophy
Cherbuin, N., Sachdev, P. S., & Anstey, K. J. (2012) · Neurology · doi:10.1212/wnl.0b013e31826846de · Cited by 170 · see citing works
Rhee, S. H. (2014) · Intestinal Research · doi:10.5217/ir.2014.12.2.90 · Cited by 162 · see citing works
Impaired glycemia increases disease progression in mild cognitive impairment
Morris, J. K., Vidoni, E. D., Honea, R. A., & Burns, J. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.033 · Cited by 157 · see citing works
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals
Berti, V., Murray, J., Davies, M., Spector, N. C., Tsui, W. H., Li, Y., Williams, S. K., Pirraglia, E., Vallabhajosula, S., McHugh, P. F., et al. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0534-0 · Cited by 152 · see citing works
NMDA Receptor Activity in Neuropsychiatric Disorders
Lakhan, S. E., Caro, M. A., & Hadzimichalis, N. M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00052 · Cited by 152 · see citing works
Tomasik, J., Yolken, R. H., Bahn, S., & Dickerson, F. (2015) · Biomarker Insights · doi:10.4137/bmi.s22007 · Cited by 152 · see citing works
Cardiovascular Risk Factors for Alzheimer's Disease
Rosendorff, C., Beeri, M. S., & Silverman, J. M. (2007) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2007.06696.x · Cited by 151 · see citing works
Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).
Zhao, Y., & Lukiw, W. J. (2015) · PubMed · Cited by 149 · see citing works
Qosa, H., Abuasal, B. S., Romero, I. A., Weksler, B., Couraud, P.-O., Keller, J. N., & Kaddoumi, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.023 · Cited by 146 · see citing works
The effects of gut microbiota on CNS function in humans
Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144 · see citing works
Functional amyloid formation by Streptococcus mutans
Oli, M. W., Otoo, H. N., Crowley, P. J., Heim, K. P., Nascimento, M. M., Ramsook, C. B., Lipke, P. N., & Brady, L. J. (2012) · Microbiology · doi:10.1099/mic.0.060855-0 · Cited by 144 · see citing works
Daulatzai, M. A. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1266-6 · Cited by 141 · see citing works
Zloković, B. V. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00310-4 · Cited by 138 · see citing works
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
Mitew, S., Kirkcaldie, M. T. K., Dickson, T. C., & Vickers, J. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.010 · Cited by 138 · see citing works
The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness
Hornig, M. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32836208de · Cited by 138 · see citing works
Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)
P, Z. Y. D. (2015) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000177 · Cited by 137 · see citing works
Esteve, E., Ricart, W., & Fernández-Real, J.-M. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328348c06d · Cited by 133 · see citing works
Amyloidogenic potential of foie gras
Solomon, A., Richey, T., Murphy, C. L., Weiss, D. T., Wall, J. S., Westermark, G. T., & Westermark, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700848104 · Cited by 132 · see citing works
Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-β and α-Synuclein Fibrils
Grelle, G., Otto, A., Lorenz, M., Frank, R. F., Wanker, E. E., & Bieschke, J. (2011) · Biochemistry · doi:10.1021/bi2012383 · Cited by 130 · see citing works
Eun, C. S., Mishima, Y., Wohlgemuth, S., Liu, B., Bower, M., Carroll, I. M., & Sartor, R. B. (2014) · Infection and Immunity · doi:10.1128/iai.01513-13 · Cited by 124 · see citing works
Probiotics, prebiotics, and the host microbiome: the science of translation
Petschow, B., Doré, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., Cani, P. D., Degnan, F. H., Foster, J., Gibson, G., et al. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12303 · Cited by 124 · see citing works
Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.
Liu, Y.-Q., Pukala, T., Musgrave, I., Williams, D. M., Dehle, F., & Carver, J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.09.071 · Cited by 121 · see citing works
An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases
Lorente‐Cebrián, S., Costa, A. G. V., Navas‐Carretero, S., Zabala, M., Laiglesia, L. M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0395-y · Cited by 120 · see citing works
Wang, Y., Xia, Z., Xu, J., Wang, Y., Hou, L., Qiu, Y. L., & Chen, H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.016 · Cited by 119 · see citing works
Platten, F., Jeworrek, C., Tiemeyer, S., Weise, K., Sellin, D., Paulus, M., Struth, B., Tolan, M., & Winter, R. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8097417 · Cited by 114 · see citing works
Is Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions?
Carlino, D., Vanna, M. D., & Tongiorgi, E. (2012) · The Neuroscientist · doi:10.1177/1073858412469444 · Cited by 113 · see citing works
Cheng, L., Quek, C. Y. J., Sun, X., Bellingham, S. A., & Hill, A. F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00150 · Cited by 112 · see citing works
Zamolodchikov, D., & Strickland, S. (2012) · Blood · doi:10.1182/blood-2011-11-389668 · Cited by 111 · see citing works
Will caloric restriction and folate protect against AD and PD?
Mattson, M. P. (2003) · Neurology · doi:10.1212/01.wnl.0000042785.02850.11 · Cited by 111 · see citing works
Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109 · see citing works
Disease to Dirt: The Biology of Microbial Amyloids
Hufnagel, D. A., Tükel, Ç., & Chapman, M. R. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003740 · Cited by 107 · see citing works
Stefani, M., & Rigacci, S. (2014) · BioFactors · doi:10.1002/biof.1171 · Cited by 105 · see citing works
Prions and the Potential Transmissibility of Protein Misfolding Diseases
Kraus, A., Groveman, B. R., & Caughey, B. W. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155735 · Cited by 105 · see citing works
Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus
Liu, R., Vaishnav, R., Roberts, A. M., & Friedland, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060621 · Cited by 95 · see citing works
Hammer, N. D., Wang, X., McGuffie, B. A., & Chapman, M. R. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13406 · Cited by 93 · see citing works
The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA
Colussi, T. M., Costantino, D. A., Hammond, J. A., Ruehle, G. M., Nix, J. C., & Kieft, J. S. (2014) · Nature · doi:10.1038/nature13378 · Cited by 90 · see citing works
Mosconi, L., Murray, J., Davies, M., Williams, S., Pirraglia, E., Spector, N. C., Tsui, W. H., Li, Y., Butler, T., Osorio, R. S., et al. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-004850 · Cited by 87 · see citing works
Ding, P., & Jin, L. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12081 · Cited by 85 · see citing works
Shared genetic etiology underlying Alzheimer’s disease and type 2 diabetes
Hao, K., Di Narzo, A. F., Ho, L., Luo, W., Li, S., Chen, R., Li, T., Dubner, L., & Pasinetti, G. M. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.06.006 · Cited by 84 · see citing works
Liang, J.-S., Sloane, J. A., Wells, J. M., Abraham, C. R., Fine, R. E., & Sipe, J. D. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00196-1 · Cited by 84 · see citing works
Bastianetto, S., Krantic, S., & Quirion, R. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708784223512 · Cited by 81 · see citing works
The various states of von Willebrand factor and their function in physiology and pathophysiology
Huck, V., Gorzelanny, C., Schneider, M. F., & Schneider, S. W. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-09-0800 · Cited by 81 · see citing works
Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease
Rigacci, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_1 · Cited by 80 · see citing works
Daulatzai, M. A. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150202152436 · Cited by 80 · see citing works
Understanding gut microbiota in elderly's health will enable intervention through probiotics
Pérez‐Martínez, G., Bäuerl, C., & Collado, M. C. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0079 · Cited by 78 · see citing works
Oral Delivery of Bioencapsulated Proteins Across Blood–Brain and Blood–Retinal Barriers
Kohli, N., Westerveld, D., Ayache, A., Verma, A., Shil, P. K., Prasad, T., Zhu, P., Chan, S. L., Li, Q., & Daniell, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.273 · Cited by 78 · see citing works
Bekkering, P., Jafri, I., van Overveld, F. J., & Rijkers, G. T. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848793 · Cited by 77 · see citing works
Microfluidic construction of minimalistic neuronal co-cultures
Dinh, N., Chiang, Y.-Y., Hardelauf, H., Baumann, J., Jackson, E., Waide, S., Sisnaiske, J., Frimat, J., van Thriel, C., Janasek, D., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc41224e · Cited by 76 · see citing works
Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites
Rincón, D., Vaquero, J., Hernando, A., Galindo, E., Ripoll, C., Puerto, M., Salcedo, M., Francés, R., Matilla, A. M., Catalina, M., et al. (2014) · Liver International · doi:10.1111/liv.12539 · Cited by 75 · see citing works
Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan
Lai, S., Liao, K., Lin, C.-L., & Sung, F. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9878-3 · Cited by 73 · see citing works
Viegas, P., Chaverot, N., Enslen, H., Perrière, N., Couraud, P., & Cazaubon, S. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03222 · Cited by 73 · see citing works
Chauhan, N., Wang, K., Węgiel, J., & Malik, M. N. (2004) · Current Alzheimer Research · doi:10.2174/1567205043332144 · Cited by 71 · see citing works
Pistollato, F., & Battino, M. A. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.07.012 · Cited by 71 · see citing works
Self-citationFasting plasma insulin and the default mode network in women at risk for Alzheimer's disease
Kenna, H. A., Hoeft, F., Kelley, R. G., Wroolie, T., DeMuth, B. N., Reiss, A. L., & Rasgon, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.006 · Cited by 70 · see citing works
Gupta, V. B., Indi, S. S., & Rao, K. S. J. (2008) · Phytotherapy Research · doi:10.1002/ptr.2574 · Cited by 70 · see citing works
Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols
Rigacci, S., & Stefani, M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.986101 · Cited by 69 · see citing works
Role of the Gut Microbiota in Age-Related Chronic Inflammation
Rehman, T. (2012) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/187153012803832620 · Cited by 67 · see citing works
Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J. (2012) · AGE · doi:10.1007/s11357-011-9294-5 · Cited by 67 · see citing works
Fallucca, F., Porrata, C., Fallucca, S., & Pianesi, M. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2518 · Cited by 65 · see citing works
Essa, M. M., Braidy, N., Awlad-Thani, K., Vaishnav, R., Al-Asmi, A. R., Guillemin, G. J., Al‐Adawi, S., & Subash, S. (2015) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.159073 · Cited by 65 · see citing works
Fold modulating function: bacterial toxins to functional amyloids
Syed, A. K., & Boles, B. R. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00401 · Cited by 65 · see citing works
Campbell, A. W. (2014) · Autoimmune Diseases · doi:10.1155/2014/152428 · Cited by 63 · see citing works
The importance of fish and docosahexaenoic acid in Alzheimer disease
Connor, W. E., & Connor, S. L. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.929 · Cited by 61 · see citing works
Apathy and APOE4 are associated with Reduced BDNF Levels in Alzheimer's Disease
Álvarez, A., Aleixandre, M., Linares, C., Masliah, E., & Moessler, H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140849 · Cited by 61 · see citing works
Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines
Hügel, H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_5 · Cited by 58 · see citing works
Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome
Greiner, A. K., Papineni, R. V. L., & Umar, S. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2014 · Cited by 58 · see citing works
Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
Lolicato, F., Raudino, A., Milardi, D., & Rosa, C. L. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.047 · Cited by 55 · see citing works
Blom, K., Emmelot‐Vonk, M. H., & Koek, H. L. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.06.011 · Cited by 54 · see citing works
How free of germs is germ-free? Detection of bacterial contamination in a germ free mouse unit
Fontaine, C., Skorupski, A. M., Vowles, C. J., Anderson, N. E., Poe, S., & Eaton, K. A. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1054596 · Cited by 52 · see citing works
Stenvinkel, P. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu338 · Cited by 52 · see citing works
TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?
Tanzi, R. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmcibr1503954 · Cited by 51 · see citing works
microRNA (miRNA)-Mediated Pathogenetic Signaling in Alzheimer’s Disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1734-7 · Cited by 48 · see citing works
Gutiérrez‐Orozco, F., Thomas‐Ahner, J. M., Berman-Booty, L. D., Galley, J. D., Chitchumroonchokchai, C., Mace, T. A., Suksamrarn, S., Bailey, M. T., Clinton, S. K., Lesinski, G. B., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300771 · Cited by 48 · see citing works
Alam, M., Alam, Q., Kamal, M., Abuzenadah, A., & Haque, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660151 · Cited by 47 · see citing works
de Gonzalo‐Calvo, D., Fernández‐Garcia, B., de Luxán‐Delgado, B., Rodríguez‐González, S., Macia, M. G., Suárez, F. M., Solano, J. J., Rodríguez‐Colunga, M. J., & Coto‐Montes, A. M. (2011) · AGE · doi:10.1007/s11357-011-9266-9 · Cited by 46 · see citing works
Apolipoprotein Serum Amyloid A in Alzheimer's Disease
Kindy, M., Yu, J., Guo, J.-T., & Zhu, H. (1999) · Journal of Alzheimer's Disease · doi:10.3233/jad-1999-1303 · Cited by 44 · see citing works
Molecular detection of bacterial contamination in gnotobiotic rodent units
Packey, C. D., Shanahan, M. T., Manick, S., Bower, M., Ellermann, M., Tonkonogy, S. L., Carroll, I. M., & Sartor, R. B. (2013) · Gut Microbes · doi:10.4161/gmic.25824 · Cited by 43 · see citing works
Role of Stress, Depression, and Aging in Cognitive Decline and Alzheimer’s Disease
Daulatzai, M. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_350 · Cited by 42 · see citing works
Considering a new paradigm for Alzheimer's disease research
Langley, G. R. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.013 · Cited by 41 · see citing works
Lipiński, B., & Pretorius, E. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00735 · Cited by 39 · see citing works
MicroRNA (miRNA): Sequence and stability, viroid-like properties, and disease association in the CNS
Pogue, A. I., Hill, J. M., & Lukiw, W. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.042 · Cited by 38 · see citing works
Serum Amyloid A Differentially Activates Microglia and Astrocytes via the PI3K Pathway
Yu, Y., Liu, J., Li, S.-Q., Lei, P., & Ye, R. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130818 · Cited by 35 · see citing works
TREM2 signaling, miRNA-34a and the extinction of phagocytosis
Zhao, Y., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00131 · Cited by 33 · see citing works
Antibodies to Potato Virus Y Bind the Amyloid β Peptide
Friedland, R. P., Tedesco, J. M., Wilson, A. C., Atwood, C., Smith, M. A., Perry, G. L., & Zagorski, M. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802088200 · Cited by 28 · see citing works
Uptake and Dynamics of Infectious Prion Protein in the Intestine
Ano, Y., Sakudo, A., Nakayama, H., & Onodera, T. (2009) · Protein and Peptide Letters · doi:10.2174/092986609787601642 · Cited by 27 · see citing works
Fighting Alzheimer's Disease and Type 2 Diabetes: Pathological links and Treatment Strategies
Dai, Y., & Kamal, M. A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660134 · Cited by 26 · see citing works
miRNAs and viroids utilize common strategies in genetic signal transfer
Hill, J. M., Zhao, Y., Bhattacharjee, S., & Lukiw, W. J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00010 · Cited by 25 · see citing works
A Human-Based Integrated Framework forAlzheimer’s Disease Research
Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 20 · see citing works
Self-citationModulation of fibrin assembly and polymerization by the ??-amyloid of Alzheimer??s disease
Merkle, D. L., Cheng, C.-H., Castellino, F., & Chibber, B. A. (1996) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-199609000-00011 · Cited by 19 · see citing works
Cross-kingdom sequence similarities between human micro-RNAs and plant viruses
Rebolledo-Mendez, J. D., Vaishnav, R., Cooper, N., & Friedland, R. P. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.24951 · Cited by 19 · see citing works
From Gut to Brain: Bioencapsulated Therapeutic Protein Reduces Amyloid Load Upon Oral Delivery
Mäger, I., Roberts, T. C., Wood, M. J. A., & Andaloussi, S. E. (2014) · Molecular Therapy · doi:10.1038/mt.2014.13 · Cited by 19 · see citing works
Why nutraceuticals do not prevent or treat Alzheimer's disease
Fisher, A. E. O., & Naughton, D. P. (2005) · Nutrition Journal · doi:10.1186/1475-2891-4-14 · Cited by 13 · see citing works
Ali‐Khan, Z., Normand, J., Alizadeh-Khiavi, K., Robitaille, Y., & Chronopoulos, S. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90849-3 · Cited by 13 · see citing works
Immunohistochemical Examination of Peyer's Patches in Senescence-Accelerated Mice
Yoshioka, H., Takeda, T., Higuchi, K., Ohshio, G., Miyake, T., Sugiyama, T., & Kita, T. (1990) · Autoimmunity · doi:10.3109/08916939008998429 · Cited by 9 · see citing works
Intestinal uptake of amyloid beta protein through columnar epithelial cells in suckling mice.
Ano, Y., Nakayama, H., Sakudo, A., Sawano, Y., Tanokura, M., Itohara, S., & Onodera, T. (2009) · PubMed · doi:10.14670/hh-24.283 · Cited by 5 · see citing works
Role of dietary patterns in the prevention and regression of insulin resistance-related cancers
Pistollato, F. (2015) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-140024 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Influence of diet on the gut microbiome and implications for human health
Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Human gut microbiota/microbiome in health and diseases: a review
Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294 · see citing works
The Human Gut Microbiome – A Potential Controller of Wellness and Disease
Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 1,116 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“As a result, proinflammatory miRNA-34a is up regulated, causing downregulation of TREM-2 (trigger receptor expressed in microglial/myeloid cell-2), which can cause deposition of Aβ-42 peptide [25].”
BackgroundBrain-Gut-Microbiota Axis in Alzheimer’s Disease
Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826 · see citing works
Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.032 · Cited by 653 · see citing works
Sochocka, M., Donskow-Łysoniewska, K., Diniz, B. S., Kurpas, D., Brzozowska, E., & Leszek, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1188-4 · Cited by 584 · see citing works
Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song, Z., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0525-3 · Cited by 532 · see citing works
Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease
Kesika, P., Suganthy, N., Sivamaruthi, B. S., & Chaiyasut, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118627 · Cited by 479 · see citing works
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works
Gut microbiota: A player in aging and a target for anti-aging intervention
Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works
Diet, Microbiota and Gut-Lung Connection
Anand, S., & Mande, S. S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02147 · Cited by 409 · see citing works
Kobayashi, Y., Sugahara, H., Shimada, K., Mitsuyama, E., Kuhara, T., Yasuoka, A., Kondo, T., Abe, K., & Xiao, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13368-2 · Cited by 406 · see citing works
The role of microbial amyloid in neurodegeneration
Friedland, R. P., & Chapman, M. R. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006654 · Cited by 389 · see citing works
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
Role of microbiota-derived short-chain fatty acids in nervous system disorders
Mirzaei, R., Bouzari, B., Hosseini‐Fard, S. R., Mazaheri, M., Ahmadyousefi, Y., Abdi, M., Jalalifar, S., Karimitabar, Z., Teimoori, A., Keyvani, H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111661 · Cited by 400 · see citing works
Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 381 · see citing works
The integration of inflammaging in age-related diseases
Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 356 · see citing works
Solfrizzi, V., Custodero, C., Lozupone, M., Imbimbo, B. P., Valiani, V., Agosti, P., Schilardi, A., D’Introno, A., Montagna, M. L., Calvani, M., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170248 · Cited by 351 · see citing works
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347 · see citing works
Çatalkaya, G., Venema, K., Lucini, L., Rocchetti, G., Delmas, D., Daglia, M., Filippis, A. D., Xiao, H., Quiles, J. L., Xiao, J., et al. (2020) · Food Frontiers · doi:10.1002/fft2.25 · Cited by 339 · see citing works
Ou, Z., Deng, L., Lu, Z., Wu, F., Liu, W., Huang, D., & Peng, Y. (2020) · Nutrition & Diabetes · doi:10.1038/s41387-020-0115-8 · Cited by 328 · see citing works
The Healthy Human Blood Microbiome: Fact or Fiction?
Castillo, D. J., Rifkin, R. F., Cowan, D. A., & Potgieter, M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00148 · Cited by 314 · see citing works
Gut microbiota in neurodegenerative disorders
Sarkar, S. R., & Banerjee, S. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.004 · Cited by 319 · see citing works
Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases
Gerhardt, S., & Mohajeri, M. H. (2018) · Nutrients · doi:10.3390/nu10060708 · Cited by 298 · see citing works
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works
Sun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302 · see citing works
Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works
Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study
Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018) · Current Alzheimer Research · doi:10.2174/1389200219666180813144834 · Cited by 269 · see citing works
Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases
Spielman, L. J., Gibson, D. L., & Klegeris, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.005 · Cited by 266 · see citing works
Microbiota in the Gastrointestinal Tract
Dieterich, W., Schink, M., & Zopf, Y. (2018) · Medical Sciences · doi:10.3390/medsci6040116 · Cited by 269 · see citing works
Gut microbiota in patients with Parkinson's disease in southern China
Lin, A., Zheng, W., He, Y., Tang, W., Wei, X., He, R., Huang, W., Su, Y., Huang, Y., Zhou, H., et al. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.05.007 · Cited by 253 · see citing works
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250 · see citing works
Pistollato, F., Iglesias, R. C., Ruiz, R., Aparicio, S., Crespo, J., Lopez, L. D., Manna, P. P., Giampieri, F., & Battino, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.012 · Cited by 247 · see citing works
Self-citationEffect of nutrition on neurodegenerative diseases. A systematic review
Bianchi, V. E., Herrera, P. F., & Rizzi, L. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1681088 · Cited by 258 · see citing works
Application of Metabolomics in Alzheimer’s Disease
Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268 · see citing works
Mancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works
Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227 · see citing works
Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease
Giau, V. V., Wu, S., Jamerlan, A., An, S. S. A., Kim, S., & Hulme, J. (2018) · Nutrients · doi:10.3390/nu10111765 · Cited by 235 · see citing works
Den, H., Dong, X., Chen, M., & Zou, Z. (2020) · Aging · doi:10.18632/aging.102810 · Cited by 230 · see citing works
Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works
Oral microbiome: possible harbinger for children’s health
Xiao, J., Fiscella, K. A., & Gill, S. R. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0082-x · Cited by 223 · see citing works
Saji, N., Niida, S., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-38218-7 · Cited by 224 · see citing works
Chen, C., Ahn, E. H., Kang, S. S., Liu, X., Alam, A., & Ye, K. (2020) · Science Advances · doi:10.1126/sciadv.aba0466 · Cited by 205 · see citing works
Bana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 207 · see citing works
Goyal, D., Ali, S. A., & Singh, R. K. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110112 · Cited by 208 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Probiotics for Alzheimer’s Disease: A Systematic Review
Naomi, R., Embong, H., Othman, F., Ghazi, H. F., Maruthey, N., & Bahari, H. (2021) · Nutrients · doi:10.3390/nu14010020 · Cited by 200 · see citing works
Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration
Solanki, R., Karande, A. A., & Ranganathan, P. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1149618 · Cited by 192 · see citing works
Steroids, stress and the gut microbiome-brain axis
Tetel, M. J., de Vries, G. J., Melcangi, R. C., Panzica, G., & O'Mahony, S. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12548 · Cited by 187 · see citing works
Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions
Gómez-Gómez, M. E., & Zapico, S. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112842 · Cited by 186 · see citing works
Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis
de Weerth, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.016 · Cited by 181 · see citing works
Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works
Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders
Tse, J. K. Y. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00176 · Cited by 172 · see citing works
Gut microbiota and pro/prebiotics in Alzheimer’s disease
Pluta, R. M., Ułamek-Kozioł, M., Januszewski, S., & Czuczwar, S. J. (2020) · Aging · doi:10.18632/aging.102930 · Cited by 171 · see citing works
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome
Lee, Y., Kamada, N., & Moon, J. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114021 · Cited by 168 · see citing works
Role of the peripheral innate immune system in the development of Alzheimer's disease
Page, A. Y. L., Dupuis, G., Frost, E. H., Larbi, A., Pawelec, G., Witkowski, J. M., & Fülöp, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.019 · Cited by 159 · see citing works
Asaoka, D., Xiao, J., Takeda, T., Yanagisawa, N., Yamazaki, T., Matsubara, Y., Sugiyama, H., Endo, N., Higa, M., Kasanuki, K., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220148 · Cited by 159 · see citing works
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153 · see citing works
Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00435 · Cited by 147 · see citing works
Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease
Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works
Gong, T., Chen, Q., Mao, H., Zhang, Y., Ren, H., Xu, M., Chen, H., & Yang, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.925435 · Cited by 138 · see citing works
Xu, M., Mo, X., Huang, H., Chen, X., Liu, H., Peng, Z., Chen, L., Rong, S., Yang, W. Q., Xu, S., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.180 · Cited by 137 · see citing works
Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease
Sharma, C., & Kim, S. R. (2021) · Antioxidants · doi:10.3390/antiox10081231 · Cited by 136 · see citing works
Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134 · see citing works
Neuroinflammation: The central enabler of postoperative cognitive dysfunction
Liu, Y., Yang, W., Xue, J., Chen, J., Liu, S., Zhang, S., Zhang, X., Gu, X., Dong, Y., & Qiu, P. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115582 · Cited by 136 · see citing works
The Relationship Between the Gut Microbiome and Neurodegenerative Diseases
Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00730-8 · Cited by 134 · see citing works
Yang, X.-D., Wang, L.-K., Wu, H.-Y., & Jiao, L. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0642-1 · Cited by 129 · see citing works
Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration
Zhao, Y., & Lukiw, W. J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1015-y · Cited by 129 · see citing works
Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder
Liu, B., Lin, W., Chen, S., Xiang, T., Yang, Y., Yin, Y., Xu, G., Liu, Z., Liu, L., Pan, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01770 · Cited by 132 · see citing works
The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer’s Disease
Narengaowa, Kong, W., Lan, F., Awan, M. U. F., Qing, H., & Ni, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633735 · Cited by 130 · see citing works
Honarpisheh, P., Reynolds, C. R., Conesa, M. P. B., Moruno-Manchon, J. F., Putluri, N., Bhattacharjee, M. B., Urayama, A., McCullough, L. D., & Ganesh, B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051711 · Cited by 127 · see citing works
Gut microbes in neurocognitive and mental health disorders
Halverson, T., & Alagiakrishnan, K. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1808239 · Cited by 125 · see citing works
The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review
Ambrosini, Y. M., Borcherding, D. C., Kanthasamy, A., Kim, H. J., Willette, A., Jergens, A., Allenspach, K., & Mochel, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00130 · Cited by 116 · see citing works
The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 128 · see citing works
The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
Zhang, X., Fu, Z., Meng, L., He, M., & Zhang, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00359 · Cited by 122 · see citing works
The gut-brain vascular axis in neuroinflammation
Carloni, S., & Rescigno, M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101802 · Cited by 123 · see citing works
Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
Wei, S., Peng, W., Mai, Y., Li, K., Wei, W., Hu, L., Zhu, S., Zhou, H., Jie, W., Wei, Z., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29362 · Cited by 122 · see citing works
Microbial involvement in Alzheimer disease development and progression
Bulgart, H. R., Neczypor, E. W., Wold, L. E., & Mackos, A. R. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00378-4 · Cited by 116 · see citing works
Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease
Bonfili, L., Cecarini, V., Gogoi, O., Gong, C., Cuccioloni, M., Angeletti, M., Rossi, G., & Eleuteri, A. M. (2020) · FEBS Journal · doi:10.1111/febs.15571 · Cited by 118 · see citing works
Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease
Kaur, H., Nagamoto‐Combs, K., Golovko, S. A., Golovko, M. Y., Klug, M. G., & Combs, C. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.009 · Cited by 112 · see citing works
Diet and Alzheimer's dementia – Nutritional approach to modulate inflammation
Szczechowiak, K., Diniz, B. S., & Leszek, J. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172743 · Cited by 112 · see citing works
Zhao, Y., Cong, L., & Lukiw, W. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00407 · Cited by 112 · see citing works
Arora, K., Green, M., & Prakash, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.537847 · Cited by 110 · see citing works
Perov, S., Lidor, O., Salinas, N., Golan, N., Tayeb-Fligelman, E., Deshmukh, M. G., Willbold, D., & Landau, M. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007978 · Cited by 109 · see citing works
Dietary Pattern, Gut Microbiota, and Alzheimer’s Disease
Zhang, M., Zhao, D., Zhou, G., & Li, C. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08309 · Cited by 106 · see citing works
Ylilauri, M. P., Voutilainen, S., Lönnroos, E., Virtanen, H. E., Tuomainen, T., Salonen, J. T., & Virtanen, J. K. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz148 · Cited by 106 · see citing works
Regulation of dietary fiber on intestinal microorganisms and its effects on animal health
Xue-bing, H., Ma, Y., Ding, S., Fang, J., & Liu, G. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.06.004 · Cited by 106 · see citing works
Harding, A., Gonder, U., Robinson, S. J., Crean, S., & Singhrao, S. K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00398 · Cited by 106 · see citing works
Yang, X., Diling, C., Yang, J. T., Ting, L., Guoyan, H., Hualun, L., Xiaocui, T., Lai, G., Shuai, O., Chaoqun, Z., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00412 · Cited by 108 · see citing works
The Exceptional Vulnerability of Humans to Alzheimer’s Disease
Walker, L. C., & Jucker, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.04.001 · Cited by 105 · see citing works
The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
Nowak, A., Kojder, K., Zielonka-Brzezicka, J., Wróbel, J., Bosiacki, M., Fabiańska, M., Wróbel, M., Sołek-Pastuszka, J., & Klimowicz, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.775034 · Cited by 105 · see citing works
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02286-z · Cited by 103 · see citing works
Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases
Jang, C. H., Oh, J., Lim, J. S., Kim, H. J., & Kim, J.-S. (2021) · Foods · doi:10.3390/foods10030636 · Cited by 100 · see citing works
Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
Lei, W., Cheng, Y., Gao, J., Liu, X., Shao, L., Kong, Q., Zheng, N., Ling, Z., & Hu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1224155 · Cited by 101 · see citing works
The gut microbiota as a key regulator of visceral pain
O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Pain · doi:10.1097/j.pain.0000000000000779 · Cited by 98 · see citing works
- Authors
- Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M.
- Affiliations
- Marche Polytechnic University (IT)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-15
- Volume
- 74
- Issue
- 10
- Pages
- 624-634
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2519408637
- Cited by
- 496
- References
- 177
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 48 · 2023: 53 · 2022: 61 · 2021: 80 · 2020: 72 · 2019: 59 · 2018: 37 · 2017: 30 · 2016: 2
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Fondazione Umberto Veronesi
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, gut microbiota, amyloid-beta, amyloid fibril formation, gut-brain axis, lipopolysaccharide, inflammatory cytokines, dietary nutrients, microbiota composition, neuroinflammation, amyloidogenesis, dietary intervention
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Amyloid, Bacteria, Brain, Diet, Humans, Cytokines, Prebiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review