The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

Weiss, Nicolas; Miller, Florence; Cazaubon, Sylvie; Couraud, Pierre-Olivier

doi:10.1016/j.bbamem.2008.10.022

Cited by 731Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsExtracellular vesicles in disease

The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

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Weiss, Nicolas, Miller, Florence, Cazaubon, Sylvie, Couraud, Pierre-Olivier·2009·Biochimica et Biophysica Acta (BBA) - Biomembranes

DOI 10.1016/j.bbamem.2008.10.022

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Abstract

Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally. They form the blood-brain-barrier (BBB) which strictly controls the exchanges between the blood and the brain compartments by limiting passive diffusion of blood-borne solutes while actively transporting nutrients to the brain. Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases with important social impacts, such as multiple sclerosis, stroke, brain tumors, epilepsy or Alzheimer's disease. This review will focus on the implication of brain endothelial tight junctions in BBB architecture and physiology, will discuss the consequences of BBB dysfunction in these CNS diseases and will present some therapeutic strategies for drug delivery to the brain across the BBB.

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Blood-brain barrier integrity can be compromised by exposures to certain toxicants and by health conditions through molecular alterations in barrier function.
“Integrity of the BBB can be compromised because of exposures to certain toxicants, such as pesticides, mixed vehicle emissions, and tobacco smoke, as well as certain health conditions including diabetes and neurological disorders reviewed in Neurotoxicity of PFAS in Sensitive Populations, through molecular alterations in barrier function (Gupta et al., 1999; Weiss et al., 2009; Mazzone et al., 201”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
Section 3 describes BBB dysfunction in neurological diseases, and §3.2.1 explains molecular changes that damage barrier integrity after stroke (page numbers unavailable). The cited passages do not substantiate the sentence’s specific claims about pesticides, vehicle emissions, tobacco smoke, or diabetes. (LLM, conf=0.84)
Experimental — accuracy not yet measured
PFAS exposure could be more hazardous for individuals with pre-existing neurological conditions or a predisposition for these diseases.
“PFAS exposure could be more hazardous for individuals with pre-existing neurological conditions or a predisposition for these diseases”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
Sections 3.1 and 3.5.1 describe blood–brain barrier dysfunction in multiple sclerosis and Alzheimer’s disease, including increased permeability, and section 3.1 discusses genetically predisposed individuals. The paper does not address PFAS exposure or establish that it is more hazardous for people with these conditions or predispositions. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Many neurological conditions confer heightened damage by PFAS and other toxicants by functionally compromising the BBB.
“Many neurological conditions, including Alzheimer’s disease (AD), Parkinson’s Disease (PD), multiple sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Huntington’s disease, and brain tumors, confer heightened damage by PFAS and other toxicants by functionally compromising the BBB”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Weiss et al., 2009
Sections 3.1, 3.3.1, and 3.5 describe BBB dysfunction in MS, brain tumors, AD, and PD; the Conclusion says the BBB protects the CNS from xenobiotics. But the paper does not establish that these conditions heighten damage from PFAS or other toxicants, and the retrieved passages do not substantiate BBB compromise in ALS or Huntington’s disease. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Asiaticoside and madecassoside cross the blood-brain barrier at a high rate, with asiaticoside showing the highest permeability, followed by madecassoside, and with higher permeability coefficient values than donepezil.
“The experiment demonstrated the remarkably high capability of the tested phytocompounds in crossing the BBB, with asiaticoside showing the highest permeability, followed by madecassoside. Notably, the compounds also showed higher permeability coefficient values than donepezil, a drug commonly used for AD. 43”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [43]
Section 2.3.1 discusses general factors affecting BBB solute permeability, but does not report permeability results for asiaticoside or madecassoside. Searches of our copy for those compounds and donepezil found no passage comparing their permeability coefficients or ranking their BBB crossing rates; page numbers were not available. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Asiaticoside and madecassoside cross the blood-brain barrier at a high rate without exerting toxic effects and while preserving the blood-brain barrier tight junction integrity.
“In the same study using primary porcine brain endothelial cells, asiaticoside and madecassoside were proved to be efficient in crossing the BBB at a high rate without exerting any toxic effects, and while preserving the BBB tight junction integrity, making them desirable neurotherapeutics.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [43]
The review’s sections 2.2 (Intercellular junctions) and 4 (Therapeutic approaches) discuss BBB integrity and drug delivery generally, but neither reports the claimed findings for asiaticoside or madecassoside. Searches of our full-text copy for both compounds and for the primary porcine brain endothelial-cell study found no passage addressing their crossing rate, toxicity, or effects on tight junctions. Page numbers were not available in our copy. (LLM, conf=0.77)
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139 · see citing works
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943 · see citing works
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.
Polman, C., O'Connor, P., Havrdová, E., Hutchinson, M., Kappos, L., Miller, D. H., Phillips, J., Lublin, F., Giovannoni, G., Wajgt, A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa044397 · Cited by 3,293 · see citing works
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Multiple Sclerosis
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016 · see citing works
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works
Multifunctional strands in tight junctions
Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,514 · see citing works
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
Plate, K. H., Breier, G., Weich, H. A., & Risau, W. (1992) · Nature · doi:10.1038/359845a0 · Cited by 2,262 · see citing works
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226 · see citing works
Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin
Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100 · see citing works
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works
Multiple sclerosis--the plaque and its pathogenesis.
Frohman, E., Racke, M., & Raine, C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052130 · Cited by 1,793 · see citing works
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759 · see citing works
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
Yednock, T. A., Cannon, C., Fritz, L. C., Sánchez‐Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737 · see citing works
Astrocytes induce blood–brain barrier properties in endothelial cells
Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,634 · see citing works
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works
Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works
Angiogenesis in brain tumours
Jain, R. K., di Tomaso, E., Duda, D. G., Loeffler, J. S., Sorensen, A. G., & Batchelor, T. T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2175 · Cited by 1,408 · see citing works
Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration
Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387 · see citing works
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line
Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325 · see citing works
Self-citation
A controlled trial of natalizumab for relapsing multiple sclerosis.
Miller, D. H., Khan, O., Sheremata, W., Blumhardt, L., Rice, G., Libonati, M., Willmer-Hulme, A., Dalton, C., Miszkiel, K., & O'Connor, P. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020696 · Cited by 1,265 · see citing works
Tight junctions of the blood-brain barrier: development, composition and regulation.
Wolburg, H., & Lippoldt, A. (2002) · PubMed · doi:10.1016/s1537-1891(02)00200-8 · Cited by 1,184 · see citing works
T‐lymphocyte entry into the central nervous system
Hickey, W. F., Hsu, B. L., & Kimura, H. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280213 · Cited by 1,176 · see citing works
Bidirectional control of CNS capillary diameter by pericytes
Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150 · see citing works
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Carro, U. D., Amadio, S., Bergami, A., et al. (2003) · Nature · doi:10.1038/nature01552 · Cited by 1,071 · see citing works
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Kim, R. B., Fromm, M. F., Wandel, C., Leake, B. F., Wood, A. J., Roden, D. M., & Wilkinson, G. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1269 · Cited by 1,054 · see citing works
VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin
Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,017 · see citing works
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004 · see citing works
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A. A. M., van Deemter, L., Smit, J. J. M., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4028 · Cited by 937 · see citing works
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922 · see citing works
Neurovascular mechanisms of Alzheimer's neurodegeneration
Zloković, B. V. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.001 · Cited by 921 · see citing works
Drug resistance in brain diseases and the role of drug efflux transporters
Löscher, W., & Potschka, H. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1728 · Cited by 904 · see citing works
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.
Balda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1031 · Cited by 876 · see citing works
Endothelial Claudin
Morita, K., Sasaki, H., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.185 · Cited by 866 · see citing works
Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain
Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861 · see citing works
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
Pluchino, S., Zanotti, L., Rossi, B., Brambilla, E., Ottoboni, L., Salani, G., Martinello, M., Cattalini, A., Bergami, A., Furlan, R., et al. (2005) · Nature · doi:10.1038/nature03889 · Cited by 762 · see citing works
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Gilbertson, R. J., & Rich, J. N. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2246 · Cited by 716 · see citing works
Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1
Antonetti, D. A., Barber, A. J., Hollinger, L. A., Wolpert, E. B., & Gardner, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23463 · Cited by 685 · see citing works
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
Engelhardt, B., & Ransohoff, R. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.07.004 · Cited by 674 · see citing works
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
Carman, C. V., & Springer, T. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404129 · Cited by 658 · see citing works
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
Taddei, A., Giampietro, C., Conti, A., Orsenigo, F., Breviario, F., Pirazzoli, V., Potente, M., Daly, C., Dimmeler, S., & Dejana, E. (2008) · Nature Cell Biology · doi:10.1038/ncb1752 · Cited by 648 · see citing works
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption
Kinoshita, M., McDannold, N. J., Jolesz, F. A., & Hynynen, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604318103 · Cited by 645 · see citing works
JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes
Ostermann, G., Weber, K. S. C., Zernecke, A., Schröder, A., & Weber, C. (2002) · Nature Immunology · doi:10.1038/ni755 · Cited by 644 · see citing works
Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis
Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
Sheikov, N. A., McDannold, N. J., Vykhodtseva, N. I., Jolesz, F. A., & Hynynen, K. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.04.010 · Cited by 619 · see citing works
Cerebral Microvessel Responses to Focal Ischemia
del Zoppo, G. J., & Mabuchi, T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000078322.96027.78 · Cited by 601 · see citing works
Occludin and claudins in tight-junction strands: leading or supporting players?
Tsukita, S., & Furuse, M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01578-0 · Cited by 597 · see citing works
Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation
Sakakibara, A., Furuse, M., Saitou, M., Ando‐Akatsuka, Y., & Tsukita, S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1393 · Cited by 590 · see citing works
Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means
KrolI, R. A., Neuwelt, E. A., & Neuwelt, E. A. (1998) · Neurosurgery · doi:10.1097/00006123-199805000-00082 · Cited by 587 · see citing works
Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
Yong, V. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1807 · Cited by 582 · see citing works
Pathogenesis of lentivirus infections
Haase, A. T. (1986) · Nature · doi:10.1038/322130a0 · Cited by 573 · see citing works
Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes
Ancuța, P., Rao, R., Moses, A. V., Mehle, A., Shaw, S. K., Luscinskas, F. W., & Gabuzda, D. H. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022156 · Cited by 566 · see citing works
ABC Transporters and the Blood-Brain Barrier
Begley, D. J. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384844 · Cited by 548 · see citing works
Use of anti-ICAM-1 therapy in ischemic stroke
Enlimomab Acute Stroke Trial Investigators (2001) · Neurology · doi:10.1212/wnl.57.8.1428 · Cited by 546 · see citing works
Clearing the brain's amyloid cobwebs
Selkoe, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00475-5 · Cited by 541 · see citing works
Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
Belayev, L., Busto, R., Zhao, W., & Ginsberg, M. D. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00815-3 · Cited by 505 · see citing works
The role of junctional adhesion molecules in vascular inflammation
Weber, C., Fraemohs, L., & Dejana, E. (2007) · Nature reviews. Immunology · doi:10.1038/nri2096 · Cited by 504 · see citing works
Transcellular Diapedesis Is Initiated by Invasive Podosomes
Carman, C. V., Sage, P. T., Sciuto, T. E., de la Fuente, M. Á., Geha, R. S., Ochs, H. D., Dvorak, H. F., Dvořàk, A. M., & Springer, T. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.015 · Cited by 497 · see citing works
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme
Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E.-H., Kalbacher, H., & Wolburg, H. (2000) · Acta Neuropathologica · doi:10.1007/s004010000180 · Cited by 491 · see citing works
Delivery of peptides and proteins through the blood–brain barrier
Bickel, U., Yoshikawa, T., & Pardridge, W. M. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00139-3 · Cited by 482 · see citing works
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481 · see citing works
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
Lee, S., Kim, W. J., Choi, Y. K., Song, H. S., Son, M. J., Gelman, I. H., Kim, Y.-J., & Kim, K. (2003) · Nature Medicine · doi:10.1038/nm889 · Cited by 473 · see citing works
Polarity complex proteins
Assémat, E., Bazellières, E., Pallesi‐Pocachard, E., Bivic, A. L., & Massey‐Harroche, D. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 471 · see citing works
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme
Wolburg, H., Wolburg‐Buchholz, K., Kraus, J., Rascher-Eggstein, G., Liebner, S., Hamm, S., Duffner, F., Grote, E.-H., Risau, W., & Engelhardt, B. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0688-z · Cited by 454 · see citing works
Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
Cayrol, R., Wosik, K., Berard, J. L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., Haqqani, A. S., Kreymborg, K., Krug, S., Moumdjian, R., et al. (2008) · Nature Immunology · doi:10.1038/ni1551 · Cited by 444 · see citing works
Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury
Kim, K. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1103 · Cited by 431 · see citing works
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4229 · Cited by 430 · see citing works
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
Rigau, V., Morin, M., Rousset, M.-C., de Bock, F., Lebrun, A., Coubes, P., Picot, M.-C., Baldy-Moulinier, M., Bockaert, J., Crespel, A., et al. (2007) · Brain · doi:10.1093/brain/awm118 · Cited by 429 · see citing works
Clearance of amyloid-β by circulating lipoprotein receptors
Sagare, A. P., Deane, R., Bell, R. D., Johnson, B., Hamm, K., Pendu, R., Marky, A. H., Lenting, P. J., Wu, Z., Zarcone, T. J., et al. (2007) · Nature Medicine · doi:10.1038/nm1635 · Cited by 428 · see citing works
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains
Millán, J., Hewlett, L. J., Glyn, M., Toomre, D. K., Clark, P., & Ridley, A. J. (2006) · Nature Cell Biology · doi:10.1038/ncb1356 · Cited by 416 · see citing works
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
Hesselgesser, J., Taub, D. D., Baskar, P. V., Greenberg, M., Hoxie, J. A., Kolson, D. L., & Horuk, R. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70230-1 · Cited by 408 · see citing works
Human Blood—Brain Barrier Insulin Receptor
Pardridge, W. M., Eisenberg, J., & Yang, J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07167.x · Cited by 399 · see citing works
Acute Ischemic Stroke
van der Worp, H. B., & van Gijn, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmcp072057 · Cited by 399 · see citing works
In vitro models for the blood–brain barrier
Garberg, P., Ball, M., Borg, N., Cecchelli, R., Fénart, L., Hurst, R. D., Lindmark, T., Mabondzo, A. M., Nilsson, J. E., Raub, T. J., et al. (2004) · Toxicology in Vitro · doi:10.1016/j.tiv.2004.06.011 · Cited by 392 · see citing works
Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.
Sobel, R. A., Mitchell, M. E., & Fondren, G. (1990) · PubMed · Cited by 390 · see citing works
Reperfusion Injury: Demonstration of Brain Damage Produced by Reperfusion after Transient Focal Ischemia in Rats
Aronowski, J. A., Strong, R., & Grotta, J. C. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199710000-00006 · Cited by 385 · see citing works
Anticancer Therapies Combining Antiangiogenic and Tumor Cell Cytotoxic Effects Reduce the Tumor Stem-Like Cell Fraction in Glioma Xenograft Tumors
Folkins, C., Man, S., Xu, P., Shaked, Y., Hicklin, D. J., & Kerbel, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4238 · Cited by 384 · see citing works
Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes
Oppenheimer‐Marks, N., Davis, L. S., Bogue, D. T., Ramberg, J. E., & Lipsky, P. E. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.9.2913 · Cited by 383 · see citing works
In vitro model for evaluating drug transport across the blood–brain barrier
Cecchelli, R., Dehouck, B., Descamps, L., Fénart, L., Buée‐Scherrer, V., Duhem, C., Lundquist, S., Rentfel, M., Torpier, G., & Dehouck, M. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00083-0 · Cited by 383 · see citing works
Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood–brain barrier leakage and active demyelination
Kirk, J., Plumb, J., Mirakhur, M., & McQuaid, S. (2003) · The Journal of Pathology · doi:10.1002/path.1434 · Cited by 375 · see citing works
Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion
Hamann, G. F., Okada, Y., Fitridge, R., & del Zoppo, G. J. (1995) · Stroke · doi:10.1161/01.str.26.11.2120 · Cited by 368 · see citing works
Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells
Nakagawa, S., Deli, M. A., Nakao, S., Honda, M., Hayashi, K., Nakaoke, R., Kataoka, Y., & Niwa, M. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9195-4 · Cited by 364 · see citing works
Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat
Zhang, R. L., Chopp, M., Li, Y., Zaloga, C., Jiang, N., Jones, M. L., Miyasaka, M., & Ward, P. A. (1994) · Neurology · doi:10.1212/wnl.44.9.1747 · Cited by 362 · see citing works
Junctional complexes of the blood–brain barrier: permeability changes in neuroinflammation
Petty, M. A., & Lo, E. H. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00128-4 · Cited by 361 · see citing works
The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion
Kuroiwa, T., Ting, P., Martínez, H. R., & KLATZO, I. (1985) · Acta Neuropathologica · doi:10.1007/bf00688633 · Cited by 359 · see citing works
CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
Fischer, T. (2001) · Journal of NeuroVirology · doi:10.1080/135502801753248114 · Cited by 359 · see citing works
Human blood-brain barrier transferrin receptor
Pardridge, W. M., Eisenberg, J., & Yang, J. (1987) · Metabolism · doi:10.1016/0026-0495(87)90099-0 · Cited by 356 · see citing works
Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases
Jou, T.-S., Schneeberger, E. E., & James Nelson, W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.101 · Cited by 354 · see citing works
A Trojan Horse mechanism for the spread of visna virus in monocytes
PELUSO, R. W., Haase, A. T., Stowring, L., Edwards, M., & Ventura, P. (1985) · Virology · doi:10.1016/0042-6822(85)90246-6 · Cited by 352 · see citing works
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase and PKB signaling
Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P., Piontek, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8329com · Cited by 347 · see citing works
Self-citation
A pericyte‐derived angiopoietin‐1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie‐2 activation in vitro
Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., & Terasaki, T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02343.x · Cited by 341 · see citing works
Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339 · see citing works
Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
Engelhardt, B., & Wolburg, H. (2004) · European Journal of Immunology · doi:10.1002/eji.200425327 · Cited by 334 · see citing works
Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
Roux, F. S., Durieu-Trautmann, O., Chaverot, N., Claire, M., Mailly, P., Bourre, J. M., Strosberg, A. D., & Couraud, P. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041590114 · Cited by 317 · see citing works
Self-citation
A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
Persidsky, Y., Stins, M. F., Way, D., Witte, M., Weinand, M. E., Kim, K. S., Bock, P., Gendelman, H. E., & Fiala, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3499 · Cited by 316 · see citing works
Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms
Hirase, T., Kawashima, S., Wong, E. Y. M., Ueyama, T., Rikitake, Y., Tsukita, S., Yokoyama, M., & Staddon, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007136200 · Cited by 312 · see citing works
Hydrogen Bonding. 33. Factors That Influence the Distribution of Solutes between Blood and Brain
Abraham, M. H., Chadha, H. S., & Mitchell, R. C. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830915 · Cited by 302 · see citing works
Matrix Metalloproteinase Expression Is Related to Hemorrhagic Transformation After Cardioembolic Stroke
Montaner, J., Alvarez-Sabín, J., Molina, C. A., Anglés, A., Abilleira, S., Arenillas, J. F., & Monasterio, J. (2001) · Stroke · doi:10.1161/hs1201.99512 · Cited by 299 · see citing works
Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway
Adamson, P., Etienne‐Manneville, S., Couraud, P., Calder, V. L., & Greenwood, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2964 · Cited by 296 · see citing works
Self-citation
The Sensory Circumventricular Organs of the Mammalian Brain
McKinley, M. J., McAllen, R. M., Davern, P. J., Giles, M., Penschow, J., Sunn, N., Uschakov, A., & Oldfield, B. J. (2003) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-55532-9 · Cited by 291 · see citing works
VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
Wang, W., Dentler, W. L., & Borchardt, R. T. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.1.h434 · Cited by 288 · see citing works
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
Lee, J. P., Jeyakumar, M., Gonzalez, R., Takahashi, H., Lee, P. J., Baek, R. C., Clark, D. B., Rose, H., Fu, G., Clarke, J., et al. (2007) · Nature Medicine · doi:10.1038/nm1548 · Cited by 285 · see citing works
Antibodies to CD44 and integrin α 4 , but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
Brocke, S., Piercy, C., Steinman, L., Weissman, I. L., & Veromaa, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6896 · Cited by 281 · see citing works
Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells.
Lee, B.-C., Lee, T.-H., Avraham, S., & Avraham, H. K. (2004) · PubMed · Cited by 281 · see citing works
Role of the α‐chemokine stromal cell‐derived factor (SDF‐1) in the developing and mature central nervous system
Lazarini, F., Tham, T. N., Casanova, P., Arenzana‐Seisdedos, F., & Dubois‐Dalcq, M. (2003) · Glia · doi:10.1002/glia.10139 · Cited by 280 · see citing works
Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
Wong, A., & Gumbiner, B. (2003) · Journal of Cell Biology · doi:10.1083/jcb.200212033 · Cited by 280 · see citing works
Endothelial ICAM-1 Expression Associated With Inflammatory Cell Response in Human Ischemic Stroke
Lindsberg, P. J., ́n, O. C., Paetau, A. E., et al. (1996) · Circulation · doi:10.1161/01.cir.94.5.939 · Cited by 279 · see citing works
Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis
Mustafa, M. M., LEBEL, M. H., Ramilo, O., Olsen, K. D., REISCH, J. S., Beutler, B., & McCracken, G. H. (1989) · The Journal of Pediatrics · doi:10.1016/s0022-3476(89)80067-8 · Cited by 275 · see citing works
Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview
Chandler, S., Miller, K., Clements, J. M., Lury, J., Corkill, D. J., Anthony, D. C., Adams, S. E., & Gearing, A. J. H. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00179-8 · Cited by 273 · see citing works
Blood–brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis
Floris, S., Blezer, E. L. A., Schreibelt, G., Döpp, E. A., van der Pol, S. M. A., Eestermans, I. L., Nicolay, K., Dijkstra, C. D., & de Vries, H. E. (2004) · Brain · doi:10.1093/brain/awh068 · Cited by 272 · see citing works
Evidence for a novel route of wheat storage proteins to vacuoles.
Levanony, H., Rubin, R., Altschuler, Y., et al. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.5.1117 · Cited by 269 · see citing works
Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization
Soppimath, K. S., Kulkarni, A. R., & Aminabhavi, T. M. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00404-7 · Cited by 267 · see citing works
Characterization of the MRP4- and MRP5-mediated Transport of Cyclic Nucleotides from Intact Cells
Wielinga, P. R., van der Heijden, I., Reid, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212723200 · Cited by 266 · see citing works
Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies
Cucullo, L., Couraud, P., Weksler, B. B., Romero, I. A., Hossain, M. K., Rapp, E., & Janigro, D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600525 · Cited by 266 · see citing works
Self-citation
Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows.
Kuroda, S., & Siesjö, B. K. (1997) · PubMed · Cited by 263 · see citing works
Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae
Leppert, D., Leib, S. L., Grygar, C., Miller, K., Schaad, U. B., & Holländer, G. A. (2000) · Clinical Infectious Diseases · doi:10.1086/313922 · Cited by 261 · see citing works
Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis
Wosik, K., Cayrol, R., Dodelet-Devillers, A., Berthelet, F., Bernard, M., Moumdjian, R. A., Bouthillier, A., Reudelhuber, T. L., & Prat, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2088-07.2007 · Cited by 259 · see citing works
Matrix Metalloproteinases Contribute to Brain Damage in Experimental Pneumococcal Meningitis
Leib, S. L., Leppert, D., Clements, J. M., & Täuber, M. G. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.615-620.2000 · Cited by 258 · see citing works
Recent studies on the structure and pathology of basement membranes
Abrahamson, D. R. (1986) · The Journal of Pathology · doi:10.1002/path.1711490402 · Cited by 255 · see citing works
Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys
Judith Miklossy, A., Doudet, D., Schwab, C., Yu, S. Y., McGeer, E. G., & McGeer, P. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.034 · Cited by 255 · see citing works
Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord
Akiyama, Y., Honmou, O., Kato, T., Uede, T., Hashi, K., & Kocsis, J. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7539 · Cited by 241 · see citing works
Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells
Yamamoto, M., Ramirez, S. H., Sato, S., Kiyota, T., Cerny, R. L., Kaibuchi, K., Persidsky, Y., & Ikezu, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070076 · Cited by 241 · see citing works
The Role of Drug Transporters at the Blood-Brain Barrier
de Boer, A. G., van der Sandt, I. C. J., & Gaillard, P. J. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140204 · Cited by 239 · see citing works
Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1α in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells
Lee, B.-C., Lee, T.-H., Avraham, S., & Avraham, H. K. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.327.2.6 · Cited by 238 · see citing works
Stem cell treatment in Amyotrophic Lateral Sclerosis
Mazzini, L., Mareschi, K., Ferrero, I., Vassallo, E., Oliveri, G., Nasuelli, N. A., Oggioni, G. D., Testa, L., & Fagioli, F. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.05.016 · Cited by 227 · see citing works
Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
Wolburg, H., Wolburg‐Buchholz, K., & Engelhardt, B. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0928-x · Cited by 225 · see citing works
High transcytosis of melanotransferrin (P97) across the blood–brain barrier
Demeule, M., Poirier, J., Jodoin, J., Bertrand, Y., Desrosiers, R. R., Dagenais, C., Nguyen, T., Lanthier, J., Gabathuler, R., Kennard, M. L., et al. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01201.x · Cited by 222 · see citing works
β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1
Giri, R., Shen, Y., Stins, M., Du Yan, S., Schmidt, A. M., Stern, D., Kim, K.-S., Zlokovic, B., & Kalra, V. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1772 · Cited by 218 · see citing works
Vascular Endothelial Growth Factor Modulates the Transendothelial Migration of MDA-MB-231 Breast Cancer Cells through Regulation of Brain Microvascular Endothelial Cell Permeability
Lee, T.-H., Avraham, H. K., Jiang, S., & Avraham, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210063200 · Cited by 214 · see citing works
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse
Wolburg, H., Wolburg-Buchholz, K., Liebner, S., & Engelhardt, B. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01927-9 · Cited by 210 · see citing works
Side by side comparison between dynamic versus static models of blood–brain barrier in vitro: A permeability study
Santaguida, S., Janigro, D., Hossain, M., Oby, E. R., Rapp, E., & Cucullo, L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.027 · Cited by 210 · see citing works
Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients
Cláudio, L. (1995) · Acta Neuropathologica · doi:10.1007/s004010050386 · Cited by 210 · see citing works
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
Tsuji, A. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.54 · Cited by 209 · see citing works
Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1 Engagement of Leukocyte LFA-1
Carman, C. V., Jun, C., Salas, A., & Springer, T. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6135 · Cited by 209 · see citing works
The cytoplasmic plaque of tight junctions: A scaffolding and signalling center
Guillemot, L., Paschoud, S., Pulimeno, P., Foglia, A., & Citi, S. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.09.032 · Cited by 207 · see citing works
A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma
Prados, M. D., Schold, S. C., Fine, H. A., Jaeckle, K. A., Hochberg, F. H., Mechtler, L. L., Fetell, M. R., Phuphanich, S., Feun, L. G., Janus, T. J., et al. (2003) · Neuro-Oncology · doi:10.1093/neuonc/5.2.96 · Cited by 207 · see citing works
Matrix metalloproteinases contribute to the blood—brain barrier disruption during bacterial meningitis
Paul, R. H., Lorenzl, S., Koedel, U., Sporer, B., Vogel, U. F., Frosch, M., & Pfister, H.-W. (1998) · Annals of Neurology · doi:10.1002/ana.410440404 · Cited by 205 · see citing works
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)
Persidsky, Y., Heilman, D., Haorah, J., Zelivyanskaya, M., Persidsky, R., Weber, G. A., Shimokawa, H., Kaibuchi, K., & Ikezu, T. (2006) · Blood · doi:10.1182/blood-2005-11-4721 · Cited by 200 · see citing works
Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis
Lee, M. A., Palace, J. A., Stabler, G., Ford, J., Gearing, A. J. H., & Miller, K. (1999) · Brain · doi:10.1093/brain/122.2.191 · Cited by 199 · see citing works
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
Ifergan, I., Kébir, H., Bernard, M., Wosik, K., Dodelet-Devillers, A., Cayrol, R., Arbour, N., & Prat, A. (2007) · Brain · doi:10.1093/brain/awm295 · Cited by 198 · see citing works
Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo.
Pardridge, W. M., Boado, R. J., & Kang, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5592 · Cited by 195 · see citing works
Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review
Perlmutter, L. S., & Chui, H. C. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90007-m · Cited by 193 · see citing works
Trans-cellular migration: cell–cell contacts get intimate
Carman, C. V., & Springer, T. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.05.007 · Cited by 189 · see citing works
Intercellular adhesion molecule‐1‐deficient mice are less susceptible to cerebral ischemia‐reperfusion lnjury
Soriano, S. G., Lipton, S. A., Wang, Y. F., Xaio, M., Springer, T. A., Gutierrez-Ramos, J.-C., & Hickey, P. R. (1996) · Annals of Neurology · doi:10.1002/ana.410390511 · Cited by 186 · see citing works
Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium
Coisne, C., Dehouck, L., Faveeuw, C., Delplace, Y., Miller, F., Landry, C., Morissette, C., Fénart, L., Cecchelli, R., Tremblay, P. J., et al. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700281 · Cited by 183 · see citing works
Self-citation
T-Cells in Alzheimer's Disease
Town, T., Tan, J., Flavell, R. A., & Mullan, M. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:3:255 · Cited by 183 · see citing works
Tissue-Type Plasminogen Activator Crosses the Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor–Related Protein-Mediated Transcytosis
Benchenane, K., Bérézowski, V., Ali, C., Fernández‐Monreal, M., López‐Atalaya, J. P., Brillault, J., Chuquet, J., Nouvelot, A., MacKenzie, E. T., Bu, G., et al. (2005) · Circulation · doi:10.1161/01.cir.0000163542.48611.a2 · Cited by 178 · see citing works
Rat Brain Endothelial Cell Lines for the Study of Blood–Brain Barrier Permeability and Transport Functions
Roux, F. S., & Couraud, P. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1376-9 · Cited by 175 · see citing works
Self-citation
E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis
Engelhardt, B., Vestweber, D., Hallmann, R., & Schulz, M. (1997) · Blood · doi:10.1182/blood.v90.11.4459 · Cited by 175 · see citing works
Pneumolysin Is the Main Inducer of Cytotoxicity to Brain Microvascular Endothelial Cells Caused by Streptococcus pneumoniae
Zysk, G., Schneider-Wald, B. K., Hwang, J. H., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.2.845-852.2001 · Cited by 174 · see citing works
Examination of Several Potential Mechanisms for the Negative Outcome in a Clinical Stroke Trial of Enlimomab, a Murine Anti-Human Intercellular Adhesion Molecule-1 Antibody: A Bedside-to-Bench Study
Furuya, K., Takeda, H., Azhar, S., McCarron, R. M., Chen, Y., Ruetzler, C., Wolcott, K., DeGraba, T. J., Rothlein, R., Hugli, T. E., et al. (2001) · Stroke · doi:10.1161/hs3211.098535 · Cited by 171 · see citing works
Potential role of ABC transporters as a detoxification system at the blood?CSF barrier
DELANGE, E. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.07.009 · Cited by 170 · see citing works
A Pilot Randomized Clinical Safety Study of Sonothrombolysis Augmentation With Ultrasound-Activated Perflutren-Lipid Microspheres for Acute Ischemic Stroke
Alexandrov, A. V., Mikulík, R., Ribó, M., Sharma, V. K., Lao, A. Y., Tsivgoulis, G. K., Sugg, R. M., Barreto, A. D., Sierzenski, P. R., Malkoff, M. D., et al. (2008) · Stroke · doi:10.1161/strokeaha.107.505727 · Cited by 164 · see citing works
A functional in vitro model of rat blood–brain barrier for molecular analysis of efflux transporters
Perrière, N., Yousif, S., Cazaubon, S. M., Chaverot, N., Bourasset, F., Cisternino, S., Declèves, X., Hori, S., Terasaki, T., Deli, M. A., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.091 · Cited by 164 · see citing works
Self-citation
Human CD34 + cells differentiate into microglia and express recombinant therapeutic protein
Asheuer, M., Pflumio, F., Benhamida, S., Dubart‐Kupperschmitt, A., Fouquet, F., Imai, Y., Aubourg, P. R., & Cartier, N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306431101 · Cited by 163 · see citing works
Interferon-beta
Markowitz, C. (2007) · Neurology · doi:10.1212/01.wnl.0000277703.74115.d2 · Cited by 163 · see citing works
Tumors of the choroid plexus
Rickert, C. H., & Paulus, W. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010101)52:1 · Cited by 160 · see citing works
Rapid transferrin efflux from brain to blood across the blood–brain barrier
Zhang, Y., & Pardridge, W. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00222.x · Cited by 159 · see citing works
How do extracellular pathogens cross the blood–brain barrier?
Nassif, X., Bourdoulous, S., Eugène, E., & Couraud, P. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02349-1 · Cited by 157 · see citing works
Self-citation
Adenovirus-Based Strategies Overcome Temozolomide Resistance by Silencing the O6-Methylguanine-DNA Methyltransferase Promoter
Alonso, M. M., Gomez‐Manzano, C., Bekele, B. N., Yung, W. K. A., & Fueyo-Margareto, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-5312 · Cited by 157 · see citing works
The Peroxynitrite Scavenger Uric Acid Prevents Inflammatory Cell Invasion into the Central Nervous System in Experimental Allergic Encephalomyelitis through Maintenance of Blood-Central Nervous System Barrier Integrity
Kean, R. B., Spitsin, S. V., Mikheeva, T., Scott, G. S., & Hooper, D. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6511 · Cited by 157 · see citing works
The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat
Zhang, R., Chopp, M., Zaloga, C., et al. (1995) · Brain Research · doi:10.1016/0006-8993(95)00346-r · Cited by 152 · see citing works
Direct effects of endotoxin on the endothelium: barrier function and injury.
Bannerman, D. D., & Goldblum, S. E. (1999) · PubMed · Cited by 150 · see citing works
Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
Laschinger, M., & Engelhardt, B. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00156-3 · Cited by 149 · see citing works
Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.
Westmoreland, S. V., Rottman, J. B., Williams, K. C., Lackner, A. A., & Sasseville, V. G. (1998) · Europe PMC (PubMed Central) · Cited by 148 · see citing works
Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration
Greenwood, J., Amos, C. L., Walters, C. E., Couraud, P., Lyck, R., Engelhardt, B., & Adamson, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.2099 · Cited by 147 · see citing works
Self-citation
Vector-mediated drug delivery to the brain
Pardridge, W. M. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00087-8 · Cited by 146 · see citing works
Distribution of Immunoglobulin Superfamily Members ICAM-1, -2, -3, and the β2 Integrin LFA-1 in Multiple Sclerosis Lesions
Bö, L., Peterson, J. W., Mørk, S. J., Hoffman, P. A., Gallatin, M. W., Ransohoff, R. M., & Trapp, B. D. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199655100-00006 · Cited by 144 · see citing works
Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells
Li, B., Zhao, W., Tan, Z., Fang, W., Zhu, L. X., & Chen, Y. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.056 · Cited by 144 · see citing works
Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis
MILLER, S. D., McMAHON, E. J., SCHREINER, B., & BAILEY, S. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1394.023 · Cited by 144 · see citing works
Ultrasound, microbubbles and the blood–brain barrier
Meairs, S. P., & Alonso, A. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.019 · Cited by 142 · see citing works
Results of 136 curative hepatectomies with a safety margin of less than 10 mm for colorectal metastases
Elias, D. M., Cavalcanti, A., Sabourin, J., Pignon, J., Ducreux, M. P., & Lasser, P. (1998) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(199810)69:2 · Cited by 139 · see citing works
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
Zloković, B. V. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00310-4 · Cited by 138 · see citing works
Signalling pathways mediating inflammatory responses in brain ischaemia
Planas, A. M., Gorina, R., & Chamorro, Á. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341267 · Cited by 137 · see citing works
Transport of Human Immunodeficiency Virus Type 1 Pseudoviruses across the Blood-Brain Barrier: Role of Envelope Proteins and Adsorptive Endocytosis
Banks, W. A., Freed, E. O., Wolf, K. M., Robinson, S. M., Franko, M. W., & Kumar, V. B. (2001) · Journal of Virology · doi:10.1128/jvi.75.10.4681-4691.2001 · Cited by 137 · see citing works
Occludin expression in microvessels of neoplastic and non‐neoplastic human brain
Papadopoulos, M. C., Saadoun, S., Woodrow, C. J., Davies, D. C., Costa‐Martins, P., Moss, R. F., Krishna, S., & Bell, B. A. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00341.x · Cited by 133 · see citing works
Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naïve Monocyte Extravasation and Transfer of Productive Virus To Enhance Hematogenous Dissemination of HCMV
Bentz, G. L., Jarquin-Pardo, M., Chan, G., Smith, M. S., Sinzger, C., & Yurochko, A. D. (2006) · Journal of Virology · doi:10.1128/jvi.01016-06 · Cited by 130 · see citing works
Trans-skull ultrasound therapy: the feasibility of using image-derived skull thickness information to correct the phase distortion
Hynynen, K., & Sun, J. (1999) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/58.764862 · Cited by 128 · see citing works
Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.
Muldoon, L. L., Nilaver, G., Kroll, R. A., Pagel, M. A., Breakefield, X. O., Chiocca, E. A., Davidson, B. L., Weissleder, R., & Neuwelt, E. A. (1995) · Europe PMC (PubMed Central) · Cited by 121 · see citing works
Inflammation and Dephosphorylation of the Tight junction Protein Occludin in an Experimental Model of Multiple Sclerosis
Morgan, L., Shah, B., Rivers, L. E., Barden, L., Groom, A. J., Chung, R., Higazi, D., Desmond, H., Smith, T., & Staddon, J. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.051 · Cited by 118 · see citing works
Pericyte–endothelial cell interaction increases MMP-9 secretion at the blood–brain barrier in vitro
Zozulya, A. L., Weidenfeller, C., & Galla, H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.099 · Cited by 117 · see citing works
Blood-brain barrier characteristic enzymatic properties in cultured brain capillary endothelial cells
Meyer, J., Mischeck, U., Veyhl, M., et al. (1990) · Brain Research · doi:10.1016/0006-8993(90)91425-g · Cited by 116 · see citing works
Agrin and microvascular damage in Alzheimer's disease.
Berzin, T., Zipser, B., Rafii, M., Kuo-Leblanc, V., Yancopouloš, G., Glass, D., Fallon, J., & Stopa, E. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00121-4 · Cited by 116 · see citing works
Highly Activated CD8+ T Cells in the Brain Correlate with Early Central Nervous System Dysfunction in Simian Immunodeficiency Virus Infection
Marcondes, M. C. G., Burudi, E. M. E., Huitrón‐Reséndiz, S., Sánchez-Alavez, M., Watry, D. D., Zandonatti, M. A., Henriksen, S. J., & Fox, H. S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5429 · Cited by 112 · see citing works
Quantitative Evaluation of Focused Ultrasound with a Contrast Agent on Blood-Brain Barrier Disruption
Yang, F., Fu, W., Yang, R., Liou, H., Kang, K., & Lin, W.-L. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.04.006 · Cited by 111 · see citing works
Biomarkers Indicative of Blood‐Brain Barrier Disruption in Multiple Sclerosis
Waubant, E. L. (2006) · Disease Markers · doi:10.1155/2006/709869 · Cited by 111 · see citing works
Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis
Opdenakker, G., Nelissen, I., & Damme, J. V. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00587-8 · Cited by 111 · see citing works
Endocytosis and Transcytosis of an Immunoliposome-Based Brain Drug Delivery System
Cerletti, A., Drewe, J., Fricker, G., Eberlé, A. N., & Huwyler, J. (2000) · Journal of drug targeting · doi:10.3109/10611860008997919 · Cited by 106 · see citing works
Neural Precursor Cells: Applications for the Study and Repair of the Central Nervous System
Fisher, L. J. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0137 · Cited by 105 · see citing works
Equivocal roles of tissue-type plasminogen activator in stroke-induced injury
Benchenane, K., López‐Atalaya, J. P., Fernández‐Monreal, M., Touzani, O., & Vivien, D. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.12.011 · Cited by 103 · see citing works
Loss of Blood-Brain Barrier Integrity in the Spinal Cord Is Common to Experimental Allergic Encephalomyelitis in Knockout Mouse Models
Fabis, M. J., Scott, G. S., Kean, R. B., Koprowski, H., & Hooper, D. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701252104 · Cited by 99 · see citing works
Kinetics of arginine-vasopressin uptake at the blood-brain barrier
Zlokovic, B. V., Hyman, S., McComb, J. G., Lipovac, M. N., Tang, G., & Davson, H. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90097-8 · Cited by 98 · see citing works
Multiple sclerosis: The increased frequency of the ICAM‐1 exon 6 gene point mutation genetic type K469
Mycko, M. P., Kwinkowski, M., Tronczyńska, E., Szymańska, B., & Selmaj, K. W. (1998) · Annals of Neurology · doi:10.1002/ana.410440113 · Cited by 97 · see citing works
Human Blood-Brain Barrier Disruption by Retroviral-Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization
Afonso, P. V., Ozden, S., Prévost, M., Schmitt, C., Seilhean, D., Weksler, B. B., Couraud, P., Antoine Gessain, A., Romero, I. A., & Ceccaldi, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2576 · Cited by 97 · see citing works
Self-citation
Endothelial cells: adhesion and tight junctions
Rubin, L. L. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90107-n · Cited by 94 · see citing works
Anti-HIV Drug Distribution to the Central Nervous System
Thomas, S. A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384835 · Cited by 94 · see citing works

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Authors: Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Couraud, Pierre-Olivier
ORCID: Weiss, Nicolas
Venue: Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher: Elsevier BV
Published: 2009-04
Volume: 1788
Issue: 4
Pages: 842-857
ISSN: 0005-2736 (ISSN-L)
DOI: 10.1016/j.bbamem.2008.10.022
OpenAlex: W1992883702
Cited by: 731
References: 244
Citations by year: 2026: 15 · 2025: 28 · 2024: 37 · 2023: 36 · 2022: 62 · 2021: 61 · 2020: 54 · 2019: 42 · 2018: 48 · 2017: 58 · 2016: 56 · 2015: 31 · 2014: 41 · 2013: 45 · 2012: 40
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1569 d)
Locations: Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: blood-brain barrier, brain endothelial cells, tight junctions, apical junctional complex, BBB dysfunction, brain homeostasis, multiple sclerosis, stroke, brain tumors, epilepsy, Alzheimer's disease, central nervous system disorders, brain drug delivery
MeSH terms: Blood-Brain Barrier, Brain, Cell Movement, Homeostasis, Humans, Leukocytes, Meningitis, Viral, Multiple Sclerosis, Nervous System Diseases, Permeability, Meningitis, Bacterial, Tight Junctions, Neurodegenerative Diseases, Stroke, Endothelial Cells

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The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

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