The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Indole prevents Escherichia coli cell division by modulating membrane potential
Open accessAbstract
Indole is a bacterial signalling molecule that blocks E. coli cell division at concentrations of 3-5 mM. We have shown that indole is a proton ionophore and that this activity is key to the inhibition of division. By reducing the electrochemical potential across the cytoplasmic membrane of E. coli, indole deactivates MinCD oscillation and prevents formation of the FtsZ ring that is a prerequisite for division. This is the first example of a natural ionophore regulating a key biological process. Our findings have implications for our understanding of membrane biology, bacterial cell cycle control and potentially for the design of antibiotics that target the cell membrane.
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Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Indole as an intercellular signal in microbial communities
Lee, J.-H., & Lee, J. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00204.x · Cited by 1,059
DNA damage checkpoints: from initiation to recovery or adaptation
Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784
Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring
Bi, E., & Lutkenhaus, J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.4.1118-1125.1993 · Cited by 407
Kasianowicz, J., Benz, R., & McLaughlin, S. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01868942 · Cited by 191
Cited by
Mechanism of antibacterial activity of copper nanoparticles
Chatterjee, A. K., Chakraborty, R., & Basu, T. (2014) · Nanotechnology · doi:10.1088/0957-4484/25/13/135101 · Cited by 868
Roles of indole as an interspecies and interkingdom signaling molecule
Lee, J.-H., Wood, T. K., & Lee, J. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.08.001 · Cited by 516
The Microbiologist’s Guide to Membrane Potential Dynamics
Benarroch, J. M., & Asally, M. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.12.008 · Cited by 333
Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
te Winkel, J. D., Gray, D. A., Seistrup, K. H., Hamoen, L. W., & Strahl, H. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00029 · Cited by 326
Li, G., & Young, K. D. (2013) · Microbiology · doi:10.1099/mic.0.064139-0 · Cited by 266
Metadata
- Authors
- Chimerel, C., Field, C. M., Piñero-Fernandez, S., Keyser, U. F., & Summers, D. K.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 1818
- Issue
- 7
- Pages
- 1590-1594
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2131545005
- Cited by
- 169
- References
- 5
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chimerel, C., Field, C. M., Piñero-Fernandez, S., Keyser, U. F., & Summers, D. K. (2012). Indole prevents Escherichia coli cell division by modulating membrane potential. Biochimica et Biophysica Acta (BBA) - Biomembranes. https://doi.org/10.1016/j.bbamem.2012.02.022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
