Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

Protein kinase C βII and TGFβRII in ω-3 fatty acid–mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C. R., Chen, L., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201127 · Cited by 72

p53 Binds Selectively to the 5′ Untranslated Region of cdk4, an RNA Element Necessary and Sufficient for Transforming Growth Factor β- and p53-Mediated Translational Inhibition of cdk4

Miller, S. J., Suthiphongchai, T., Zambetti, G. P., & Ewen, M. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8420-8431.2000 · Cited by 71

Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.

Fink, S. P., Swinler, S. E., Lutterbaugh, J., Massagué, J., Thiagalingam, S., Kinzler, K. W., Vogelstein, B., Willson, J. K. V., & Markowitz, S. D. (2001) · PubMed · Cited by 71

Transforming growth factor beta signaling through Smad1 in human breast cancer cells.

Liu, X., Yue, J., Frey, R. S., Zhu, Q., & Mulder, K. M. (1998) · PubMed · Cited by 70

Intracerebral and Intrathecal Infusion of the TGF-β2-Specific Antisense Phosphorothioate Oligonucleotide AP 12009 in Rabbits and Primates: Toxicology and Safety

Schlingensiepen, R., Goldbrunner, M., Szyrach, M., Stauder, G., Jachimczak, P., Bogdahn, U., Schulmeyer, F. J., Hau, P., & Schlingensiepen, K. (2005) · Oligonucleotides · doi:10.1089/oli.2005.15.94 · Cited by 69

Defective Expression of Transforming Growth Factor β Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer

Zhang, H., Chen, X., Wang, M., Wang, J., Qi, Q.-Y., Zhang, R., Xu, W., Fei, Q.-Y., Wang, F., Cheng, Q., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0959-3 · Cited by 69

Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells.

Gong, J., Ammanamanchi, S., Ko, T. C., & Brattain, M. G. (2003) · PubMed · Cited by 68

Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection

Monteleone, G., Blanco, G. D. V., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., Battista, S., Spagnoli, L. G., Romano, M., Borrelli, M., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.048 · Cited by 68

TGFβ1/Smad3 counteracts BRCA1-dependent repair of DNA damage

Dubrovska, A., Kanamoto, T., Lomnytska, M. I., Heldin, C., Volodko, N., & Souchelnytskyi, S. (2005) · Oncogene · doi:10.1038/sj.onc.1208443 · Cited by 67

Restoration of Transforming Growth Factor-β Signaling through Receptor RI Induction by Histone Deacetylase Activity Inhibition in Breast Cancer Cells

Ammanamanchi, S., & Brattain, M. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402691200 · Cited by 67

Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation

Roelen, B. A. J., Cohen, O. S., Raychowdhury, M. K., Chadee, D. N., Zhang, Y. E., Kyriakis, J. M., Alessandrini, A., & Lin, H. Y.-F. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00053.2003 · Cited by 66

Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas

Kim, Y., Lee, H. S., Lee, H., Hur, K., Kim, W. H., Bang, Y. J., Kim, S., Lee, K., Choe, K. J., & Yang, H.-K. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh131 · Cited by 65

Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

Glick, A. B., Popescu, N. C., Alexander, V., Ueno, H., Böttinger, E. P., & Yuspa, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14949 · Cited by 65

Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski

Takeda, M., Mizuide, M., Oka, M., Watabe, T., Inoue, H., Suzuki, H., Fujita, T., Imamura, T., Miyazono, K., & Miyazawa, K. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0478 · Cited by 65

Thioredoxin Is Downstream of Smad7 in a Pathway That Promotes Growth and Suppresses Cisplatin-Induced Apoptosis in Pancreatic Cancer

Arnold, N. B., Ketterer, K., Kleeff, J. H., Friess, H., Büchler, M. W., & Korc, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2999 · Cited by 64

Frequent Alterations of Smad Signaling in Human Head and Neck Squamous Cell Carcinomas: A Tissue Microarray Analysis

Xie, W. Q., Bharathy, S., Kim, D. S., et al. (2003) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/000000003108748612 · Cited by 64

In vivo disruption of TGF-β signaling by Smad7 leads to premalignant ductal lesions in the pancreas

Kuang, C., Xiao, Y., Liu, X., Stringfield, T. M., Zhang, S., Wang, Z., & Chen, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508977103 · Cited by 63

Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines

Cerutti, J. M., Ebina, K. N., Matsuo, S. E., Martins, L., Maciel, R. M. B., & Kimura, E. T. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345213 · Cited by 61

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 Phosphorylation

Prunier, C., Pessah, M., Ferrand, N., Seo, S. R., Howe, P. H., & Atfi, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304459200 · Cited by 60

Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer

Maliekal, T. T., Antony, M. L., Nair, S. A., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206806 · Cited by 60

Overexpression of the TGF-β antagonist Smad7 in endometrial cancer

Dowdy, S. C., Mariani, A., Reinholz, M. M., Keeney, G. L., Spelsberg, T. C., Podratz, K. C., & Janknecht, R. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.10.006 · Cited by 59

Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP

Cui, Q., Lim, S. K., Zhao, B. M., & Hoffmann, F. M. (2005) · Oncogene · doi:10.1038/sj.onc.1208556 · Cited by 56

Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells

Okado, T., Terada, Y., Tanaka, H., Inoshita, S., Nakao, A., & Sasaki, S. (2002) · Kidney International · doi:10.1111/j.1523-1755.2002.kid583.x · Cited by 56

ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-β/Smad-induced growth arrest of prostate cells

Noda, D., Itoh, S., Watanabe, Y., Inamitsu, M., Dennler, S., Itoh, F., Koike, S., Danielpour, D., ten Dijke, P., & Kato, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209571 · Cited by 56

Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc.

Sasaki, T., Suzuki, H., Yagi, K., Furuhashi, M., Yao, R., Susa, S., Noda, T., Arai, Y., Miyazono, K., & Kato, M. (2003) · PubMed · Cited by 55

A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

Muñoz-Antonia, T., Li, X., Reiss, M., Jackson, R., & Antonia, S. J. (1996) · PubMed · Cited by 53

Inhibition of Transforming Growth Factor-β Signaling by Low Molecular Weight Compounds Interfering with ATP- or Substrate-Binding Sites of the TGFβ Type I Receptor Kinase

Yakymovych, I., Engström, U., Grimsby, S., Heldin, C., & Souchelnytskyi, S. (2002) · Biochemistry · doi:10.1021/bi025936u · Cited by 51

Evidence That Smad2 Is a Tumor Suppressor Implicated in the Control of Cellular Invasion

Prunier, C., Mazars, A., Noë, V., Bruyneel, E. A., Mareel, M. M. K., Gespach, C. P., & Atfi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22919 · Cited by 46

Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFβ

Hu, B., Tack, D. C., Liu, T., Wu, Z., Ullenbruch, M. R., & Phan, S. H. (2005) · Oncogene · doi:10.1038/sj.onc.1209140 · Cited by 46

MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins.

Yam, C. H., Siu, W. Y., Arooz, T., Chiu, C. H. S., Lau, A. W. S., Wang, X. Q., & Poon, R. Y. C. (1999) · PubMed · Cited by 46

Critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression

Katuri, V., Tang, Y., Li, C., Jogunoori, W. S., Deng, C.-X., Rashid, A., Sidawy, A. N., Evans, S. R. T., Reddy, E. P., Mishra, B., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209211 · Cited by 46

Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor β–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity

Hjelmeland, A. B., Hjelmeland, M. D., Shi, Q., Hart, J. L., Bigner, D. D., Wang, X.-F., Kontos, C. D., & Rich, J. N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3016 · Cited by 46

Involvement of Interferon Regulatory Factor 1 and S100C/A11 in Growth Inhibition by Transforming Growth Factor β1 in Human Hepatocellular Carcinoma Cells

Miyazaki, M., Sakaguchi, M., Akiyama, I., Sakaguchi, Y. M., Nagamori, S., & Huh, N.-H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2750 · Cited by 44

Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells

Zhu, Q., Pearson-White, S. H., & Luo, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10731-10744.2005 · Cited by 44

Expression, regulation and clinical significance of bone morphogenetic protein 6 in esophageal squamous-cell carcinoma

Raida, M., Sarbia, M., Clement, J. H., Adam, S., Gabbert, H. E., & H�ffken, K. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990924)83:1<38::aid-ijc8>3.0.co;2-b · Cited by 43

TGFβ1 induces a cell-cycle-dependent increase in motility of epithelial cells

Zicha, D., Genot, E. M., Dunn, G., & Kramer, I. M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.4.447 · Cited by 42

Transforming Growth Factor β1 Induces Proliferation in Colon Carcinoma Cells by Ras-dependent, smad-independent Down-regulation of p21cip1

Yan, Z., Kim, G.-Y., Deng, X., & Friedman, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107646200 · Cited by 40

MdmX inhibits Smad transactivation

Kadakia, M., Brown, T. L., McGorry, M. M., & Berberich, S. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205993 · Cited by 39

Oncogenic Ki-ras Confers a More Aggressive Colon Cancer Phenotype through Modification of Transforming Growth Factor-β Receptor III

Yan, Z., Deng, X., & Friedman, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004553200 · Cited by 39

TGFβ-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferation

Muñoz, O., Fend, F., de Beaumont, R., Husson, H., Astier, A., & Freedman, A. S. (2004) · Leukemia · doi:10.1038/sj.leu.2403485 · Cited by 39

Smad7 Abrogates Transforming Growth Factor-β1-mediated Growth Inhibition in COLO-357 Cells through Functional Inactivation of the Retinoblastoma Protein

Arnold, N. B., & Korc, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500583200 · Cited by 39

Elucidation of Epigenetic Inactivation of SMAD8 in Cancer Using Targeted Expressed Gene Display

Cheng, K., Ponte, J. F., & Thiagalingam, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2688 · Cited by 38

Mechanism for Mutational Inactivation of the Tumor Suppressor Smad2

Prunier, C., Ferrand, N., Frottier, B., Pessah, M., & Atfi, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3302-3313.2001 · Cited by 37

Induction of Angiogenesis by Expression of Soluble Type II Transforming Growth Factor-β Receptor in Mouse Hepatoma

Kim, K.-Y., Jeong, S.-Y., Won, J., Ryu, P. D., & Nam, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104944200 · Cited by 36

The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma.

Anbazhagan, R., Bornman, D. M., Johnston, J. C., Westra, W. H., & Gabrielson, E. (1999) · PubMed · Cited by 35

Reconstitution of Smad3 restores TGF-β response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells

Xu, G., Chakraborty, C., & Lala, P. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02845-0 · Cited by 35

Measurement of total and local bone morphogenetic protein concentration in bone tumours

Laitinen, M., Jortikka, L., Halttunen, T., et al. (1997) · International Orthopaedics · doi:10.1007/s002640050148 · Cited by 34

Tuberous Sclerosis Complex 2 Gene Product Interacts with Human SMAD Proteins

Birchenall-Roberts, M. C., Fu, T., Bang, O., Dambach, M., Resau, J. H., Petrow‐Sadowski, C., Bertolette, D. C., Lee, H.-J., Kim, S., & Ruscetti, F. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402790200 · Cited by 32

Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer.

Fukushima, T., Mashiko, M., Takita, K.-I., Otake, T., Endo, Y., Sekikawa, K., & Takenoshita, S. (2003) · PubMed · Cited by 32

Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ

Adnane, J., Bizouarn, F. A., Chen, Z., Ohkanda, J., Hamilton, A. D., Muñoz-Antonia, T., & Sebti, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203920 · Cited by 29

No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.

Takaku, K., Wrana, J. L., Robertson, E. J., & Taketo, M. M. (2002) · PubMed · Cited by 28

SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

Zimonjic, D. B., Durkin, M. E., Keck-Waggoner, C. L., Park, S., Thorgeirsson, S. S., & Popescu, N. C. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80041-6 · Cited by 27

Expression of a Soluble Transforming Growth Factor-β (TGFβ) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo

Witham, T. F., Villa, L., Yang, T., Pollack, I. F., Okada, H., Robbins, P. D., & Chambers, W. H. (2003) · Journal of Neuro-Oncology · doi:10.1007/bf02700021 · Cited by 26

CAPTOPRIL RESTORES TRANSFORMING GROWTH FACTOR-β TYPE II RECEPTOR AND SENSITIVITY TO TRANSFORMING GROWTH FACTOR-β IN MURINE RENAL CELL CANCER CELLS

Miyajima, A., Asano, T., & Hayakawa, M. (2001) · The Journal of Urology · doi:10.1097/00005392-200102000-00083 · Cited by 23

Different Sensitivity of the Transforming Growth Factor-β Cell Cycle Arrest Pathway to c-Myc and MDM-2

Blain, S. W., & Massagué, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006496200 · Cited by 23

Smad2 mediates Erk1/2 activation by TGF-β1 in suspended, but not in adherent, gastric carcinoma cells

Lee, M.-S., Ko, S., Kim, H., Kim, Y. B., Lee, S.-Y., Kim, S., Jong, H.-S., Kim, T.-Y., Lee, S. E., & Bang, Y. (2004) · International Journal of Oncology · doi:10.3892/ijo.24.5.1229 · Cited by 16

Evidence for a Role of Smad3 and Smad2 in Stabilization of the Tumor-derived Mutant Smad2.Q407R

Dumont, E., Lallemand, F., Prunier, C., Ferrand, N., Guillouzo, A., Clément, B., Atfi, A., & Théret, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212496200 · Cited by 15

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

Yuan, J.-H., Yang, F., Wang, F., Ma, J.-Z., Guo, Y.-J., Tao, Q.-F., Liu, F., Pan, W., Wang, T.-T., Zhou, C.-C., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.010 · Cited by 1,515

Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

Wipff, P.-J., & Hinz, B. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.012 · Cited by 517

Ion channels and the hallmarks of cancer

Prevarskaya, N., Skryma, R., & Shuba, Y. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.01.005 · Cited by 448