Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)

Strutz, F., Zeisberg, M., Renziehausen, A., Raschke, B., Becker, V., Van Kooten, C., & Müller, G. A. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.059002579.x · Cited by 250

Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF‐β1 involves MAPK, Smad and AP‐1 signalling pathways

Davies, M., Robinson, M., Smith, E., Huntley, S., Prime, S., & Paterson, I. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20458 · Cited by 250

Effect of Conditional Knockout of the Type II TGF-β Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis

Forrester, E., Chytil, A., Bierie, B., Aakre, M., Gorska, A. E., Sharif-Afshar, A.-R., Muller, W. J., & Moses, H. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3272 · Cited by 249

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

Sun, Y., Liu, X., Ng-Eaton, E., Lodish, H. F., & Weinberg, R. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12442 · Cited by 247

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

Grady, W. M., Rajput, A., Myeroff, L. L., Liu, D. F., Kwon, K., Willis, J. E., & Markowitz, S. D. (1998) · PubMed · Cited by 244

Transforming growth factor-?1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

Hasegawa, Y., Takanashi, S., Kanehira, Y., Tsushima, T., Imai, T., & Okumura, K. (2001) · Cancer · doi:10.1002/1097-0142(20010301)91:5<964::aid-cncr1086>3.0.co;2-o · Cited by 244

c-myc Is a Downstream Target of the Smad Pathway

Yagi, K., Furuhashi, M., Aoki, H., Goto, D., Kuwano, H., Sugamura, K., Miyazono, K., & Kato, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104170200 · Cited by 244

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

Nagatake, M., Takagi, Y., Osada, H., Uchida, K., Mitsudomi, T., Saji, S., Shimokata, K., Takahashi, T., & Takahashi, T. (1996) · PubMed · Cited by 241

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.

Tachibana, I., Imoto, M., Adjei, P. N., Gores, G. J., Subramaniam, M., Spelsberg, T. C., & Urrutia, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119418 · Cited by 241

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation 1

Ehrhart, E. J., Segarini, P., Tsang, M. L. ‐., Carroll, A. G., & Barcellos‐Hoff, M. H. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.12.9337152 · Cited by 236

Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

Feng, X.-H., Liang, Y.-Y., Liang, M., Zhai, W., & Lin, X. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00430-0 · Cited by 231

Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase

Yi, J. Y., Shin, I., & Arteaga, C. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413223200 · Cited by 228

Dual role for TGF-?1 in apoptosis

SANCHEZCAPELO, A. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.11.002 · Cited by 228

Role of Rho/ROCK and p38 MAP Kinase Pathways in Transforming Growth Factor-β-mediated Smad-dependent Growth Inhibition of Human Breast Carcinoma Cells in Vivo

Kamaraju, A. K., & Roberts, A. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m403960200 · Cited by 227

Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Edlund, S., Bu, S., Schuster, N., Aspenström, P., Heuchel, R., Heldin, N.-E., ten Dijke, P., Heldin, C.-H., & Landström, M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0037 · Cited by 226

Hyaluronan Promotes Signaling Interaction between CD44 and the Transforming Growth Factor β Receptor I in Metastatic Breast Tumor Cells

Bourguignon, L. Y. W., Singleton, P. A., Zhu, H., & Zhou, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204320200 · Cited by 224

Distinct mechanisms of TGF- 1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

Han, G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24399 · Cited by 224

TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest

Petritsch, C., Beug, H., Balmain, A., & Oft, M. (2000) · Genes & Development · doi:10.1101/gad.854200 · Cited by 223

A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes

Gotzmann, J., Fischer, A. N. M., Zojer, M., Mikula, M., Proell, V, Huber, H., Jechlinger, M., Waerner, T., Weith, A., Beug, H., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209083 · Cited by 223

Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Frederick, J. P., Liberati, N. T., Waddell, D. S., Shi, Y., & Wang, X.-F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2546-2559.2004 · Cited by 221

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN

Stroschein, S. L., Bonni, S., Wrana, J. L., & Luo, K. (2001) · Genes & Development · doi:10.1101/gad.912901 · Cited by 218

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

Xie, W. Q., Mertens, J. C., Reiss, D. J., Rimm, D. L., Camp, R. L., Haffty, B. G., & Reiß, M. (2002) · PubMed · Cited by 217

Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes

Grände, M., Franzen, A., Karlsson, J.-O., Ericson, L. E., Heldin, N.-E., & Nilsson, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00091 · Cited by 215

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

Garrigue‐Antar, L., Muñoz-Antonia, T., Antonia, S. J., Gesmonde, J. F., Vellucci, V. F., & Reiss, M. (1995) · PubMed · Cited by 214

Preoperative Plasma Levels of Transforming Growth Factor Beta1 (TGF-β1) Strongly Predict Progression in Patients Undergoing Radical Prostatectomy

Shariat, S. F., Shalev, M., Menesses-Diaz, A., Kim, I. Y., Kattan, M. W., Wheeler, T. M., & Slawin, K. M. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.11.2856 · Cited by 214

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.

Valdés, F., Alvarez, A. M., Locascio, A., Vega, S., Herrera, B. M., Fernández, M., Benito, M., Nieto, M. A., & Fabregat, I. (2002) · PubMed · Cited by 211

Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

Itoh, S., Thorikay, M., Kowanetz, M., Moustakas, A., Itoh, F., Heldin, C.-H., & ten Dijke, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208258200 · Cited by 209

Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling

Chacko, B. M., Qin, B. Y., Tiwari, A., Shi, G., Lam, S., Hayward, L. J., de Caestecker, M., & Lin, K. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.016 · Cited by 209

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

Dalal, B. I., Keown, P. A., & Greenberg, A. H. (1993) · PubMed · Cited by 208

Bone Morphogenetic Protein-6 Promotes Osteoblastic Prostate Cancer Bone Metastases through a Dual Mechanism

Dai, J., Keller, J., Zhang, J., Lu, Y., Yao, Z., & Keller, E. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1891 · Cited by 208

TGF-β1 as an Enhancer of Fas-Mediated Apoptosis of Lung Epithelial Cells

Hagimoto, N., Kuwano, K., Inoshima, I., Yoshimi, M., Nakamura, N., Fujita, M., Maeyama, T., & Hara, N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6470 · Cited by 207

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway

Woodford-Richens, K. L., Rowan, A. J., Gorman, P., Halford, S., Bicknell, D. C., Wasan, H. S., Roylance, R. R., Bodmer, W. F., & Tomlinson, I. P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171321498 · Cited by 199

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.

Takaku, K., Miyoshi, H., Matsunaga, A., Oshima, M., Sasaki, N., & Taketo, M. M. (1999) · PubMed · Cited by 198

A Novel Role for the Adaptor Molecule CD2-associated Protein in Transforming Growth Factor-β-induced Apoptosis

Schiffer, M., Mundel, P., Shaw, A. S., & Böttinger, E. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403534200 · Cited by 198

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

Xu, J., & Attisano, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4820 · Cited by 197

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

Lu, S.-L., Reh, D., Li, A. G., Woods, J., Corless, C. L., Kulesz-Martin, M., & Wang, X.-J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1032 · Cited by 197

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

Böttinger, E. P., Jakubczak, J. L., Haines, D. C., Bagnall, K. M., & Wakefield, L. M. (1997) · PubMed · Cited by 196

Targeted tumor therapy with the TGF-β2 antisense compound AP 12009

SCHLINGENSIEPEN, K., SCHLINGENSIEPEN, R., STEINBRECHER, A., HAU, P., BOGDAHN, U., FISCHERBLASS, B., & JACHIMCZAK, P. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.002 · Cited by 195

Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model.

Tuxhorn, J. A., McAlhany, S. J., Yang, F., Dang, T. D., & Rowley, D. R. (2002) · PubMed · Cited by 195

p53-Independent Role of MDM2 in TGF-β1 Resistance

Sun, P., Dong, P., Dai, K., Hannon, G. J., & Beach, D. (1998) · Science · doi:10.1126/science.282.5397.2270 · Cited by 195

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

Xu, W., Angelis, K., Danielpour, D., Haddad, M. M., Bischof, O., Campisi, J., Stavnezer, E., & Medrano, E. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090097797 · Cited by 194

Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia

Liu, W., Rui, H., Wang, J., Lin, S., He, Y., Chen, M., Li, Q., Ye, Z., Zhang, S., Chan, S. C., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601057 · Cited by 193

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

Muraoka, R. S., Koh, Y., Roebuck, L. R., Sanders, M. E., Brantley-Sieders, D., Gorska, A. E., Moses, H. L., & Arteaga, C. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8691-8703.2003 · Cited by 191

RUNX3 Suppresses Gastric Epithelial Cell Growth by Inducing p21WAF1/Cip1 Expression in Cooperation with Transforming Growth Factor β-Activated SMAD

Chi, X.-Z., Yang, J.-O., Lee, K.-Y., Ito, K., Sakakura, C., Li, Q.-L., Kim, H.-R., Cha, E.-J., Lee, Y.-H., Kaneda, A., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8097-8107.2005 · Cited by 189

Transforming growth factor β (TGFβ) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)

Nawshad, A., LaGamba, D., & Hay, E. D. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.05.007 · Cited by 188

Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-β-dependent Apoptosis

Yamamura, Y., Hua, X., Bergelson, S., & Lodish, H. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006023200 · Cited by 188

Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro

Brown, K. A., Aakre, M. E., Gorska, A. E., Price, J. O., Eltom, S. E., Pietenpol, J. A., & Moses, H. L. (2004) · Breast Cancer Research · doi:10.1186/bcr778 · Cited by 187

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

Chen, R.-H., Su, Y.-H., Chuang, R. L., & Chang, T.-Y. (1998) · Oncogene · doi:10.1038/sj.onc.1202111 · Cited by 186

Novel roles of Akt and mTOR in suppressing TGF‐β/ALK5‐mediated Smad3 activation

Song, K., Wang, H., Krebs, T. L., & Danielpour, D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600917 · Cited by 185

Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.

Portella, G., Cumming, S. A., Liddell, J., Cui, W., Ireland, H., Akhurst, R. J., & Balmain, A. (1998) · PubMed · Cited by 185

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness

Gotzmann, J., Huber, H., Thallinger, C., Wolschek, M., Jansen, B., Schulte-Hermann, R., Beug, H., & Mikulits, W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.6.1189 · Cited by 185

Slug is an Essential Target of TGFβ2 Signaling in the Developing Chicken Heart

Romano, L. A., & Runyan, R. B. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9750 · Cited by 184

The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

Gottfried, Y., Rotem, A., Lotan, R., Steller, H., & Larisch, S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600155 · Cited by 184

Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers

Friedl, W., Uhlhaas, S., Schulmann, K., Stolte, M., Loff, S., Back, W., Mangold, E., Stern, M., Knaebel, H.-P., Sutter, C., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0748-9 · Cited by 181

Regulation of Smad signaling by protein kinase C

Yakymovych, I., Dijke, P. T., Heldin, C., & Souchelnytskyi, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0474fje · Cited by 180

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

Shin, I., Bakin, A. V., Rodeck, U., Brunet, A., & Arteaga, C. L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3328 · Cited by 178

Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.

Tian, F., Byfield, S. D., Parks, W. T., Yoo, S. S., Felici, A., Tang, B., Piek, E., Wakefield, L. M., & Roberts, A. B. (2003) · PubMed · Cited by 177

Elevated plasma levels of TGF-β1 in patients with invasive prostate cancer

Ivanovic, V., Melman, A., Davis-Joseph, B., Valcic, M., & Geliebter, J. (1995) · Nature Medicine · doi:10.1038/nm0495-282 · Cited by 176

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

Takekawa, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf643 · Cited by 175

The Anaphase-Promoting Complex Mediates TGF-β Signaling by Targeting SnoN for Destruction

Wan, Y., Liu, X., & Kirschner, M. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00382-3 · Cited by 169

Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis

Raida, M., Clement, J. H., Leek, R. D., Ameri, K., Bicknell, R., Niederwieser, D., & Harris, A. L. (2005) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-005-0024-1 · Cited by 169

Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP

Valderrama-Carvajal, H., Cocolakis, E., Lacerte, A., Lee, E.-H., Krystal, G., Ali, S., & Lebrun, J.-J. (2002) · Nature Cell Biology · doi:10.1038/ncb885 · Cited by 169

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

Yakicier, M. C., Irmak, M. B., Romano, A., Kew, M., & Ozturk, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202866 · Cited by 167

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

Ewen, M. E., Oliver, C. J., Sluss, H. K., Miller, S. J., & Peeper, D. S. (1995) · Genes & Development · doi:10.1101/gad.9.2.204 · Cited by 166

Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells.

Benckert, C., Jonas, S., Cramer, T., von Marschall, Z., Schäfer, G., Peters, M., Wagner, K., Radke, C., Wiedenmann, B., Neuhaus, P., et al. (2003) · PubMed · Cited by 164

Loss of Smad3 in Acute T-Cell Lymphoblastic Leukemia

Wolfraim, L. A., Fernandez, T. M., Mamura, M., Fuller, W. L., Kumar, R., Cole, D. E., Byfield, S., Felici, A., Flanders, K. C., Walz, T. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031197 · Cited by 163

Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway

Atfi, A., Buisine, M., Mazars, A., & Gespach, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24731 · Cited by 162

Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy

Micke, P., & Östman, A. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.6.1217 · Cited by 162

Axin Facilitates Smad3 Activation in the Transforming Growth Factor β Signaling Pathway

Furuhashi, M., Yagi, K., Yamamoto, H., Furukawa, Y., Shimada, S., Nakamura, Y., Kikuchi, A., Miyazono, K., & Kato, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5132-5141.2001 · Cited by 162

Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation

Kurisaki, K., Kurisaki, A., Valcourt, U., Terentiev, A. A., Pardali, K., ten Dijke, P., Heldin, C.-H., Ericsson, J., & Moustakas, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4494-4510.2003 · Cited by 162

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding

De Wever, O., Westbroek, W., Verloes, A., Bloemen, N., Bracke, M., Gespach, C., Bruyneel, E., & Mareel, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01322 · Cited by 160

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

Nishihara, A., Hanai, J., Okamoto, N., Yanagisawa, J., Kato, S., Miyazono, K., & Kawabata, M. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00217.x · Cited by 159

Conditional Overexpression of Active Transforming Growth Factor β1 In vivo Accelerates Metastases of Transgenic Mammary Tumors

Muraoka-Cook, R. S., Kurokawa, H., Koh, Y., Forbes, J. T., Roebuck, L. R., Barcellos-Hoff, M. H., Moody, S. E., Chodosh, L. A., & Arteaga, C. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2111 · Cited by 159

TGFβ-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN

Vogelmann, R., Nguyen-tat, M.-D., Giehl, K., Adler, G., Wedlich, D., & Menke, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02594 · Cited by 159

CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness

Michl, P., Ramjaun, A. R., Pardo, O. E., Warne, P. H., Wagner, M., Poulsom, R., D’Arrigo, C., Ryder, K., Menke, A., Gress, T., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.018 · Cited by 159

Autocrine Transforming Growth Factor-β Signaling Mediates Smad-independent Motility in Human Cancer Cells

Dumont, N., Bakin, A. V., & Arteaga, C. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m204623200 · Cited by 159

Transforming Growth Factor-β1 Triggers Hepatocellular Carcinoma Invasiveness via α3β1 Integrin

Giannelli, G., Fransvea, E., Marinosci, F., Bergamini, C., Colucci, S. C., Schiraldi, O., & Antonaci, S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64170-3 · Cited by 154

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

Arrick, B. A., Lopez, A. R., Elfman, F., Ebner, R., Damsky, C. H., & Derynck, R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.3.715 · Cited by 154

Transforming Growth Factor β Receptor Type II Inactivation Promotes the Establishment and Progression of Colon Cancer

Biswas, S., Chytil, A. M., Washington, K., Romero–Gallo, J., Gorska, A. E., Wirth, P. S., Gautam, S., Moses, H. L., & Grady, W. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3255 · Cited by 153

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

Chen, T., Carter, D., Garrigue‐Antar, L., & Reiss, M. (1998) · PubMed · Cited by 150

Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer.

Tsushima, H., Ito, N., Tamura, S., Matsuda, Y., Inada, M., Yabuuchi, I., Imai, Y., Nagashima, R., Misawa, H., Takeda, H., et al. (2001) · PubMed · Cited by 149

A role for Id in the regulation of TGF-β-induced epithelial–mesenchymal transdifferentiation

Kondo, M., Cubillo, E., Tobiume, K., Shirakihara, T., Fukuda, N., Suzuki, H. I., Shimizu, K., Takehara, K., Cano, A., Saitoh, M., et al. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401467 · Cited by 149

β-Catenin and TGFβ signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition

Eger, A., Stockinger, A., Park, J., Langkopf, E., Mikula, M., Gotzmann, J., Mikulits, W., Beug, H., & Foisner, R. (2004) · Oncogene · doi:10.1038/sj.onc.1207416 · Cited by 148

Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.

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Invasion and metastasis of a mammary tumor involves TGF-? signaling

McEarchern, J. A., Kobie, J. J., Mack, V. E., Wu, R. S., Meade‐Tollin, L. C., Arteaga, C. L., Dumont, N., Besselsen, D. G., Seftor, E. A., Hendrix, M. J. C., et al. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20010101)91:1<76::aid-ijc1012>3.0.co;2-8 · Cited by 147

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