Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

The hallmarks of cancer

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Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

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Angiogenesis in life, disease and medicine

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A multigenic program mediating breast cancer metastasis to bone

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Smad transcription factors

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

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Stromal fibroblasts in cancer initiation and progression

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Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

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TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

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Putting tumours in context

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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

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pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

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Molecular requirements for epithelial–mesenchymal transition during tumor progression

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Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

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Epithelial–mesenchymal transitions in development and pathologies

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SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

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Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

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Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

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TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

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The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

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TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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G1 cell-cycle control and cancer

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Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

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Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

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Type beta transforming growth factor: a bifunctional regulator of cellular growth.

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NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

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Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

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Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

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A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

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Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

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TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

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Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

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Non-Smad TGF-β signals

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Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

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Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

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Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

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Deactivation of macrophages by transforming growth factor-β

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Defective Angiogenesis in Mice Lacking Endoglin

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Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

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MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo

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Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation.

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LKB1-Dependent Signaling Pathways

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Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

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Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

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TGF- β signaling in cancer – a double-edged sword

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A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)

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The two faces of transforming growth factor β in carcinogenesis

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Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition

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Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

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TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

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Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

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Role of Transforming Growth Factor Beta in Human Cancer

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Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

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Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

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Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

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DPC4 gene in various tumor types.

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Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

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Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

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TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

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Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines

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The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

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Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

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TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

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TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

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Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition

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TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

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Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

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Apoptosis in podocytes induced by TGF-β and Smad7

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Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

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Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton

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Repression of p15INK4b expression by Myc through association with Miz-1

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Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice

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Transcriptional regulation of cadherins during development and carcinogenesis

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A Self-Enabling TGFβ Response Coupled to Stress Signaling

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Development of TGF-β signalling inhibitors for cancer therapy

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SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions

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