The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation
Open accessAbstract
Summary There is a growing acceptance that tumor-infiltrating myeloid cells play an active role in tumor growth and mast cells are one of the earliest cell types to infiltrate developing tumors. Mast cells accumulate at the boundary between healthy tissues and malignancies and are often found in close association with blood vessels within the tumor microenvironment. They express many pro-angiogenic compounds, and may play an early role in angiogenesis within developing tumors. Mast cells also remodel extracellular matrix during wound healing, and this function is subverted in tumor growth, promoting tumor spread and metastasis. In addition, mast cells modulate immune responses by dampening immune rejection or directing immune cell recruitment, depending on local stimuli. In this review, we focus on key roles for mast cells in angiogenesis, tissue remodeling and immune modulation and highlight recent findings on the integral role that mast cells play in tumor growth. New findings suggest that mast cells may serve as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may lead to tumor regression.
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Cited by
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290
Komi, D. E. A., Khomtchouk, K., & Santa Maria, P. L. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08729-w · Cited by 384
Regulation of Mast Cell Responses in Health and Disease
Gilfillan, A. M., & Beaven, M. A. (2011) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v31.i6.30 · Cited by 259
Targeting the tumor microenvironment in renal cell cancer biology and therapy
Heidegger, I., Pircher, A., & Pichler, R. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00490 · Cited by 133
Policastro, L. L., Ibañez, I. L., Notcovich, C., Duran, H. A., & Podhajcer, O. L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4367 · Cited by 120
Metadata
- Authors
- Maltby, S., Khazaie, K., & McNagny, K. M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 1796
- Issue
- 1
- Pages
- 19-26
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W2026210456
- Cited by
- 288
- References
- 94
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
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