The role of myeloid cells in the promotion of tumour angiogenesis
Abstract
The use of various transgenic mouse models and analysis of human tumour biopsies has shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils, eosinophils, mast cells and dendritic cells, have an important role in regulating the formation and maintenance of blood vessels in tumours. In this Review the evidence for each of these cell types driving tumour angiogenesis is outlined, along with the mechanisms regulating their recruitment and activation by the tumour microenvironment. We also discuss the therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies.
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CXCR2 receptor is expressed by several stromal cell types such as endothelial and myeloid cells.
“CXCR2 receptor is expressed by several stromal cell types such as endothelial and myeloid cells (Murdoch et al., 2008).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Murdoch et al., 2008
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- Authors
- Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Lewis, Claire E.
- Venue
- Nature Reviews Cancer
- Published
- 2008-07-17
- Volume
- 8
- Issue
- 8
- Pages
- 618-631
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2023164440
- Cited by
- 1,642
- References
- 197
- Citations by year
- 2026: 25 · 2025: 43 · 2024: 39 · 2023: 93 · 2022: 94 · 2021: 86 · 2020: 89 · 2019: 78 · 2018: 81 · 2017: 120 · 2016: 97 · 2015: 101 · 2014: 119 · 2013: 136 · 2012: 127
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Cancer Research UK
- Breast Cancer Campaign
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor angiogenesis, myeloid cells, tumour-associated macrophages, mast cells, neutrophils, eosinophils, dendritic cells, tumor microenvironment, myeloid cell recruitment, anti-angiogenic therapy, chemoresistance, bone marrow-derived cells
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Chemokines, Angiogenesis Inhibitors, Myeloid Cells, Mice
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