Cited by 1,642Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

The role of myeloid cells in the promotion of tumour angiogenesis

Murdoch, Craig, Muthana, Munitta, Coffelt, Seth B., Lewis, Claire E.·2008·Nature Reviews Cancer

Abstract

The use of various transgenic mouse models and analysis of human tumour biopsies has shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils, eosinophils, mast cells and dendritic cells, have an important role in regulating the formation and maintenance of blood vessels in tumours. In this Review the evidence for each of these cell types driving tumour angiogenesis is outlined, along with the mechanisms regulating their recruitment and activation by the tumour microenvironment. We also discuss the therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies.

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Crossref · 10.1038/nrc2444

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197 of 197 references verified0 citation errors · 0 not checkable

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  • CXCR2 receptor is expressed by several stromal cell types such as endothelial and myeloid cells.

    “CXCR2 receptor is expressed by several stromal cell types such as endothelial and myeloid cells (Murdoch et al., 2008).”

    From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Murdoch et al., 2008

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Authors
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E.
Affiliations
University of Sheffield (GB)
Corresponding author
Lewis, Claire E.
Venue
Nature Reviews Cancer
Published
2008-07-17
Volume
8
Issue
8
Pages
618-631
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2023164440
Cited by
1,642
References
197
Citations by year
2026: 25 · 2025: 43 · 2024: 39 · 2023: 93 · 2022: 94 · 2021: 86 · 2020: 89 · 2019: 78 · 2018: 81 · 2017: 120 · 2016: 97 · 2015: 101 · 2014: 119 · 2013: 136 · 2012: 127
FWCI
7.10
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • AstraZeneca
  • Cancer Research UK
  • Breast Cancer Campaign
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
tumor angiogenesis, myeloid cells, tumour-associated macrophages, mast cells, neutrophils, eosinophils, dendritic cells, tumor microenvironment, myeloid cell recruitment, anti-angiogenic therapy, chemoresistance, bone marrow-derived cells
MeSH terms
Animals, Humans, Neoplasms, Neovascularization, Pathologic, Chemokines, Angiogenesis Inhibitors, Myeloid Cells, Mice

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