The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Tumor angiogenesis: therapeutic implications

Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Angiogenesis in cancer and other diseases

Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070 · see citing works

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452 · see citing works

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630 · see citing works

Tumorigenesis and the angiogenic switch

Bergers, G., & Benjamin, L. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1093 · Cited by 3,559 · see citing works

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works

Otto Warburg's contributions to current concepts of cancer metabolism

Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340 · see citing works

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288 · see citing works

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 2× · see citing works

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172 · see citing works

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828 · see citing works

Transplacental Carcinogenesis by Stilbestrol

Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Structure, mechanism and regulation of peroxiredoxins

Wood, Z. A., Schröder, E., Harris, J. R., & Poole, L. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00003-8 · Cited by 2,546 · see citing works

Production of large amounts of hydrogen peroxide by human tumor cells.

Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504 · see citing works

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works

Paradoxical roles of the immune system during cancer development

de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,261 · see citing works

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228 · see citing works

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

Putting tumours in context

Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works

Autophagy and Metabolism

Rabinowitz, J. D., & White, E. (2010) · Science · doi:10.1126/science.1193497 · Cited by 1,982 · see citing works

Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007) · Blood · doi:10.1182/blood-2006-07-035972 · Cited by 1,946 · see citing works

The cancer stem cell: premises, promises and challenges

Clevers, H. (2011) · Nature Medicine · doi:10.1038/nm.2304 · Cited by 1,915 · see citing works

MicroRNAs in Cancer

Garzon, R., Calin, G. A., & Croce, C. M. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.59.053006.104707 · Cited by 1,791 · see citing works

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742 · see citing works

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

Ostrand‐Rosenberg, S., & Sinha, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802740 · Cited by 1,733 · see citing works

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707 · see citing works

Openings Between Defective Endothelial Cells Explain Tumor Vessel Leakiness

Hashizume, H., Baluk, P., Morikawa, S., McLean, J. W., Thurston, G., Roberge, S., Jain, R. K., & McDonald, D. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65006-7 · Cited by 1,689 · see citing works

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545 · see citing works

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,535 · see citing works

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

Taguchi, K., Motohashi, H., & Yamamoto, M. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01473.x · Cited by 1,478 · see citing works

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H., Nakada, K., Honma, Y., & Hayashi, J.-I. (2008) · Science · doi:10.1126/science.1156906 · Cited by 1,444 · see citing works

HMGB1 and RAGE in Inflammation and Cancer

Sims, G. P., Rowe, D. C., Rietdijk, S. T., Herbst, R., & Coyle, A. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132603 · Cited by 1,436 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

The impact of O2 availability on human cancer

Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2540 · Cited by 1,365 · see citing works

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,364 · see citing works

Bone-marrow haematopoietic-stem-cell niches

Wilson, A., & Trumpp, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1779 · Cited by 1,350 · see citing works

From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

Papp, L. V., Lu, J., Holmgren, A., & Khanna, K. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1528 · Cited by 1,331 · see citing works

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

Lü, J., Lin, P. H., Yao, Q. C., & Chen, C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00897.x · Cited by 1,331 · see citing works

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Radisky, D. C., Levy, D. D., Littlepage, L. E., Liu, H., Nelson, C. M., Fata, J. E., Leake, D., Godden, E. L., Albertson, D. G., Angela Nieto, M., et al. (2005) · Nature · doi:10.1038/nature03688 · Cited by 1,284 · see citing works

Regulation of autophagy by ROS: physiology and pathology

Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263 · see citing works

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Levine, A. J., & Puzio-Kuter, A. M. (2010) · Science · doi:10.1126/science.1193494 · Cited by 1,243 · see citing works

Macrophage polarization in tumour progression

Sica, A., Larghi, P., Mancino, A., Rubino, L., Porta, C., Totaro, M. G., Rimoldi, M., Biswas, S. K., Allavena, P., & Mantovani, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.004 · Cited by 1,241 · see citing works

Persistent oxidative stress in cancer

Toyokuni, S., Okamoto, K., Yodoi, J., & Hiai, H. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01368-b · Cited by 1,219 · see citing works

The sites and topology of mitochondrial superoxide production

Brand, M. D. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.003 · Cited by 1,217 · see citing works

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179 · see citing works

Hydrogen Peroxide: A Signaling Messenger

Stone, J. R., & Yang, S. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.243 · Cited by 1,175 · see citing works

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works

Mitochondria and reactive oxygen species

Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162 · see citing works

Hypoxia, DNA repair and genetic instability

Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140 · see citing works

Hallmarks of cancer: Interactions with the tumor stroma

Pietras, K., & Östman, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.045 · Cited by 1,137 · see citing works

Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,091 · see citing works

Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085 · see citing works

The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044 · see citing works

Oxidative protein folding in eukaryotes

Tu, B. P., & Weissman, J. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311055 · Cited by 1,041 · see citing works

Integration of Oxygen Signaling at the Consensus HRE

Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032 · see citing works

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.041 · Cited by 1,001 · see citing works

Chronic inflammation and oxidative stress in human carcinogenesis

Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.23192 · Cited by 1,001 · see citing works

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06667 · Cited by 995 · see citing works

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

Morikawa, S., Bałuk, P., Kaidoh, T., Haskell, A., Jain, R. K., & McDonald, D. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64920-6 · Cited by 987 · see citing works

Role of superoxide dismutase in cancer: a review.

Oberley, L. W., & Buettner, G. R. (1979) · PubMed · Cited by 982 · see citing works

TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 981 · see citing works

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

Gaengel, K., Genové, G., Armulik, A., & Betsholtz, C. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.161521 · Cited by 933 · see citing works

Reactive Oxygen Species: A Breath of Life or Death?

Fruehauf, J. P., & Meyskens, F. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2082 · Cited by 908 · see citing works

Does vitamin C act as a pro‐oxidant under physiological conditions?

Carr, A. C., & Frei, B. B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.1007 · Cited by 883 · see citing works

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

Hayes, J. D., & McMahon, M. J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.12.008 · Cited by 870 · see citing works

The effects of extracellular pH on immune function

Lardner, A. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.522 · Cited by 864 · see citing works

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855 · see citing works

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

Limón-Pacheco, J. H., & Gonsebatt, M. E. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.015 · Cited by 842 · see citing works

Pyruvate kinase type M2 and its role in tumor growth and spreading

Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.009 · Cited by 812 · see citing works

Chromosome aberrations in solid tumors

Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W. (2003) · Nature Genetics · doi:10.1038/ng1215 · Cited by 812 · see citing works

The role of hypoxia-inducible factors in tumorigenesis

Rankin, E. B., & Giaccia, A. J. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.21 · Cited by 806 · cited 2× · see citing works

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Shoshan‐Barmatz, V., Pinto, V. D., Zweckstetter, M., Raviv, Z., Keinan, N., & Arbel, N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.03.002 · Cited by 792 · see citing works

Cancer cell killing via ROS: To increase or decrease, that is the question

Wang, J., & Yi, J. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.12.7067 · Cited by 790 · see citing works

Acid-Mediated Tumor Invasion: a Multidisciplinary Study

Gatenby, R. A., Gawlinski, E. T., Gmitro, A. F., Kaylor, B., & Gillies, R. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4193 · Cited by 771 · see citing works

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

Corzo, C. A., Cotter, M. J., Cheng, P., Cheng, F., Kusmartsev, S. A., Sotomayor, E. M., Padhya, T. A., McCaffrey, T. V., McCaffrey, J. C., & Gabrilovich, D. I. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900092 · Cited by 765 · see citing works

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., Brahimi-Horn, M. C., & Pouysségur, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2470 · Cited by 753 · see citing works

Oxidative stress and apoptosis: Impact on cancer therapy

Ozben, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20874 · Cited by 751 · see citing works

The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

Kaelin, W. G. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2502 · Cited by 731 · see citing works

Hypoxia and hypoxia-inducible factors: master regulators of metastasis

Lu, X., & Kang, Y. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1360 · Cited by 723 · see citing works

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

Gregory, A. D., & Houghton, A. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2583 · Cited by 707 · see citing works

Vasculogenic Mimicry and Tumor Angiogenesis

Folberg, R., Hendrix, M. J. C., & Maniotis, A. J. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64739-6 · Cited by 682 · see citing works

Cancer associated fibroblasts (CAFs) in tumor microenvironment

Xing, F. (2010) · Frontiers in Bioscience · doi:10.2741/3613 · Cited by 682 · see citing works

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

Arnér, E. S. J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.014 · Cited by 675 · see citing works

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 671 · see citing works

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

Ushio‐Fukai, M., & Nakamura, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.044 · Cited by 651 · see citing works

Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

Rhee, S. G., Bae, Y. S., Lee, S.-R., & Kwon, J. (2000) · Science s STKE · doi:10.1126/stke.2000.53.pe1 · Cited by 646 · see citing works

Dual roles of Nrf2 in cancer

LAU, A., VILLENEUVE, N., Sun, Z., Wong, P. K., & Zhang, D. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.003 · Cited by 645 · see citing works

Hypoxia and mitochondrial oxidative metabolism

Solaini, G., Baracca, A., Lenaz, G., & Sgarbi, G. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.011 · Cited by 608 · see citing works

The thioredoxin system in cancer

Arnér, E. S. J., & Holmgren, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.10.009 · Cited by 589 · see citing works

Cell death assays for drug discovery

Kepp, O., Galluzzi, L., Lipinski, M. M., Yuan, J., & Kroemer, G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3373 · Cited by 556 · see citing works

Mechanisms that regulate production of reactive oxygen species by cytochrome P450

Zangar, R. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.01.018 · Cited by 555 · see citing works

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

Niture, S. K., & Jaiswal, A. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312694 · Cited by 548 · see citing works

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

Fang, J. Q., Seki, T., & Maeda, H. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.005 · Cited by 545 · see citing works

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage

Indo, H. P., Davidson, M. M., Yen, H., Suenaga, S., Tomita, K., Nishii, T., Higuchi, M., Koga, Y., Ozawa, T., & Majima, H. J. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.11.026 · Cited by 536 · see citing works

Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma?

Jose, C., Bellance, N., & Rossignol, R. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.012 · Cited by 518 · see citing works

High-mobility group box 1 and cancer

Tang, D., Kang, R., Zeh, H. J., & Lotze, M. T. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.014 · Cited by 513 · see citing works

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

DeNardo, D. G., Andreu, P., & Coussens, L. M. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9223-6 · Cited by 513 · see citing works

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

Ungerstedt, J. S., Sowa, Y., Xu, W., Shao, Y., Dokmanovic, M., Perez, G., Ngo, L., Holmgren, A., Jiang, X., & Marks, P. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408732102 · Cited by 504 · see citing works

Redox signaling in angiogenesis: Role of NADPH oxidase

Ushio‐Fukai, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.015 · Cited by 489 · see citing works

Reactive oxygen generated by Nox1 triggers the angiogenic switch

Arbiser, J. L., Petros, J. A., Klafter, R., Govindajaran, B., McLaughlin, E. R., Brown, L. F., Cohen, C., Moses, M. A., Kilroy, S. M., Arnold, R. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022630199 · Cited by 489 · see citing works

Redox Regulation in Cancer: A Double‐edged Sword with Therapeutic Potential

Acharya, A., Das, I., Chandhok, D., & Saha, T. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10095 · Cited by 487 · see citing works

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

Meyer, Y., Buchanan, B. B., Vignols, F., & Reichheld, J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134201 · Cited by 482 · see citing works

Targeting NOX, iNOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals

Murakami, A., & Ohigashi, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.23161 · Cited by 478 · see citing works

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.

Church, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S., & Trent, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3113 · Cited by 474 · see citing works

Should Supplemental Antioxidant Administration Be Avoided During Chemotherapy and Radiation Therapy?

Lawenda, B. D., Kelly, K. M., Ladas, E. J., Sagar, S. M., Vickers, A. J., & Blumberg, J. B. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn148 · Cited by 474 · see citing works

Bmi1 regulates mitochondrial function and the DNA damage response pathway

Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature · doi:10.1038/nature08040 · Cited by 474 · see citing works

High-Mobility Group Box 1, Oxidative Stress, and Disease

Tang, D., Kang, R., Zeh, H. J., & Lotze, M. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3356 · Cited by 465 · see citing works

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

Martinez‐Outschoorn, U., Balliet, R. M., Rivadeneira, D. B., Chiavarina, B., Pavlides, S., Wang, C., Whitaker‐Menezes, D., Daumer, K. M., Lin, Z., Witkiewicz, A. K., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12553 · Cited by 460 · see citing works

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

Fukumura, D., Duda, D. G., Munn, L. L., & JAIN, R. K. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00029.x · Cited by 452 · see citing works

Mitochondrial complex III regulates hypoxic activation of HIF

Klimova, T., & Chandel, N. S. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402307 · Cited by 433 · see citing works

Mitochondrial Regulation of Cell Cycle and Proliferation

Arciuch, V. G. A., Elguero, M. E., Poderoso, J. J., & Carreras, M. C. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4085 · Cited by 428 · see citing works

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

Frey, R. S., Ushio‐Fukai, M., & Malik, A. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2220 · Cited by 423 · see citing works

Autophagy in cancer associated fibroblasts promotes tumor cell survival

Martinez‐Outschoorn, U., Trimmer, C., Zhao, L., Whitaker‐Menezes, D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Cantarin, M. P. M., Capozza, F., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12928 · Cited by 406 · see citing works

The chemokine system in cancer biology and therapy

Mantovani, A., Savino, B., Locati, M., Zammataro, L. A., Allavena, P., & Bonecchi, R. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.007 · Cited by 395 · see citing works

Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis

Vaupel, P. W. (2008) · The Oncologist · doi:10.1634/theoncologist.13-s3-21 · Cited by 383 · see citing works

Heme Oxygenase-1 in Tumors: Is It a False Friend?

Józkowicz, A., Waś, H., & Dulak, J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1659 · Cited by 381 · see citing works

Redox Control of the Cell Cycle in Health and Disease

Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2513 · Cited by 379 · see citing works

Superoxide dismutases in malignant cells and human tumors

Kinnula, V. L., & Crapo, J. D. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.010 · Cited by 373 · see citing works

RNAi -Mediated Silencing of Nuclear Factor Erythroid-2–Related Factor 2 Gene Expression in Non–Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

Singh, A., Boldin‐Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J. B., Blackford, A. L., Goodman, S. N., Bunz, F., Watson, W. H., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1401 · Cited by 371 · see citing works

Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme

Toppo, S., Flohé, L., Ursini, F., Vanin, S., & Maiorino, M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.007 · Cited by 368 · see citing works

Alternative Vascularization Mechanisms in Cancer

Döme, B., Hendrix, M. J. C., Paku, S., Tóvári, J., & Tímár, J. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060302 · Cited by 359 · see citing works

pH control mechanisms of tumor survival and growth

Parks, S. K., Chiche, J., & Pouysségur, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22400 · Cited by 359 · see citing works

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

Waypa, G. B., Marks, J. D., Guzy, R. D., Mungai, P. T., Schriewer, J. M., Đokić, D., & Schumacker, P. T. (2009) · Circulation Research · doi:10.1161/circresaha.109.206334 · Cited by 358 · see citing works

Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity

Jochéms, C., & Schlom, J. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011007 · Cited by 353 · see citing works

Pharmacology of the Eosinophil

Giembycz, M. A., & Lindsay, M. A. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01404-2 · Cited by 350 · see citing works

Eosinophils in health and disease: the LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P., & Lee, N. A. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03484.x · Cited by 335 · see citing works

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

Ralph, S. J., Rodríguez‐Enríquez, S., Neužil, J., Saavedra, E., & Moreno‐Sánchez, R. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.02.008 · Cited by 335 · see citing works

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

Banjac, A., Perisic, T., Sato, H., Seiler, A., Bannai, S., Weiss, N., Kölle, P., Tschoep, K., Issels, R. D., Daniel, P. T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210796 · Cited by 324 · see citing works

Metastasis: cancer cell’s escape from oxidative stress

Pani, G., Galeotti, T., & Chiarugi, P. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9225-4 · Cited by 312 · see citing works

Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

Nagaraj, S., & Gabrilovich, D. I. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6229 · Cited by 305 · see citing works

Hypoxia signalling controls metabolic demand

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.003 · Cited by 298 · see citing works

Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation

Maltby, S., Khazaie, K., & McNagny, K. M. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.001 · Cited by 289 · see citing works

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

Jiang, T., Chen, N., Zhao, F., Wang, X.-J., Kong, B., Zheng, W., & Zhang, D. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0713 · Cited by 286 · see citing works

Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

Hu, Y.-M., Rosen, D., Zhou, Y., Feng, L., Yang, G., Liu, J.-S., & Huang, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503296200 · Cited by 280 · see citing works

NADPH oxidase and endothelial cell function

Ray, R., & Shah, A. M. (2005) · Clinical Science · doi:10.1042/cs20050067 · Cited by 278 · see citing works

Reactive oxygen species-dependent signaling regulates cancer

Weinberg, F. D., & Chandel, N. S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0099-y · Cited by 276 · see citing works

The Role of p53 in Metabolic Regulation

Puzio-Kuter, A. M. (2011) · Genes & Cancer · doi:10.1177/1947601911409738 · Cited by 273 · see citing works

Revisiting the TCA cycle: signaling to tumor formation

Raimundo, N., Baysal, B. E., & Shadel, G. S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.001 · Cited by 271 · see citing works

Deviant energetic metabolism of glycolytic cancer cells

Baggetto, L. G. (1992) · Biochimie · doi:10.1016/0300-9084(92)90016-8 · Cited by 268 · see citing works

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

Klotzsch, E., Smith, M. L., Kubow, K. E., Muntwyler, S., Little, W. C., Beyeler, F., Gourdon, D., Nelson, B. J., & Viola Vogel, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907518106 · Cited by 264 · see citing works

The cancer stem cell niche—there goes the neighborhood?

Cabarcas‐Petroski, S., Mathews, L., & Farrar, W. L. (2011) · International Journal of Cancer · doi:10.1002/ijc.26312 · Cited by 264 · see citing works

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production

Funes, J. M., Quintero, M., Henderson, S. R., Martínez, D., Qureshi, U., Westwood, C., Clements, M. O., Bourboulia, D., Pedley, R. B., Moncada, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700690104 · Cited by 256 · see citing works

Matricellular proteins: an overview

BORNSTEIN, P. K. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0069-z · Cited by 256 · see citing works

EMT: A new vision of hypoxia promoting cancer progression

Jiang, J. D., Tang, Y., & Liang, X. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.8.15274 · Cited by 254 · see citing works

Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells

Mochizuki, T., Furuta, S., Mitsushita, J., Shang, W. H., Ito, M., Yokoo, Y., Yamaura, M., Ishizone, S., Nakayama, J., Konagai, A., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209406 · Cited by 253 · see citing works

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

Werner, E., & Werb, Z. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111028 · Cited by 252 · see citing works

Mitochondrial and energy metabolism‐related properties as novel indicators of lung cancer stem cells

Ye, X., Li, Q., Wang, G., Sun, F., Gui-jun, H., Bian, X., Yu, S., & Qian, G. (2011) · International Journal of Cancer · doi:10.1002/ijc.25944 · Cited by 251 · see citing works

A threshold concept for cancer therapy

Kong, Q., Beel, J. A., & Lillehei, K. O. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0982 · Cited by 250 · see citing works

Mitochondrial O2⋅¯ and H2O2 Mediate Glucose Deprivation-induced Stress in Human Cancer Cells

Ahmad, I. M., Aykin‐Burns, N., Sim, J. E., Walsh, S. A., Higashikubo, R., Buettner, G. R., Venkataraman, S., Mackey, M. A., Flanagan, S. W., Oberley, L. W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411662200 · Cited by 246 · see citing works

Unique Function of the Nrf2–Keap1 Pathway in the Inducible Expression of Antioxidant and Detoxifying Enzymes

Kobayashi, A., Ohta, T., & Yamamoto, M. P. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78021-0 · Cited by 242 · see citing works

Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer

Jaruga, P., Zastawny, T. H., Skokowski, J., Dizdaroğlu, M., & Oliński, R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80240-8 · Cited by 242 · see citing works

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

Diaz, B., Shani, G., Pass, I., Anderson, D., Quintavalle, M., & Courtneidge, S. A. (2009) · Science Signaling · doi:10.1126/scisignal.2000368 · Cited by 242 · see citing works

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

Mathew, R., & White, E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.008 · Cited by 235 · see citing works

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

Swietach, P., Hulı́ková, A., Vaughan‐Jones, R. D., & Harris, A. L. (2010) · Oncogene · doi:10.1038/onc.2010.455 · Cited by 233 · see citing works

Mechanism of the tumor suppressive effect of MnSOD overexpression

Oberley, L. W. (2005) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2005.03.006 · Cited by 232 · see citing works

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

Dewhirst, M. W. (2009) · Radiation Research · doi:10.1667/rr1926.1 · Cited by 228 · see citing works

Hypoxia and energetic tumour metabolism

Brahimi-Horn, M. C., Bellot, G. L., & Pouysségur, J. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.006 · Cited by 227 · see citing works

NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity

Albertsson, P., Basse, P. H., Hokland, M., Goldfarb, R. H., Nagelkerke, J. F., Nannmark, U., & Kuppen, P. J. K. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.09.007 · Cited by 226 · see citing works

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

Smolková, K., Plecitá‐Hlavatá, L., Bellancé, N., Bénard, G., Rossignol, R., & Ježek, P. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.003 · Cited by 224 · see citing works

Adaptation to Oxidative Stress, Chemoresistance, and Cell Survival

Landriscina, M., Maddalena, F., Laudiero, G., & Esposito, F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2692 · Cited by 215 · see citing works

R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways

Cao, Y., Cao, R., & Hedlund, E. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0337-z · Cited by 215 · see citing works

Physiological Roles of Xanthine Oxidoreductase

Harrison, R. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-120037569 · Cited by 215 · see citing works

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

Giannoni, E., Bianchini, F., Calorini, L., & Chiarugi, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3727 · Cited by 208 · see citing works

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

Achuthan, S., Santhoshkumar, T. R., Prabhakar, J., Nair, S. A., & Pillai, M. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200675 · Cited by 207 · see citing works

Angiogenesis in pre-malignant conditions

Raica, M., Cîmpean, A. M., & Ribatti, D. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.04.007 · Cited by 207 · see citing works

Probing the structural and molecular diversity of tumor vasculature

Pasqualini, R., Arap, W., & McDonald, D. M. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02429-2 · Cited by 205 · see citing works

Understanding the "lethal" drivers of tumor-stroma co-evolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor microenvironment

Lisanti, M. P., Martinez-Outschoorn, U. E., Chiavarina, B., Pavlides, S., Whitaker-Menezes, D., Tsirigos, A., Witkiewicz, A. K., Lin, Z., Balliet, R. M., Howell, A., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.6.13370 · Cited by 199 · see citing works

Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

Elsabahy, M., Nazarali, A. J., & Földvári, M. (2011) · Current Drug Delivery · doi:10.2174/156720111795256174 · Cited by 199 · see citing works

Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks

Pries, A. R., Cornelissen, A. J. M., Sloot, A. A., Hinkeldey, M., Dreher, M. R., Höpfner, M., Dewhirst, M. W., & Secomb, T. W. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000394 · Cited by 192 · see citing works

Salivary analysis in oral cancer patients

Bahar, G., Feinmesser, R., Shpitzer, T., Popovtzer, A., & Nagler, R. M. (2006) · Cancer · doi:10.1002/cncr.22386 · Cited by 191 · see citing works

Roles of Nox1 and other Nox isoforms in cancer development

Kamata, T. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01207.x · Cited by 190 · see citing works

Redox Signaling in Cancer Biology

Gius, D. R., & Spitz, D. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1249 · Cited by 189 · see citing works

Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.

Soini, Y., Kahlos, K., Näpänkangas, U., Kaarteenaho–Wiik, R., Säily, M., Koistinen, P., Pääakkö, P., Holmgren, A., & Kinnula, V. L. (2001) · PubMed · Cited by 188 · see citing works

High Thioredoxin Expression Is Associated with Resistance to Docetaxel in Primary Breast Cancer

Kim, S. J., Miyoshi, Y., Taguchi, T., Tamaki, Y., Nakamura, H., Yodoi, J., Kato, K., & Noguchi, S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0449 · Cited by 185 · see citing works

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

Venkataraman, S., Alimova, I. N., Fan, R., Harris, P. S., Foreman, N. K., & Vibhakar, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010748 · Cited by 178 · see citing works

Immunogenic cell death and DAMPs in cancer therapy

Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223 · see citing works

Damage-associated molecular patterns in cancer: a double-edged sword

Hernandez, C., Huebener, P., & Schwabe, R. F. (2016) · Oncogene · doi:10.1038/onc.2016.104 · Cited by 483 · see citing works

Targeting cancer vulnerabilities with high-dose vitamin C

Ngo, B., Van Riper, J. M., Cantley, L. C., & Yun, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0135-7 · Cited by 423 · see citing works

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Kuo, C., Babuharisankar, A. P., Lin, Y.-C., Lien, H.-W., Lo, Y.-K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A., & Lee, A. (2022) · Journal of Biomedical Sciences · doi:10.1186/s12929-022-00859-2 · Cited by 316 · see citing works

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

Inoue, H., & Tani, K. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.84 · Cited by 352 · see citing works

Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms

Rochette, L., Guénancia, C., Gudjoncik, A., Hachet, O., Zeller, M., Cottin, Y., & Vergely, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.005 · Cited by 251 · see citing works

ROS-induced ROS release in plant and animal cells

Zandalinas, S. I., & Mittler, R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.028 · Cited by 233 · see citing works

Redox Regulation of Inflammation: Old Elements, a New Story

Lei, Y., Wang, K., Deng, L., Chen, Y., Nice, E. C., & Huang, C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21330 · Cited by 208 · see citing works

Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression

Griess, B., Mir, S. U. R., Datta, K., & Teoh-Fitzgerald, M. L. T. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.018 · Cited by 200 · see citing works

Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress

Kucharzewska, P., & Belting, M. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20304 · Cited by 183 · see citing works

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

Miele, L., Espinoza, I. C., Pochampally, Watabe, & Xing, F. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s36162 · Cited by 185 · see citing works

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 170 · see citing works

Lipid peroxidation causes endosomal antigen release for cross-presentation

Dingjan, I., Verboogen, D. R. J., Paardekooper, L. M., Revelo, N. H., Sittig, S. P., Visser, L. J., von Mollard, G. F., Henriet, S., Figdor, C. G., ter Beest, M., et al. (2016) · Scientific Reports · doi:10.1038/srep22064 · Cited by 153 · see citing works

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

Radogna, F., & Diederich, M. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.006 · Cited by 142 · see citing works

Nanoparticle Conjugation of Ginsenoside Rg3 Inhibits Hepatocellular Carcinoma Development and Metastasis

Ren, Z., Chen, X., Hong, L., Zhao, X., Cui, G., Li, A., Liu, Y., Zhou, L., Sun, R., Shen, S., et al. (2019) · Small · doi:10.1002/smll.201905233 · Cited by 125 · see citing works

Redox-sensitive nanoscale drug delivery systems for cancer treatment

Mirhadi, E., Mashreghi, M., Maleki, M. F., Alavizadeh, S. H., Arabi, L., Badiee, A., & Jaafari, M. R. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119882 · Cited by 123 · see citing works

Hyaluronan and Reactive Oxygen Species Signaling—Novel Cues from the Matrix?

Berdiaki, A., Neagu, M. T., Spyridaki, I., Николаевич, К. А., Pérez, S., & Nikitovic, D. (2023) · Antioxidants · doi:10.3390/antiox12040824 · Cited by 118 · see citing works

Nanocarriers in Gene Therapy: A Review

Xu, H., Li, Z., & Jin, S. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.2044 · Cited by 106 · see citing works

Redox Imbalance in the Development of Colorectal Cancer

Liu, H., Liu, X., Zhang, C., Zhu, H., Xu, Q., Bu, Y., & Lei, Y. (2017) · Journal of Cancer · doi:10.7150/jca.18735 · Cited by 106 · see citing works

Janus-Faced Tumor Microenvironment and Redox

Khramtsov, V. V., & Gillies, R. J. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5864 · Cited by 95 · see citing works

Biotinylated Bilirubin Nanoparticles as a Tumor Microenvironment‐Responsive Drug Delivery System for Targeted Cancer Therapy

Lee, Y., Lee, S., & Jon, S. (2018) · Advanced Science · doi:10.1002/advs.201800017 · Cited by 92 · see citing works

Metabolic Dependencies in Pancreatic Cancer

Gohar, A. V., Zarei, M., Brody, J. R., & Winter, J. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00617 · Cited by 87 · see citing works

Oxygen in the tumor microenvironment: effects on dendritic cell function

Paardekooper, L. M., de Vos, W., & van den Bogaart, G. (2019) · Oncotarget · doi:10.18632/oncotarget.26608 · Cited by 87 · see citing works

Bioinspired Hydrogels to Engineer Cancer Microenvironments

Park, K. M., Lewis, D. M., & Gerecht, S. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044619 · Cited by 83 · see citing works

Oxidative stress in melanogenesis and melanoma development

Kamiński, K., Kazimierczak, U., & Kolenda, T. (2022) · Współczesna Onkologia · doi:10.5114/wo.2021.112447 · Cited by 83 · see citing works

Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids

Dai, F., Liu, G., Li, Y., Yan, W., Wang, Q., Yang, J., Lu, D., Ding, D., Lin, D., & Zhou, B. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.017 · Cited by 79 · see citing works

High-Dose Vitamin C for Cancer Therapy

Mussa, A., Idris, R. A. M., Ahmed, N., Ahmad, S., Murtadha, A. H., Din, T. A. D. A. T., Yean, C. Y., Rahman, W. F. W. A., Lazim, N. M., Uskoković, V., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060711 · Cited by 81 · see citing works

Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies

Shah, D. D., Chorawala, M. R., Raghani, N. R., Patel, R., Fareed, M., Kashid, V. A., & Prajapati, B. G. (2025) · Medical Oncology · doi:10.1007/s12032-025-02641-4 · Cited by 78 · see citing works

ROS-major mediators of extracellular matrix remodeling during tumor progression

Nikitovic, D., Corsini, E., Kouretas, D., Tsatsakis, A. M., & Tzanakakis, G. N. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.013 · Cited by 78 · see citing works

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

Seebacher, N. A., Lane, D. J. R., Richardson, D. R., & Jansson, P. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.201 · Cited by 77 · see citing works

Mesoporous silica nanoparticles: Synthesis and multifaceted functionalization for controlled drug delivery

Gupta, J. R., Quadros, M., & Momin, M. M. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104305 · Cited by 74 · see citing works

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Wu, X., Zhou, Z., Li, K., & Liu, S. (2024) · Advanced Science · doi:10.1002/advs.202308632 · Cited by 71 · see citing works

Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies

Hernández, Á., Juanes‐Velasco, P., Landeira‐Viñuela, A., Bareke, H., Montalvillo, E., Góngora, R., & Fuentes, M. (2021) · Cancers · doi:10.3390/cancers13112821 · Cited by 67 · see citing works

Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges

Zagorodko, O., Arroyo‐Crespo, J. J., Nebot, V. J., & Vicent, M. J. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600316 · Cited by 67 · see citing works

Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells

Ji, Y., Dai, F., & Zhou, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.017 · Cited by 64 · see citing works

Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment

Cabezas‐Sainz, P., Pensado‐López, A., Sáinz, B., & Sanchez, L. E. (2020) · Cells · doi:10.3390/cells9091978 · Cited by 62 · see citing works

NQO1 Suppresses NF-κB–p300 Interaction to Regulate Inflammatory Mediators Associated with Prostate Tumorigenesis

Thapa, D., Meng, P., Bedolla, R. G., Reddick, R. L., Kumar, A. P., & Ghosh, R. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0562 · Cited by 62 · see citing works

Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation

Yan, W., Wang, Q., Yuan, C., Wang, F., Ji, Y., Dai, F., Jin, X., & Zhou, B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.021 · Cited by 57 · see citing works

Understanding nano-bio interactions to improve nanocarriers for drug delivery

Pearson, R. M., Hsu, H.-J., Bugno, J., & Hong, S. (2014) · MRS Bulletin · doi:10.1557/mrs.2014.9 · Cited by 57 · see citing works

Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities

Sorolla, M. A., Hidalgo, I. A., Sorolla, A., Montal, R., Pallisé, O., Salud, A., & Parisi, E. (2021) · Cancers · doi:10.3390/cancers13205037 · Cited by 57 · see citing works

Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells

Zhang, J., Duan, D., Xu, J., & Fang, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b11061 · Cited by 54 · see citing works

Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death

Malla, R. R., Kumari, S., Ganji, S. P., Srilatha, M., Nellipudi, H. R., & Nagaraju, G. P. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189154 · Cited by 48 · see citing works

Reduction Sensitive Poly( l -glutamic acid) (PGA)-Protein Conjugates Designed for Polymer Masked–Unmasked Protein Therapy

Talelli, M., & Vicent, M. J. (2014) · Biomacromolecules · doi:10.1021/bm5011883 · Cited by 48 · see citing works

Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathways

Moradi‐Marjaneh, R., Hassanian, S. M., Mehramiz, M., Rezayi, M., Ferns, G. A., Khazaei, M., & Avan, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27881 · Cited by 47 · see citing works

Natural modulators of the hallmarks of immunogenic cell death

Radogna, F., Dicato, M. A., & Diederich, M. F. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.12.016 · Cited by 46 · see citing works

MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness

Li, J., Pu, T., Yin, L., Li, Q., Liao, C., & Wu, B. J. (2020) · Oncogene · doi:10.1038/s41388-020-1217-4 · Cited by 47 · see citing works

Shaping of Dendritic Cell Function by the Metabolic Micro-Environment

Brombacher, E. C., & Everts, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00555 · Cited by 47 · see citing works

Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy

Zhu, S., Gu, Z., & Zhao, Y. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800050 · Cited by 44 · see citing works

Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis

Zhou, M., Aziz, M., & Wang, P. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0008 · Cited by 44 · see citing works

Wound Healing versus Metastasis: Role of Oxidative Stress

Lopez, T. E., Wendremaire, M., Lagarde, J., Duquet, O., Alibert, L., Paquette, B., Garrido, C., & Lirussi, F. (2022) · Biomedicines · doi:10.3390/biomedicines10112784 · Cited by 40 · see citing works

Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy

Zhou, R., Zhu, S., Gong, L., Fu, Y., Gu, Z., & Zhao, Y. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03240h · Cited by 41 · see citing works

Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis

Luanpitpong, S., Wang, L., Stueckle, T. A., Tse, W., Chen, Y., & Rojanasakul, Y. (2014) · Oncotarget · doi:10.18632/oncotarget.1956 · Cited by 40 · see citing works

Extracellular redox state shift: A novel approach to target prostate cancer invasion

Zhong, W., Weiss, H. L., Jayswal, R. D., Hensley, P. J., Downes, L. M., Clair, D. K. S., & Chaiswing, L. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.023 · Cited by 40 · see citing works

Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention

Li, Y., Zhang, L., Dai, F., Yan, W.-J., Wang, H., Tu, Z.-S., & Zhou, B. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02011 · Cited by 39 · see citing works

Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

Mir, S. U. R., Ormsbee, B. D., Griess, B., Vengoji, R., Tom, E. C., Kosmacek, E. A., Oberley‐Deegan, R. E., Talmon, G. A., Band, V., & Teoh-Fitzgerald, M. L. T. (2022) · Breast Cancer Research · doi:10.1186/s13058-022-01548-6 · Cited by 38 · see citing works

Investigating a pathogenic role for TXNDC5 in tumors

Chang, X., Xu, B., Wang, L., Wang, Y., Wang, Y., & Yan, S. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2123 · Cited by 37 · see citing works

New 2,6-diaminopyridines containing a sterically hindered benzylphosphonate moiety in the aromatic core as potential antioxidant and anti-cancer drugs

Гибадуллина, Э. М., Nguyen, T. T., Strelnik, A., Sapunova, А. S., Voloshina, A. D., Sudakov, I. A., Vyshtakalyuk, A. B., Voronina, J. К., Pudovik, M. A., & Burilov, A. R. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111735 · Cited by 37 · see citing works

Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8

Paardekooper, L. M., Bendix, M. B., Ottria, A., de Haer, L. W., ter Beest, M., Radstake, T. R. D. J., Marut, W., & van den Bogaart, G. (2018) · Bioscience Reports · doi:10.1042/bsr20182019 · Cited by 36 · see citing works

Mechanisms of immunogenic cell death and immune checkpoint blockade therapy

Lin, R. A., Lin, J. K., & Lin, S. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12375 · Cited by 35 · see citing works

Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

Bao, X., Dai, F., Li, X., & Zhou, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.021 · Cited by 33 · see citing works

Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition

Liu, X., Cui, H., Li, M., Chai, Z.-H., Wang, H., Jin, X., Dai, F., Liu, Y., & Zhou, B. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115191 · Cited by 32 · see citing works

Bioluminescent Probe for Tumor Hypoxia Detection via CYP450 Reductase in Living Animals

Gao, Y., Lin, Y., Liu, T., Chen, H., Yang, X., Tian, C., Du, L., & Li, M. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03597 · Cited by 31 · see citing works

Metabolic Remodeling Induced by Adipocytes: A New Achilles' Heel in Invasive Breast Cancer?

Attané, C., Milhas, D., Hoy, A. J., & Muller, C. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180426165001 · Cited by 31 · see citing works

Noninvasive ROS imaging and drug delivery monitoring in the tumor microenvironment

Jung, W., Asaduddin, M., Yoo, D., Lee, D. Y., Son, Y., Kim, D., Keum, H., Lee, J., Park, S., & Jon, S. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122633 · Cited by 30 · see citing works

Redox regulation of leukocyte-derived microparticle release and protein content in response to cold physical plasma-derived oxidants

Bekeschus, S., Moritz, J., Schmidt, A., & Wende, K. (2017) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2017.07.001 · Cited by 28 · see citing works

Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin

Cerda, M. B., Lloyd, R., Batalla, M., Giannoni, F., Casal, M., & Policastro, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.12.009 · Cited by 27 · see citing works

Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma

Wang, X., Dong, H.-S., Li, Q., Li, Y., & Hong, A. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1027471 · Cited by 24 · see citing works

Hybrid Nanoparticles as Drug Carriers for Controlled Chemotherapy of Cancer

Li, M., Luo, Z. Y., & Zhao, Y. (2016) · The Chemical Record · doi:10.1002/tcr.201600029 · Cited by 24 · see citing works

Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs

Bao, X., Dai, F., Wang, Q., Jin, X., & Zhou, B. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.033 · Cited by 23 · see citing works

Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages

Bekeschus, S., Scherwietes, L., Freund, E., Liedtke, K. R., Hackbarth, C., von Woedtke, T., & Partecke, L.-I. (2018) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2018.06.001 · Cited by 21 · see citing works

Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma

Mészáros, M., Yusenko, M. V., Domonkos, L., Péterfi, L., Kovács, G., & Bányai, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-96220-y · Cited by 21 · see citing works

Plasma, cancer, immunity

Bekeschus, S., & Clemen, R. (2022) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ac9398 · Cited by 21 · see citing works

Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids

Chugunova, E., Гибадуллина, Э. М., Matylitsky, K., Bazarbayev, B., Евгеньевна, Н. М., Volcho, K. P., Rogachev, A. D., Akylbekov, N., Nguyen, H. B. T., Voloshina, A. D., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16040499 · Cited by 21 · see citing works

Design of Nanoparticles in Cancer Therapy Based on Tumor Microenvironment Properties

Firouzabadi, B. M., Gigliobianco, M. R., Joseph, J. M., Censi, R., & Martino, P. D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122708 · Cited by 20 · see citing works

TCR-T cell therapy for solid tumors: challenges and emerging solutions

He, W., Cui, K., Farooq, M. A., Huang, N., Zhu, S., Jiang, D., Zhang, X., Chen, J., Liu, Y., & Xu, G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1493346 · Cited by 19 · see citing works

Metabolic vulnerabilities in cancer: A new therapeutic strategy

El‐Tanani, M., Rabbani, S. A., El‐Tanani, Y., & Matalka, I. I. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104438 · Cited by 19 · see citing works

A novel quinazoline-based analog induces G2/M cell cycle arrest and apoptosis in human A549 lung cancer cells via a ROS-dependent mechanism

Shi, H., Li, Y., Ren, X., Zhang, Y., Yang, Z., & Qi, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.03.034 · Cited by 17 · see citing works

Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia

Estarás, M., Martinez‐Morcillo, S., Sánchez, A. G., Martínez, R., Estévez, M., Pérez‐López, M., Míguez, M. P., Fernández‐Bermejo, M., Mateos, J. M., Vara, D., et al. (2020) · Biology of the Cell · doi:10.1111/boc.202000020 · Cited by 16 · see citing works

Smart Polymeric Nanocarriers for Drug Delivery

Duro‐Castaño, A., Talelli, M., Rodríguez-Escalona, G., & Vicent, M. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102416-4.00013-2 · Cited by 16 · see citing works

Antioxidant Polymers with Phenolic Pendants for the Mitigation of Cellular Oxidative Stress

Mondal, A., Pal, A., Sarkar, S., Datta, R., & De, P. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c01193 · Cited by 14 · see citing works

Oxystressed tumor microenvironment potentiates epithelial to mesenchymal transition and alters cellular bioenergetics towards cancer progression

Sridaran, D., Ramamoorthi, G., Rasool, M., & Premkumar, K. (2016) · Tumor Biology · doi:10.1007/s13277-016-5224-6 · Cited by 13 · see citing works

Vitamin C-induced competitive binding of HIF-1α and p53 to ubiquitin E3 ligase CBL contributes to anti-breast cancer progression through p53 deacetylation

Xiong, Y., Xu, S. S., Fu, B., Tang, W., Zaky, M. Y., Tian, R., Yao, R., Zhang, S., Zhao, Q., Nian, W., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113321 · Cited by 13 · see citing works

Histamine-related genes participate in the establishment of an immunosuppressive microenvironment and impact the immunotherapy response in hepatocellular carcinoma

Zhang, X., Zheng, P., Meng, B., Zhuang, H., Lu, B., Yao, J., Han, F., & Luo, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01399-9 · Cited by 12 · see citing works

Role of thermal and reactive oxygen species-responsive synthetic hydrogels in localized cancer treatment (bibliometric analysis and review)

Ahmed, Y. W., Tsai, H., Wu, T.-Y., Darge, H. F., & Chen, Y.-S. (2023) · Materials Advances · doi:10.1039/d3ma00341h · Cited by 11 · see citing works

NRF2-driven redox metabolism takes center stage in cancer metabolism from an outside-in perspective

Choi, E.-J., & Jeon, S. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01224-3 · Cited by 10 · see citing works

Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas

Ferreira, W. A. S., Vitiello, G. A. F., Medina, T. D. S., & de Oliveira, E. H. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-10114-1 · Cited by 11 · see citing works

Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the cellular invasion process in vitro

Polloni, L., Costa, T. R., Morais, L. P., Borges, B. C., Teixeira, S. C., Fernandes, T. A. D. M., Correia, L. I. V., Bastos, L. M., Amorim, F. G., Quinton, L., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110785 · Cited by 11 · see citing works

Structure-centered design of lipid-based nanocarriers to overcome biological barriers

Woo, Y., Yoon, J., Seo, Y., Han, Y., Yoo, H. Y., Sohn, H., Lee, M. H., & Lee, T. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102425 · Cited by 10 · see citing works

A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent

Dai, F., Du, Y., Zheng, Y.-L., & Zhou, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.018 · Cited by 10 · see citing works

The activity of redox-regulatory systems in the tumor and its surrounding tissues in various histological types of tumor

Surikova, E. I., Goroshinskaya, I. A., Nerodo, G. A., Frantsiyants, E. M., Malejko, M. L., Shalashnaya, E. V., Kachesova, P. S., Nemashkalova, L. A., & Leonova, A. (2016) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20166202187 · Cited by 9 · see citing works

Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals

Dai, F., Yan, W., Fu, X., Zheng, Y.-L., Du, Y., Bao, X., Kang, Y., Jin, X., & Zhou, B. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.075 · Cited by 8 · see citing works

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Dao, N. V., Ercole, F., Li, Y., Davis, T. P., Kaminskas, L. M., Sloan, E. K., Quinn, J. F., & Whittaker, M. R. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00812a · Cited by 7 · see citing works

Ortho-dihydroxychalcones as cupric ion-dependent prooxidants: Activity and mechanisms

Wang, Q., Qian, Y., Dai, F., Lu, D., Yan, W., Chen, Y., & Zhou, B. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.04.022 · Cited by 7 · see citing works

Redox forms of glutathione in malignant lesions of the stomach with varying aggressiveness degrees

Goroshinskaya, I. A., Surikova, E. I., Frantsiyants, E. M., Neskubina, I. V., Nemashkalova, L. A., Medvedeva, D. E., & Maslov, A. A. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2020-4-53-60 · Cited by 7 · see citing works

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ALHulais, R. A., & Ralph, S. J. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2018.71 · Cited by 7 · see citing works

Oxidative Stress and Redox Signaling in the Pathophysiology of Sickle Cell Disease: A Review

Obeagu, E. I. (2024) · Haematology International Journal · doi:10.23880/hij-16000247 · Cited by 5 · see citing works

Recent Advances Ultra-Porous Drug Nano-Carriers: Synthesis and Targeting Approaches

Hady, M. A. (2023) · Silicon · doi:10.1007/s12633-023-02662-6 · Cited by 4 · see citing works

Therapeutic Potential of Chemical Compounds in Targeting Cancer Stem Cells

Raghav, P. K., Mann, Z., & Mohanty, S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_87-1 · Cited by 4 · see citing works

Tumor microenvironment in a minipig model of spinal cord glioma

Tora, M. S., Neill, S. G., Lakhina, Y., Assed, H., Zhang, M. H., Nagarajan, P. P., Federici, T., Gutierrez, J., Hoang, K. B., Du, Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04531-7 · Cited by 4 · see citing works

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He, W., Li, Y., Liu, S., Chang, Y., Han, S., Han, X., Ma, Z., Amin, H. M., Song, Y.-H., & Zhou, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449525 · Cited by 4 · see citing works

The tumor microenvironment: characterization, redox considerations and novel approaches for ROS-targeted gene therapy.

Policastro, L., Ibañez, I. L., Notcovich, C., Durán, H., & Podhajcer, O. L. (2013) · CONICET Digital (CONICET) · Cited by 4 · see citing works

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Khramtsov, V. V., & Gillies, R. J. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5864 · Cited by 95 · see citing works

Microenvironmental and metabolic influences in tumor cell redox homeostasis

Leslie, M. T. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation

Moen, I. N., Jevne, C., Wang, J., Kalland, K.-H., Chekenya, M., Akslen, L. A., Sleire, L., Enger, P. Ø., Reed, R. K., Oyan, A. M., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-21 · Cited by 23 · see citing works

The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited

Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146 · see citing works