Cited by 85Protease and Inhibitor MechanismsGlioma Diagnosis and TreatmentPeptidase Inhibition and Analysis

Lost in disruption: Role of proteases in glioma invasion and progression

Mentlein, Rolf, Hattermann, Kirsten, Held-Feindt, Janka·2012·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Abstract

A characteristic feature of malignant glial tumors (gliomas) is their tendency to diffusely infiltrate the nervous system preventing their complete surgical resection. Proteases play a decisive role in this malignant process, either by degradation of brain extracellular matrix (ECM) components, adhesion molecules, or by regulating the activity of growth and chemotactic factors. Secreted matrix metalloproteinases (MMPs) and ADAMTS proteases (ADAMs with thrombospondin motifs) cleave different ECM components like the proteoglycans (lecticans) aggrecan, versican, neurocan and brevican with selective preferences; they are further regulated by endogenous inhibitors and activating metallo- and serine proteases. Cell surface proteases of the ADAM family (A Disintegrin And Metalloproteinase), but also serine proteases regulate the activity of growth factors and chemokines that act as autocrine / paracrine stimulators within gliomas. Thus, proteases play a decisive role for the spread and growth of gliomas and are prominent targets for their therapy.

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Crossref · 10.1016/j.bbcan.2011.12.001

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Authors
Mentlein, R., Hattermann, K., & Held-Feindt, J.
Affiliations
Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author
Mentlein, Rolf
Venue
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher
Elsevier BV
Published
2012-04
Volume
1825
Issue
2
Pages
178-185
ISSN
0304-419X (ISSN-L)
OpenAlex
W2023393975
Cited by
85
References
96
Citations by year
2025: 4 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 12 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 2
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
Keywords
glioma, proteolytic enzymes, tumor invasion, tumor progression, matrix metalloproteinases, ADAMTS proteases, ADAM family, extracellular matrix degradation, proteoglycans, aggrecan, versican, neurocan, brevican, serine protease, growth factor activation, chemokines, autocrine and paracrine signaling, protease inhibitors, glioma treatment
MeSH terms
Animals, Brain Neoplasms, Glioma, Humans, Neoplasm Invasiveness, Peptide Hydrolases, Disease Progression

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