The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Cholesterol metabolism: New functions and therapeutic approaches in cancer
Abstract
Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer. In recent years, numerous studies have reported the functions of cholesterol metabolism in the regulation of tumor biological processes, especially oncogenic signaling pathways, ferroptosis, and tumor microenvironment. Preclinical studies have over the years indicated the inhibitory effects of blocking cholesterol synthesis and uptake on tumor formation and growth. Besides, some new cholesterol metabolic molecules such as SOAT1, SQLE, and NPC1 have recently emerged as promising drug targets for cancer treatment. Here, we systematically review the roles of cholesterol and its metabolites, and the latest advances in cancer therapy targeting cholesterol metabolism.
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FSP1 is a glutathione-independent ferroptosis suppressor
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Cited by
Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538
Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model
Pei, Z., Qin, Y., Fu, X., Yang, F., Huo, F., Liang, X., Wang, S., Cui, H., Lin, P., Zhou, G., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102509 · Cited by 269
Why cells need iron: a compendium of iron utilisation
Teh, M. R., Armitage, A. E., & Drakesmith, H. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2024.04.015 · Cited by 114
Zhang, F., Gao, J., Liu, X., Sun, Y., Liu, L., Hu, B., Wang, Z., Shi, J., Guo, W., & Zhang, S. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23538 · Cited by 12
Metadata
- Authors
- Xu, H., Zhou, S., Tang, Q., Xia, H., & Bi, F.
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 1874
- Issue
- 1
- Pages
- 188394
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W3043543310
- Cited by
- 365
- References
- 127
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, H., Zhou, S., Tang, Q., Xia, H., & Bi, F. (2020). Cholesterol metabolism: New functions and therapeutic approaches in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2020.188394
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
