The DOI matches its Crossref record; 254 of the 254 references it cites were found in a registry or an index.
Tumor-associated neutrophils and neutrophil-targeted cancer therapies
Open accessAbstract
Neutrophils are the frontline cells in response to microbial infections and are involved in a range of inflammatory disorders in the body. In recent years, neutrophils have gained considerable attention in their involvement of complex roles in tumor development and progression. Tumor-associated neutrophils (TANs) that accumulate in local region could be triggered by external stimuli from tumor microenvironment (TME) and switch between anti- and pro-tumor phenotypes. The anti-tumor neutrophils kill tumor cells through direct cytotoxic effects as well as indirect effects by activating adaptive immune responses. In contrast, the pro-tumor phenotype of neutrophils might be associated with cell proliferation, angiogenesis, and immunosuppression in TME. More recently, neutrophils have been proposed as a potential target in cancer therapy for their ability to diminish the pro-tumor pathways, such as by immune checkpoint blockade. This review discusses the complex roles of neutrophils in TME and highlights the strategies in neutrophil targeting in cancer treatment with a particular focus on the progresses of ongoing clinical trials involving neutrophil-targeted therapies.
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Cites
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Cited by
Neutrophils and Neutrophil-Based Drug Delivery Systems in Anti-Cancer Therapy
Wahnou, H., El Kebbaj, R., Hba, S., Ouadghiri, Z., El Faqer, O., Pinon, A., Liagre, B., Limami, Y., & Duval, R. E. (2025) · Cancers · doi:10.3390/cancers17071232 · Cited by 35
Chen, L., Huang, Y., Zhang, N., Qu, J., Fang, Y., Fu, J., Yuan, Y., Zhang, Q., Li, H., Wen, Z., et al. (2024) · MedComm · doi:10.1002/mco2.654 · Cited by 15
Metadata
- Authors
- Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X.
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 1877
- Issue
- 5
- Pages
- 188762
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W4285600182
- Cited by
- 312
- References
- 254
- FWCI
- 19.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X. (2022). Tumor-associated neutrophils and neutrophil-targeted cancer therapies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2022.188762
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
