The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4
Abstract
The influence of an exercise training program and age on inflammatory cytokine production and CD14+cell-surface expression of toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4) was examined in 60 younger and older subjects. Subjects were assigned to: young physically active (YPA, n = 15; 25.2 +/- 5.0 years), young physically inactive (YPI, n = 14; 24.9 +/- 4.7 years), older physically active (OPA, n = 14; 71.2 +/- 4.4 years) or older physically inactive (OPI, n = 17; 71.0 +/- 4.3 years) groups. YPI and OPI completed 12 weeks (3 days/week) of endurance (20 min) and resistance exercise (eight exercises, two sets). YPA and OPA groups were instructed to continue their normal activity for 12 weeks. Blood was collected at rest, before and after the 12-week training and control period. A whole blood method was used to determine lipopolysaccharide-(LPS) and peptidoglycan-(PGN) stimulated IL-6, IL-1beta, and TNF-alpha production with supernatants analyzed using ELISA. CD14+ cell-surface expression of TLR2 and TLR4 were measured using flow cytometry. Training increased estimated VO(2max) by 10.4% and increased strength by an average of 38.1%. YPI and OPI had a post-training reduction in LPS-stimulated IL-6 production (P < .01), but LPS-stimulated IL-1beta and TNF-alpha and PGN-stimulated cytokines were not changed. CD14+ cell TLR4 was significantly reduced (P < .05) in YPI and OPI groups after training, but TLR2 was not significantly changed. An exercise training program reduced LPS-stimulated IL-6, concomitant with lower TLR4. These results provide further support for a training- or physical activity-induced lowering of TLR4 and inflammation.
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“a-Tocopherol (800 mg/d for 3 months) decreased plasma CRP concentrations in type 2 diabetics (788) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [788]
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Position statement. Part one: Immune function and exercise.
Walsh, N. P., Gleeson, M., Shephard, R. J., Gleeson, M., Woods, J. A., Bishop, N. C., Fleshner, M., Green, C., Pedersen, B. K., Hoffman‐Goetz, L., et al. (2011) · PubMed · Cited by 1,252
Dietary factors and low-grade inflammation in relation to overweight and obesity
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Immune function in sport and exercise
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Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000
Metadata
- Authors
- Stewart, L. K., Flynn, M. G., Campbell, W. W., Craig, B. A., Robinson, J. P., McFarlin, B. K., Timmerman, K. L., Coen, P. M., Felker, J., & Talbert, E.
- Affiliations
- Purdue University West Lafayette (US)
- University of Houston (US)
- Corresponding author
- Flynn, Michael G.
- ORCID
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 19
- Issue
- 5
- Pages
- 389-397
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2062539824
- Cited by
- 213
- References
- 40
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 8 · 2020: 15 · 2019: 5 · 2018: 13 · 2017: 14 · 2016: 15 · 2015: 7 · 2014: 12 · 2013: 13 · 2012: 7
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- exercise training, TLR2, TLR4, CD14+ cells, age, physical activity, inflammation, inflammatory cytokines, interleukin-6, lipopolysaccharide, peptidoglycan, resistance training, endurance exercise, older adults, VO2max
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Female, Fluorescent Dyes, Humans, Lipopolysaccharides, Longitudinal Studies, Male, Membrane Glycoproteins, Middle Aged, Peptidoglycan, Physical Endurance, Physical Fitness, Receptors, Cell Surface, Stimulation, Chemical, Weight Lifting, Anaerobic Threshold, Cytokines, Muscle, Skeletal, Lipopolysaccharide Receptors, Toll-Like Receptors, Toll-Like Receptor 2, Toll-Like Receptor 4
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