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Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
Open accessAbstract
The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFN gamma), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4(+)) and T-cytotoxic (CD8(+)) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values<0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values<0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4(+) cells producing IFN gamma (TH(1) cells) vs. IL-4 (TH(2) cells) in all compartments (depressed mood: P=0.012; anxiety: P=0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8(+) cells producing IFN gamma (TC(1)) vs. IL-4 (TC(2)) (P=0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.
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“Some studies have also reported that MDD may predict lower T-cell cytokine expression and reduce treatment adherence or initiation87,88, while improvement in depressive symptoms has been associated with increased survival in people with cancer89.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [87]
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“Some studies have also reported that MDD may predict lower T-cell cytokine expression and reduce treatment adherence or initiation87,88, while improvement in depressive symptoms has been associated with increased survival in people with cancer89.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [87]
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Metadata
- Authors
- Lutgendorf, S. K., Lamkin, D. M., DeGeest, K., Anderson, B., Dao, M., McGinn, S., Zimmerman, B., Maiseri, H., Sood, A. K., & Lubaroff, D. M.
- Affiliations
- University of Iowa (US)
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Lutgendorf, Susan K.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 22
- Issue
- 6
- Pages
- 890-900
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2605940
- OpenAlex
- W2095272581
- Cited by
- 126
- References
- 68
- Citations by year
- 2026: 6 · 2025: 3 · 2023: 49 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 13
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R21CA088293, R21 CA 88293, R01CA104825)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ovarian cancer, depressive mood, anxiety, T cell cytokines, interferon-gamma, IL-4, Th1/Th2 balance, tumor-infiltrating lymphocytes, ascites, tumor microenvironment, adaptive immunity, psychosocial factors, CD4+ T cells, CD8+ T cells
- MeSH terms
- Aged, Anxiety, Cells, Cultured, Depression, Female, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Interferon Type I, Lymphocyte Activation, Lymphocytes, Middle Aged, Ovarian Neoplasms, Surveys and Questionnaires, T-Lymphocytes, Cytotoxic, Interleukin-4, Cytokines
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