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Cited by 160Tryptophan and brain disordersStress Responses and CortisolVagus Nerve Stimulation Research

Psychoneuroimmunology of depression: clinical implications

Irwin, Michael·2002·Brain, Behavior, and Immunity
DOI 10.1006/brbi.2001.0654
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Abstract

Psychoneuroimmunology is a field that investigates the interactions between the brain and the immune system. One important goal of this field of research is to translate basic research in order to understand how behavior affects health and resistance to disease in humans. This review evaluates the impact of depression on morbidity and mortality risk and asks whether neuroimmune mechanisms contribute to this association. Examples are drawn from three diseases: cardiovascular disease, infectious disease, and rheumatoid arthritis. Finally, the potential for biobehavioral interventions to impact psychological adaptation and the course of immune related disease is discussed.

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Crossref · 10.1006/brbi.2001.0654

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  • Higher plasma IL-6 levels are associated with adverse health habits: higher in smokers, less physical activity, impaired sleep, higher BMI.

    “Other researchers have demonstrated that higher plasma IL-6 levels are associated with adverse health habits: values are higher in smokers than nonsmokers, in individuals who report less physical activity, in those whose sleep is impaired, and in those with a higher BMI, all behaviors that are adversely affected by stress (14, 34, 37, 50-52).”

    From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [52]

  • Depressive symptoms further exacerbate inflammation and contribute to the pathogenesis of various diseases of aging, many of which involve excessive cytokine activity.

    “These symptoms are thought to further exacerbate inflammation and, in doing so, contribute to the pathogenesis of various diseases of aging (6–8), many of which involve excessive cytokine activity (9, 10).”

    From Clustering of depression and inflammation in adolescents previously exposed to childhood adversity (2012) · cites this paper as [8]

  • Inflammation has been implicated in the development or etiology of depression across various populations and study designs.

    “A wealth of evidence has implicated inflammation in the development of depression.”

    From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Irwin, 2002

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Authors
Irwin, M.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Irwin, Michael
ORCID
Irwin, Michael
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2002-02
Volume
16
Issue
1
Pages
1-16
ISSN
0889-1591 (ISSN-L)
DOI
10.1006/brbi.2001.0654
OpenAlex
W1987890594
Cited by
160
References
102
Citations by year
2025: 4 · 2024: 2 · 2023: 8 · 2022: 2 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 1 · 2015: 9 · 2014: 5 · 2013: 2 · 2012: 8
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01aa010215-02)
  • National Institute on Alcohol Abuse and Alcoholism (AA13239, AA10215, R01AA013239)
  • National Institute on Aging (AG 18367, R01AG018367)
  • National Institute of Mental Health (MH-55253, T32-MH-18399, R01MH055253, T32MH018399)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR/AG41867)
  • National Center for Complementary and Integrative Health (AT00255, R21AT000255)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
depression, psychoneuroimmunology, neuroimmune mechanisms, morbidity and mortality risk, cardiovascular disease, infectious diseases, rheumatoid arthritis, biobehavioral interventions, psychological adjustment, immune-related diseases
MeSH terms
Behavior Therapy, Depressive Disorder, Humans, Nervous System, Biomarkers

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