Effects of prenatal infection on brain development and behavior: A review of findings from animal models

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177

Toll-like receptors in the induction of the innate immune response

Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,082

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269

Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic

Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,203

Disorders of Childhood and Adolescence: Gender and Psychopathology

Zahn-Waxler, C., Shirtcliff, E. A., & Marceau, K. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091358 · Cited by 1,072

A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology

McGrath, J., Saha, S., Welham, J., El Saadi, O., MacCauley, C., & Chant, D. (2004) · BMC Medicine · doi:10.1186/1741-7015-2-13 · Cited by 1,072

Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

Swerdlow, N. R., Geyer, M. A., & BRAFF, D. L. (2001) · Psychopharmacology · doi:10.1007/s002130100799 · Cited by 1,053

Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia

Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048

Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring

Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025

IL-1β inhibits axonal growth of developing sympathetic neurons

Nolan, A. M., Nolan, Y. M., & O’Keeffe, G. W. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.07.003 · Cited by 29

Prenatal immune activation interacts with stress and corticosterone exposure later in life to modulate N-methyl-d-aspartate receptor synaptic function and plasticity

Burt, M. A., Tse, Y. C., Boksa, P., & Wong, T. P. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000229 · Cited by 29

unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model

Auger, M. L., Schmidt, E. R. E., Manitt, C., Dal-Bo, G., Pasterkamp, R., & Flores, C. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12270 · Cited by 14

Brain Structural and Functional Alterations in Mice Prenatally Exposed to LPS Are Only Partially Rescued by Anti-Inflammatory Treatment

Aria, F., Bonini, S. A., Cattaneo, V., Premoli, M., Mastinu, A., Maccarinelli, G., & Memo, M. (2020) · Brain Sciences · doi:10.3390/brainsci10090620 · Cited by 28

Impact of maternal immune activation on dendritic spine development

Pękała, M., Doliwa, M., & Kalita, K. B. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22804 · Cited by 27

Season of birth in schizophrenia: a maternal-fetal chronobiological hypothesis.

Schwartz, P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.019 · Cited by 32

Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring

Zhang, J., Yu, J., Zhang, H., Bilkey, D. K., & Liu, P. (2018) · Synapse · doi:10.1002/syn.22072 · Cited by 27

Functional genomics of human brain development and implications for autism spectrum disorders

Ziats, M. N., Grosvenor, L. P., & Rennert, O. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.153 · Cited by 27

Do prenatal immune activation and maternal iron deficiency interact to affect neurodevelopment and early behavior in rat offspring?

Harvey, L., & Boksa, P. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.009 · Cited by 28

Maternal Immune Activation Alters Adult Behavior, Gut Microbiome and Juvenile Brain Oscillations in Ferrets

Li, Y., Dugyala, S., Ptacek, T., Gilmore, J. H., & Frӧhlich, F. (2018) · eNeuro · doi:10.1523/eneuro.0313-18.2018 · Cited by 27

Amelioration of Maternal Immune Activation-Induced Autism Relevant Behaviors by Gut Commensal Parabacteroides goldsteinii

Lin, T., Lu, C.-C., Chen, T.-W., Huang, C., Lu, J., Lai, W.-F., Wu, T., Lai, C., Lai, H., & Chen, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113070 · Cited by 29

Immune imbalance of global gene expression, and cytokine, chemokine and selectin levels in the brains of offspring with social deficits via maternal immune activation

Hsueh, P., Lin, H., Wang, H. ‐., Liu, C., Ni, W.-F., Liu, J. ‐., Chang, H., Sun, D., Chen, Y. ‐., & Chen, Y. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12479 · Cited by 27

Neonatal Levels of Inflammatory Markers and Later Risk of Schizophrenia

Nielsen, P. R., Agerbo, E., Skogstrand, K., HOUGAARD, D. M., Meyer, U., & Mortensen, P. B. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.013 · Cited by 25

Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta

Tsukada, T., Shimada, H., Sakata‐Haga, H., Iizuka, H., & Hatta, T. (2018) · Congenital Anomalies · doi:10.1111/cga.12323 · Cited by 27

Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism

Solmaz, V., Erdoğan, M. A., Alnak, A., Meral, A., & Erbaş, O. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102073 · Cited by 26

Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives

Pathmanandavel, K., Starling, J., Dale, R. C., & Brilot, F. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/257184 · Cited by 27

Toll-like receptor 4-mediated immune stress in pregnant rats activates STAT3 in the fetal brain: role of interleukin-6

Mouihate, A., & Mehdawi, H. (2015) · Pediatric Research · doi:10.1038/pr.2015.86 · Cited by 26

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Chow, K.-H. K., Yan, Z., & Wu, W. (2016) · Journal of Visualized Experiments · doi:10.3791/53643 · Cited by 29

Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats

Györffy, B. A., Gulyássy, P., Gellén, B., Völgyi, K., Madarasi, D., Kis, V., Ozohanics, O., Papp, I., Kovács, P., Lübec, G., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.002 · Cited by 27

Autism and EMF? Plausibility of a pathophysiological link part II

Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.002 · Cited by 28

Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia

Chamera, K., Trojan, E., Kotarska, K., Szuster-Głuszczak, M., Bryniarska, N., Tylek, K., & Basta‐Kaim, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041558 · Cited by 25

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

Casey, S., Carter, M., Looney, A.-M., Livingstone, V., Moloney, G. M., O’Keeffe, G. W., Taylor, R. S., Kenny, L. C., McCarthy, F. P., McCowan, L. M. E., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05271-7 · Cited by 28

SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

Dubey, H., Sharma, R. K., Krishnan, S., & Knickmeyer, R. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1021721 · Cited by 27

Single early prenatal lipopolysaccharide exposure impairs striatal monoamines and maternal care in female rats

Soto, A. M. S., Kirsten, T. B., Reis-Silva, T. M., Martins, M. D. F. M., Teodorov, E., Flório, J. C., Palermo‐Neto, J., Bernardi, M. M., & Bondan, E. F. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.03.003 · Cited by 25

Can we understand modern humans without considering pathogens?

Frédéric Thomas, A., Daoust, S. P., & Michel Raymond, A. (2012) · Evolutionary Applications · doi:10.1111/j.1752-4571.2011.00231.x · Cited by 25

Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders

Marco, E. M., Velarde, E., Llorente, R., & Laviola, G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_419 · Cited by 25

Prenatal immune challenge induces behavioral deficits, neuronal remodeling, and increases brain nitric oxide and zinc levels in the male rat offspring

Tellez-Merlo, G., Morales‐Medina, J. C., Camacho‐Abrego, I., Juárez, I., Aguilar‐Alonso, P., de la Cruz, F., Iannitti, T., & Flores, G. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.018 · Cited by 24

Effects of prenatal immune activation on amphetamine-induced addictive behaviors: Contributions from animal models

Borçoi, A. R., Patti, C. L., Zanin, K. A., Hollais, A. W., Santos-Baldaia, R., Ceccon, L. M. B., Berro, L. F., Wuo‐Silva, R., Grapiglia, S. B., Ribeiro, L. T. C., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.05.015 · Cited by 24

Neonatal manipulation of oxytocin prevents lipopolysaccharide-induced decrease in gene expression of growth factors in two developmental stages of the female rat

Bakoš, J., Lestanova, Z., Štrbák, V., Havránek, T., & Bačová, Z. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.06.004 · Cited by 24

Serological evidences link toxoplasmosis with schizophrenia and major depression disorder

Alhussainy, N. H., Al-saedi, A. M., Al-lehaibi, J. H., Al-lehaibi, Y. A., Al-Sehli, Y. M., & Afifi, M. A. (2015) · Journal of Microscopy and Ultrastructure · doi:10.1016/j.jmau.2015.03.006 · Cited by 24

Role of IL-6 In The Etiology Of Hyperexcitable Neuropsychiatric Conditions: Experimental Evidence And Therapeutic Implications

Atzori, M., García‐Oscos, F., & Méndez, J. A. T. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.156 · Cited by 25

Nicotine self‐administration reverses cognitive deficits in a rat model for schizophrenia

Waterhouse, U., Brennan, K. A., & Ellenbroek, B. A. (2017) · Addiction Biology · doi:10.1111/adb.12517 · Cited by 22

The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism

Ali, A. A., Cui, X., Alexander, S., & Eyles, D. W. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.01.015 · Cited by 24

Bridging the species gap in translational research for neurodevelopmental disorders

Ryan, A. M., Berman, R. F., & Bauman, M. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.006 · Cited by 25

Therapeutic efficacy of environmental enrichment on behavioral, endocrine, and synaptic alterations in an animal model of maternal immune activation

Zhao, X., Rondón-Ortiz, A. N., Lima, E. P., Puracchio, M. J., Roderick, R. C., & Kentner, A. C. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100043 · Cited by 24

Maternal Metabolic Conditions and Risk for Autism and Other Neurodevelopmental Disorders

(2012) · PEDIATRICS · doi:10.1542/peds.2011-2583d · Cited by 24

Testing a cascade model linking prenatal inflammation to child executive function

Camerota, M., Wylie, A. C., Goldblum, J., Wideman, L., Cheatham, C. L., & Propper, C. B. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113959 · Cited by 23

Translational Neuroscience Approaches to Understanding Autism

Veenstra-VanderWeele, J. M., O’Reilly, K. C., Dennis, M. Y., Uribe‐Salazar, J. M., & Amaral, D. G. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230153 · Cited by 25

Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response

Richtand, N. M., Ahlbrand, R., Horn, P. S., Tambyraja, R., Grainger, M., Bronson, S. L., & McNamara, R. K. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.004 · Cited by 24

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Jantzie, L. L., Winer, J. L., Maxwell, J. R., Chan, L. A. S., & Robinson, S. (2015) · Journal of Visualized Experiments · doi:10.3791/53196 · Cited by 23

GABA system as the cause and effect in early development

Topchiy, I., Mohbat, J., Folorunso, O. O., Wang, Z., Lazcano-Etchebarne, C., & Engin, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105651 · Cited by 26

Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model

Patrich, E., Piontkewitz, Y., Peretz, A. S., Weiner, I., & Attali, B. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.021 · Cited by 27

Sex differences in cerebral blood flow following chorioamnionitis in healthy term infants

Koch, F. R., Wagner, C. L., Jenkins, D., Caplan, M. J., Perkel, J. K., Rollins, L. G., Katikaneni, L. D. P., & Mulvihill, D. M. (2014) · Journal of Perinatology · doi:10.1038/jp.2013.179 · Cited by 22

N-acetyl-cysteine prevents pyramidal cell disarray and reelin-immunoreactive neuron deficiency in CA3 after prenatal immune challenge in rats

Novais, A. R. B., Guiramand, J., Cohen‐Solal, C., Crouzin, N., Ferreira, M. D. J., Vignes, M., Barbanel, G., & Cambonie, G. (2013) · Pediatric Research · doi:10.1038/pr.2013.40 · Cited by 22

The role of microglia in the second and third postnatal weeks of life in rat hippocampal development and memory

Soch, A., Sominsky, L., Younesi, S., Luca, S. N. D., Gunasekara, M., Bozinovski, S., & Spencer, S. J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.082 · Cited by 21

Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: Possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes

Brunssen, S., Moy, S. S., Toews, A. D., McPherson, C. A., & Harry, G. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.017 · Cited by 23

Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: A longitudinal small animal PET study using [18F]MK-9470

Verdurand, M., Dalton, V. S., Nguyen, V., Grégoire, M., Zahra, D., Wyatt, N. A., Burgess, L., Greguric, I. D., & Zavitsanou, K. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.004 · Cited by 21

N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain

Chao, M., Chen, C., Yang, Y.-H., Chuang, Y.-C., Chu, T.-Y., & Tseng, C. (2016) · Scientific Reports · doi:10.1038/srep32373 · Cited by 22

Neurodevelopmental insights into circuit dysconnectivity in schizophrenia

Nath, M., Wong, T. P., & Srivastava, L. K. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110047 · Cited by 24

Cytokine changes associated with the maternal immune activation (MIA) model of autism: A penalized regression approach

Paraschivescu, C., Barbosa, S., Lorivel, T., Glaichenhaus, N., & Davidovic, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231609 · Cited by 22

Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders

Prieto‐Villalobos, J., Alvear, T. F., Liberona, A., Lucero, C. M. J., Martínez-Araya, C. J., Balmazabal, J., Inostroza, C. A., Ramírez, G., Gómez, G. I., & Orellana, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179503 · Cited by 21

A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway

Pinault, D. (2017) · Brain Sciences · doi:10.3390/brainsci7040034 · Cited by 23

Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice

Guma, E., Snook, E., Spring, S., Lerch, J. P., Nieman, B. J., Devenyi, G. A., & Chakravarty, M. M. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102868 · Cited by 20

Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats

Visco, D. B., Manhães‐de‐Castro, R., da Silva, M. M., de Santana, B. J. R. C., dos Santos, J. P., Saavedra, L. M., de Lemos, M. D. T. B., Valdez-Alarcón, J. J., Lagranha, C. J., Guzmán‐Quevedo, O., et al. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2156034 · Cited by 20

Nicotine ameliorates cognitive deficits induced by maternal LPS exposure: A study in rats

Waterhouse, U., Roper, V., Brennan, K. A., & Ellenbroek, B. A. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.025072 · Cited by 19

Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation

Ventura, L., Freiberger, V., Thiesen, V. B., Dias, P., Dutra, M. L., Silva, B. B., Schlindwein, A. D., & Comim, C. M. (2020) · Acta Neuropsychiatrica · doi:10.1017/neu.2020.27 · Cited by 20

Perinatal IL-1β-induced inflammation suppresses Tbr2+ intermediate progenitor cell proliferation in the developing hippocampus accompanied by long-term behavioral deficits

Veerasammy, S., Steenwinckel, J. V., Charpentier, T. L., Seo, J. H., Fleiss, B., Gressèns, P., & Levison, S. W. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100106 · Cited by 23

Maternal immune activation as a risk factor for psychiatric illness in the context of the SARS-CoV-2 pandemic

Lins, B. R. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100297 · Cited by 22

Disorganization of Oscillatory Activity in Animal Models of Schizophrenia

Speers, L. J., & Bilkey, D. K. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.741767 · Cited by 21

Characterization of genomic regions escaping epigenetic reprogramming in sheep

Braz, C. U., Passamonti, M. M., & Khatib, H. (2024) · Environmental Epigenetics · doi:10.1093/eep/dvad010 · Cited by 19

Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration

Girard, S., Tremblay, L., Lepage, M., & Sébire, G. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.01.008 · Cited by 19

Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells

Hester, M. S., Tulina, N. M., Brown, A. G., Barila, G., & Elovitz, M. A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.005 · Cited by 21

Studies on Haloperidol and Adjunctive α-Mangostin or Raw Garcinia mangostana Linn Pericarp on Bio-Behavioral Markers in an Immune-Inflammatory Model of Schizophrenia in Male Rats

Lotter, J., Möller, M., Dean, O. M., Berk, M., & Harvey, B. H. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00121 · Cited by 20

New insights into epigenetics as an influencer: An associative study between maternal prenatal factors in Autism Spectrum Disorder (ASD)

Vellingiri, B., Mahalaxmi, I., Neethu, R., Arul, N., & Abhilash, V. G. (2022) · Neurology Perspectives · doi:10.1016/j.neurop.2022.01.002 · Cited by 21

The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases

Teng, P., Li, Y., Ku, L., Wang, F., Goldsmith, D. R., Wen, Z., Yao, B., & Feng, Y. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.009 · Cited by 18

Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia

Oliver, P. L. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.128 · Cited by 18

Using rodents to model schizophrenia and substance use comorbidity

Ng, E., McGirr, A., Wong, A. H. C., & Roder, J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.025 · Cited by 19

Placental Inflammation in Preterm Premature Rupture of Membranes and Risk of Neurodevelopmental Disorders

Cervantes, E., & Girard, S. (2025) · Cells · doi:10.3390/cells14130965 · Cited by 17

Current knowledge, challenges, new perspectives of the study, and treatments of Autism Spectrum Disorder

Denucci, B. L., de Lima, L. S., Mota, I. F. L., Azevedo, J. R. M., Veras, L. G., Bicca, J. V. M. L., Santana, B. D. M., Pinheiro, G. B., Coelho, G. G., & Mortari, M. R. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.10.010 · Cited by 20

Dose-dependent sickness behavior, abortion and inflammation induced by systemic LPS injection in pregnant mice

Toyama, R. P., Xikota, J. C., Schwarzbold, M. L., Fröde, T. S., Buss, Z. D. S., Nunes, J. C., Funchal, G. D. G., Nunes, F. C., Walz, R., & Pires, M. M. D. S. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.918600 · Cited by 17

Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood

Yin, P., Liu, J., Li, Z., Wang, Y., Qiao, N., Huang, S., Li, B., & Sun, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.047 · Cited by 21

The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age

Nolan, A. M., Collins, L., Wyatt, S. L., Gutiérrez, H., & O’Keeffe, G. W. (2014) · Differentiation · doi:10.1016/j.diff.2014.12.006 · Cited by 17

Maternal Obesity: Risks for Developmental Delays in Early Childhood

Duffany, K. O., McVeigh, K. H., Kershaw, T., Lipkind, H. S., & Ickovics, J. R. (2015) · Maternal and Child Health Journal · doi:10.1007/s10995-015-1821-z · Cited by 17

Prenatal Activation of Toll-Like Receptor-4 Dampens Adult Hippocampal Neurogenesis in An IL-6 Dependent Manner

Mouihate, A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00173 · Cited by 17

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice

Wang, F., Zhang, Z., Cao, L., Yang, Q., Lu, Q., & Chen, G. (2020) · Brain and Behavior · doi:10.1002/brb3.1546 · Cited by 19

Early-life risk factors for chronic nonrespiratory diseases

Chacko, A., Carpenter, D. O., Callaway, L. K., & Sly, P. D. (2014) · European Respiratory Journal · doi:10.1183/09031936.00070214 · Cited by 18

A two-hit model of suicide-trait-related behaviors in the context of a schizophrenia-like phenotype: Distinct effects of lithium chloride and clozapine

Deslauriers, J., Belleville, K., Beaudet, N., Sarret, P., & Grignon, S. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.002 · Cited by 18

Prenatal maternal lipopolysaccharide administration leads to age- and region-specific oxidative stress in the early developmental stage in offspring

Al-Amin, M. M., Alam, T., Hasan, S. M. N., Hasan, A. T., & Quddus, A. H. M. R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.002 · Cited by 17

Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years

Kariuki, M., Raudino, A., Green, M. J., Laurens, K. R., Dean, K., Brinkman, S. A., Lenroot, R., Liu, E., Harris, F., Luo, L., et al. (2016) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.13239 · Cited by 18

Environmental Factors in the Preconception and Prenatal Periods in Relation to Risk for ASD

Lyall, K., Schmidt, R. J., & Hertz‐Picciotto, I. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc18 · Cited by 17

Pilot Study of Maternal Autoantibody–Related Autism

Angkustsiri, K., Fussell, J. J., Bennett, A., Schauer, J. D., Ramirez-Celis, A., Hansen, R. L., & de Water, J. V. (2022) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000001100 · Cited by 16

Sources and Translational Relevance of Heterogeneity in Maternal Immune Activation Models

Meyer, U. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_398 · Cited by 17

Callosal septa express guidance cues and are paramedian guideposts for human corpus callosum development

Čuljat, M., & Milošević, N. J. (2019) · Journal of Anatomy · doi:10.1111/joa.13011 · Cited by 16

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Daini, E., Hagmeyer, S., Benedictis, C. A. D., Cristóvão, J. S., Bodria, M., Ross, A. M., Raab, A., Boeckers, T. M., Feldmann, J., Gomes, C. M., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01694-z · Cited by 19

Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation

Novais, A. R. B., Crouzin, N., Cavalier, M., Boubal, M., Guiramand, J., Cohen‐Solal, C., Ferreira, M. D. J., Cambonie, G., Vignes, M., & Barbanel, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106302 · Cited by 18

Tryptophan Metabolism in Developmental Origins of Health and Disease

de Souza, S. L., Gomes, D. A., da Silva, C. M., Barros, W. M. A., Alves, S. M., & de Castro, R. M. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf127 · Cited by 15

Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents

Millevert, C., Vidas-Guscic, N., Vanherp, L., Jonckers, E., Verhoye, M., Staelens, S. G., Bertoglio, D., & Weckhuysen, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1043-23.2023 · Cited by 17

Autism genes and the leukocyte transcriptome in autistic toddlers relate to pathogen interactomes, infection and the immune system. A role for excess neurotrophic sAPPα and reduced antimicrobial Aβ

Carter, C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.007 · Cited by 15

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia

Santos‐Toscano, R., Borcel, É., Ucha, M., Orihuel, J., Capellán, R., Roura‐Martínez, D., Ambrosio, E., & Higuera‐Matas, A. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.008 · Cited by 15

Positive modulation of α5 GABAAreceptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide

Batinić, B., Santrač, A., Jančić, I., Li, G., Vidojević, A., Marković, B. D., Cook, J. M., & Savić, M. M. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.06.001 · Cited by 15

Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation

Khalil, O. S., Forrest, C. M., Pisar, M., Smith, R. A., Darlington, L. G., & Stone, T. W. (2013) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2013.828745 · Cited by 14

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Wu, Y.-F., Zhang, Y., Ge, H.-H., Ren, C.-Y., Zhang, Z., Cao, L., Wang, F., & Chen, G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.578719 · Cited by 14

The role of infections and inflammation in schizophrenia: review of the evidence

Ahmed, G. K., Ramadan, H. K., Elbeh, K., & Haridy, N. A. (2024) · Middle East Current Psychiatry · doi:10.1186/s43045-024-00397-7 · Cited by 16

Disturbance of Metabotropic Glutamate Receptor-Mediated Long-Term Depression (mGlu-LTD) of Excitatory Synaptic Transmission in the Rat Hippocampus After Prenatal Immune Challenge

Cavalier, M., Sedrine, A. B., Thevenet, L., Crouzin, N., Guiramand, J., Ferreira, M. D. J., Cohen‐Solal, C., Barbanel, G., & Vignes, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2476-0 · Cited by 14

Early prenatal exposure to pandemic influenza A (H1N1) infection and child psychomotor development at 6 months – A population-based cohort study

Borren, I., Tambs, K., Gustavson, K., Schjølberg, S., Eriksen, W., Håberg, S. E., Hungnes, O., Mjaaland, S., & Trogstad, L. (2018) · Early Human Development · doi:10.1016/j.earlhumdev.2018.05.005 · Cited by 15

Fetal brain inflammation may prime hyperexcitability and behavioral dysfunction later in life

Vezzani, A. (2013) · Annals of Neurology · doi:10.1002/ana.23930 · Cited by 14

Emotion and the Development of Psychopathology

Cole, P. M. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy107 · Cited by 14

Maternal Immune Activation and Neurodevelopmental Disorders: Integrating Molecular, Cellular and Systems Mechanisms

Yong, Q., Zhao, C., Xia, L., Zhu, T., & Xia, K. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s533813 · Cited by 14

Effects of Subcutaneous LPS Injection on Gestational Length and Intrauterine and Neonatal Mortality in Mice

Lopez, Y. P., Steinbusch, H. W. M., Rutten, B. P. F., Kenis, G., van den Hove, D., & Myint, A.-M. (2015) · NeuroImmunoModulation · doi:10.1159/000368554 · Cited by 13

The role of maternal immune activation in immunological and neurological pathogenesis of autism

Liu, K., Huang, Y., Zhu, Y., Zhao, Y., & Kong, X. (2022) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2022.100030 · Cited by 13

30.4 PRENATAL INFECTION AND LONG-TERM BRAIN PATHOLOGY: FROM PRECLINICAL MODELS TO MECHANISMS

Richetto, J. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby014.125

Prenatal infection, maternal immune activation, and risk for schizophrenia

Canetta, S., & Brown, A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0045-6 · Cited by 117

Maternal immune activation and abnormal brain development across CNS disorders

Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880

Evidence that prenatal infection is a risk factor for brain and behaviour changes relevant to schizophrenia and autism

Edward, W. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/conf.neuro.08.2009.09.228

In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

Meyer, U., Feldon, J., & Fatemi, S. H. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.001 · Cited by 382