Effects of prenatal infection on brain development and behavior: A review of findings from animal models

Epigenetic programming by maternal behavior

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Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

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Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic

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A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology

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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

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Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia

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Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring

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Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models

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Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation

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Autism spectrum disorders pathogenesis: Toward a comprehensive model based on neuroanatomic and neurodevelopment considerations

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BOARD INVITED REVIEW: The importance of the gestation period for welfare of calves: Maternal stressors and difficult births1

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Behavioral impact of maternal allergic-asthma in two genetically distinct mouse strains

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Prevention or Amelioration of Autism-Like Symptoms in Animal Models: Will it Bring Us Closer to Treating Human ASD?

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Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention

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An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD)

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Early Effects of Lipopolysaccharide-Induced Inflammation on Foetal Brain Development in Rat

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Unlocking mechanisms in interleukin-1β-induced changes in hippocampal neurogenesis—a role for GSK-3β and TLX

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Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood

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Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection

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Meningeal and choroid plexus cells—Novel drug targets for CNS disorders

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Animal Models of Maternal Immune Activation in Depression Research

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Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation

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Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment

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Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota

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A sexually dichotomous, autistic‐like phenotype is induced by Group B Streptococcus maternofetal immune activation

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LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage

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Allergic fetal priming leads to developmental, behavioral and neurobiological changes in mice

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Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition

Zavitsanou, K., Lim, C. K., Purves-Tyson, T., Karl, T., Kassiou, M., Banister, S. D., Guillemin, G. J., & Weickert, C. S. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.011 · Cited by 46

NF-κB: Emerging roles in hippocampal development and function

Crampton, S. J., & O’Keeffe, G. W. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.037 · Cited by 48

Dietary docosahexaenoic acid alleviates autistic-like behaviors resulting from maternal immune activation in mice

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Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB

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Lipopolysaccharide exposure during late embryogenesis results in diminished locomotor activity and amphetamine response in females and spatial cognition impairment in males in adult, but not adolescent rat offspring

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Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation

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Childhood cognitive function and adult psychopathology: associations with psychotic and non-psychotic symptoms in the general population

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Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring

Xia, Y., Qi, F., Zou, J., Yang, J., & Yao, Z. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.202 · Cited by 43

Effect of Maternal Lipopolysaccharide Administration on the Development of Dopaminergic Receptors and Transporter in the Rat Offspring

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N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges

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Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment

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Timing of maternal immune activation and sex influence schizophrenia-relevant cognitive constructs and neuregulin and GABAergic pathways

Nakamura, J., Schroeder, A., Gibbons, A. S., Sundram, S., & Hill, R. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.006 · Cited by 43

Thinking about HIV: the intersection of virus, neuroinflammation and cognitive dysfunction

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Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice

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LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

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Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence

de Cossío, L. F., Lacabanne, C., Bordeleau, M., Castino, G., Kyriakakis, P., & Tremblay, M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.025 · Cited by 43

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

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Child Intellectual Development in Relation to Cytokine Levels in Umbilical Cord Blood

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The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

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A Critical Review of Models of Perinatal Infection

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Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats

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Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure

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Maternal immune activation with staphylococcal enterotoxin A produces unique behavioral changes in C57BL/6 mouse offspring

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Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters

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Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum

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Effects of immune activation during early or late gestation on N-methyl‑d-aspartate receptor measures in adult rat offspring

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MHC class I protein is expressed by neurons and neural progenitors in mid-gestation mouse brain

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Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

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Perinatal complications and schizophrenia: involvement of the immune system

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Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice

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Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical Models

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Mitochondria play an essential role in the trajectory of adolescent neurodevelopment and behavior in adulthood: evidence from a schizophrenia rat model

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Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective

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Statistical and theoretical considerations for the platform re-location water maze

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Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

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Pallidal Hyperdopaminergic Innervation Underlying D2 Receptor-Dependent Behavioral Deficits in the Schizophrenia Animal Model Established by EGF

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Animal models for autism in 2017 and the consequential implications to drug discovery

Chadman, K. K. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1383982 · Cited by 39

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders

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Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation

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Lipopolysaccharide injected to pregnant mice affects behavior of their offspring in adulthood

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Effects of maternal immune activation on adult neurogenesis in the subventricular zone–olfactory bulb pathway and olfactory discrimination

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Activation of the IL-1β/CXCL1/MMP-10 axis in chorioamnionitis induced by inactivated Group B Streptococcus

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Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide

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Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism

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Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes

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Research Progress on the Role of Vitamin D in Autism Spectrum Disorder

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Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy

Aguilar‐Valles, A., & Luheshi, G. N. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.006 · Cited by 38

Altered GSK3β signaling in an infection-based mouse model of developmental neuropsychiatric disease

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Autism and EMF? Plausibility of a pathophysiological link – Part I

Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.001 · Cited by 37

Individual and combined effects of maternal anemia and prenatal infection on risk for schizophrenia in offspring

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Maternal Omega-3 Supplement Improves Dopaminergic System in Pre- and Postnatal Inflammation-Induced Neurotoxicity in Parkinson’s Disease Model

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Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury

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Healing autism spectrum disorder with cannabinoids: a neuroinflammatory story

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Altered Hippocampal Gene Expression and Morphology in Fetal Piglets following Maternal Respiratory Viral Infection

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Effects of ω-3 fatty acids on stereotypical behavior and social interactions in Wistar rats prenatally exposed to lipopolysaccarides

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Maternal deprivation induces alterations in cognitive and cortical function in adulthood

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Risk of Cerebral Palsy and Childhood Epilepsy Related to Infections before or during Pregnancy

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Prenatal lipopolysaccharide disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety: studies of F1 and F2 generations

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Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling

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Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime

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Transplacental Transfer of Interleukin‐1 Receptor Agonist and Antagonist Following Maternal Immune Activation

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Prenatal LPS exposure reduces olfactory perception in neonatal and adult rats

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Aberrant fetal macrophage/microglial reactions to cytomegalovirus infection

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Maternal serum C-reactive protein (CRP) and offspring attention deficit hyperactivity disorder (ADHD)

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A comprehensive approach to modeling maternal immune activation in rodents

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Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes

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Maternal immune activation and its multifaceted effects on learning and memory in rodent offspring: A systematic review

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CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development

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Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood

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Pandemic beyond the virus: maternal COVID-related postnatal stress is associated with infant temperament

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Early Development of Parvalbumin-, Somatostatin-, and Cholecystokinin-Expressing Neurons in Rat Brain following Prenatal Immune Activation and Maternal Iron Deficiency

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Δ9-Tetrahydrocannabinol During Adolescence Attenuates Disruption of Dopamine Function Induced in Rats by Maternal Immune Activation

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Staphylococcus epidermidisBacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways

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Increased white matter neuron density in a rat model of maternal immune activation — Implications for schizophrenia

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The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

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Maternal inflammation linearly exacerbates offspring age-related changes of spatial learning and memory, and neurobiology until senectitude

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Investigating the “two-hit hypothesis”: Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice

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Prenatal infection, maternal immune activation, and risk for schizophrenia

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Maternal immune activation and abnormal brain development across CNS disorders

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Evidence that prenatal infection is a risk factor for brain and behaviour changes relevant to schizophrenia and autism

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In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

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