Cited by 32Gut microbiota and healthGastrointestinal motility and disordersNeurotransmitter Receptor Influence on Behavior

Narrative review on potential role of gut microbiota in certain substance addiction

Qin, Chenyuan, Hu, Jiawei, Wan, Yiming, Cai, Mengyao, Wang, Zhenting, Peng, Zhao, Liao, Yuxiao, Li, Dan +6 more·2021·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

As a neuropsychiatric disorder, substance addiction represents a major public health issue with high prevalence and mortality in many countries. Recently, gut microbiota has been certified to play a part in substance addiction through various mechanisms. Hence, we mainly focused on three substance including alcohol, cocaine and methamphetamine in this review, and summarized their relationships with gut microbiota, respectively. Besides, we also concluded the possible treatments for substance addiction from the perspective of applying gut microbiota. This review aims to build a bridge between substance addiction and gut microbiota according to existing evidences, so as to excavate the possible bi-directional function of microbiota-gut-brain axis in substance addiction for developing therapeutic strategies in the future.

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Crossref · 10.1016/j.pnpbp.2020.110093

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190 of 190 references verified0 citation errors · 0 not checkable

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Authors
Qin, C., Hu, J., Wan, Y., Cai, M., Wang, Z., Peng, Z., Liao, Y., Li, D., Yao, P., Liu, L., Rong, S., Bao, W., Xu, G., & Yang, W.
Affiliations
  • Huazhong University of Science and Technology (CN)
  • Wuhan University of Science and Technology (CN)
  • University of Iowa (US)
Corresponding author
Yang, Wei
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2021-03
Volume
106
Pages
110093
ISSN
0278-5846 (ISSN-L)
OpenAlex
W3083465799
Cited by
32
References
193
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 3 · 2021: 5
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Natural Science Foundation of Hubei Province
  • National Key Research and Development Program of China
  • Health and Family Planning Commission of Hubei Province
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
gut microbiota, substance addiction, microbiota-gut-brain axis, alcoholism, cocaine dependence, methamphetamine dependence, addiction treatment, bidirectional signaling
MeSH terms
Gastrointestinal Microbiome, Brain-Gut Axis, Alcoholism, Cocaine, Humans, Methamphetamine, Probiotics, Substance-Related Disorders, Prebiotics, Dysbiosis

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