Narrative review on potential role of gut microbiota in certain substance addiction
Abstract
As a neuropsychiatric disorder, substance addiction represents a major public health issue with high prevalence and mortality in many countries. Recently, gut microbiota has been certified to play a part in substance addiction through various mechanisms. Hence, we mainly focused on three substance including alcohol, cocaine and methamphetamine in this review, and summarized their relationships with gut microbiota, respectively. Besides, we also concluded the possible treatments for substance addiction from the perspective of applying gut microbiota. This review aims to build a bridge between substance addiction and gut microbiota according to existing evidences, so as to excavate the possible bi-directional function of microbiota-gut-brain axis in substance addiction for developing therapeutic strategies in the future.
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Probiotic supplement has shown some promise in the treatment of alcohol use disorder because restoration of the gut microbiota may reduce systemic inflammation and increase brain derived neurotrophic factor and glutamate receptors in the hippocampus.
“Probiotic supplement have shown some promise in the treatment of AUD as restoration of the gut microbiota may reduce systemic inflammation, increase brain derived neurotrophic factor and glutamate receptors in the hippocampus [34].”
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“Probiotic supplement have shown some promise in the treatment of AUD as restoration of the gut microbiota may reduce systemic inflammation, increase brain derived neurotrophic factor and glutamate receptors in the hippocampus [34].”
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Impact of evolution on lifestyle in microbiome
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Roles of gut and oral microbiota in methamphetamine-induced multi-organ toxicity
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Additional Biological Mechanisms of Hedonic Eating
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Gut microbiota in psychiatric disorders: Better understanding or more complexity to be resolved?
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- Authors
- Qin, C., Hu, J., Wan, Y., Cai, M., Wang, Z., Peng, Z., Liao, Y., Li, D., Yao, P., Liu, L., Rong, S., Bao, W., Xu, G., & Yang, W.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Wuhan University of Science and Technology (CN)
- University of Iowa (US)
- Corresponding author
- Yang, Wei
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 106
- Pages
- 110093
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W3083465799
- Cited by
- 32
- References
- 193
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 3 · 2021: 5
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China
- Health and Family Planning Commission of Hubei Province
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- gut microbiota, substance addiction, microbiota-gut-brain axis, alcoholism, cocaine dependence, methamphetamine dependence, addiction treatment, bidirectional signaling
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Alcoholism, Cocaine, Humans, Methamphetamine, Probiotics, Substance-Related Disorders, Prebiotics, Dysbiosis
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