Cited by 233Fatty Acid Research and HealthTryptophan and brain disordersNutritional Studies and Diet

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Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial

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Kiecolt-Glaser, Janice K., Belury, Martha A., Andridge, Rebecca, Malarkey, William B., Hwang, Beom Seuk, Glaser, Ronald·2012·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2012.05.011PMC PMC3398219

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Abstract

Observational studies have linked lower levels of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) with inflammation and depression. This study was designed to determine whether n-3 supplementation would decrease serum cytokine production and depressive symptoms in 138 healthy middle-aged and older adults (average age=51.04, SD=7.76) who were sedentary and overweight (average BMI=30.59, SD=4.50). This three-arm randomized, placebo-controlled, double-blind 4-month trial compared responses to (1) 2.5 g/d n-3 PUFAs, or (2) 1.25 g/d n-3 PUFAs, or (3) placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Serum interleukin-6 decreased by 10% and 12% in our low and high dose n-3 groups, respectively, compared to a 36% increase in the placebo group. Similarly, low and high dose n-3 groups showed modest 0.2% and -2.3% changes in serum tumor necrosis factor alpha, compared to a 12% increase in the control group. Depressive symptoms were quite low at baseline and did not change significantly in response to supplementation. Our data suggest that n-3 PUFAs can reduce inflammation in overweight, sedentary middle-aged and older adults, and thus could have broad health benefits. These data provide a window into the ways in which the n-3 PUFAs may impact disease initiation, progression, and resolution. ClinicalTrials.gov identifier: NCT00385723.

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Authors: Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., Hwang, B. S., & Glaser, R.
Affiliations: The Ohio State University (US)
ORCID: Belury, Martha A.
Andridge, Rebecca
Malarkey, William B.
Hwang, Beom Seuk
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2012-08
Volume: 26
Issue: 6
Pages: 988-995
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2012.05.011
PMC: PMC3398219
OpenAlex: W2124212092
Cited by: 233
References: 63
Citations by year: 2026: 14 · 2025: 12 · 2024: 13 · 2023: 23 · 2022: 14 · 2021: 13 · 2020: 21 · 2019: 14 · 2018: 22 · 2017: 17 · 2016: 10 · 2015: 19 · 2014: 20 · 2013: 17 · 2012: 2
FWCI: 17.33
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (AG029562, UL1RR025755, CA16058)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: omega-3 polyunsaturated fatty acids, dietary supplementation, inflammation, interleukin-6, TNF-α, depressive symptoms, overweight, sedentary lifestyle, middle-aged and older adults, serum cytokines
MeSH terms: Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Body Weight, Depression, Dose-Response Relationship, Drug, Fatty Acids, Female, Humans, Male, Middle Aged, Tumor Necrosis Factor-alpha, Health Behavior, Fatty Acids, Omega-3, Interleukin-6, Treatment Outcome, Sample Size, Dietary Supplements, Overweight, Waist Circumference, Sedentary Behavior

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Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial

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