Psychiatric disorders, morbidity, and mortality: tracing mechanistic pathways to accelerated aging

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270 · see citing works

Risks of all-cause and suicide mortality in mental disorders: a meta-review

Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115 · see citing works

Association between telomere length in blood and mortality in people aged 60 years or older

Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761 · see citing works

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · see citing works

DNA methylation age of blood predicts all-cause mortality in later life

Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0584-6 · Cited by 1,261 · see citing works

Epigenetic Predictor of Age

Bocklandt, S., Lin, W., Sehl, M. E., Sánchez, F. J., Sinsheimer, J. S., Horvath, S., & Vilain, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014821 · Cited by 1,012 · see citing works

Inflammation: Depression Fans the Flames and Feasts on the Heat

Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works

Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress

Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works

Obesity accelerates epigenetic aging of human liver

Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., Schönfels, W. V., Ahrens, M., Heits, N., Bell, J. T., Tsai, P.-C., Spector, T. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412759111 · Cited by 760 · see citing works

Life Stress, the "Kindling" Hypothesis, and the Recurrence of Depression: Considerations From a Life Stress Perspective.

Monroe, S. M., & Harkness, K. L. (2005) · Psychological Review · doi:10.1037/0033-295x.112.2.417 · Cited by 693 · see citing works

Expression of <i>p16</i> ^<i>INK4a</i> in peripheral blood T‐cells is a biomarker of human aging

Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00489.x · Cited by 509 · see citing works

Lifetime stress accelerates epigenetic aging in an urban, African American cohort: Relevance of glucocorticoid signaling

Zannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., Röh, S., Ressler, K. J., Nemeroff, C. B., Smith, A. K., Bradley, B., Heim, C., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0828-5 · Cited by 469 · see citing works

Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults

Carpenter, L. L., Gawuga, C. E., Tyrka, A. R., Lee, J. K., Anderson, G. M., & Price, L. H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.159 · Cited by 464 · see citing works

Stressful early life experiences and immune dysregulation across the lifespan

Fagundes, C. P., Glaser, R., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.014 · Cited by 371 · see citing works

Oxidative stress in anxiety and comorbid disorders

Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works

The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration

Epel, E. S., Merkin, S. S., Cawthon, R., Blackburn, E. H., Adler, N. E., Pletcher, M. J., & Seeman, T. E. (2008) · Aging · doi:10.18632/aging.100007 · Cited by 315 · see citing works

Peripheral Blood Leukocyte Telomere Length and Mortality Among 64 637 Individuals From the General Population

Rode, L., Nordestgaard, B. G., & Bojesen, S. E. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv074 · Cited by 297 · see citing works

Frailty is associated with the epigenetic clock but not with telomere length in a German cohort

Breitling, L. P., Saum, K.-U., Perna, L., Schöttker, B., Holleczek, B., & Brenner, H. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0186-5 · Cited by 296 · see citing works

Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study

Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 290 · see citing works

Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans

Houtepen, L. C., Vinkers, C. H., Carrillo-Roa, T., Hiemstra, M., van Lier, P. A., Meeus, W., Branje, S., Heim, C. M., Nemeroff, C. B., Mill, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10967 · Cited by 242 · see citing works

Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial

Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., Hwang, B. S., & Glaser, R. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.011 · Cited by 233 · see citing works

Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder

Boks, M. P., Mierlo, H. C. V., Rutten, B. P. F., Radstake, T. R. D. J., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, L. C., Vinkers, C. H., Broen, J. C. A., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.011 · Cited by 231 · see citing works

The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons

Darrow, S. M., Verhoeven, J. E., Révész, D., Lindqvist, D., Penninx, B. W. J. H., Delucchi, K. L., Wolkowitz, O. M., & Mathews, C. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000356 · Cited by 229 · see citing works

Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis

Needham, B. L., Smith, J. A., Zhao, W., Wang, X., Mukherjee, B., Kardia, S. L. R., Shively, C. A., Seeman, T. E., Liu, Y., & Roux, A. V. D. (2015) · Epigenetics · doi:10.1080/15592294.2015.1085139 · Cited by 210 · see citing works

Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study

Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E., & Whooley, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008612 · Cited by 203 · see citing works

Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay

Ehrlenbach, S., Willeit, P., Kiechl, S. J., Willeit, J., Reindl, M., Schanda, K., Kronenberg, F., & Kloss‐Brandstätter, A. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp273 · Cited by 192 · see citing works

The Individual Blood Cell Telomere Attrition Rate Is Telomere Length Dependent

Nordfjäll, K., Svenson, U., Norrback, K., Adolfsson, R., Lenner, P., & Roos, G. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000375 · Cited by 184 · see citing works

Depressive symptoms enhance stress-induced inflammatory responses.

Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.006 · Cited by 151 · see citing works

Accelerated DNA methylation age: Associations with PTSD and neural integrity

Wolf, E. J., Logue, M. W., Hayes, J. P., Sadeh, N., Schichman, S. A., Stone, A., Salat, D. H., Milberg, W., McGlinchey, R. E., & Miller, M. W. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.020 · Cited by 146 · see citing works

Traumatic stress and human DNA methylation: A critical review

Vinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z., Turner, J. D., & Boks, M. P. (2015) · Epigenomics · doi:10.2217/epi.15.11 · Cited by 112 · see citing works

Epigenetics and Social Context: Implications for Disparity in Cardiovascular Disease

Saban, K. L. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500346 · Cited by 83 · see citing works

The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length

Verhoeven, J. E., van Oppen, P., Puterman, E. M., Elzinga, B. M., & Penninx, B. W. J. H. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000226 · Cited by 81 · see citing works

Ageing as developmental decay: insights from p16INK4a.

Martin, N., Beach, D., & Gil, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.008 · Cited by 76 · see citing works

Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients

Lin, J., Blalock, J. A., Chen, M., Ye, Y., Gu, J., Cohen, L., Cinciripini, P. M., & Wu, X. (2015) · Cancer Epidemiology, Biomarkers &amp; Prevention · doi:10.1158/1055-9965.epi-14-0992 · Cited by 42 · see citing works

History of Major Depressive Disorder Prospectively Predicts Worse Quality of Life in Women with Breast Cancer

Jim, H. S. L., Small, B. J., Minton, S., Andrykowski, M., & Jacobsen, P. B. (2012) · Annals of Behavioral Medicine · doi:10.1007/s12160-011-9333-6 · Cited by 32 · see citing works

Comparison of Telomere Length in Black and White Teachers From South Africa

von Känel, R., Malan, N. T., Hamer, M., & Malan, L. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000123 · Cited by 18 · see citing works

Telomere Length Integrates Psychological Factors in the Successful Aging Story, But What About the Biology?

Meyer, T. D. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31822ed876 · Cited by 13 · see citing works

Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases

Bennett, J. M., Reeves, G., Billman, G. E., & Sturmberg, J. P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00316 · Cited by 531 · see citing works

Guidelines for wrist-worn consumer wearable assessment of heart rate in biobehavioral research

Nelson, B. W., Low, C. A., Jacobson, N., Areán, P., Torous, J., & Allen, N. B. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0297-4 · Cited by 241 · see citing works

Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project

Wade, M., Fox, N. A., Zeanah, C. H., Nelson, C. A., & Drury, S. S. (2020) · Journal of the American Academy of Child &amp; Adolescent Psychiatry · doi:10.1016/j.jaac.2019.02.013 · Cited by 43 · see citing works

Supplementary Figure 1-12, Table 1 from Functional Diversity of Human Protection of Telomeres 1 Isoforms in Telomere Protection and Cellular Senescence

Qin, Y., Zhang, R., Horikawa, I., et al. (2023) · doi:10.1158/0008-5472.22370694

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

Bernadotte, A., Mikhelson, V. M., & Spivak, I. M. (2016) · Aging · doi:10.18632/aging.100871 · Cited by 466 · see citing works

Five dysfunctional telomeres predict onset of senescence in human cells

Kaul, Z., Cesare, A. J., Huschtscha, L. I., Neumann, A. A., & Reddel, R. R. (2012) · The EMBO Reports · doi:10.1038/embor.2011.227 · Cited by 225 · see citing works

On enzymes in tumors

Waldschmidt‐Leitz, E., McDonald, E., & Co-workers (1948) · Journal of the Franklin Institute · doi:10.1016/0016-0032(48)90025-8 · Cited by 1 · see citing works

Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process

Shi-liang, T. (2007) · Journal of Chongqing College of Education