The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
Open accessAbstract
Stress is a common occurrence in everyday life and repeated or traumatic stress can be a precipitating factor for illnesses of the central nervous system, as well as peripheral organ systems. For example, severe or long-term psychological stress can not only induce depression, a leading illness worldwide, but can also cause psychosomatic diseases such as asthma and rheumatoid arthritis. Related key questions include how psychological stress influences both brain and peripheral systems, and what detection mechanisms underlie these effects? A clue is provided by the discovery of the pathways underlying the responses to host "danger" substances that cause systemic diseases, but can also contribute to depression. The inflammasome is a protein complex that can detect diverse danger signals and produce the accompanying immune-inflammatory reactions. Interestingly, the inflammasome can detect not only pathogen-associated molecules, but also cell damage-associated molecules such as ATP. Here, we propose a new inflammasome hypothesis of depression and related comorbid systemic illnesses. According to this hypothesis, the inflammasome is a central mediator by which psychological and physical stressors can contribute to the development of depression, and as well as a bridge to systemic diseases. This hypothesis includes an explanation for how psychological stress can influence systemic diseases, and conversely how systemic diseases can lead to psychiatric illnesses. The evidence suggests that the inflammasome may be a new target for the development of treatments for depression, as well as psychosomatic and somato-psycho diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“On a cellular level, the release of danger-associated molecular patterns, such as heat-shock proteins and adenosine triphosphate, in response to stress exposure induces a NLRP3 inflammasome response that leads to the release of IL-1β and other cytokines (Iwata et al, 2013;Maslanik et al, 2013).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Iwata et al, 2013
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“recent focus has been shifted towards inflammasomes, which may represent a crucial immunological interface between stress and inflammation40”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [40]
In the citing paper
“The canonical stress pathway, involving the hypothalamus–pituitary–adrenal axis, exhibits dysregulation in depression (for review ref. 155) associated with increased cortisol156 and subsequent neuronal atrophy in the hippocampus157 and mPFC158.”
From Paying attention to attention in depression (2019) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Flagged first, then by citations
Research works printed but not linked: 1
- Banasr, 2011, Cell growth and survival in the pathophysiology and treatment of depression, Curr. Opin. Mol. Cell Neurosci., 91, 333
Cited by
Sorted by citations
Items 301–400 of 582
L- lactate inhibits lipopolysaccharide-induced inflammation of microglia in the hippocampus
Liang, L., Liu, P., Deng, Y., Li, J., & Zhao, S. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2084089 · Cited by 19
Qian, X., Zhong, Z.-D., Zhang, Y., Qiu, L., & Tan, H.-J. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148723 · Cited by 19
Lucido, M. J., & Dunlop, B. W. (2025) · Brain Sciences · doi:10.3390/brainsci15020161 · Cited by 20
Stress-Induced NLRP3 Inflammasome in Human Diseases
Alcocer‐Gómez, E., Castejón‐Vega, B., & Cordero, M. D. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.002 · Cited by 19
Dutheil, S., Watson, L. S., Davis, R. E., & Snyder, G. L. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-22.2022 · Cited by 19
Maciak, K., Dziedzic, A., & Saluk, J. (2022) · The FASEB Journal · doi:10.1096/fj.202201348r · Cited by 18
The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside
von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 19
Yang, E., Rahim, M. A., Griggs, E., Iban‐Arias, R., & Pasinetti, G. M. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad251 · Cited by 19
Akçay, E., & Karataş, H. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100853 · Cited by 18
Neuroprotective effects of gypenosides on LPS-induced anxiety and depression-like behaviors
Guo, M., Pei, W., Liu, L., Chen, K., Cheng, Y., & Piao, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113367 · Cited by 18
Mechanisms of vagal plasticity influencing feeding behavior
de Lartigue, G., & Xu, C. Y. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.030 · Cited by 18
Şahin, C., Dursun, S. M., Çetin, M., & Arıcıoğlu, F. (2016) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20160520092044 · Cited by 19
How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes
Hosseini, S., & Korte, M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220771 · Cited by 17
Wang, C., Jiang, S.-Y., Liao, S.-M., Tian-Liu, Wu, Q.-S., Pan, H., Wei-Nie, Zhang, W., Pan, B., & Liu, W.-Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112414 · Cited by 17
Pujos, M., Chamayou-Robert, C., Parat, M., Bonnet, M., Couret, S., Robiolo, A., & Doucet, O. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16634 · Cited by 17
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Díaz, R., López-González, L., Monserrat, J., Barrena-Blázquez, S., Álvarez-Mon, M. Á., Lahera, G., & Álvarez‐Mon, M. (2024) · Military Medical Research · doi:10.1186/s40779-024-00577-w · Cited by 21
Jenkins, R., Ong’echa, J. M., Othieno, C. J., Ongeri, L., Sifuna, P., Omollo, R., Leonard, B. E., & Ogutu, B. R. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.064 · Cited by 17
A Review of Skin Disease in Schizophrenia
McPhie, M. L., Bridgman, A. C., & Kirchhof, M. G. (2020) · Dermatology · doi:10.1159/000508868 · Cited by 17
Kamimura, Y., Kuwagaki, E., Hamano, S., Kobayashi, M., Yamada, Y., Takahata, Y., Yoshimoto, W., Morimoto, H., Yasukawa, T., Uozumi, Y., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119821 · Cited by 16
Moura, C. D. A., Cagni, F. C., Costa, L. R. F., Tiago, P. R. F., Croyal, M., Aguesse, A., Reyes‐Castro, L. A., Zambrano, E., Bolaños, F. J., & Gavioli, E. C. (2022) · Developmental Neuroscience · doi:10.1159/000526647 · Cited by 16
Reduce stress and the risk of burnout by using yoga techniques. Pilot study
Żok, A., Matecka, M., Bienkowski, A., & Cieśla, M. M. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1370399 · Cited by 18
Olmert, T., Cooper, J. D., Han, S. Y. S., Barton‐Owen, G., Farrag, L. P., Bell, E., Friend, L. V., Özcan, S., Rustogi, N., Preece, R. L., et al. (2020) · JMIR Research Protocols · doi:10.2196/18453 · Cited by 17
Al‐Hakeim, H. K., Twayej, A. J., & Al-Dujaili, A. H. (2018) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2018.10.001 · Cited by 16
Liu, H., Lin, J., & Lin, W. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1354220 · Cited by 21
Liu, C., Zhao, Y., & Zhao, W. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10123-z · Cited by 15
Cattaneo, A., Bellenghi, M., Ferroni, E., Mangia, C., Marconi, M., Rizza, P., Borghini, A., Martini, L., Luciani, M. N., Ortona, E., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14090908 · Cited by 15
Breese, G. R., & Knapp, D. J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.01.005 · Cited by 16
Type 2 diabetes and mental disorders; a plausible link with inflammation
Hajebrahimi, B., Kiamanesh, A. R., Farid, A. A. A., & Asadikaram, G. (2016) · Cellular and Molecular Biology · doi:10.14715/cmb/2016.62.13.13 · Cited by 15
Craddock, T. J. A., Michalovicz, L. T., Kelly, K. A., Rice, M. A., Miller, D. B., Klimas, N. G., Morris, M., O'Callaghan, J. P., & Broderick, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00336 · Cited by 15
Papachristou, E., Flouri, E., Kokosi, T., & Francesconi, M. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02143-7 · Cited by 15
Misztak, P., Sowa-Kućma, M., Pańczyszyn-Trzewik, P., Szewczyk, B., & Nowak, G. (2021) · Molecules · doi:10.3390/molecules27010022 · Cited by 17
Depressive Syndromes Associated with Alcohol Dependence.
Napryeyenko, O., Напрєєнко, Н. Ю., Marazziti, D., Loganovsky, K., Mucci, F., Loganovskaja, T. K., & Tsekhmister, Y. V. (2019) · PubMed Central · doi:10.36131/clinicalnpsych2019050603 · Cited by 15
Subjective Memory Change, Mood, and Cerebrovascular Risk Factors in Older African Americans
Sperling, S. A., Tsang, S., Williams, I. C., Park, M. H., Helenius, I. M., & Manning, C. A. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717732153 · Cited by 15
Zhong, M., Goh, P. H., Li, D., Bao, J., & Xu, W. (2020) · Journal of Health Psychology · doi:10.1177/1359105317736576 · Cited by 14
Wang, F., Tong, J., Gao, Y., Wang, S., & Ji, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18468 · Cited by 15
Hassan, M.-A. M., Wahdan, S. A., El‐Naga, R. N., Abdelghany, T. M., & El‐Demerdash, E. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116875 · Cited by 14
Li, X., Qi, S., Wang, Y., Jiang, H., Li, Y., Zhao, B., Zhang, T., Sun, Y., Gao, X., Quan, S., et al. (2021) · The Anatomical Record · doi:10.1002/ar.24740 · Cited by 14
Karanikas, E. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4419 · Cited by 14
Gawande, D. Y., Barewar, S., Taksande, J., Umekar, M. J., Ghule, B., Taksande, B. G., & Kotagale, N. R. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.06.001 · Cited by 14
Rachubińska, K., Cybulska, A. M., Kupcewicz, E., Jurewicz, A., Pańczyk, M., Cymbaluk‐Płoska, A., Jurczak, J., & Grochans, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216288 · Cited by 14
Gądek-Michalska, A., Tadeusz, J., Rachwalska, P., & Bugajski, J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.003 · Cited by 14
Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms
Thomas, A. M., & Duman, R. S. (2017) · Neuronal Signaling · doi:10.1042/ns20170010 · Cited by 14
Self-citationWoźny-Rasała, I., & Ogłodek, E. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157506 · Cited by 13
Guillaume, M., Endomba, F. T., Dornier, A., & Chauvet‐Gélinier, J. (2022) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.jaclp.2022.12.006 · Cited by 13
Gerdle, B. U. C., Leinhard, O. D., Lund, E., Lundberg, P., Forsgren, M. F., & Ghafouri, B. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1288024 · Cited by 17
Nabirumbi, R., Onohuean, H., Drago, K. C., Alagbonsi, A. I., & Adedeji, A. A. (2024) · Science Progress · doi:10.1177/00368504241234786 · Cited by 13
Brain inflammaging in the pathogenesis of late-life depression
Ishizuka, T., Nagata, W., Nakagawa, K., & Takahashi, S. (2024) · Human Cell · doi:10.1007/s13577-024-01132-4 · Cited by 13
Lan, L., Chen, C.-Y., Wang, Y., Guo, Z., & Zhang, Y. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111401 · Cited by 13
Lin, C. D., Poretto, A., Scodro, M., Marra, M. P., Iliceto, S., & Tona, F. (2015) · Journal of Integrative Cardiology · doi:10.15761/jic.1000136 · Cited by 13
The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review
Minuti, A., Brufani, F., Menculini, G., Moretti, P., & Tortorella, A. A. V. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100044 · Cited by 13
Perspectives on Agmatine Neurotransmission in Acute and Chronic Stressrelated Conditions
Hassanshahi, A., Soti, M., Ranjbar, H., Razavinasab, M., Pirmoradi, Z., Kohlmeier, K. A., Janahmadi, M., & Shabani, M. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230125104753 · Cited by 13
Les inflammasomes et les maladies humaines
Jamilloux, Y., Sève, P., & Henry, T. (2014) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2014.04.017 · Cited by 15
Bipolar disorder and 1513A>C P2RX7 polymorphism frequency
Gubert, C., Andrejew, R., Moritz, C. E. J., Dietrich, F., Vasconcelos-Moreno, M. P., Tietbohl-Santos, B., Fijtman, A., Kauer‐Sant’Anna, M., Kapczinski, F. P., Magalhães, P. V. D. S., et al. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.055 · Cited by 13
Future Directions of Cytokine Hypothesis in Depression: ‘NLRP3 inflamazomu’
Şahin, C., & Arıcıoğlu, F. (2013) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20130927070724 · Cited by 13
Family Member Deaths in Childhood Predict Systemic Inflammation in Late Life
Norton, M. C., Hatch, D., Munger, R. G., & Smith, K. R. (2017) · Biodemography and Social Biology · doi:10.1080/19485565.2017.1281099 · Cited by 13
Chen, P., Yang, Z., Fan, Z., Wang, B., Tang, Y., Xiao, Y., Chen, X., Luo, D., Xiao, S., Li, J., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1096687 · Cited by 12
Lushchak, O. V., Orrù, M., Strilbytska, O. M., Berezovskyi, V., Cherkas, A., Storey, K. B., & Bayliak, M. M. (2023) · EXCLI journal · doi:10.17179/excli2023-6391 · Cited by 12
Yoga and Cardiovascular Diseases – A Mechanistic Review
Murugesan, P. (2024) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_55_24 · Cited by 12
Ali, M. A., Michel, H. E., Menze, E. T., Tadros, M., & Wahdan, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177525 · Cited by 12
Holmes, B., Jung, S. H., Lu, J. N., Wagner, J. A., Rubbi, L., Pellegrini, M. A., & Jankord, R. (2016) · Neural Plasticity · doi:10.1155/2016/5942980 · Cited by 12
Cho, Y., Mishiro, I., Akaki, T., Akimoto, T., & Fujikawa, K. (2022) · BMJ Open · doi:10.1136/bmjopen-2020-048233 · Cited by 12
On the road to resilience: Epigenetic effects of meditation
Verdone, L., Caserta, M., Ben‐Soussan, T. D., & Venditti, S. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2022.12.009 · Cited by 12
Gan, R., Xue, J., & Chen, S. (2023) · Psychology Health & Medicine · doi:10.1080/13548506.2023.2177686 · Cited by 12
Toxoplasma gondii infection associated with inflammasome activation and neuronal injury
Andreou, D., Steen, N. E., Mørch-Johnsen, L. E., Jørgensen, K. N., Wortinger, L. A., Barth, C., Szabó, A., O’Connell, K. S., Lekva, T., Hjell, G., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-55887-9 · Cited by 13
Quam bene vivas referre: curing and caring in psycho‐oncology
Grassi, L. G. (2013) · Psycho-Oncology · doi:10.1002/pon.3333 · Cited by 12
Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder
Zheng, X., Zhang, X., Wang, G., & Hao, H. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.03.015 · Cited by 12
Mendoza, C., Perez-Urrutia, N., Alvarez-Ricartes, N., Barreto, G. E., Ordás, R. P., Iarkov, A., & Echeverrı́a, V. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00952 · Cited by 12
Modeling of Hot Rolling Industrial Process Using Fuzzy Logic.
Sheta, A. F., Öznergiz, E., Abdelrahman, M., & Babuška, R. (2009) · Computer Applications in Industry and Engineering · Cited by 12
Dixon, R. S., Malave, L. B., Thompson, R., Wu, S. S., Li, Y., Sadik, N., & Anacker, C. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01999-9 · Cited by 12
Akute und posttraumatische Belastungsstörung
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_71 · Cited by 11
Czarny, P. L., Wigner, P., Strycharz, J., Watała, C. W., Świderska, E., Synowiec, E., Gałecki, P., Talarowska, M. E., Szemraj, J., Su, K., et al. (2018) · PeerJ · doi:10.7717/peerj.5116 · Cited by 11
Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats
Zhang, Y., Hao, J., Ma, X., Zhao, Q., Gao, X., Wang, X., & Xu, Q. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2530431 · Cited by 11
Innate Immune Memory: Implications for Microglial Function and Neuroprogression
Salam, A. P., Pariante, C. M., & Zunszain, P. A. (2017) · Modern trends in psychiatry · doi:10.1159/000470808 · Cited by 11
Özkartal, C. Ş., Arıcıoğlu, F., Tüzün, E., & Küçükali, C. İ. (2018) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2018.1426694 · Cited by 12
Gerdle, B. U. C., Wåhlén, K., & Ghafouri, B. (2020) · Medicine · doi:10.1097/md.0000000000020497 · Cited by 11
The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity
Baysak, E., Yıldırım, Ç., Sayar, N., Sayar, M. K., Halaris, A. E., & Arıcıoğlu, F. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091295 · Cited by 10
Khantakova, J. N., Bondar, N. P., Antontseva, E. V., & Reshetnikov, V. V. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1066794 · Cited by 10
Langreck, C. B., Wauson, E., Nerland, D., Lamb, B., Folkerts, T., Winter, L., Lu, E., Tague, S. E., McCarson, K. E., Ploski, J. E., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114617 · Cited by 10
Self-citationVollmer, L. L., Schmeltzer, S. N., Ahlbrand, R., & Sah, R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.012 · Cited by 11
Grassi, L. G., Wise, T. N., Cockburn, D., Caruso, R., & Riba, M. (2018) · Integrating psychiatry and primary care · doi:10.1007/978-3-319-74736-1_2 · Cited by 13
Luo, S., Duan, K., Fang, C., Li, D., Zheng, S., Yang, S., Yang, S., Yang, M., Zhang, L.-B., & Wang, S. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s278248 · Cited by 10
Neurobiological advances identify novel antidepressant targets
Duman, R. S. (2013) · World Psychiatry · doi:10.1002/wps.20058 · Cited by 10
Self-citationZha, T., Fang, X., Wan, J., Chen, X., Lin, J., & Chen, Q. (2025) · Biomolecules · doi:10.3390/biom15020165 · Cited by 9
Ruiz-Sánchez, E., López-Ramírez, A. M., Ruíz-Chow, Á. A., Calvillo, M., Reséndiz‐Albor, A. A., Anguiano, B., & Rojas, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312700 · Cited by 10
Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors
Lou, S., Wu, M., & Cui, S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673289984231127062528 · Cited by 9
Glitches in the brain: the dangerous relationship between radiotherapy and brain fog
Marino, N., Bedeschi, M., Vaccari, M. E., Cambiaghi, M., & Tesei, A. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1328361 · Cited by 9
ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice
Li, W., Ali, T., He, K., Zheng, C., Li, N., Yu, Z., & Li, S. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18160 · Cited by 9
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders
de Miranda, A. S., Toscano, E. C. D. B., O’Connor, J. C., & Teixeira, A. L. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2366872 · Cited by 10
Xu, M., Li, L., Xu, B., Yuan, S., Zheng, Q., & Sun, W. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1451060 · Cited by 9
RetractedSantos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., & Medeiros, R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.026 · Cited by 9
The Future of Psychoneuroimmunology: Promises and Challenges
Halaris, A. E., Bechter, K., Haroon, E., Leonard, B. E., Miller, A. H., Pariante, C. M., & Zunszain, P. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-70554-5_15 · Cited by 9
Fresh approaches to antidepressant drug discovery
Anacker, C. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.892071 · Cited by 9
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies
Kwon, S., & Cheon, S. Y. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.2005027 · Cited by 9
Rachubińska, K., Cybulska, A. M., Kupcewicz, E., Pańczyk, M., Grochans, S., Walaszek, I., & Grochans, E. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1305734 · Cited by 8
Genetic analyses of the bidirectional associations between common mental disorders and asthma
Yan, Z., Chen, J., Guo, L., Zhang, H., Ding, Y., Ren, G., Mao, Y., Bai, R., & Ma, X. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1372842 · Cited by 8
Wu, Z., Yin, Y., Liu, R., Li, X., Wang, Z., Wu, C., Tan, J., Fu, Z., Song, C., Wong, N. L., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119031 · Cited by 9
Miyao, M., Hirotsu, A., Tatsumi, K., & Tanaka, T. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16904 · Cited by 8
Pearson, T. L. (2015) · Workplace Health & Safety · doi:10.1177/2165079915593032 · Cited by 8
Suh, K. S., Chon, S., & Choi, E. M. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3521 · Cited by 8
Jackson, S. E., Firth, J., Grabovac, I., Koyanagi, A., Stubbs, B., Soysal, P., Willmott, A. G. B., Yang, L., & Smith, L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104375 · Cited by 8
Metadata
- Authors
- Iwata, M., Ota, K. T., & Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, Ronald S.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 31
- Pages
- 105-114
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4426992
- OpenAlex
- W1964744961
- Cited by
- 580
- References
- 135
- Citations by year
- 2026: 23 · 2025: 27 · 2024: 49 · 2023: 41 · 2022: 56 · 2021: 58 · 2020: 56 · 2019: 44 · 2018: 55 · 2017: 58 · 2016: 41 · 2015: 31 · 2014: 21 · 2013: 17
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH045481)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- inflammasome, psychological stress, depression, psychosomatic disorders, asthma, rheumatoid arthritis, damage-associated molecular patterns, ATP, neuroinflammation, systemic disease, comorbidities
- MeSH terms
- Depressive Disorder, Humans, Inflammation, Models, Theoretical, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
