NLRP3 inflammasome: common nexus between depression and cardiovascular diseases

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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Depression and coronary heart disease

Carney, R. M., & Freedland, K. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.181 · Cited by 705 · see citing works

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

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NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443 · see citing works

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

Paramel, G. V., Folkersen, L., Strawbridge, R. J., Halvorsen, B. L., Yndestad, A., Ranheim, T., Krohg‐Sørensen, K., Skjelland, M., Espevik, T., Aukrust, P., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003031 · Cited by 308 · see citing works

Sensing damage by the NLRP3 inflammasome

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Drivers of age‐related inflammation and strategies for healthspan extension

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Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9408-7 · Cited by 172 · see citing works

Receptor-mediated mitophagy

Yamaguchi, O., Murakawa, T., Nishida, K., & Otsu, K. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.03.010 · Cited by 84 · see citing works

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis

Bando, S., Fukuda, D., Soeki, T., Nishimoto, S., Uematsu, E., Matsuura, T., Ise, T., Tobiume, T., Yamaguchi, K., Yagi, S., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.07.043 · Cited by 64 · see citing works

Hierarchical Regulation of Wound Healing by NOD-Like Receptors in Cardiovascular Disease

Bracey, N. A., Duff, H. J., & Muruve, D. A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6125 · Cited by 24 · see citing works

Cardiovascular Pathobiology of Inflammasomes: Inflammatory Machinery and Beyond

Li, P. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6319 · Cited by 21 · see citing works

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

Mehto, S., Jena, K. K., Nath, P., Chauhan, S., Kolapalli, S. P., Das, S. K., Sahoo, P. K., Jain, A., Taylor, G. A., & Chauhan, S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.018 · Cited by 238 · see citing works

Cardiovascular disease and depression: a narrative review

Li, X., Zhou, J., Wang, M., Yang, C., & Sun, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1274595 · Cited by 101 · see citing works

Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

Pan, H., Lin, Y., Dou, J., Fu, Z. F., Yao, Y., Ye, S., Zhang, S., Wang, N., Liu, A., Li, X., et al. (2020) · Cell Proliferation · doi:10.1111/cpr.12868 · Cited by 80 · see citing works

Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE−/− mice exposed to unpredictable chronic mild stress

Huang, H., Lin, Y., Panyod, S., Chen, R.-A., Lin, Y., Chai, L. M. X., Hsu, C., Wu, W., Lu, K., Huang, Y., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115872 · Cited by 47 · see citing works

Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury

Liu, P., Chen, J., Ma, S., Zhang, J., & Zhou, J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa076 · Cited by 45 · see citing works

NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment

Zhao, S., Chen, F., Wang, D., Han, W., Zhang, Y., & Yin, Q. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01387-z · Cited by 30 · see citing works

The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans

Akóṣílè, W., Voisey, J., Lawford, B. R., Colquhounc, D., Young, R. M., & Mehta, D. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.10.051 · Cited by 29 · see citing works

Stress-Induced NLRP3 Inflammasome in Human Diseases

Alcocer‐Gómez, E., Castejón‐Vega, B., & Cordero, M. D. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.002 · Cited by 19 · see citing works

The influence of psychological factors on coronary heart disease: A review of the evidence and implications for psychological interventions

Xu, W., Fang, L., Bai, H., Ke, K., Li, W., Huang, H., Liang, X., & Chen, C. (2023) · Medicine · doi:10.1097/md.0000000000034248 · Cited by 19 · see citing works

The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity

Baysak, E., Yıldırım, Ç., Sayar, N., Sayar, M. K., Halaris, A. E., & Arıcıoğlu, F. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091295 · Cited by 10 · see citing works

Gut Microbiota and Its Metabolites: The Emerging Bridge Between Coronary Artery Disease and Anxiety and Depression?

Chen, H., Zhang, L., Li, Y., Meng, X., Chi, Y., & Liu, M. (2024) · Aging and Disease · doi:10.14336/ad.2024.0538 · Cited by 11 · see citing works

MiR‐599 Protects Cardiomyocytes against Oxidative Stress‐Induced Pyroptosis

Fan, X., Zhan, E., Yao, Y., Zhang, R., Sun, Y., & Tian, X. (2021) · BioMed Research International · doi:10.1155/2021/3287053 · Cited by 10 · see citing works

Higher atherogenic index of plasma is associated with increased major depressive disorder: insights from a nationally representative study

Tao, S., Yu, L., Li, J., Huang, X., Xue, T., Yang, D., & Tan, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1441119 · Cited by 9 · see citing works

The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway

Wang, Y., Chen, Y., Li, B., Zhou, Y., Guan, J., Huang, F., Wu, J., Dong, Y., Sun, P., Tian, X. Q., et al. (2024) · Brain and Behavior · doi:10.1002/brb3.3586 · Cited by 8 · see citing works

Tabersonine ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in a mouse model

Shi, Y., Hu, Y., Gan, Y., Mi, Z., Luo, S., Lei, J., Fang, Q., & Li, H. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110432 · Cited by 6 · see citing works

NLRP3 inflammasome as a mechanism linking depression and cardiovascular diseases

Carney, R. M., & Freedland, K. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.215 · Cited by 5 · see citing works

Inflammasomes in Clinical Practice: A Brief Introduction

Alcocer‐Gómez, E., Castejón‐Vega, B., López-Sánchez, M., & Cordero, M. D. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_1 · Cited by 4 · see citing works

Suicide, Depression, and Cardiovascular Disease

Mehta, J. L. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.03.006 · Cited by 2 · see citing works

Is depression associated with the risk of cardiovascular disease or vice versa?

Baysak, E., & Arıcıoğlu, F. (2020) · Clinical and Experimental Health Sciences · doi:10.33808/clinexphealthsci.824534

NLRP3 inflammasome as a mechanism linking depression and cardiovascular diseases

Carney, R. M., & Freedland, K. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.215 · Cited by 5 · see citing works

Connecting the Dots: NLRP3 Inflammasome as a Key Mediator in the Intersection of Depression and Cardiovascular Disease – A Narrative Review

Jahromi, G. G., & Rezaei, N. (2025) · Heart and Mind · doi:10.4103/hm.hm-d-24-00076 · Cited by 14 · see citing works

<scp>NLRP</scp> 3 Inflammasome: A New Target in Major Depressive Disorder

Alcocer‐Gómez, E., & Cordero, M. D. (2014) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.12230 · Cited by 75 · see citing works

The NLRP3 inflammasome as a bridge between myocardial infarction and depression: mechanisms, bidirectional link, and therapeutic potential

Zhou, P., Ma, Y., Hou, C., Chen, C., & Deng, S. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1924945

The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity

Baysak, E., Yıldırım, Ç., Sayar, N., Sayar, M. K., Halaris, A. E., & Arıcıoğlu, F. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091295 · Cited by 10 · see citing works