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The effects of exercise on vaccination responses: A review of chronic and acute exercise interventions in humans
Abstract
Vaccination programs, although feted for success in reducing infectious disease morbidity and mortality, are limited by vaccine efficacy, which is particularly problematic in populations with reduced immune function. Exercise has been identified as a behavioural factor that can improve immune function in some settings and cohorts, and therefore, in the setting of vaccination, it may serve as an adjuvant for immune responses. Here, we summarise the body of evidence that has investigated the effects of chronic or acute exercise interventions on vaccination responses. A systematic search of the literature was conducted including six major databases. Randomised control trials (RCTs), cross-sectional and observational studies that involved a variety of population samples and that employed any modality or intensity of acute exercise or chronic training prior to vaccine administration and measured any immune response were included. Twenty trials met the inclusion criteria for this review. Nine studies investigated the effect of acute exercise on the immune response to vaccination, whilst the remaining eleven studies investigated the effect of chronic exercise. Most of the current published literature suggests that exposure to either acute or chronic exercise significantly augments the immune response to vaccination. The clinical importance of this adjuvant action of exercise, if any, as well as variability in responsiveness across different cohorts, dose-response relationships and the optimal exercise modality to employ for this indication deserve further study.
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“For example, in vivo antibody responses to novel antigens can be improved with just minutes of exercise undertaken at the time of vaccination.”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Pascoe et al. 2014
In the citing paper
“Moreover, acute bouts of exercise (and also exercise training interventions) have been shown to improve in vivo immune responses in the young and elderly, such as antibody responses to influenza vaccines (Pascoe et al. 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Pascoe et al. 2014
In the citing paper
“Encouragingly though, even in vaccine studies that have not directly investigated, characterised or controlled for the degree of immunological ageing in the volunteers examined, it has been shown that acute and chronic exercise can improve the response to this in vivo novel antigen challenge (de Araujo et al. 2015; Pascoe et al. 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Pascoe et al. 2014
Citations
Cites
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064
Nicholson, K. G., Wood, J., & Zambon, M. C. F. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14854-4 · Cited by 696
Mortality from invasive pneumococcal pneumonia in the era of antibiotic resistance, 1995-1997
Feikin, D. R., Schuchat, A., KOLCZAK, M. S., Barrett, N. L., Harrison, L. H., Lefkowitz, L. B., McGeer, A., Farley, M. M., Vugia, D. J., Lexau, C., et al. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.2.223 · Cited by 586
T Cell Responses Are Better Correlates of Vaccine Protection in the Elderly
McElhaney, J. E., Xie, D., Hager, W. D., Barry, M. B., Wang, Y., Kleppinger, A., Ewen, C., Kane, K. P., & Bleackley, R. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.6333 · Cited by 561
Characterization of inflammatory responses to eccentric exercise in humans
Peake, J. M., Nosaka, K., & Suzuki, K. (2026) · PubMed · doi:10.22029/eir.2005.1616 · Cited by 499
Nieman, D. C., & Pedersen, B. K. (1999) · Sports Medicine · doi:10.2165/00007256-199927020-00001 · Cited by 466
Exercise‐induced increase in serum interleukin‐6 in humans is related to muscle damage.
Brüünsgaard, H., Galbo, H., Halkjær-Kristensen, J., Johansen, T., MacLean, D. A., & Pedersen, B. K. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021972 · Cited by 455
Coudeville, L., Bailleux, F., Riche, B., Megas, F., Andre, P., & Écochard, R. (2010) · BMC Medical Research Methodology · doi:10.1186/1471-2288-10-18 · Cited by 376
Immunosenescence and vaccine failure in the elderly
Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269
Immunogenicity and protective efficacy of influenza vaccination
HANNOUN, C., Megas, F., & Piercy, J. (2004) · Virus Research · doi:10.1016/j.virusres.2004.02.025 · Cited by 261
Vaccines in historic evolution and perspective: a narrative of vaccine discoveries
Hilleman, M. R. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00434-x · Cited by 227
Kakanis, M., Peake, J. M., Hooper, S., Gray, B., & Marshall‐Gradisnik, S. (2010) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2010.10.642 · Cited by 226
Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype
Campbell, J. P., Riddell, N. E., Burns, V. E., Turner, M., van Zanten, J. J. C. S. V., Drayson, M. T., & Bosch, J. A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.02.011 · Cited by 220
Challenges for vaccination in the elderly
Aspinall, R., Giudice, G. D., Effros, R. B., Grubeck‐Loebenstein, B., & Sambhara, S. R. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-9 · Cited by 208
Exercise and Psychosocial Factors Modulate Immunity to Influenza Vaccine in Elderly Individuals
Kohut, M. L., Cooper, M. M., Nickolaus, M. S., Russell, D. R., & Cunnick, J. E. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.9.m557 · Cited by 193
Valenzuela, T. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.11.001 · Cited by 184
Moderate exercise improves antibody response to influenza immunization in older adults
Kohut, M. L., Arntson, B. A., Lee, W.-L., Rozeboom, K., Yoon, K. J., Cunnick, J. E., & McElhaney, J. E. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.11.023 · Cited by 184
Woods, J. A., Keylock, K. T., Lowder, T., Vieira‐Potter, V. J., Zelkovich, W., Dumich, S. A., Colantuano, K., Lyons, K. L., Leifheit, K. A., Cook, M. D., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02563.x · Cited by 179
Effect of sport stress on lymphocyte transformation and antibody formation.
Eskola, J., Ruuskanen, O., Soppi, E. T., Viljanen, M., Järvinen, M., Toivonen, H., & Kouvalainen, K. (1978) · PubMed Central · Cited by 175
Acute stress exposure prior to influenza vaccination enhances antibody response in women
Edwards, K. M., Burns, V. E., Reynolds, T., Carroll, D., Drayson, M., & Ring, C. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.07.001 · Cited by 161
Self-citationRock, K. L., Hearn, A. R., Chen, C., & Shi, Y. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-004-0173-3 · Cited by 158
In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise
Brüünsgaard, H., Hartkopp, A., Mohr, T. T., Konradsen, H. B., Heron, I., Mordhorst, C. H., & Pedersen, B. K. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199709000-00009 · Cited by 137
Dhabhar, F. S., & Viswanathan, K. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00145.2005 · Cited by 126
Eccentric exercise as an adjuvant to influenza vaccination in humans
Edwards, K. M., Burns, V. E., Allen, L. M., McPhee, J. S., Bosch, J. A., Carroll, D., Drayson, M. T., & Ring, C. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.04.158 · Cited by 124
Self-citationSilberman, D. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.031 · Cited by 119
Ho, C. S. K., López, J. A., Vučković, S., Pyke, C., Hockey, R., & Hart, D. N. J. (2001) · Blood · doi:10.1182/blood.v98.1.140 · Cited by 117
Smith, T. P., Kennedy, S. L., & Fleshner, M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01404.2003 · Cited by 107
Meningococcal A Vaccination Response is Enhanced by Acute Stress in Men
Edwards, K. M., Burns, V. E., Adkins, A., Carroll, D., Drayson, M. T., & Ring, C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318164232e · Cited by 80
Self-citationFrasca, D., Diaz, A., Romero, M., Mendez, N. V., Landin, A. M., & Blomberg, B. B. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-14 · Cited by 77
Immunosenescence: Implications for vaccination programmes in adults
Lang, P. O., Govind, S., Michel, J. P., Aspinall, R., & Mitchell, W. A. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.01.011 · Cited by 76
The Acute Stress-Induced Immunoenhancement Hypothesis
Edwards, K. M., Burns, V. E., Carroll, D., Drayson, M. T., & Ring, C. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3180a031bd · Cited by 71
Self-citationHigher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly
Keylock, K. T., Lowder, T., Leifheit, K. A., Cook, M. D., Mariani, R., Ross, K. M., Kim, K., Chapman‐Novakofski, K., McAuley, E., & Woods, J. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00790.2006 · Cited by 68
Villari, P., Manzoli, L., & Boccia, A. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.068 · Cited by 67
Yang, Y., Verkuilen, J., Rosengren, K. S., Mariani, R., Reed, M., Grubisich, S. A., & Woods, J. A. (2007) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x07005090 · Cited by 65
Grant, R. W., Mariani, R., Vieira‐Potter, V. J., Fleshner, M., Smith, T. P., Keylock, K. T., Lowder, T., McAuley, E., Hu, L., Chapman‐Novakofski, K., et al. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.01.006 · Cited by 60
Edwards, K. M., Pung, M. A., Tomfohr‐Madsen, L. M., Ziegler, M. G., Campbell, J. P., Drayson, M. T., & Mills, P. J. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.08.022 · Cited by 58
Self-citationShort and long restraint differentially affect humoral and cellular immune functions
Millán, S., González-Quijano, M. I., Giordano, M., Soto, L., Martı́n, A. I., & López‐Calderón, A. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00471-7 · Cited by 58
Long, J. E., Ring, C., Drayson, M. T., Bosch, J. A., Campbell, J. P., Bhabra, J., Browne, D., Dawson, J., Harding, S., Lau, J., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.02.004 · Cited by 58
IL-6 induces long-term protective immunity against a lethal challenge of influenza virus
Lee, S. W., Youn, J. W., Seong, B. L., & Sung, Y. C. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00223-0 · Cited by 56
Schuerman, L., Prymula, R., Henckaerts, I., & POOLMAN, J. T. (2007) · Vaccine · doi:10.1016/j.vaccine.2006.12.008 · Cited by 52
The scientific basis for offering seasonal influenza immunisation to risk groups in Europe
Nicoll, A., Ciancio, B. C., Tsolova, S., Blank, P. R., & Yılmaz, C. (2008) · Eurosurveillance · doi:10.2807/ese.13.43.19018-en · Cited by 52
Campbell, J. P., Edwards, K. M., Ring, C., Drayson, M. T., Bosch, J. A., Inskip, A., Long, J. E., Pulsford, D., & Burns, V. E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.001 · Cited by 51
Self-citationEffect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults
Ranadive, S. M., Cook, M. D., Kappus, R. M., Yan, H., Lane, A. D., Woods, J. A., Wilund, K. R., Iwamoto, G. A., Vanar, V., Tandon, R., et al. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a75ff2 · Cited by 49
Infectious disease risk in the elderly
Bender, B. S. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00078-4 · Cited by 49
Edwards, K. M., Campbell, J. P., Ring, C., Drayson, M. T., Bosch, J. A., Downes, C., Long, J. E., Lumb, J. A., Merry, A., Paine, N. J., et al. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.009 · Cited by 47
Self-citationSchuler, P. B., LeBlanc, P. A., & Marzilli, T. S. (2003) · PubMed · Cited by 36
Albumin Clearance from Human Skeletal Muscle During Prolonged Steady‐State Running
Havas, E., Lehtonen, M., Vuorela, J., Parviainen, T., & Vihko, V. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.02042.x · Cited by 28
Restraint stress augments antibody production in cyclophosphamide-treated mice
Karp, J. D. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00267-5 · Cited by 26
Stressor-Induced Alterations of Adaptive Immunity to Vaccination and Viral Pathogens
Powell, N. D., Allen, R. G., Mackos, A. R., Sheridan, J. F., & Bailey, M. T. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.002 · Cited by 24
The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice
Kapasi, Z. F., Catlin, P. A., Joyner, D. R., Lewis, M. L., Schwartz, A. L., & Townsend, E. L. (2000) · Physical Therapy · doi:10.1093/ptj/80.11.1076 · Cited by 24
Long, J. E., Ring, C., Bosch, J. A., Eves, F., Drayson, M. T., Calver, R., Say, V., Allen, D., & Burns, V. E. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182a0b664 · Cited by 21
The effect of physical activity and fitness on specific antibody production in college students.
Schuler, P. B., Lloyd, L. K., LeBlanc, P. A., Clapp, T., Abadie, B. R., & Collins, R. K. (1999) · PubMed · Cited by 21
Krakauer, T. (1995) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.2.4.487-488.1995 · Cited by 20
The effect of exercise training on the kinetics of the antibody response to influenza vaccination
Whitham, M., & Blannin, A. (2003) · Journal of Sports Sciences · doi:10.1080/0264041031000140464 · Cited by 15
Acute Exercise as an Adjuvant to Influenza Vaccination
Edwards, K. M., & Campbell, J. P. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827610395486 · Cited by 13
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Metadata
- Authors
- Pascoe, A. R., Fiatarone Singh, M. A., & Edwards, K. M.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Edwards, Kate M.
- ORCID
- Edwards, Kate M.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 39
- Pages
- 33-41
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2077828153
- Cited by
- 149
- References
- 56
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 31 · 2022: 17 · 2021: 23 · 2020: 18 · 2019: 11 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- physical activity, vaccination, vaccine response, acute exercise, exercise training, immune function, vaccine efficacy, dose-response relationship, exercise modalities
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Vaccination, Vaccines, Exercise, Treatment Outcome, Young Adult
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