Acute and Chronic Stress Exert Opposing Effects on Antibody Responses Associated with Changes in Stress Hormone Regulation of T-Lymphocyte Reactivity
Abstract
Here we show that stress exerts a differential effect on T-cell-dependent antibody production. IgG production is augmented after acute stress and impaired in a chronic situation. We found catecholamines and corticosterone levels were increased in acute situations although they were not modified after prolonged stress conditions. However, lymphocyte sensitivity to corticosterone and catecholamines was altered under stress conditions. These results point out the role of the adrenal's hormones as mediators of the differential effects of stress on the immune response providing the basis for a functional significance of stress hormone receptors on lymphocytes.
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From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [63]
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From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [63]
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- Authors
- Silberman, D.
- Corresponding author
- Silberman, D
- ORCID
- Silberman, D
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 144
- Issue
- 1-2
- Pages
- 53-60
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2058303679
- Cited by
- 119
- References
- 37
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 6
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto Nacional de Tecnología Agropecuaria
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- acute stress, chronic stress, antibody response, IgG production, T cell-dependent antibody production, corticosterone, catecholamines, adrenal hormones, stress and immune response
- MeSH terms
- Acute Disease, Animals, Blood Group Antigens, Catecholamines, Cells, Cultured, Chronic Disease, Corticosterone, Female, Immunoglobulin G, Lymphocyte Activation, Mice, Inbred BALB C, Restraint, Physical, Sheep, Stress, Physiological, Thymus Gland, Down-Regulation, Up-Regulation, T-Lymphocyte Subsets, Mice
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