Impact of traumatic brain injury on sleep structure, electrocorticographic activity and transcriptome in mice
Abstract
Traumatic brain injury (TBI), including mild TBI (mTBI), is importantly associated with vigilance and sleep complaints. Because sleep is required for learning, plasticity and recovery, we here evaluated the bidirectional relationship between mTBI and sleep with two specific objectives: (1) Test that mTBI rapidly impairs sleep-wake architecture and the dynamics of the electrophysiological marker of sleep homeostasis (i.e., non-rapid eye movement sleep delta (1-4Hz) activity); (2) evaluate the impact of sleep loss following mTBI on the expression of plasticity markers that have been linked to sleep homeostasis and on genome-wide gene expression. A closed-head injury model was used to perform a 48h electrocorticographic (ECoG) recording in mice submitted to mTBI or Sham surgery. mTBI was found to immediately decrease the capacity to sustain long bouts of wakefulness as well as the amplitude of the time course of ECoG delta activity during wakefulness. Significant changes in ECoG spectral activity during wakefulness, non-rapid eye movement and rapid eye movement sleep were observed mainly on the second recorded day. A second experiment was performed to measure gene expression in the cerebral cortex and hippocampus after a mTBI followed either by two consecutive days of 6h sleep deprivation (SD) or of undisturbed behavior (quantitative PCR and next-generation sequencing). mTBI modified the expression of genes involved in immunity, inflammation and glial function (e.g., chemokines,…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some animal studies report a disordered sleep phenotype of increased wakefulness, more latency to sleep, or insomnia, which are also phenotypes of sleep disorders in human TBI patients.
“Some studies report a disordered sleep phenotype of increased wakefulness, more latency to sleep, or insomnia in animals,65,70–72 which are also phenotypes of sleep disorders in human TBI patients.”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [72]
Cites
Vyazovskiy, V. V., Olcese, U., Hanlon, E. C., Nir, Y., Cirelli, C., & Tononi, G. (2011) · Nature · doi:10.1038/nature10009 · Cited by 865 · see citing works
A BDNF autocrine loop in adult sensory neurons prevents cell death
Acheson, A., Conover, J. C., Fandl, J. P., DeChiara, T. M., Russell, M., Thadani, A., Squinto, S. P., Yancopoulos, G. D., & Lindsay, R. M. (1995) · Nature · doi:10.1038/374450a0 · Cited by 765 · see citing works
Mild traumatic brain injury and diffuse axonal injury in swine
Browne, K. D., Chen, X.-H., Meaney, D. F., & Smith, D. H. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1913 · Cited by 248 · see citing works
Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works
Loss of hypocretin (orexin) neurons with traumatic brain injury
Baumann, C. R., Bassetti, C. L., Valko, P. O., Haybaeck, J., Keller, M., Clark, E., Stocker, R., Tolnay, M., & Scammell, T. E. (2009) · Annals of Neurology · doi:10.1002/ana.21836 · Cited by 185 · cited 1× · see citing works
“Alternatively, these changes may be linked to alterations in other neuronal circuits involved in sleep-wake regulation, such as hypothalamic orexin neurons or the thalamic reticular nucleus that were both shown to be modified by TBI (Baumann et al., 2009; Hazra et al., 2014; Willie et al., 2012).”
BackgroundNeuropsychological Performance and Sleep Disturbance Following Traumatic Brain Injury
Mahmood, O., Rapport, L. J., Hanks, R. A., & Fichtenberg, N. L. (2004) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200409000-00003 · Cited by 157 · see citing works
Involvement of cytokines in slow wave sleep
Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00003-x · Cited by 126 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies
Sandsmark, D. K., Elliott, J. E., & Lim, M. M. (2017) · Sleep · doi:10.1093/sleep/zsx044 · Cited by 183 · see citing works
Effects of Traumatic Brain Injury on the Orexin/Hypocretin System
Somach, R. T., Lim, M. M., & Cohen, A. S. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0111 · Cited by 2 · see citing works
- Authors
- Sabir, M., Gaudreault, P.-O., Freyburger, M., Massart, R., Blanchet-Cohen, A., Jaber, M., Gosselin, N., & Mongrain, V.
- Affiliations
- Hôpital du Sacré-Cœur de Montréal (CA)
- McGill University (CA)
- Montreal Clinical Research Institute (CA)
- Corresponding author
- Mongrain, Valérie
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 47
- Pages
- 118-130
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2091321139
- Cited by
- 47
- References
- 7
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (CBI-127051)
- Research Center of the Hôpital du Sacré-Coeur de Montréal
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- mild traumatic brain injury, sleep-wake architecture, sleep homeostasis, electrocorticography, sleep deprivation, glial fibrillary acidic protein, Arc, neuroinflammation, glial activation, circadian rhythm, brain recovery
- MeSH terms
- Electrocorticography, Animals, Brain, Brain Injuries, Circadian Rhythm, Male, Sleep, Sleep Deprivation, Mice, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
