The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury
Open accessAbstract
OBJECTIVE: Preterm brain injury is a major cause of disability in later life, and may result in motor, cognitive and behavioural impairment for which no treatment is currently available. The aetiology is considered as multifactorial, and one underlying key player is inflammation leading to white and grey matter injury. Extracellular vesicles secreted by mesenchymal stem/stromal cells (MSC-EVs) have shown therapeutic potential in regenerative medicine. Here, we investigated the effects of MSC-EV treatment on brain microstructure and maturation, inflammatory processes and long-time outcome in a rodent model of inflammation-induced brain injury. METHODS: cell equivalents of MSC-EVs per kg bodyweight. Cellular degeneration and reactive gliosis at P5 and myelination at P11 were evaluated by immunohistochemistry and western blot. Long-term cognitive and motor function was assessed by behavioural testing. Diffusion tensor imaging at P125 evaluated long-term microstructural white matter alterations. RESULTS: MSC-EV treatment significantly ameliorated inflammation-induced neuronal cellular degeneration reduced microgliosis and prevented reactive astrogliosis. Short-term myelination deficits and long-term microstructural abnormalities of the white matter were restored by MSC-EV administration. Morphological effects of MSC-EV treatment resulted in improved long-lasting cognitive functions INTERPRETATION: MSC-EVs ameliorate inflammation-induced cellular damage in a rat model of preterm brain injury. MSC-EVs may serve as a novel therapeutic option by prevention of neuronal cell death, restoration of white matter microstructure, reduction of gliosis and long-term functional improvement.
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Cited by
Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
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Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
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Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
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Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine
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MSC exosome works through a protein-based mechanism of action
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Metadata
- Authors
- Drommelschmidt, K., Serdar, M., Bendix, I., Herz, J., Bertling, F., Prager, S., Keller, M., Ludwig, A.-K., Duhan, V., Radtke, S., de Miroschedji, K., Horn, P. A., van de Looij, Y., Giebel, B., & Felderhoff-Müser, U.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 60
- Pages
- 220-232
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2552379881
- Cited by
- 269
- References
- 7
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Drommelschmidt, K., Serdar, M., Bendix, I., Herz, J., Bertling, F., Prager, S., Keller, M., Ludwig, A.-K., Duhan, V., Radtke, S., de Miroschedji, K., Horn, P. A., van de Looij, Y., Giebel, B., & Felderhoff-Müser, U. (2017). Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2016.11.011
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