Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: a longitudinal in vivo MRI study
Open accessAbstract
Genetic and environmental risk factors for psychiatric disorders are suggested to disrupt the trajectory of brain maturation during adolescence, leading to the development of psychopathology in adulthood. Rodent models are powerful tools to dissect the specific effects of such risk factors on brain maturational profiles, particularly when combined with Magnetic Resonance Imaging (MRI; clinically comparable technology). We therefore investigated the effect of maternal immune activation (MIA), an epidemiological risk factor for adult-onset psychiatric disorders, on rat brain maturation using atlas and tensor-based morphometry analysis of longitudinal in vivo MR images. Exposure to MIA resulted in decreases in the volume of several cortical regions, the hippocampus, amygdala, striatum, nucleus accumbens and unexpectedly, the lateral ventricles, relative to controls. In contrast, the volumes of the thalamus, ventral mesencephalon, brain stem and major white matter tracts were larger, relative to controls. These volumetric changes were maximal between post-natal day 50 and 100 with no differences between the groups thereafter. These data are consistent with and extend prior studies of brain structure in MIA-exposed rodents. Apart from the ventricular findings, these data have robust face validity to clinical imaging findings reported in studies of individuals at high clinical risk for a psychiatric disorder. Further work is now required to address the relationship of these MRI changes to behavioral dysfunction and to establish thier cellular correlates.
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Prenatal POL exposure increased volume of thalamus, ventral mesencephalon, brain stem, and major white matter tracts relative to controls.
“prenatal POL exposure resulted in larger volume in the thalamus, ventral mesencephalon, brain stem and major white matter tracts relative to controls (Crum et al., 2017).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Crum et al., 2017
Prenatal POL exposure decreased volume of anterior cingulate cortex, hippocampus, amygdala, striatum, nucleus accumbens, and lateral ventricles in rat offspring.
“Exposure to polyriboinosinic-polyribocytidylic acid (POL) during gestation decreased the volume of the anterior cingulate cortex, hippocampus, amygdala, striatum, nucleus accumbens and lateral ventricles in rat offspring (Crum et al., 2017).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Crum et al., 2017
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Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
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- Authors
- Crum, W. R., Sawiak, S. J., Chege, W., Cooper, J. D., Williams, S. C. R., & Vernon, A. C.
- Affiliations
- King's College London (GB)
- University of Cambridge (GB)
- Corresponding author
- Vernon, Anthony C.
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 63
- Pages
- 50-59
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC5441572
- OpenAlex
- W2560077862
- Cited by
- 76
- References
- 75
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 11 · 2017: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Funders
- British Heart Foundation
- Medical Research Council (MR/N026063/1)
- Menzies Centre for Australian Studies, King's College London, University of London
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- maternal immune activation, brain maturation, brain structure, brain volume, mental illness, adolescent brain development, hippocampus, amygdala, striatum, nucleus accumbens, lateral ventricle, thalamus, white matter, in vivo MRI, rat model
- MeSH terms
- Amygdala, Animals, Mental Disorders, Brain, Disease Models, Animal, Female, Hippocampus, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Sprague-Dawley, Rats
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