Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice
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Maternal infection during pregnancy increases the risk for neurodevelopmental disorders such as schizophrenia and autism in the offspring. This association appears to be critically dependent on the precise prenatal timing. However, the extent to which distinct adult psychopathological and neuropathological traits may be sensitive to the precise times of prenatal immune activation remains to be further characterized. Here, we evaluated in a mouse model of prenatal immune challenge by the viral mimic, polyriboinosinic-polyribocytidilic acid (PolyIC), whether prenatal immune activation in early/middle and late gestation may influence the susceptibility to some of the critical cognitive, pharmacological, and neuroanatomical dysfunctions implicated in schizophrenia and autism. We revealed that PolyIC-induced prenatal immune challenge on gestation day (GD) 9 but not GD17 significantly impaired sensorimotor gating and reduced prefrontal dopamine D1 receptors in adulthood, whereas prenatal immune activation specifically in late gestation impaired working memory, potentiated the locomotor reaction to the NMDA-receptor antagonist dizocilpine, and reduced hippocampal NMDA-receptor subunit 1 expression. On the other hand, potentiation of the locomotor reaction to the dopamine-receptor agonist amphetamine and reduction in Reelin- and Parvalbumin-expressing prefrontal neurons emerged independently of the precise times of prenatal immune challenge. Our findings thus highlight that prenatal immune challenge during early/middle and late fetal development in mice leads to distinct brain and behavioral pathological symptom clusters in adulthood. Further examination and evaluation of in utero immune challenge at different times of gestation may provide important new insight into the neuroimmunological and neuropathological mechanisms underlying the segregation of different symptom clusters in heterogeneous neuropsychiatric disorders such as schizophrenia and autism.
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Early-life pro-inflammatory conditions, such as maternal and neonatal immune challenges, cause a persistent decrease in the number of prefrontal and/or hippocampal parvalbumin-immunoreactive interneurons.
“Early-life pro-inflammatory conditions, such as maternal and neonatal immune challenges, cause a persistent decrease in number of prefrontal and/or hippocampal parvalbumin-immunoreactive interneurons (Jenkins et al., 2009; Meyer et al., 2008).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Meyer et al., 2008
Inflammation induced at different prenatal periods can lead to distinct adult phenotypes.
“Moreover, inflammation induced at different prenatal periods can lead to distinct adult phenotypes (Meyer et al., 2008).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Meyer et al., 2008
The oxidative stress-induced PVI deficit may also hold for other brain regions like the hippocampus, as shown in some models of schizophrenia (e.g., GCLM KO, ketamine, MAM, poly(I:C), and social defeat).
“Although our analysis focused on oxidative stress-induced PVI deficit in the prefrontal cortex, this deficit may also hold for other brain regions like the hippocampus, as shown in some models of schizophrenia (for example, GCLM KO, ketamine, MAM, poly(I:C) and social defeat.22, 37, 47, 48, 84”
From Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia (2017) · cites this paper as [22]
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- Authors
- Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Feldon, Joram
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 22
- Issue
- 4
- Pages
- 469-486
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2022230955
- Cited by
- 457
- References
- 77
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 23 · 2023: 11 · 2022: 20 · 2021: 28 · 2020: 28 · 2019: 20 · 2018: 29 · 2017: 21 · 2016: 30 · 2015: 37 · 2014: 30 · 2013: 32 · 2012: 42
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Branco Weiss Fellowship – Society in Science
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- prenatal immune activation, maternal infection, poly(I:C), schizophrenia, autism spectrum disorder, pregnancy timing, sensorimotor gating, dopamine D1 receptor, prefrontal cortex, working memory, MK-801, NMDA receptor, hippocampus, amphetamine sensitivity, reelin, parvalbumin, neurodevelopmental disorders, neuroimmunology
- MeSH terms
- Reelin Protein, Acoustic Stimulation, Age Factors, Amphetamines, Central Nervous System Stimulants, Animals, Autistic Disorder, Brain, Female, gamma-Aminobutyric Acid, Interferon Inducers, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Parvalbumins, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Serine Endopeptidases, Specific Pathogen-Free Organisms, Reflex, Startle, Cell Adhesion Molecules, Neuronal, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Extracellular Matrix Proteins, Receptors, Dopamine D1, Excitatory Amino Acid Antagonists, Mice
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