Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578 · see citing works

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269 · see citing works

Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic

Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,198 · see citing works

Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia

Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048 · see citing works

Schizophrenia, “just the facts” 4. Clinical features and conceptualization

Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.005 · Cited by 1,031 · see citing works

Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring

Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works

Early Life Programming and Neurodevelopmental Disorders

Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works

Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders

Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1006-y · Cited by 916 · see citing works

Maternal Intrauterine Infection, Cytokines, and Brain Damage in the Preterm Newborn

Dammann, O., & Leviton, A. (1997) · Pediatric Research · doi:10.1203/00006450-199707000-00001 · Cited by 886 · see citing works

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860 · see citing works

The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology

Meyer, U., Nyffeler, M., Engler, A., Urwyler, A., Schedlowski, M., Knuesel, I., Yee, B. K., & Feldon, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-06.2006 · Cited by 774 · see citing works

The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD)

Halbreich, U. M., Borenstein, J. E., Pearlstein, T., & Kahn, L. S. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00098-2 · Cited by 758 · see citing works

The environment and susceptibility to schizophrenia

Brown, A. S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.003 · Cited by 664 · see citing works

Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults

Hagberg, H., Gressèns, P., & Mallard, C. E. (2011) · Annals of Neurology · doi:10.1002/ana.22620 · Cited by 519 · see citing works

Maternal Infections and Subsequent Psychosis Among Offspring

Buka, S. L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1032 · Cited by 512 · see citing works

Immune Activation During Pregnancy in Rats Leads to a PostPubertal Emergence of Disrupted Latent Inhibition, Dopaminergic Hyperfunction, and Altered Limbic Morphology in the Offspring: A Novel Neurodevelopmental Model of Schizophrenia

Zuckerman, L., Rehavi, M., Nachman, R., & Weiner, I. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300248 · Cited by 501 · see citing works

Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia

Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494 · see citing works

Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring

Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Liu, L., Babulas, V. P., & Susser, E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.767 · Cited by 490 · see citing works

Elevated Maternal Interleukin-8 Levels and Risk of Schizophrenia in Adult Offspring

Brown, A. S., Hooton, J. W. L., Schaefer, C. A., Zhang, H., Petkova, E., Babulas, V. P., Perrin, M. A., Gorman, J. M., & Susser, E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.889 · Cited by 484 · see citing works

Schizophrenia, just the facts

Wyatt, R. J., Alexander, R., Egan, M. F., & Kirch, D. G. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90034-5 · Cited by 478 · see citing works

Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground

Weinberger, D. R., & Lipska, B. K. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)00013-c · Cited by 468 · see citing works

Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia

Ozawa, K., Hashimoto, K., Kishimoto, T., Shimizu, E., Ishikura, H., & Iyo, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.031 · Cited by 467 · see citing works

Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice

Giovanoli, S., Engler, H., Engler, A., Richetto, J., Voget, M., Willi, R., Winter, C., Riva, M. A., Mortensen, P. B., Feldon, J., et al. (2013) · Science · doi:10.1126/science.1228261 · Cited by 459 · see citing works

Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice

Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works

The stress cascade and schizophrenia: Etiology and onset

Corcoran, C., Walker, E., Huot, R., Mittal, V., Tessner, K., Kestler, L., & Malaspina, D. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007038 · Cited by 439 · see citing works

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

Hsiao, E. Y., & Patterson, P. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.12.017 · Cited by 402 · see citing works

Toxoplasma gondii and Other Risk Factors for Schizophrenia: An Update

Torrey, E. F., Bartko, J. J., & Yolken, R. H. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs043 · Cited by 394 · see citing works

The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia

Ashdown, H. F., Dumont, Y., Ng, M., Poole, S., Boksa, P., & Luheshi, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001748 · Cited by 387 · see citing works

Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Maynard, T. M., Sikich, L., Lieberman, J. A., & LaMantia, A.-S. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006887 · Cited by 383 · see citing works

Transfer of Inflammatory Cytokines Across the Placenta

Zaretsky, M. V., Alexander, J. M., Byrd, W., & Bawdon, R. E. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000114980.40445.83 · Cited by 376 · see citing works

In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

Meyer, U., Feldon, J., & Fatemi, S. H. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.001 · Cited by 367 · see citing works

Epidemiology-driven neurodevelopmental animal models of schizophrenia

Meyer, U., & Feldon, J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.018 · Cited by 366 · see citing works

Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?

MEYER, U., FELDON, J., & DAMMANN, O. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212c196 · Cited by 357 · see citing works

Elevated maternal C-reactive protein and autism in a national birth cohort

Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343 · see citing works

Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence

Moreno-De-Luca, A., Myers, S. M., Challman, T. D., Moreno-De-Luca, D., Evans, D. W., & Ledbetter, D. H. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70011-5 · Cited by 330 · see citing works

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)

Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.007 · Cited by 318 · see citing works

A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia

Meyer, U., Feldon, J., & Yee, B. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn022 · Cited by 318 · see citing works

Maternal Cytokine Levels during Pregnancy and Adult Psychosis

Buka, S. L., Tsuang, M. T., Torrey, E. F., Klebanoff, M. A., Wagner, R., & Yolken, R. H. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0644 · Cited by 316 · see citing works

The neurodevelopmental impact of prenatal infections at different times of pregnancy: the earlier the worse?

Meyer, U., Yee, B. K., & Feldon, J. (2007) · The Neuroscientist · doi:10.1177/1073858406296401 · Cited by 303 · see citing works

Prenatal rubella, premorbid abnormalities, and adult schizophrenia

Brown, A. S., Cohen, P., Harkavy‐Friedman, J., Babulas, V. P., Malaspina, D., Gorman, J., & Susser, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01068-x · Cited by 298 · see citing works

Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA A dysregulation and impaired spatial learning

Samuelsson, A., Jennische, E., Hansson, H., & Holmäng, A. B. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2005 · Cited by 283 · see citing works

How TNF was recognized as a key mechanism of disease

Clark, I. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.04.002 · Cited by 269 · see citing works

Association Between Prenatal Exposure to Bacterial Infection and Risk of Schizophrenia

Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn121 · Cited by 261 · see citing works

Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice

Fatemi, S. H., Emamian, E. S., Kist, D. A., Sidwell, R. W., Nakajima, K., Akhter, P., Shier, A. C., Sheikh, S. A., & Bailey, K. W. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000520 · Cited by 259 · see citing works

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255 · see citing works

Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling

Meyer, U., Murray, P. J., Urwyler, A., Yee, B. K., Schedlowski, M., & Feldon, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002042 · Cited by 252 · see citing works

Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders

Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Huang, H., Oishi, K., Mori, S., Smee, D. F., Pearce, D. A., Winter, C., Sohr, R., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.11.018 · Cited by 250 · see citing works

To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models

Meyer, U., & Feldon, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.009 · Cited by 247 · see citing works

Models of Fetal Brain Injury, Intrauterine Inflammation, and Preterm Birth

Burd, I. D., Balakrishnan, B., & Kannan, S. (2012) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2012.01110.x · Cited by 238 · see citing works

PHYSIOLOGY AND PATHOLOGY OF THE NERVOUS SYSTEM,

Bayle, A. (1824) · The Lancet · doi:10.1016/s0140-6736(02)83548-6 · Cited by 235 · see citing works

Maternal Exposure to Herpes Simplex Virus and Risk of Psychosis Among Adult Offspring

Buka, S. L., Cannon, T. D., Torrey, E. F., & Yolken, R. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.022 · Cited by 233 · see citing works

Prenatal Exposure to Maternal Genital and Reproductive Infections and Adult Schizophrenia

Babulas, V. P., Factor-Litvak, P. R., Goetz, R. R., Schaefer, C. A., & Brown, A. S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.927 · Cited by 233 · see citing works

Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy

Fortier, M., Luheshi, G. N., & Boksa, P. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.04.016 · Cited by 229 · see citing works

Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8

Ellman, L. M., Deicken, R. F., Vinogradov, S., Kremen, W. S., Poole, J. H., Kern, D. M., Tsai, W. Y., Schaefer, C. A., & Brown, A. S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.014 · Cited by 225 · see citing works

A Longitudinal Examination of the Neurodevelopmental Impact of Prenatal Immune Activation in Mice Reveals Primary Defects in Dopaminergic Development Relevant to Schizophrenia

Vuillermot, S., Weber, L., Feldon, J., & Meyer, U. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5408-09.2010 · Cited by 217 · see citing works

Evidence for an Interaction Between Familial Liability and Prenatal Exposure to Infection in the Causation of Schizophrenia

Clarke, M. C., Tanskanen, A. J., HUTTUNEN, M. O., Whittaker, J. C., & Cannon, M. D. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08010031 · Cited by 216 · see citing works

Exposure to infection and brain development: cytokines in the pathogenesis of schizophrenia

GILMORE, J., & FREDRIKJARSKOG, L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00123-5 · Cited by 209 · see citing works

Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey

Short, S. J., Lubach, G. R., Karasin, A. I., Olsen, C. W., Styner, M., Knickmeyer, R. C., Gilmore, J. H., & Coe, C. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.026 · Cited by 202 · see citing works

Association Between Prenatal Exposure to Poliovirus Infection and Adult Schizophrenia

Suvisaari, J., Haukka, J. K., Tanskanen, A. J., Hovi, T., & Lönnqvist, J. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1100 · Cited by 192 · see citing works

Schizophrenic births and viral diseases in two states

Torrey, Ε. F., Rawlings, R. R., & Waldman, I. N. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90043-6 · Cited by 185 · see citing works

Autistic Disorders and Schizophrenia: Related or Remote? An Anatomical Likelihood Estimation

Cheung, C., Yu, K., Fung, G., Leung, M.-K., Wong, C. H. Y., Li, Q., Sham, P. C., Chua, S. E., & McAlonan, G. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012233 · Cited by 180 · see citing works

Role of the fetus in perinatal infection and neonatal brain damage

Dammann, O., & Leviton, A. (2000) · Current Opinion in Pediatrics · doi:10.1097/00008480-200004000-00002 · Cited by 178 · see citing works

Prenatal Exposure to Maternal Infection and Executive Dysfunction in Adult Schizophrenia

Brown, A. S., Vinogradov, S., Kremen, W. S., Poole, J. H., Deicken, R. F., Penner, J. D., McKeague, I. W., Kochetkova, A. S., Kern, D. M., & Schaefer, C. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08010089 · Cited by 177 · see citing works

Early Infections of Toxoplasma gondii and the Later Development of Schizophrenia

Mortensen, P. B., Nørgaard‐Pedersen, B., Waltoft, B. L., Sørensen, T. L., HOUGAARD, D. M., & Yolken, R. H. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm009 · Cited by 171 · see citing works

Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long term losses of dopamine neurons in offspring a potential new model of parkinson s disease

Carvey, P. M. (2003) · Frontiers in bioscience · doi:10.2741/1158 · Cited by 161 · see citing works

Viral infection, inflammation and schizophrenia

Kneeland, R. E., & Fatemi, S. H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.001 · Cited by 152 · see citing works

Prenatal and postnatal animal models of immune activation: Relevance to a range of neurodevelopmental disorders

Harvey, L., & Boksa, P. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22043 · Cited by 149 · see citing works

Prenatal Immune Challenge Is an Environmental Risk Factor for Brain and Behavior Change Relevant to Schizophrenia: Evidence from MRI in a Mouse Model

Li, Q., Cheung, C., Wei, R., Hui, E. S. K., Feldon, J., Meyer, U., Chung, S. K., Chua, S. E., Sham, P. C., Wu, E. X., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006354 · Cited by 149 · see citing works

Maternal Immune Activation during Gestation Interacts withDisc1Point Mutation to Exacerbate Schizophrenia-Related Behaviors in Mice

Lipina, T. V., Zai, C. C. H., Hlousek, D., Roder, J., & Wong, A. H. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0091-13.2013 · Cited by 146 · see citing works

Abnormal Trajectories of Neurodevelopment and Behavior Following In Utero Insult in the Rat

Piontkewitz, Y., Arad, M., & Weiner, I. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.007 · Cited by 144 · see citing works

Clozapine Administration in Adolescence Prevents Postpubertal Emergence of Brain Structural Pathology in an Animal Model of Schizophrenia

Piontkewitz, Y., Assaf, Y., & Weiner, I. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.005 · Cited by 143 · see citing works

Risperidone Administered During Asymptomatic Period of Adolescence Prevents the Emergence of Brain Structural Pathology and Behavioral Abnormalities in an Animal Model of Schizophrenia

Piontkewitz, Y., Arad, M., & Weiner, I. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq040 · Cited by 143 · see citing works

poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages

Reimer, T., Brcic, M., Schweizer, M., & Jungi, T. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607412 · Cited by 141 · see citing works

Neonatal Behavioral Changes in Rats With Gestational Exposure to Lipopolysaccharide: A Prenatal Infection Model for Developmental Neuropsychiatric Disorders

Baharnoori, M., Bhardwaj, S. K., & Srivastava, L. K. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq098 · Cited by 134 · see citing works

Prenatal Immune Activation Interacts with Genetic<i>Nurr1</i>Deficiency in the Development of Attentional Impairments

Vuillermot, S., Joodmardi, E., Perlmann, T., Ove Ögren, S., Feldon, J., & Meyer, U. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4831-11.2012 · Cited by 127 · see citing works

Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT 2A and mGlu 2 Receptors in the Adult Offspring

Moreno, J. L., Kurita, M., Holloway, T. D., López, J., Cadagan, R., Martínez‐Sobrido, L., García‐Sastre, A., & González‐Maeso, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4230-10.2011 · Cited by 120 · see citing works

Evaluating Early Preventive Antipsychotic and Antidepressant Drug Treatment in an Infection-Based Neurodevelopmental Mouse Model of Schizophrenia

Meyer, U., Spoerri, E., Yee, B. K., Schwarz, M., & Feldon, J. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn131 · Cited by 115 · see citing works

Hormonal aspects of schizophrenias: an overview

Halbreich, U. M., & Kahn, L. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00124-5 · Cited by 111 · see citing works

Tracing the development of psychosis and its prevention: what can be learned from animal models

Piontkewitz, Y., Arad, M., & Weiner, I. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.019 · Cited by 108 · see citing works

SLOW AND LATENT VIRUSES IN SCHIZOPHRENIA

Torrey, E. F., & Peterson, M. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91952-1 · Cited by 105 · see citing works

Comparison of acute phase responses induced in rabbits by lipopolysaccharide and double-stranded RNA

Kimura, M., Toth, L. A., Agostini, H. T., Cady, A. B., Majde, J. A., & Krueger, J. M. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.6.r1596 · Cited by 102 · see citing works

PSYCHOSES ASSOCIATED WITH INFLUENZA

Menninger, K. A. (1919) · JAMA · doi:10.1001/jama.1919.02610040001001 · Cited by 100 · see citing works

Environmental influences that affect attention deficit/hyperactivity disorder: Study of a genetic isolate

Pineda, D. A., Palacio, L. G., Puerta, I. C., Merchán, V., Arango, C. P., Galvis, A. Y., Gómez, M., Aguirre, D. C., Lopera, F., & Arcos-Burgos, M. (2007) · European Child &amp; Adolescent Psychiatry · doi:10.1007/s00787-007-0605-4 · Cited by 98 · see citing works

Schizophrenia and 1957 Pandemic of Influenza: Meta-analysis

Selten, J., Frissen, A., Lensvelt‐Mulders, G., & Morgan, V. A. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp147 · Cited by 97 · see citing works

Dopamine and serotonin levels following prenatal viral infection in mouse—implications for psychiatric disorders such as schizophrenia and autism

Winter, C., Reutiman, T. J., Folsom, T. D., Sohr, R., Wolf, R. J., Juckel, G., & Fatemi, S. H. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.001 · Cited by 92 · see citing works

Brain enlargement and increased behavioral and cytokine reactivity in infant monkeys following acute prenatal endotoxemia

Willette, A. A., Lubach, G. R., Knickmeyer, R. C., Short, S. J., Styner, M. A., Gilmore, J. H., & Coe, C. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.023 · Cited by 91 · see citing works

Animal models of gene–environment interactions in schizophrenia

Ayhan, Y., Sawa, A., Ross, C. A., & Pletnikov, M. V. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.010 · Cited by 87 · see citing works

Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality

Owen, M. J. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.105551 · Cited by 78 · see citing works

No Evidence of Relation Between Maternal Exposure to Herpes Simplex Virus Type 2 and Risk of Schizophrenia?

Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Shen, L., & Susser, E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2178 · Cited by 76 · see citing works

Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia

Aguilar-Valles, A., Flores, C., & Luheshi, G. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010967 · Cited by 72 · see citing works

Early, Time-Dependent Disturbances of Hippocampal Synaptic Transmission and Plasticity After In Utero Immune Challenge

Escobar, M., Crouzin, N., Cavalier, M., Quentin, J., Roussel, J., Lanté, F., Novais, A. R. B., Cohen‐Solal, C., Ferreira, M. D. J., Guiramand, J., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.009 · Cited by 59 · see citing works

Implications of Genetic Findings for Understanding Schizophrenia

Owen, M. J. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs103 · Cited by 58 · see citing works

Prenatal Exposure to Maternal Genital and Reproductive Infections and Adult Schizophrenia

Babulas, V. P. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.5.927 · Cited by 57 · see citing works

Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats

Hopwood, N., Maswanganyi, T., & Harden, L. M. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-003 · Cited by 50 · see citing works

Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation

Aguilar‐Valles, A., Jung, S., Poole, S., Flores, C., & Luheshi, G. N. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.11.003 · Cited by 45 · see citing works

Why Schizophrenia Epidemiology Needs Neurobiology--and Vice Versa

McGrath, J. J., & Richards, L. J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp004 · Cited by 40 · see citing works

Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation

Richtand, N. M., Ahlbrand, R. A., Horn, P. S., Stanford, K. E., Bronson, S. L., & McNamara, R. K. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.02.007 · Cited by 38 · see citing works

Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy

Aguilar‐Valles, A., & Luheshi, G. N. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.006 · Cited by 36 · see citing works

Animal Models of Schizophrenia and Related Disorders

(2011) · Neuromethods · doi:10.1007/978-1-61779-157-4 · Cited by 22 · see citing works

No Evidence of Relation Between Maternal Exposure to Herpes Simplex Virus Type 2 and Risk of Schizophrenia?

Brown, A. S. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.12.2178 · Cited by 22 · see citing works

Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man

Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., Schughart, K., & Hovatta, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002917 · Cited by 20 · see citing works

Maternal immune activation: Implications for neuropsychiatric disorders

Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206 · see citing works

Maternal immune activation and abnormal brain development across CNS disorders

Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

Han, V. X., Patel, S., Jones, H. F., & Dale, R. C. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00530-8 · Cited by 683 · see citing works

Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis

Jiang, H.-Y., Xu, L.-L., Shao, L., Xia, R.-M., Yu, Z.-H., Ling, Z.-X., Yang, F., Deng, M., & Ruan, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.005 · Cited by 391 · see citing works

Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates

Careaga, M., Murai, T., & Bauman, M. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.020 · Cited by 348 · see citing works

DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways

Nardone, S., Sharan Sams, D., Reuveni, E., Getselter, D., Oron, O., Karpuj, M., & Elliott, E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.70 · Cited by 266 · see citing works

Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis

Mondelli, V., Ciufolini, S., Belvederi Murri, M., Bonaccorso, S., Di Forti, M., Giordano, A., Marques, T. R., Zunszain, P. A., Morgan, C., Murray, R. M., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv028 · Cited by 286 · see citing works

The future of rodent models in depression research

Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269 · see citing works

The placental interleukin-6 signaling controls fetal brain development and behavior

Wu, W.-L., Hsiao, E. Y., Yan, Z., Mazmanian, S. K., & Patterson, P. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.007 · Cited by 275 · see citing works

Cross talk: the microbiota and neurodevelopmental disorders

Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works

Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

Goeden, N., Velasquez, J., Arnold, K. A., Chan, Y., Lund, B. T., Anderson, G. M., & Bonnin, A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2534-15.2016 · Cited by 264 · see citing works

Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data

Tylee, D. S., Sun, J., Hess, J. L., Tahir, M. A., Sharma, E., Malik, R., Worrall, B. B., Levine, A. J., Martinson, J. J., Nejentsev, S., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32652 · Cited by 219 · see citing works

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

Mattei, D., Ivanov, A., Ferrai, C., Jordan, P., Guneykaya, D., Buonfiglioli, A., Schaafsma, W., Przanowski, P., Deuther-Conrad, W., Brust, P., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.80 · Cited by 222 · see citing works

Schizophrenia and influenza at the centenary of the 1918–1919 Spanish Influenza Pandemic: mechanisms of psychosis risk

Kępińska, A. P., Iyegbe, C. O., Vernon, A. C., Yolken, R., Murray, R. M., & Pollak, T. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00072 · Cited by 193 · see citing works

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

Lombardo, M. V., Moon, H. M., Su, J., Palmer, T. D., Courchesne, E., & Pramparo, T. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.15 · Cited by 201 · see citing works

Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167 · see citing works

Maternal immune activation in neurodevelopmental disorders

Solek, C. M., Farooqi, N., Verly, M., Lim, T. K., & Ruthazer, E. S. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24612 · Cited by 168 · see citing works

Transgenerational transmission and modification of pathological traits induced by prenatal immune activation

Weber-Stadlbauer, U., Richetto, J., Labouesse, M. A., Bohacek, J., Mansuy, I. M., & Meyer, U. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.41 · Cited by 170 · see citing works

Fever and sickness behavior: Friend or foe?

Harden, L. M., Kent, S., Pittman, Q. J., & Roth, J. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.012 · Cited by 161 · see citing works

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids

Notaras, M., Lodhi, A., Dündar, F., Collier, P., Sayles, N. M., Tilgner, H., Greening, D., & Colak, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01316-6 · Cited by 150 · see citing works

Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders

Richetto, J., Massart, R., Weber-Stadlbauer, U., Szyf, M., Riva, M. A., & Meyer, U. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.010 · Cited by 148 · see citing works

Maternal immune activation induces<i>GAD1</i>and<i>GAD2</i>promoter remodeling in the offspring prefrontal cortex

Labouesse, M. A., Dong, E., Grayson, D. R., Guidotti, A., & Meyer, U. (2015) · Epigenetics · doi:10.1080/15592294.2015.1114202 · Cited by 138 · see citing works

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141 · see citing works

Maternal immune activation in nonhuman primates alters social attention in juvenile offspring

Machado, C. J., Whitaker, A. M., Smith, S. E. P., Patterson, P. H., & Bauman, M. D. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.035 · Cited by 136 · see citing works

Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

O’Loughlin, E., Pakan, J. M. P., Yilmazer-Hanke, D., & McDermott, K. W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0981-8 · Cited by 127 · see citing works

Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging

Giovanoli, S., Notter, T., Richetto, J., Labouesse, M. A., Vuillermot, S., Riva, M. A., & Meyer, U. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0437-y · Cited by 124 · see citing works

Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder

Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works

Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: Implications for autism spectrum disorders

Foley, K. A., MacFabe, D. F., Vaz, A., Ossenkopp, K., & Kavaliers, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.04.001 · Cited by 116 · see citing works

Bridging autism spectrum disorders and schizophrenia through inflammation and biomarkers – pre-clinical and clinical investigations

Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works

Neurobehavioral comorbidities of epilepsy: Role of inflammation

Mazarati, A. M., Lewis, M. L., & Pittman, Q. J. (2017) · Epilepsia · doi:10.1111/epi.13786 · Cited by 96 · see citing works

Perineuronal nets and schizophrenia: The importance of neuronal coatings

Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works

Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: a longitudinal in vivo MRI study

Crum, W. R., Sawiak, S. J., Chege, W., Cooper, J. D., Williams, S. C. R., & Vernon, A. C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.008 · Cited by 76 · see citing works

Intrauterine inflammation induces sex-specific effects on neuroinflammation, white matter, and behavior

Makinson, R., Lloyd, K., Rayasam, A., McKee, S., Brown, A., Barila, G., Grissom, N., George, R., Marini, M., Fabry, Z., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.016 · Cited by 67 · see citing works

Sex Differences in Neurodevelopmental Disorders: A Key Role for the Immune System

Breach, M. R., & Lenz, K. M. (2022) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2022_308 · Cited by 62 · see citing works

Maternal immune activation epigenetically regulates hippocampal serotonin transporter levels

Reisinger, S. N., Kong, E., Khan, D., Schulz, S., Ronovsky, M., Berger, S., Horvath, O., Cabatic, M., Berger, A., & Pollak, D. D. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.02.007 · Cited by 62 · see citing works

Distinct alterations in motor &amp; reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation

Straley, M. E., Van Oeffelen, W., Theze, S., Sullivan, A. M., O’Mahony, S. M., Cryan, J. F., & O’Keeffe, G. W. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.002 · Cited by 52 · see citing works

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

da Silveira, V. T., de Castro Medeiros, D., Ropke, J., Guidine, P. A., Rezende, G. H., Moraes, M. F. D., Mendes, E. M. A. M., Macedo, D., Moreira, F. A., & de Oliveira, A. C. P. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.01.009 · Cited by 51 · see citing works

The association between infections and general cognitive ability in young men – a nationwide study

Benros, M. E., Sørensen, H. J., Nielsen, P. R., Nordentoft, M., Mortensen, P. B., & Petersen, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124005 · Cited by 50 · see citing works

Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Suprunowicz, M., Tomaszek, N., Urbaniak, A., Zackiewicz, K., Modzelewski, S., & Waszkiewicz, N. (2024) · Nutrients · doi:10.3390/nu16040549 · Cited by 44 · see citing works

The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder

Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works

Effect of the Age of Pregnant Females on Brain Development in the Offspring

Ryzhavskii, B. Y., Sapozhnikov, Y. A., Учакина, Р. В., et al. (2004) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000048385.61529.af · Cited by 3 · see citing works

Metabolic syndrome in Korean adolescents and young adult offspring and their parents.

Lee, K. (2017) · PubMed · doi:10.6133/apjcn.082016.02 · Cited by 7 · see citing works

Effects of perinatal exposure to bisphenol A on the behavior of offspring in F344 rats

Negishi, T., Kawasaki, K., Takatori, A., Ishii, Y., Kyuwa, S., Kuroda, Y., & Yoshikawa, Y. (2003) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(03)00044-9 · Cited by 57 · see citing works

The relationship between maternal phenotype and offspring quality: Do older mothers really produce the best offspring?

Marshall, D. J., Heppell, S. S., Munch, S. B., et al. (2010) · Ecology · doi:10.1890/09-0156.1 · Cited by 155 · see citing works

Food transfer in common marmosets: parents change their tolerance depending on the age of offspring

Saito, A., Izumi, A., & Nakamura, K. (2008) · American Journal of Primatology · doi:10.1002/ajp.20593 · Cited by 14 · see citing works