The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety
Open accessAbstract
Women appear to be more vulnerable to the depressogenic effects of inflammation than men. Chronic stress, one of the most pertinent risk factors of depression and anxiety, is known to induce behavioral and affective-like deficits via neuroimmune alterations including activation of the brain’s immune cells, proinflammatory cytokine expression, and subsequent changes in neurotransmission and synaptic plasticity within stress-related neural circuitry. Despite well-established sexual dimorphisms in the stress response, immunity, and prevalence of stress-linked psychiatric illnesses, much of current research investigating the neuroimmune impact of stress remains exclusively focused on male subjects. We summarize and evaluate here the available data regarding sex differences in the neuro-immune consequences of stress, and some of the physiological factors contributing to these differences. Furthermore, we discuss the extent to which sex differences in stress-related neuroinflammation can account for the overall female bias in stress-linked psychiatric disorders including major depressive disorder and anxiety disorders. The currently available evidence from rodent studies does not unequivocally support the peripheral inflammatory changes seen in women following stress. Replication of many recent findings in stress-related neuroinflammation in female subjects is necessary in order to build a framework in which we can assess the extent to which sex differences in stress-related inflammation contribute to the overall female bias in stress-related affective disorders.
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Citations
Cites
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Background
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Sex Differences in Synaptic Plasticity: Hormones and Beyond
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The Use of Digital Technologies, Impulsivity and Psychopathological Symptoms in Adolescence
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Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice
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“However, males and females may respond differently to these environmental and immune challenges [6].”
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Dziabis, J. E., & Bilbo, S. D. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_242 · Cited by 42
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Stress-Related Disease: A Review
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Metadata
- Authors
- Bekhbat, M., & Neigh, G. N.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 67
- Pages
- 1-12
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2588883201
- Cited by
- 343
- References
- 31
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
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