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A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice

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Adriamycin nephropathy induces sensorineural hearing loss via blood–labyrinth barrier breakdown in BALB/c mice

Gajbhiye, A., Jin, S. C., Lyu, A., Kim, S. J., Kim, T. H., Shin, S.-A., Huh, Y. H., Je, A. R., Sohrabji, F., Park, M. J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-32154-z · Cited by 4 · see citing works

Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway

Ge, W., Feng, Y., Zhang, L., Wang, Q., Zhang, C., Wang, Z.-H., Zhou, G., Sun, S.-Y., Miao, X., Liu, T., et al. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01600-x · Cited by 3 · see citing works

Identification of Novel LCN2 Inhibitors Based on Construction of Pharmacophore Models and Screening of Marine Compound Libraries by Fragment Design

Zheng, N., Li, X., Zhou, N., & Luo, L. (2025) · Marine Drugs · doi:10.3390/md23010024 · Cited by 3 · see citing works

Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches

Hu, J., Chen, Z., Wang, J., Xu, A., Sun, J., Xiao, W., & Yang, M. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s504390 · Cited by 3 · see citing works

Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging

Petrican, R., Fornito, A., Murgatroyd, C., Boyland, E. J., & Hardman, C. A. (2025) · Nature Communications · doi:10.1038/s41467-025-60686-5 · Cited by 5 · see citing works

Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study

Motooka, Y., Shinohara, R., Kitaoka, S., Uryu, A., Li, D., Neyama, H., Cui, Y., Kida, T., Arakaki, W., Doi, H., et al. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.01.006 · Cited by 3 · see citing works

Endurance Exercise Training Alleviates Hepatic Lipocalin‐2 Release and Prevents Anxiety‐Like Disorders in Chronically Stressed Mice

Yang, F., Wang, Y., Wang, X., Wang, M., So, K., Yan, L., & Zhang, L. (2025) · Advanced Biology · doi:10.1002/adbi.202500015 · Cited by 2 · see citing works

Exploratory Cohort Study of Depressive Symptoms in South Africans with HIV-1 Subtype C: Associations with Kynurenine Pathway Metabolites and Inflammatory Markers

Williams, M. E., Schutte, L., Asia, L. K., Wissing, M. P., & van Vuren, E. J. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10278-3 · Cited by 2 · see citing works

COF-Zincon dual signal amplification: A sensitive real-time electrochemical sensor for Zn2+ detection towards anxiety disorder diagnosis

Zou, H., Song, Y., Shao, J., Lai, B., Fu, Q., Ai, Z., Liu, Y., Ping, Y., Su, D., Zhang, Y., et al. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.345220 · Cited by 2 · see citing works

Metabolic-dysfunction-associated steatohepatitis impairs cochlear integrity and delays auditory recovery after noise trauma

Jin, S. L., Kim, S. J., Lyu, A., Shin, S.-A., Kim, T. H., Jin, L. G., Heo, J. Y., Park, M. J., & Park, Y.-H. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02760-z · Cited by 2 · see citing works

Brain-organ axis: How does stress regulate peripheral immunity through neural signaling?

Yu, X., Zhu, H., Su, Y., Zhou, L., Chen, Z., Li, P., & Wang, Y. (2026) · Physics of Life Reviews · doi:10.1016/j.plrev.2026.04.001 · Cited by 2 · see citing works

Optogenetic activation of liver-innervating vagal sensory neurons increases anxiety-like behavior in mice

Lee, S., Hwang, J., & Jo, Y. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04074-7 · Cited by 1 · see citing works

Revisiting the effects of physical activity on anxiety and mediation from plasma proteins: triangulation of evidence from observational study, Mendelian randomization, mediation and meta-analysis

Chen, Y., Wen, J., Liu, A., Wen, S. W., & Zhou, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120422 · Cited by 1 · see citing works

Sociocultural factors affecting health-related quality of life in patients with Cirrhosis-Related Hepatocellular Carcinoma (HCC): A psychosocial perspective

Zhou, L., Shen, A., Huang, W., Wu, Y., & Huang, Y. (2025) · Psycho-Oncologie · doi:10.18282/po3723 · Cited by 1 · see citing works

Down-regulation of lipocalin-2 alleviates depressive-like behaviors in mice through modulation of microglial activation

Yu, X., Gao, S., Chen, Y., Ye, L., Wang, B., Xu, L., Sun, A., Liang, C., Lu, S., Li, X., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00862 · Cited by 2 · see citing works

Lcn2 deficiency leads to social impairments independent of maternal immune activationPreprint

Pękała, M., Zawiślak, S., Romanis, S., Nader, K., Cabaj, A., Madecka, A., Puścian, A., Knapska, E., Pawlak, R., Kaczmarek, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.27.661499

Plasma concentrations of the inflammatory adipokine lipocalin-2 are not affected by chronic alcohol exposure in rats or acute alcohol administration in people with alcohol use disorder

Richardson, R. S., Farokhnia, M., Vendruscolo, L. F., & Leggio, L. (2025) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2025.2582563

Bidirectional peripheral-central communication: Unveiling a new paradigm in major depressive disorder pathogenesis and treatment

Liu, M., Gao, C., Cao, Y., Sun, J., & Zhang, Z. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102106

Animal Models of CNS Neurodegenerative Disease/Research Implications of Animal Models of CNS Neurodegenerative Diseases

Godad, A. P., Bhatia, T., Shaikh, M., & Doshi, G. (2026) · Springer eBooks · doi:10.1007/978-981-95-6099-8_15

Hippocampal Neuronal Ferroptosis Driven by Lipocalin-2 Mediates Comorbid Visceral Pain and Anxiety in Irritable Bowel Syndrome

Tang, Y., He, Z., Zhang, Q., Liu, Y., Li, L., Chen, Y., Chen, A., & Lin, C. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05737-8

Lcn2 deficiency leads to long-lasting social impairments independent of maternal immune activation

Pekala, M., Zawiślak, S., Romanis, S., Nader, K., Dzwonek, J., Cabaj, A., Madecka, A., Puścian, A., Knapska, E., Pawlak, R., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03742-1

Secretome-driven machine learning for prioritization of blood-based biomarker panels in major depressive disorder

Salimian, N. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100323

LCN2/SLC22A17 mediates the phagocytosis of GABAergic synapses by oligodendrocyte progenitor cells and contributes to cancer-induced pain and comorbid anxiety-like behaviors in mice

Jiang, L., Hou, Y., Mao, Y., Huang, S., Wang, Y., Ni, K., Yao, Y., Yu, J., Huang, Y.-L., Xu, R., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02296-w

Hepatic Gluconeogenesis and the Antidepressant Effects of Exercise: A Narrative Review

Gong, H., Miao, J., Yuan, J., Zhu, Y., Xiang, H., Yu, Y., Zhou, S., Zhang, Q., & Han, Y. (2026) · Metabolites · doi:10.3390/metabo16050310

Liver-nervous system axis: pathways, dysregulation, and translational perspectives

Hao, D., Hu, Y., Luo, W., Li, S., Yan, Y., & Zhou, J. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03875-3

Green light relieves stress-induced anxiety-like behaviors via visual-to-prefrontal projections in mice.

Zhang, M.-J., Liu, S.-B., Wang, X., Ye, B., Ni, Z., Ma, J., Liu, Y., Liu, A., Zhang, Z., Yu, J.-M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117426

The liver-hippocampus metabolic dialogue: a novel target and mechanism for the antidepressant action of Zhi-Zi-Hou-Po decoction

Ye, X., Li, X., Han, Y., Tang, K., Lin, W., Chen, J., Li, Y., Wang, Z., Chang, W., Kong, W., et al. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.125151

Nitric Oxide-Mediated Minimally Invasive Neuromodulation through Gut-Brain Axis via a Bioelectronic Microdevice for Relieving Depressive Symptoms

Ren, Q., Chang, Z., Zhang, Y., Guo, B., He, X., Yang, D., Wu, H., Li, X. Z., Wang, B., & Fang, Y. (2026) · ACS Nano · doi:10.1021/acsnano.6c03685

Modulating hepatic hypoxanthine metabolism relieve metabolic stress-related neurovascular resilience disturbance via the liver-brain axis

Tu, H., Hou, Y., Cui, W., Wang, X., Chen, M., Shi, M., Kang, T., Jiang, Y., Wu, Q., Li, W., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.07.024

Hepatic sEH drives stress-induced neuroinflammation via IL-6 and liver-brain axis

Yang, S., Song, Y., Zhang, S., Liu, C., Cui, J., Wang, D., Tian, X., & Cong, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1895669

Hepatic Orosomucoid 2 aggravates demyelination and drives microglial DAM-like activation

Bi, H., Xu, Y., Xu, M., Zhang, N., Li, X., Chen, C., 郑明华, Lü, Y., Shi, W., & Wang, Q. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03988-9

Chronic stress promotes hepatic immune remodeling through glucocorticoid-driven neutrophil extracellular trap formation in gastric cancer liver metastasis

Wang, D., Li, W., Guan, L., Wang, Z., Zhu, C., Huang, L., Hu, Z., Yuan, W., Guo, X., Lu, L., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106941

Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs

Qiu, W., Nagai, H., Ota, K., Nagai, M., & Furuyashiki, T. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag046

Liver-eye axis in metabolic syndrome: integrated evidence from mendelian randomization, single-cell sequencing, and clinical sample validation

Yuan, T.-H., Fang, Y.-F., Zhang, H., Zhang, H., Zhou, Z.-Y., Yue, Z., Li, B., Wang, L., Wang, Y.-S., & Dou, G. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1878316

Rescuing anxiety by targeting the neuronal-astrocytic iron signaling axis in male mice

Wang, Z., Yang, S., Tan, S., Huang, T., Yang, Q., Fu, J., Liu, Z., Li, B., Wu, Z., Min, J., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02921-z

Chaihu-Shugan-San Attenuates Depression by Downregulating Liver LCN2 to Suppress LHb GluN2B-Associated Glutamatergic Signaling

You, X., Song, C., Chen, W., Zheng, Y., Wang, R., Liu, W., & Wei, Y. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122557

Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation

Mucha, M. W., Skrzypiec, A. E., Schiavon, E., Attwood, B. K., Kucerova, E., & Pawlak, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107936108 · Cited by 189 · see citing works

Role of Lipocalin-2 in Neuroinflammation and Affective Behavior

Yang, S. (2026) · University of Michigan Library · doi:10.7302/dspace/30697

Lipocalin-2 is involved in emotional behaviors and cognitive function

Ferreira, A. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00122 · Cited by 96 · see citing works

Stress-Induced Lipocalin-2 Controls Dendritic Spine Formation and Neuronal Activity in the Amygdala

Skrzypiec, A. E., Shah, R. S., Schiavon, E., Baker, E., Skene, N., Pawlak, R., & Mucha, M. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061046 · Cited by 47 · see citing works

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

McCall, J. G., Al-Hasani, R., Siuda, E. R., Hong, D. Y., Norris, A. J., Ford, C. P., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.002 · Cited by 666 · see citing works