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Cited by 28Neuroinflammation and Neurodegeneration MechanismsDiet and metabolism studiesTryptophan and brain disorders

Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social defeat

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González Ibáñez, Fernando, Halvorson, Torin, Sharma, Kaushik, McKee, Chloe Grace, Carrier, Micaël, Picard, Katherine, Vernoux, Nathalie, Bisht, Kanchan +3 more·2023·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2023.09.006
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Abstract

Psychological stress confers an increased risk for several diseases including psychiatric conditions. The susceptibility to psychological stress is modulated by various factors, many of them being modifiable lifestyle choices. The ketogenic diet (KD) has emerged as a dietary regime that offers positive outcomes on mood and health status. Psychological stress and elevated inflammation are common features of neuropsychiatric disorders such as certain types of major depressive disorder. KD has been attributed anti-inflammatory properties that could underlie its beneficial consequences on the brain and behavior. Microglia are the main drivers of inflammation in the central nervous system. They are known to respond to both dietary changes and psychological stress, notably by modifying their production of cytokines and relationships among the brain parenchyma. To assess the interactions between KD and the stress response, including effects on microglia, we examined adult male mice on control diet (CD) versus KD that underwent 10 days of repeated social defeat (RSD) or remained non-stressed (controls; CTRLs). Through a social interaction test, stressed mice were classified as susceptible (SUS) or resistant (RES) to RSD. The mouse population fed a KD tended to have a higher proportion of individuals classified as RES following RSD. Microglial morphology and ultrastructure were then analyzed in the ventral hippocampus CA1, a brain region known to present structural alterations as a re…

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Authors
González Ibáñez, F., Halvorson, T., Sharma, K., McKee, C. G., Carrier, M., Picard, K., Vernoux, N., Bisht, K., Deslauriers, J., Lalowski, M., & Tremblay, M.-È.
Affiliations
  • University of British Columbia (CA)
  • Purdue University West Lafayette (US)
  • University of Victoria (CA)
  • Centre de recherche du CHU de Québec-Université Laval (CA)
  • Université Laval (CA)
  • University of Helsinki (FI)
Corresponding author
Tremblay, Marie-Ève
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2023-11
Volume
114
Pages
383-406
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2023.09.006
OpenAlex
W4386521941
Cited by
28
References
25
Citations by year
2026: 8 · 2025: 10 · 2024: 9 · 2023: 1
FWCI
2.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (acceptedVersion)
  • PubMed (publishedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion)
Funders
  • NSERC (RGPIN-2014-05308)
  • FRQS (298905)
  • NIH (1R21MH119561-01A1)
  • Canada Research Chairs
  • Academy of Finland (318857, JTC2017)
  • University of Victoria
  • Consejo Nacional de Ciencia y Tecnología
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
ketogenic diet, microglial morphology, social defeat, stress vulnerability, hippocampus, lipidomics, neuroinflammation, depression
MeSH terms
Lipidomics, Social Defeat, Animals, Major Depressive Disorder, Hippocampus, Inflammation, Male, Mice, Inbred C57BL, Social Behavior, Stress, Psychological, Microglia, Mice, Diet, Ketogenic

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