Cited by 199Gut microbiota and healthSchizophrenia research and treatmentTryptophan and brain disorders

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Altered gut microbiota and mucosal immunity in patients with schizophrenia

Xu, Ruihuan, Wu, Bingbing, Liang, Jingwen, He, Fusheng, Gu, Wen, Li, Kang, Luo, Yi, Chen, Jianxia, Gao, Yongbo, Wu, Ze, Wang, Yongqiang, Zhou, Wenhao, Wang, Mingbang·2020·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2019.06.039

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Abstract

Evidence shows that gut microbiota may play important roles in schizophrenia pathogenesis via the "gut-brain" axis, but the mechanisms remain unclear. Here, eighty-four patients with schizophrenia and 84 sex- and age-matched healthy controls were enrolled. Shotgun metagenomic sequencing and 16S rRNA sequencing were performed, and the gut microbiota-associated epitopes (MEs) were predicted, which, together with IgA content, were used to determine the gut microbiota composition associated with gut immune status. Patients with schizophrenia had significantly reduced gut microbiota richnesses compared with those of the healthy controls, and the gut microbiota compositions clearly distinguished the patients with schizophrenia from the healthy controls. Based on two-stage metagenomic-wide association studies, nineteen gut microbiota taxonomies were associated with schizophrenia, and the microbial dysbiosis (MD) index was calculated based on the abundance of differential taxonomies. We found that MD index was positively correlated with MEs diversity and gut IgA levels, and negatively correlated with gut microbiota richness. Glutamate synthase (GOGAT) was more active in the guts of patients with schizophrenia than in those of healthy controls, and high GOGAT activity was associated with altered gut microbiota taxonomies associated with gut IgA levels. Our results may imply a role of the microbiome in the etiology of schizophrenia and contribute to the development of microbiome targeted interventions for schizophrenia.

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Authors: Xu, R., Wu, B., Liang, J., He, F., Gu, W., Li, K., Luo, Y., Chen, J., Gao, Y., Wu, Z., Wang, Y., Zhou, W., & Wang, M.
Affiliations: Guangzhou University of Chinese Medicine (CN)
Fudan University (CN)
Shenzhen KangNing Hospital (CN)
Longgang Central Hospital (CN)
Shenzhen Luohu People's Hospital (CN)
Corresponding author: Xu, Ruihuan
Zhou, Wenhao
Wang, Mingbang
ORCID: Wu, Bingbing
Liang, Jingwen
Li, Kang
Luo, Yi
Chen, Jianxia
Zhou, Wenhao
Wang, Mingbang
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2020-03
Volume: 85
Pages: 120-127
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2019.06.039
OpenAlex: W2953864347
Cited by: 198
References: 38
Citations by year: 2026: 11 · 2025: 36 · 2024: 28 · 2023: 20 · 2022: 47 · 2021: 29 · 2020: 23
FWCI: 8.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81701351, 31560265)
Shenzhen Science and Technology Innovation Commission (JCYJ20160427101538845)
National Key Research and Development Program of China (2016YFC1102602)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: schizophrenia, gut microbiota, gut-brain axis, mucosal immunity, dysbiosis, glutamate synthase, microbiota-targeted interventions
MeSH terms: Gastrointestinal Microbiome, Humans, RNA, Ribosomal, 16S, Schizophrenia, Immunity, Mucosal, Dysbiosis

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Altered gut microbiota and mucosal immunity in patients with schizophrenia

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