The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Altered gut microbiota and mucosal immunity in patients with schizophrenia
Abstract
Evidence shows that gut microbiota may play important roles in schizophrenia pathogenesis via the "gut-brain" axis, but the mechanisms remain unclear. Here, eighty-four patients with schizophrenia and 84 sex- and age-matched healthy controls were enrolled. Shotgun metagenomic sequencing and 16S rRNA sequencing were performed, and the gut microbiota-associated epitopes (MEs) were predicted, which, together with IgA content, were used to determine the gut microbiota composition associated with gut immune status. Patients with schizophrenia had significantly reduced gut microbiota richnesses compared with those of the healthy controls, and the gut microbiota compositions clearly distinguished the patients with schizophrenia from the healthy controls. Based on two-stage metagenomic-wide association studies, nineteen gut microbiota taxonomies were associated with schizophrenia, and the microbial dysbiosis (MD) index was calculated based on the abundance of differential taxonomies. We found that MD index was positively correlated with MEs diversity and gut IgA levels, and negatively correlated with gut microbiota richness. Glutamate synthase (GOGAT) was more active in the guts of patients with schizophrenia than in those of healthy controls, and high GOGAT activity was associated with altered gut microbiota taxonomies associated with gut IgA levels. Our results may imply a role of the microbiome in the etiology of schizophrenia and contribute to the development of microbiome targeted interventions for schizophrenia.
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“Only few papers report on decreased microbial diversity/richness within patients suffering from schizophrenia [173,184,185].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [185]
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
McGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01456-3 · Cited by 502
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Aburto, M. R., & Cryan, J. F. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00890-0 · Cited by 407
Metadata
- Authors
- Xu, R., Wu, B., Liang, J., He, F., Gu, W., Li, K., Luo, Y., Chen, J., Gao, Y., Wu, Z., Wang, Y., Zhou, W., & Wang, M.
- Affiliations
- Guangzhou University of Chinese Medicine (CN)
- Fudan University (CN)
- Shenzhen KangNing Hospital (CN)
- Longgang Central Hospital (CN)
- Shenzhen Luohu People's Hospital (CN)
- Corresponding author
- Xu, Ruihuan
- Zhou, Wenhao
- Wang, Mingbang
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 85
- Pages
- 120-127
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2953864347
- Cited by
- 198
- References
- 38
- Citations by year
- 2026: 11 · 2025: 36 · 2024: 28 · 2023: 20 · 2022: 47 · 2021: 29 · 2020: 23
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81701351, 31560265)
- Shenzhen Science and Technology Innovation Commission (JCYJ20160427101538845)
- National Key Research and Development Program of China (2016YFC1102602)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, gut microbiota, gut-brain axis, mucosal immunity, dysbiosis, glutamate synthase, microbiota-targeted interventions
- MeSH terms
- Gastrointestinal Microbiome, Humans, RNA, Ribosomal, 16S, Schizophrenia, Immunity, Mucosal, Dysbiosis
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