Correlation between immune response and self-reported depression during convalescence from COVID-19
Open accessAbstract
Self-reported depression has been observed in coronavirus disease-2019 (COVID-19) patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during discharge from the hospital. However, the cause of this self-reported depression during the convalescent period remains unclear. Here, we report the mental health status of 96 convalescent COVID-19 patients who were surveyed using an online questionnaire at the Shenzhen Samii Medical Center from March 2 to March 12, 2020 in Shenzhen, China. After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. The results suggested that patients with self-reported depression exhibited increased immune response, as indicated by increased white blood cell and neutrophil counts, as well as neutrophil-to-lymphocyte ratio. However, the mechanism linking self-reported depression to these cellular changes needs further study. In conclusion, self-reported depression occurred at an early stage in convalescent COVID-19 patients, and changes in immune function were apparent during short-term follow-up of these patients after discharge. Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.
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Convalescent COVID-19 patients with elevated NLR have been reported to have more depression.
“This finding is consistent with the reported higher depression in convalescent COVID-19 patients with higher NLR (Yuan et al., 2020).”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Yuan et al., 2020
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Self-citation
- Authors
- Yuan, B., Li, W., Liu, H., Cai, X., Song, S., Zhao, J., Hu, X., Li, Z., Chen, Y., Zhang, K., Liu, Z., Peng, J., Wang, C., Wang, J., & An, Y.
- Corresponding author
- Wang, Cheng
- Wang, Jianchun
- An, Yawen
- ORCID
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 88
- Pages
- 39-43
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC7247486
- OpenAlex
- W3027799134
- Cited by
- 105
- References
- 26
- Citations by year
- 2025: 6 · 2024: 12 · 2023: 15 · 2022: 32 · 2021: 27 · 2020: 13
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, depression, convalescence, immune response, neutrophil-to-lymphocyte ratio, white blood cell count, neutrophil count, mental health, psychological intervention, post-discharge follow-up
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Basophils, C-Reactive Protein, China, Convalescence, Depression, Depressive Disorder, Eosinophils, Female, Humans, Length of Stay, Leukocyte Count, Male, Middle Aged, Monocytes, Neutrophils, Pneumonia, Viral, Severity of Illness Index, Interleukin-6, Coronavirus Infections, Lymphocyte Count, Young Adult, Self Report, Pandemics
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