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Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances

Haapakoski, Rita, Ebmeier, Klaus P., Alenius, Harri, Kivimäki, Mika·2016·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2015.11.012PMC PMC4736094
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  • Depressive symptoms are positively associated with chronic inflammatory disorders.

    “The correlation between psychiatric disorders and neuroinflammation was reported decades ago: increased levels of inflammatory markers often occurred in patients with depression, while the presence of depressive symptoms was positively associated with patients suffering from chronic inflammatory disorders [4, 5].”

    From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [4]

    The section on inflammatory and neuroendocrine mechanisms (page unavailable) describes a high prevalence of immune-related chronic disorders, such as diabetes, among depressed patients. The Evidence on immune–brain relations section also links depression with inflammatory markers. Neither passage establishes the claimed positive association between depressive symptoms and chronic inflammatory disorders as a group. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • Increased levels of inflammatory markers often occur in patients with depression.

    “The correlation between psychiatric disorders and neuroinflammation was reported decades ago: increased levels of inflammatory markers often occurred in patients with depression, while the presence of depressive symptoms was positively associated with patients suffering from chronic inflammatory disorders [4, 5].”

    From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [4]

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Cited by

Sorted by citations

Authors
Haapakoski, R., Ebmeier, K. P., Alenius, H., & Kivimäki, M.
ORCID
Haapakoski, Rita
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2016-04
Volume
66
Pages
63-72
ISSN
0278-5846
DOI
10.1016/j.pnpbp.2015.11.012
PMC
PMC4736094
Cited by
137
References
37
Language
en
Licence
Funders
  • NordForsk (75021)
  • Medical Research Council (K013351, G1001354)
  • Economic and Social Research Council (ES/J023299)

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