Inflammation and Depression Treatment Response to Electroconvulsive Therapy: Sex-Specific Role of Interleukin-8
Open accessAbstract
Females suffer from depression at twice the rate of males and have differential neural and emotional responses to inflammation. However, sex-specific evaluation of relationships between inflammation and response to depression treatments are lacking. Some data suggest that interleukin(IL)-8 predicts treatment response to antidepressants and has a relationship with depressive symptom severity. This study examines whether IL-8 predicts treatment response to electroconvulsive therapy (ECT), and whether there are sex specific effects. In 40 depressed patients (22 female), plasma levels of IL-8, as well as other markers of inflammation including IL-6, IL-10, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were obtained prior to administration of ECT and after completion of the index treatment series. Depression treatment response was defined as ≥ 50% reduction in Hamilton Depression Rating Scale (HAM-D) Score. Baseline levels of IL-8 differed by responder status, depending on sex (group × sex interaction: β = -0.571, p = 0.04), with female responders having lower levels of IL-8 at baseline as compared to female non-responders [t(20) = 2.37, p = 0.03]. Further, IL-8 levels from baseline to end of treatment differed by responder status, depending on sex (group × sex × time interaction: [F(1,36) = 9.48, p = 0.004]), and change in IL-8 from baseline to end of treatment was negatively correlated with percentage change in HAM-D score in females (β = -0.458, p = 0.03), but not in males (β = 0.315, p = 0.20). Other inflammatory markers did not differ in relation to responder status and sex. Further evaluation of sex differences in the relationship between IL-8, depression, and treatment response, across disparate treatment modalities, may inform mechanisms of response and aid in development of personalized medicine strategies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Female rats with lower IL-8 levels are more susceptible to medication and electroconvulsive therapy.
“Female rats with lower IL-8 levels are more susceptible to medication and electroconvulsive therapy (ECT) [92,93].”
From Selected biomarkers of depression: what are the effects of cytokines and inflammation (2022) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Cross-national epidemiology of DSM-IV major depressive episode
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., de Graaf, R., Demyttenaere, K., Hu, C., Iwata, N., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-90 · Cited by 2,221 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
Depression Is the Leading Cause of Disability Around the World
Friedrich, M. J. (2017) · JAMA · doi:10.1001/jama.2017.3826 · Cited by 1,459 · see citing works
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596 · see citing works
Self-citationGimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561 · see citing works
What does plasma CRP tell us about peripheral and central inflammation in depression?
Felger, J. C., Haroon, E., Patel, T. A., Goldsmith, D. R., Wommack, E. C., Woolwine, B. J., Le, N.-A., Feinberg, R., Tansey, M. G., & Miller, A. H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0096-3 · Cited by 448 · see citing works
Liu, J. J., Wei, Y. B., Strawbridge, R., Bao, Y., Chang, S., Shi, L., Que, J., Gadad, B. S., Trivedi, M. H., Kelsoe, J. R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0474-5 · Cited by 429 · see citing works
Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works
Human Astrocytes: Secretome Profiles of Cytokines and Chemokines
Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411 · see citing works
Joshi, S. H., Espinoza, R. T., Pirnia, T., Shi, J., Wang, Y., Ayers, B., Leaver, A., Woods, R. P., & Narr, K. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.029 · Cited by 320 · see citing works
Self-citationInterferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., Rietschel, M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.020 · Cited by 283 · see citing works
Moieni, M., Irwin, M. R., Jevtic, I., Olmstead, R., Breen, E. C., & Eisenberger, N. I. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.17 · Cited by 273 · see citing works
Self-citationAraujo, D. M., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90400-h · Cited by 237 · see citing works
Hestad, K. A., Tønseth, S., Støen, C. D., Ueland, T., & Aukrust, P. (2003) · The Journal of ECT · doi:10.1097/00124509-200312000-00002 · Cited by 235 · see citing works
Cytokine Regulation of Human Microglial Cell IL-8 Production
Ehrlich, L. C., Hu, S., Sheng, W. S., Sutton, R. L., Rockswold, G. L., Peterson, P. K., & Chao, C. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1944 · Cited by 232 · see citing works
Zou, W., Feng, R., & Yang, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0197267 · Cited by 224 · see citing works
Nordanskog, P., Dahlstrand, U., Larsson, M. R., Larsson, E.-M., Knutsson, L., & Johanson, A. (2010) · The Journal of ECT · doi:10.1097/yct.0b013e3181a95da8 · Cited by 219 · see citing works
Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders
Dukart, J., Regen, F., Kherif, F., Colla, M., Bajbouj, M., Heuser, I., Frackowiak, R. S., & Draganski, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321399111 · Cited by 195 · see citing works
Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy
Oltedal, L., Narr, K. L., Abbott, C., Anand, A., Árgyelán, M., Bartsch, H., Dannlowski, U., Dols, A., van Eijndhoven, P., Emsell, L., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.05.017 · Cited by 184 · see citing works
Self-citationElectroconvulsive therapy, depression, the immune system and inflammation: A systematic review
Yrondi, A., Sporer, M., Péran, P., Schmitt, L., Arbus, C., & Sauvaget, A. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.10.013 · Cited by 183 · see citing works
Bengtsson, A. K., Ryan, E. J., Giordano, D., Magaletti, D. M., & Clark, E. A. (2004) · Blood · doi:10.1182/blood-2003-10-3380 · Cited by 161 · see citing works
Liu, L., Li, J., Su, W., Wang, B., & Jiang, C. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.012 · Cited by 152 · see citing works
Giovannelli, A., Limatola, C., Ragozzino, D., Mileo, A. M., Ruggieri, A., Ciotti, M. T., Mercanti, D., Santoni, A., & Eusebi, F. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00192-1 · Cited by 150 · see citing works
Lyden, H. M., Espinoza, R. T., Pirnia, T., Clark, K., Joshi, S. K., Leaver, A. M., Woods, R. P., & Narr, K. L. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.21 · Cited by 141 · see citing works
Self-citationPuma, C., Danik, M., Quirion, R., Ramon, F., & Williams, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00469.x · Cited by 138 · see citing works
Pirnia, T., Joshi, S. H., Leaver, A. M., Vasavada, M., Njau, S., Woods, R. P., Espinoza, R., & Narr, K. L. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.102 · Cited by 122 · see citing works
Self-citationTreatment response and cognitive impairment in major depression: Association with C-reactive protein
Chang, H. H., Lee, I. H., Gean, P. W., Lee, S.-Y., Chi, M. H., Yang, Y. K., Lu, R.-B., & Chen, P. S. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.239 · Cited by 120 · see citing works
van Buel, E. M., Patas, K., Peters, M., Bosker, F. J., Eisel, U. L. M., & Klein, H. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.100 · Cited by 109 · see citing works
Inflaming sex differences in mood disorders
Rainville, J. R., & Hodes, G. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0124-7 · Cited by 106 · see citing works
Kruse, J. L., Congdon, E. L., Olmstead, R., Njau, S. N., Breen, E. C., Narr, K. L., Espinoza, R. T., & Irwin, M. R. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11597 · Cited by 105 · see citing works
Self-citationIsung, J., Aeinehband, S., Mobarrez, F., Mårtensson, B., Nordström, P., Åsberg, M., Piehl, F., & Jokinen, J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.123 · Cited by 98 · see citing works
Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder
Wade, B., Joshi, S. H., Njau, S. N., Leaver, A. M., Vasavada, M. M., Woods, R. P., Gutman, B. A., Thompson, P. M., Espinoza, R. T., & Narr, K. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.48 · Cited by 95 · see citing works
Self-citationAn inflammatory profile linked to increased suicide risk
Keaton, S. A., Madaj, Z. B., Heilman, P., Smart, L., Grit, J., Gibbons, R., Postolache, T. T., Roaten, K., Achtyes, E. D., & Brundin, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.100 · Cited by 95 · see citing works
Lehtimäki, K. A., Keränen, T., Huuhka, M., Palmio, J., Hurme, M., Leinonen, E. V. J., & Peltola, J. (2008) · Journal of Ect · doi:10.1097/yct.0b013e3181571abb · Cited by 92 · see citing works
Janelidze, S., Suchankova, P., Ekman, A., Erhardt, S., Sellgren, C., Samuelsson, M., Westrin, A., Minthon, L., Hansson, O., Träskman‐Bendz, L., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12339 · Cited by 86 · see citing works
Au, B., Smith, K. J., Gariépy, G., & Schmitz, N. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4250 · Cited by 79 · see citing works
Amitai, M., Taler, M., Carmel, M., Michaelovsky, E., Eilat, T., Yablonski, M., Yosha‐Orpaz, N., Chen, A., Apter, A. S., Weizman, A., et al. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0147 · Cited by 79 · see citing works
Järventausta, K., Sorri, A., Kampman, O., Björkqvist, M., Tuohimaa, K., Hämäläinen, M., Moilanen, E., Leinonen, E. V. J., Peltola, J., & Lehtimäki, K. A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12665 · Cited by 75 · see citing works
Vasavada, M. M., Leaver, A. M., Njau, S., Joshi, S. H., Ercoli, L., Hellemann, G., Narr, K. L., & Espinoza, R. (2017) · The Journal of ECT · doi:10.1097/yct.0000000000000426 · Cited by 73 · see citing works
Self-citationFronto-Temporal Connectivity Predicts ECT Outcome in Major Depression
Leaver, A. M., Wade, B., Vasavada, M. M., Hellemann, G., Joshi, S. H., Espinoza, R. T., & Narr, K. L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00092 · Cited by 68 · see citing works
Self-citationModulation of Intrinsic Brain Activity by Electroconvulsive Therapy in Major Depression
Leaver, A. M., Espinoza, R. T., Pirnia, T., Joshi, S. H., Woods, R. P., & Narr, K. L. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.09.001 · Cited by 66 · see citing works
Self-citationLeaver, A. M., Vasavada, M. M., Joshi, S. H., Wade, B., Woods, R. P., Espinoza, R. T., & Narr, K. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.021 · Cited by 63 · see citing works
Self-citationChanges of Cytokine Profiles During Electroconvulsive Therapy in Patients With Major Depression
Rotter, A., Biermann, T., Stark, C., Decker, A., Demling, J. H., Zimmermann, R., Sperling, W., Kornhuber, J., & Henkel, A. W. (2013) · Journal of Ect · doi:10.1097/yct.0b013e3182843942 · Cited by 51 · see citing works
Moieni, M., Tan, K. M., Inagaki, T. K., Muscatell, K. A., Dutcher, J. M., Jevtic, I., Breen, E. C., Irwin, M. R., & Eisenberger, N. I. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.03.010 · Cited by 51 · see citing works
Self-citationEpstein, M. M., Breen, E. C., Magpantay, L. I., Detels, R., Lepone, L. M., Penugonda, S., Bream, J. H., Jacobson, L. P., Martı́nez-Maza, O., & Birmann, B. M. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0379 · Cited by 49 · see citing works
Desynchronization and Plasticity of Striato-frontal Connectivity in Major Depressive Disorder
Leaver, A. M., Espinoza, R. T., Joshi, S. H., Vasavada, M. M., Njau, S. N., Woods, R. P., & Narr, K. L. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv207 · Cited by 47 · see citing works
Self-citationKranaster, L., Hoyer, C., Aksay, S. S., Bumb, J. M., Müller, N., Zill, P., Schwarz, M., & Sartorius, A. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1355473 · Cited by 46 · see citing works
Jha, M. K., Minhajuddin, A., Chin-Fatt, C., Greer, T. L., Carmody, T. J., & Trivedi, M. H. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.013 · Cited by 40 · see citing works
Carlier, A., Berkhof, J. G., Rozing, M. P., Bouckaert, F., Sienaert, P. A., Eikelenboom, P., Veerhuis, R., Vandenbulcke, M., Berkhof, J. H., Stek, M. L., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.040 · Cited by 39 · see citing works
A self-defence mechanism of astrocytes against Fas-mediated death involving interleukin-8 and CXCR2
Saas, P., Walker, P. R., Quiquerez, A., Chalmers, D., Arrighi, J.-F., Li??nard, A., Boucraut, J., & Dietrich, P. (2002) · Neuroreport · doi:10.1097/00001756-200210280-00018 · Cited by 38 · see citing works
Kubicki, A., Leaver, A. M., Vasavada, M. M., Njau, S. N., Wade, B., Joshi, S. H., Loureiro, J. R., Hellemann, G., Woods, R. P., Espinoza, R. T., et al. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.11.003 · Cited by 32 · see citing works
Self-citationWade, B., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Hellemann, G., Leaver, A. M., Espinoza, R. T., Woods, R. P., Abbott, C., Joshi, S. H., & Narr, K. L. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0020-7 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
1 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Selected biomarkers of depression: what are the effects of cytokines and inflammation
Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works
Jiao, W., Lin, J., Deng, Y., Ji, Y., Liang, C., Wei, S., Xi, J., & Yan, F. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03312-3 · Cited by 126 · see citing works
Silva, R. C., Pisanu, C., Maffioletti, E., Menesello, V., Bortolomasi, M., Gennarelli, M., Baune, B. T., Squassina, A., & Minelli, A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.012 · Cited by 53 · see citing works
Kruse, J. L., Vasavada, M. M., Olmstead, R., Hellemann, G., Wade, B., Breen, E. C., Brooks, J. O., Congdon, E., Espinoza, R., Narr, K. L., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01268-z · Cited by 48 · see citing works
Self-citationGay, F., Roméo, B., Martelli, C., Benyamina, A., & Hamdani, N. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113735 · Cited by 52 · see citing works
Gasparini, A., Callegari, C., Lucca, G., Bellini, A., Caselli, I., & Ielmini, M. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4425 · Cited by 49 · see citing works
Kaurani, L., Besse, M., Methfessel, I., Methi, A., Zhou, J., Pradhan, R., Burkhardt, S., Kranaster, L., Sartorius, A., Habel, U., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02582-4 · Cited by 34 · see citing works
Breit, S., Mazza, E. A., Poletti, S., & Benedetti, F. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.12.009 · Cited by 28 · see citing works
Kruse, J. L., Olmstead, R., Hellemann, G., Breen, E. C., Tye, S. J., Brooks, J. O., Wade, B., Congdon, E. L., Espinoza, R. T., Narr, K. L., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.06.009 · Cited by 28 · see citing works
Self-citationIL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions
Shkundin, A., & Halaris, A. E. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14050488 · Cited by 28 · see citing works
Coelho, D. R. A., Salvi, J. D., Vieira, W. F., & Cassano, P. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25317 · Cited by 25 · see citing works
Advances in biosensors for major depressive disorder diagnostic biomarkers
Dong, T., Yu, C., Mao, Q., Han, F., Yang, Z., Yang, Z., Pires, N. M. M., Wei, X., Jing, W., Lin, Q., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116291 · Cited by 25 · see citing works
Dellink, A., Vanderhaegen, G., Coppens, V., Ryan, K. M., McLoughlin, D. M., Kruse, J. L., van Exel, E. R., van Diermen, L., Belge, J.-B., Aarsland, T. I. M., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106060 · Cited by 23 · see citing works
Self-citationKruse, J. L., Boyle, C. C., Olmstead, R., Breen, E. C., Tye, S. J., Eisenberger, N. I., & Irwin, M. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-16364-3 · Cited by 22 · see citing works
Self-citationInflammation: What’s There and What’s New?
Calhelha, R. C., Haddad, H., Ribeiro, L. M. M., Heleno, S. A., Carocho, M., & Barros, L. (2023) · Applied Sciences · doi:10.3390/app13042312 · Cited by 20 · see citing works
Paolini, M., Harrington, Y. A., Raffaelli, L., Poletti, S., Zanardi, R., Colombo, C., & Benedetti, F. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.010 · Cited by 20 · see citing works
Dogaru, I.-A., Puiu, M. G., Manea, M., & Dionisie, V. (2022) · Brain Sciences · doi:10.3390/brainsci12101403 · Cited by 19 · see citing works
Llorca-Bofí, V., Palacios‐Garrán, R., Routo, D. R., Buil-Reiné, E., Adrados-Pérez, M., Gich, I. J., Bioque, M., & Mur, M. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.08.021 · Cited by 18 · see citing works
Desfossés, C.-Y., Peredo, R., Chabot, A., Carmel, J.-P., Tremblay, P.-M., Mérette, C., Picher, G., Lachance, I., Patry, S., & Lemasson, M. (2021) · Journal of Ect · doi:10.1097/yct.0000000000000782 · Cited by 17 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Dı́az, R., López-González, L., Monserrat, J., Barrena-Blázquez, S., Álvarez-Mon, M. Á., Lahera, G., & Álvarez‐Mon, M. (2024) · Military Medical Research · doi:10.1186/s40779-024-00577-w · Cited by 17 · see citing works
Irwin, M. R., Olmstead, R., Kruse, J., Breen, E. C., & Haque, R. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.07.003 · Cited by 14 · see citing works
Self-citationHuang, Y., Sun, P., Wu, Z., Guo, X., Wu, X., Chen, J., Yang, L., Wu, X., & Fang, Y. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114972 · Cited by 13 · see citing works
Xue, S., Kuai, C., Xiao, Y., Zhao, L., & Lan, Z. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0386 · Cited by 11 · see citing works
Strawbridge, R., Izurieta, E., Day, E., Tee, H., Young, K., Tong, C. C. H. Y., Young, A. H., & Cleare, A. J. (2022) · Neuroscience Applied · doi:10.1016/j.nsa.2022.101014 · Cited by 11 · see citing works
Beydoun, H. A., Beydoun, M. A., Wassertheil-Smoller, S. W., Saquib, N., Manson, J. E., Snetselaar, L. G., Weiss, J., Zonderman, A. B., & Brunner, R. L. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02872-5 · Cited by 9 · see citing works
Mechanisms Underlying Treatment‐Resistant Depression: Exploring Sex‐Based Biological Differences
da Silva, F. E. R., Yücel, A., Menezes, A. P. M., Ruiz, A. C., Tamez, M. C. C., Barichello, T., Scaini, G., & Quevedo, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70215 · Cited by 11 · see citing works
Shan, L.-L., Wang, Y., Qiao, T., Bian, Y., Huo, Y., Guo, C., Liu, Q., Yang, Z., Li, Z., Liu, M., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.938655 · Cited by 8 · see citing works
Brooks, J. O., Kruse, J. L., Kubicki, A., Hellemann, G., Espinoza, R. T., Irwin, M. R., & Narr, K. L. (2023) · Psychological Medicine · doi:10.1017/s0033291722003555 · Cited by 9 · see citing works
Self-citationGao, S., Ding, Y., Tian, H., Li, G., Xu, G., Zhang, J., Xie, S., & Cheng, J. R. (2025) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13916 · Cited by 8 · see citing works
Wang, W., Liang, W., Sun, C., & Liu, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413412 · Cited by 7 · see citing works
Geng, D., Wang, W., Du, N., Niwenahisemo, L. C., Xu, H., Wang, Y., & Kuang, L. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1413608 · Cited by 6 · see citing works
Clinical and biological markers of electroconvulsive therapy effectiveness: a narrative review
Zilles‐Wegner, D., von Mücke-Heim, I.-A., Yrondi, A., & Takamiya, A. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03900-2 · Cited by 7 · see citing works
Melink, Z., Lustberg, M. B., Schnell, P., Mezzanotte-Sharpe, J., & Orchard, T. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07457-w · Cited by 4 · see citing works
Hough, C. M., Kruse, J. L., Espinoza, R. T., Brooks, J. O., Congdon, E. L., Norris, V., Craske, M. G., & Narr, K. L. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100925 · Cited by 5 · see citing works
Self-citationJoão, R. B., de Azevedo, J. P. R. P. T., Pereira, D. A., Ragazzo, P. C., & de Oliveira, P. M. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1577530 · Cited by 2 · see citing works
Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants
O’Hora, K., Amir, C., Chiem, E., Schleifer, C. H., Grigoryan, V., Kushan, L., Chiang, J. J., Cole, S. W., Irwin, M. R., & Bearden, C. E. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107135 · Cited by 2 · see citing works
Self-citationBaminiwatta, A., & Menon, V. (2024) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00286-7 · Cited by 2 · see citing works
Yin, J., Jiang, L., Zhang, H., Zhang, J., Zhang, J., Yao, N., Shi, Y., & Han, Z. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112131 · Cited by 1 · see citing works
Cytokines as Predictors of Response to Electroconvulsive Therapy: an Update
Rajkumar, R. P. (2023) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-023-00265-4
Restrepo, J. E., Ossa-Giraldo, A. C., Higuita‐Gutiérrez, L. F., Zapata, W., & Montoya, G. P. C. (2023) · Psicologia Teoria e Pesquisa · doi:10.1590/0102.3772e39204.en
Fathi, P., Karkanitsa, M. L., Rupert, A. W., Lin, A., Darrah, J. R., Thomas, F. D., Lai, J., Babu, K. M., Neavyn, M., Kozar, R. A., et al. (2024) · medRxiv · doi:10.1101/2024.04.22.24306188
Qiao, M.-X., Yu, H., Fu, Z., Wei, W., Li, X., Deng, W., Guo, W., & Li, T. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s516881
Breit, S. (2026) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20260006
MARCOLIN, K. A. D. S. F., Carlotto, M. D. S., Fagundes, C., Welter, C. W., Franke, B., LIMA, T. A. D., Zanon, I., & Bochi, G. V. (2026) · Journal of Ect · doi:10.1097/yct.0000000000001291
Liu, Z., Su, J., Zhang, Y., Pan, X., Han, Q., & Sun, X. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08344-y
Hough, C. M., Kruse, J. L., Espinoza, R. T., Brooks, J. O., Congdon, E. L., Norris, V., Craske, M. G., & Narr, K. L. (2026) · Journal of Ect · doi:10.1097/yct.0000000000001338
Self-citation
- Authors
- Kruse, J. L., Olmstead, R., Hellemann, G., Wade, B., Jiang, J., Vasavada, M. M., Brooks III, J. O., Congdon, E., Espinoza, R., Narr, K. L., & Irwin, M. R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Kruse, Jennifer L.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 89
- Pages
- 59-66
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC7572496
- OpenAlex
- W3029845229
- Cited by
- 46
- References
- 69
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 8 · 2021: 5
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- electroconvulsive therapy, depression, interleukin-8, sex differences, treatment response prediction, inflammation, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, IL-10, personalized medicine
- MeSH terms
- Depression, Depressive Disorder, Major, Major Depressive Disorder, Electroconvulsive Therapy, Female, Humans, Inflammation, Male, Psychiatric Status Rating Scales, Interleukin-8, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
