Cited by 137Gut microbiota and healthNeurogenesis and neuroplasticity mechanismsGastrointestinal motility and disorders

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Myelin as a regulator of development of the microbiota-gut-brain axis

Open access

Keogh, Ciara E., Kim, Danielle H.J., Pusceddu, Matteo M., Knotts, Trina A., Rabasa, Gonzalo, Sladek, Jessica A., Hsieh, Michael T., Honeycutt, Mackenzie, Brust-Mascher, Ingrid, Barboza, Mariana, Gareau, Mélanie G.·2021·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2020.11.001PMC PMC7749851

Open this paper in CoChat — free account

Abstract

Myelination in the peripheral and central nervous systems is critical in regulating motor, sensory, and cognitive functions. As myelination occurs rapidly during early life, neonatal gut dysbiosis during early colonization can potentially alter proper myelination by dysregulating immune responses and neuronal differentiation. Despite common usage of antibiotics (Abx) in children, the impact of neonatal Abx-induced dysbiosis on the development of microbiota, gut, brain (MGB) axis, including myelination and behavior, is unknown. We hypothesized that neonatal Abx-induced dysbiosis dysregulates host-microbe interactions, impairing myelination in the brain, and altering the MGB axis. Neonatal C57BL/6 mice were orally gavaged daily with an Abx cocktail (neomycin, vancomycin, ampicillin) or water (vehicle) from postnatal day 7 (P7) until weaning (P23) to induce gut dysbiosis. Behavior (cognition; anxiety-like behavior), microbiota sequencing, and qPCR (ileum, colon, hippocampus and pre-frontal cortex [PFC]) were performed in adult mice (6-8 weeks). Neonatal Abx administration led to intestinal dysbiosis in adulthood, impaired intestinal physiology, coupled with perturbations of bacterial metabolites and behavioral alterations (cognitive deficits and anxiolytic behavior). Expression of myelin-related genes (Mag, Mog, Mbp, Mobp, Plp) and transcription factors (Sox10, Myrf) important for oligodendrocytes were significantly increased in the PFC region of Abx-treated mice. Increased myelination was confirmed by immunofluorescence imaging and western blot analysis, demonstrating increased expression of MBP, SOX10 and MYRF in neonatally Abx-treated mice compared to sham controls in adulthood. Finally, administration of the short chain fatty acid butyrate following completion of the Abx treatment restored intestinal physiology, behavior, and myelination impairments, suggesting a critical role for the gut microbiota in mediating these effects. Taken together, we identified a long-lasting impact of neonatal Abx administration on the MGB axis, specifically on myelin regulation in the PFC region, potentially contributing to impaired cognitive function and bacterial metabolites are effective in reversing this altered phenotype.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2020.11.001

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Katoh, K., & Standley, D. M. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst010 · Cited by 46,209
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al-Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0209-9 · Cited by 23,742
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 5×
“The PFC region is also a key brain region implicated in numerous neuropsychiatric disorders, including MDD and ASD, both of which have increasing evidence of gut dysbiosis associated with disease Brain Behav Immun.”
BackgroundInfluential
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781
UniFrac: an effective distance metric for microbial community comparison
Lozupone, C., Lladser, M. E., Knights, D., Stombaugh, J., & Knight, R. (2011) · The ISME Journal · doi:10.1038/ismej.2010.133 · Cited by 2,825

Show all 75 references

Sorted by citations

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis
Ratsika, A., Codagnone, M. G., O’Mahony, S. M., Stanton, C., & Cryan, J. F. (2021) · Nutrients · doi:10.3390/nu13020423 · Cited by 194
Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders
Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 193
The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review
Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 191
Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment
Lynch, C. M. K., Cowan, C. S. M., Bastiaanssen, T. F. S., Moloney, G. M., Theune, N., van de Wouw, M., Florensa-Zanuy, E., Ventura‐Silva, A. P., Codagnone, M. G., Villalobos-Manríquez, F., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.008 · Cited by 137
Enteric nervous system and intestinal epithelial regulation of the gut-brain axis
Dowling, L. R. C., Strazzari, M. R., Keely, S., & Kaiko, G. E. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.07.015 · Cited by 112
The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research
Schächtle, M., & Rosshart, S. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.698172 · Cited by 99
Autism Spectrum Disorders and the Gastrointestinal Tract: Insights into Mechanisms and Clinical Relevance
Hung, L. Y., & Margolis, K. G. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00857-1 · Cited by 96
Roles for the gut microbiota in regulating neuronal feeding circuits
Yu, K. B., & Hsiao, E. Y. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143772 · Cited by 84
Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health
Ramadan, Y. N., Alqifari, S. F., Alshehri, K., Alhowiti, A., Mirghani, H. O., Alrasheed, T., Aljohani, F., Alghamdi, A. M., & Hetta, H. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04846-0 · Cited by 100
Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood
Zhou, B., Jin, G., Pang, X., Mo, Q., Bao, J., Liu, T., Wu, J., Xie, R., Liu, X., Liu, J., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106090 · Cited by 85
Microbiome as an immune regulator in health, disease, and therapeutics
Juarez, V. M., Montalbine, A. N., & Singh, A. K. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114400 · Cited by 77
The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges
Kuijer, E. J., & Steenbergen, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105296 · Cited by 76
Myelin in Alzheimer’s disease: culprit or bystander?
Maitre, M., Jeltsch-David, H., Okechukwu, N. G., Klein, C., Patte-Mensah, C., & Mensah-Nyagan, A.-G. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01554-5 · Cited by 66
Trace Element Selenium Effectively Alleviates Intestinal Diseases
Ye, R., Huang, J., Wang, Z., Chen, Y., & Dong, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111708 · Cited by 71
Exploring the microbiota-gut-brain axis: impact on brain structure and function
Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 64
Gut microbiota: a new insight into neurological diseases
Liu, L., Wang, H., Chen, X., & Xie, P. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002212 · Cited by 52
The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment
Freimer, D., Yang, T. T., Ho, T. C., Tymofiyeva, O., & Leung, C. Y. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100541 · Cited by 60
Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-Derived Neurotrophic Factor
Agnihotri, N., & Mohajeri, M. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415934 · Cited by 47
Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring
Morel, C., Sánchez, I. M., Cherifi, Y., Chartrel, N., & Heijtz, R. D. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109479 · Cited by 42
Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation
Chen, L.-P., Ye, Z.-H., Li, J.-H., Wang, L., Chen, Y., Yu, M., Han, J., Huang, J., Li, D.-Y., Lv, Y., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-05873-6 · Cited by 43
Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders
Shiadeh, S. M. J., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S. R. L., Westberg, L., Elfvin, A., Mallard, C. E., & Ardalan, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03504-2 · Cited by 52
Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes
Ji, X., Tian, L., Niu, S., Yao, S., & Qu, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.963876 · Cited by 38
Antibiotic-induced gut dysbiosis and cognitive, emotional, and behavioral changes in rodents: a systematic review and meta-analysis
Hayer, S. S., Hwang, S., & Clayton, J. B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1237177 · Cited by 38
A role for microglia in mediating the microbiota–gut–brain axis
Keane, L., Clarke, G. A., & Cryan, J. F. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01188-9 · Cited by 43
Oligodendrocyte pathology in Huntington’s disease: from mechanisms to therapeutics
Bardile, C. F., Radulescu, C. I., & Pouladi, M. A. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.07.010 · Cited by 38
IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders
Lee, S.-H., Han, C., & Shin, C. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107749 · Cited by 38
The influence of genetic and acquired factors on the vulnerability to develop depression: a review
Zhang, X., Qiao, Y., Wang, M., Liang, X., Zhang, M., Li, C., Cairang, J., Wang, J., Bi, H., & Gao, T. (2023) · Bioscience Reports · doi:10.1042/bsr20222644 · Cited by 36
Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
Hudson, K. M., Shiver, E., Yu, J., Mehta, S., Jima, D. D., Kane, M. A., Patisaul, H. B., & Cowley, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-95630-2 · Cited by 28
Early life gut microbiota: Consequences for health and opportunities for prevention
Wang, S., Cui, J., Jiang, S., Zheng, C., Zhao, J., Zhang, H., & Zhai, Q. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2158451 · Cited by 29
Kai-xin-san improves cognitive impairment in D-gal and Aβ25-35 induced ad rats by regulating gut microbiota and reducing neuronal damage
Wang, H., Zhou, L., Zheng, Q., Song, Y., Huang, W., Yang, L., Xiong, Y., Cai, Z., Chen, Y., & Yuan, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118161 · Cited by 30
Trigeminal nerve stimulation restores hippocampal dopamine deficiency to promote cognitive recovery in traumatic brain injury
Xu, J., Wu, S., Huo, L., Zhang, Q., Liu, L., Ye, Z., Cao, J., Ma, H., Shang, C., & Ma, C. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102477 · Cited by 27
Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice
Dong, H., Dai, X., Zhou, Y., Shi, C., Bhuiyan, P., Sun, Z., Li, N., & Jin, W. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03028-4 · Cited by 27
Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk
Zucoloto, A. Z., Schlechte, J., Ignácio, A., Thomson, C. A., Pyke, S., Yu, I.-L., Geuking, M. B., McCoy, K. D., Yipp, B. G., Gillrie, M. R., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112507 · Cited by 24
Role of the gut-microbiota-metabolite-brain axis in the pathogenesis of preterm brain injury
Li, L., Yang, J., Liu, T., & Shi, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115243 · Cited by 28
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation
Merchak, A. R., Cahill, H. J., Brown, L. C., Brown, R. M., Rivet-Noor, C. R., Beiter, R. M., Slogar, E. R., Olgun, D. G., & Gaultier, A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002000 · Cited by 25
Dietary Nucleotides Promote Neonatal Rat Microbiota–Gut–Brain Axis Development by Affecting Gut Microbiota Composition and Metabolic Function
Qu, Z., Tian, P., Wang, L., Jin, X., Guo, M., Lu, J., Zhao, J., Chen, W., & Wang, G. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07349 · Cited by 24
Gut microbiota depletion delays somatic peripheral nerve development and impairs neuromuscular junction maturation
Cescon, M., Gambarotta, G., Calabrò, S., Cicconetti, C., Anselmi, F., Kankowski, S., Lang, L., Basic, M., Bleich, A., Bolsega, S., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363015 · Cited by 25
Wrapping Things Up: Recent Developments in Understanding the Role of the Microbiome in Regulating Myelination
Lynch, C. M. K., Nagpal, J. K., Clarke, G. A., & Cryan, J. F. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100468 · Cited by 25
Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex
Takahashi, K., Hong, L., Kurokawa, K., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110666 · Cited by 23
Skin-brain axis signaling mediates behavioral changes after skin wounding
Fregoso, D. R., Hadian, Y., Gallegos, A., Degovics, D., Maaga, J., Keogh, C. E., Kletenik, I., Gareau, M. G., & Isseroff, R. R. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100279 · Cited by 22
Self-citation
Role of the microbiota-gut-brain axis in postacute COVID syndrome
Gareau, M. G., & Barrett, K. E. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2022 · Cited by 24
Self-citation
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 25
Probiotic strategies for mitigating heat stress effects on broiler chicken performance
AYDIN, S. S., & Hatipoğlu, D. (2024) · International Journal of Biometeorology · doi:10.1007/s00484-024-02779-2 · Cited by 18
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice
Wilburn, A. N., McAlees, J. W., Haslam, D. B., Graspeuntner, S., Schmudde, I., Laumonnier, Y., Rupp, J., Chougnet, C. A., Deshmukh, H. S., Zacharias, W. J., et al. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0367oc · Cited by 17
Prenatal PM2.5 Exposure Associated with Neonatal Gut Bacterial Colonization and Early Children’s Cognitive Development
Liu, Y., Zhang, L., Wang, J., Sui, X., Li, J., Gui, Y., Wang, H., Zhao, Y., Xu, Y., Cao, W., et al. (2024) · Environment & Health · doi:10.1021/envhealth.4c00050 · Cited by 17
The emerging role of the gut microbiome in depression: implications for precision medicine
Liu, L., Wang, H., Guo, S., Liu, S., Du, Y., Wang, L. Y., He, D., Mo, X., Zhang, H., Cheng, Q., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03191-x · Cited by 17
Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
Esposito, P., & Ismail, N. (2022) · Microorganisms · doi:10.3390/microorganisms10112163 · Cited by 14
Nutritional strategies modulating the gut microbiome as a preventative and therapeutic approach in normal and pathological age-related cognitive decline: a systematic review of preclinical and clinical findings
Sproten, R., Nöhr, D., & Guseva, D. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2296727 · Cited by 15
Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation
Tao, Y., Yuan, J., Zhou, H., Li, Z., Yao, X., Wu, H., Shi, H., Huang, F., & Wu, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117846 · Cited by 14
The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders
Tang, W., Wang, Q., Sun, M., Liu, C., Huang, Y., Zhou, M., Zhang, X., Meng, Z., & Zhang, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122952 · Cited by 14
How the gut microbiome shapes learning and memory: A comprehensive review
Alavian, F., & Safaeian, M. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.08.005 · Cited by 15
Gut microbiome diversity mediates the association between right dorsolateral prefrontal cortex and anxiety level
Huang, X., Li, L., Ling, Z., Gao, L., Chen, H., & Duan, X. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00513-9 · Cited by 12
Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury
Mei, R., Qiu, W., Yang, Y., Xu, S., Rao, Y., Li, Q., Luo, Y., Huang, H., Yang, A., Tao, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210318 · Cited by 12
Early depletion of gut microbiota shape oligodendrocyte response after traumatic brain injury
Shumilov, K., Ni, A., García‐Bonilla, M., Celorrio, M., & Friess, S. H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03158-9 · Cited by 12
Changes in short-chain fatty acids affect brain development in mice with early life antibiotic-induced dysbacteriosis
Zhang, Q., Li, H., Yin, S., Feng, X., Chen, G., Zhou, J., Liu, K., & Cheng, Y. (2024) · Translational Pediatrics · doi:10.21037/tp-24-128 · Cited by 13
Treatment of preterm brain injury via gut‐microbiota–metabolite–brain axis
Li, L., Liu, T., & Shi, Y. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14556 · Cited by 10
Role of the Gut-Lung Microbiome Axis in Airway Inflammation in OVA-Challenged Mice and the Effect of Azithromycin
Zheng, J., Huang, Y., Zhang, L., Liu, T., Ya, Z., Li, H., & Guo, S. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s506688 · Cited by 10
Neuroglia and the microbiota-gut-brain axis
Blair, H., Morales, L., Cryan, J. F., & Aburto, M. R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00001-2 · Cited by 12
Germ-Free Animals
Lynch, C. M. K., Nagpal, J. K., Luczynski, P., Neufeld, K. M., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00012-6 · Cited by 9
Neuroimmunophysiology of the gastrointestinal tract
McKay, D. M., Defaye, M., Rajeev, S., MacNaughton, W. K., Nasser, Y., & Sharkey, K. A. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00075.2024 · Cited by 9
Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model
Hsieh, C. C., Lo, Y., Wang, H., Shen, H.-Y., Chen, Y., & Lee, Y. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02752-y · Cited by 8
The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals
Tu, G., Jiang, N., Chen, W., Liu, L., Hu, M., & Liao, B. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0058 · Cited by 12
Bidirectional causal associations between plasma metabolites and bipolar disorder
Zhao, Q., Baranova, A. V., Liu, D., Cao, H., & Zhang, F. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02977-3 · Cited by 8
Washed Microbiota Transplantation Accelerates the Recovery of Abnormal Changes by Light-Induced Stress in Tree Shrews
Wang, J., Li, Q., Huang, Q., Lv, M., Li, P., Dai, J., Zhou, M., Xu, J., Zhang, F., & Gao, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.685019 · Cited by 8
Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway
Ju, C., Yuan, F., Wang, L., Zang, C., Ning, J., Shang, M., Ma, J., Li, G. L., Yang, Y., Chen, Q., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.105988 · Cited by 7
Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice
Zhao, M., Eguchi, A., Murayama, R., Xu, D., Zhu, T., Xu, B., Liu, G., Mori, C., Yang, J., & Hashimoto, K. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177345 · Cited by 7
Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and MyelinationPreprint
Dubey, H., Roychoudhury, R., Alex, A., Best, C., Liu, S., White, A., Carlson, A. L., Azcárate-Peril, M. A., Mansfield, L. S., & Knickmeyer, R. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563309 · Cited by 6
Fecal microbiota transplantation alleviates chronic cerebral hypoperfusion-induced axonal hypomyelination by regulating gut microbiota-derived metabolism and oligodendrogenesis
Su, S., Chen, M., Lu, D., Wu, Y.-F., Huang, X.-S., & Zhang, L. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110122 · Cited by 5
Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut
Milhouse, W., Organski, A. C., Sun, X., Ai, D., Zhou, B., Cross, T.-W., & Ren, H. (2025) · Physiological Reports · doi:10.14814/phy2.70373 · Cited by 5
Gut Microbes: The Gut Brain Connection
Lynch, C. M. K., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_4 · Cited by 5
Gut microbiota and myelination: Crosstalk across the lifespan and microbiota-based modulation strategies
Li, Q., Wang, G., Zhao, J., Chen, W., & Tian, P. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128286 · Cited by 6
Gut microbiome and glial cell dialog: Role of TCM in the treatment of depression
Zhang, X., Chen, X., Ruan, S., Wang, H., Xu, Y., Fu, H., Lin, S., Efferth, T., Tian, Y., Li, C., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157196 · Cited by 4
The Microbiota Shapes Central Nervous System Myelination in Early Life
Lynch, C. M. K., Knox, E. G., Soong, D. Y. H., Bastiaanssen, T. F. S., Trontti, K., Tofani, G. S. S., Ivaschuk, S., Collins, M., Arafa, D., Nagpal, J. K., et al. (2026) · Advanced Science · doi:10.1002/advs.202515671 · Cited by 4
Gut microbiota and cognitive development in infant mice: Quantity and source of potable water
Kim, C.-S., & Shin, D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286951 · Cited by 4
Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System
Tabatabaee, M. S. (2024) · Neuroglia · doi:10.3390/neuroglia5020007 · Cited by 4
Microbiota-gut-brain Axis: Novel Potential Pathways for Developing Antiepileptogenic Drugs
Li, H., Lai, H., Xing, Y., Zou, S., & Yang, X. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250414094040 · Cited by 4
Navigating the Lipid Landscape: The Role of Fatty Acid Synthase in Neural Stem Cell Fate and Central Nervous System Function
Gupta, R., Abdulazeez, A. M., Kedhim, M., Alkhathami, A. G., Malathi, H., Kundlas, M., Maharana, L., Chauhan, A. S., Alnajar, M. J., & Hammoodi, H. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05430-2 · Cited by 5
Association between Intestinal Microbiota in Infants and their Neurodevelopment: Systematic Literature Review on Scoping Review Methodology
Малыгина, О. Г., Александровна, У. А., & Makarova, A. A. (2024) · Вопросы современной педиатрии · doi:10.15690/vsp.v23i1.2706 · Cited by 3
Biodegradable polyurethane-decellular extracellular matrix based bioscaffolds promote nerve repair after spinal cord injury
Luo, M., Lin, J., Li, J., He, M., Hu, H., Wang, X., Li, J., Wu, C., Ma, L., Wang, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168336 · Cited by 3
Fluoxetine attenuates the anxiolytic effects of the probiotic VSL#3 in a stress-vulnerable genetic line of aves in the chick social-separation stress test, a dual screening assay
White, S. W., Callahan, H., Smith, S. J., & Padilla, F. M. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173880 · Cited by 3
Korean Red Ginseng and Rb1 restore altered social interaction, gene expressions in the medial prefrontal cortex, and gut metabolites under post-weaning social isolation in mice
Kwon, O. W., Park, Y. H., Kim, D., Kwon, H. Y., & Yang, H. (2024) · Journal of Ginseng Research · doi:10.1016/j.jgr.2024.03.005 · Cited by 2
Self-citation
The role of intestinal homeostasis in sevoflurane-induced myelin development and cognitive impairment in neonatal mice
Liu, C., Li, J., Liu, R., & Zhao, G. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1541757 · Cited by 2
PRTS: Predicting Single-Cell Spatial Transcriptomic Maps from Histological Images
Wen, J., Zou, L., Liu, J., Guo, X., Liu, C., Wang, B., Deng, T., Liu, C., Tang, R., Yang, Y., et al. (2025) · Research · doi:10.34133/research.0961 · Cited by 2
The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition
Jama, Y. M., Khan, W. I., & Collins, S. M. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2643373 · Cited by 2
Maternal and infant gut microbiome
Wang, H., Tin, F., Chen, H., Jiao, F., Wu, M., Sun, S., Lin, L., Li, D., Zheng, H., Niu, Z., et al. (2026) · iMeta · doi:10.1002/imt2.70151 · Cited by 2
Oral exposure to perfluorooctanoic acid disrupts the microbiota-gut-liver axis and enhances the severity of chemically induced colitis in mice
Park, J., Miller, A. S., Pore, G., Banginwar, M., Lee, S., Li, J., Jung, E., Wagner, A., Smith, J., Malone, C., et al. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128915 · Cited by 2
Self-citation
Neonatal enteric infection disrupts the microbiota–gut–brain axis through pattern recognition receptors and altered neuroimmune signaling
Park, J., Orahood, O., Banginwar, M., Andrade, A., Pore, G., Sanchez, K., Cremin, M., Miller, A. S., Reynoso-Garcia, J., Lee, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2606222123 · Cited by 2
Self-citation
Role of the intestinal microbiota in the pathogenesis of multiple sclerosis. Part 2. Gut microbiota as a predisposition factor for the multiple sclerosis development
Abdurasulova, I. N. (2023) · Medical academic journal · doi:10.17816/maj115019 · Cited by 2
Gut microbiota regulates optic nerve fiber myelination
Ronchi, G., Pellegrino, D., Soury, M. E., Amato, O., Gaia, F., Farzin, S., Nuzzi, R., Basic, M., Bolsega, S., Geuna, S., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1526855 · Cited by 3
Melatonin alleviates intestinal damage in neonate mice following Salmonella Typhimurium and LPS challenges involving gut microbiota remodeling.
Zheng, Z., Wang, X., Su, Z., Li, S., Qin, J., Ren, N., He, L., & Zhang, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115761 · Cited by 2
Two-hit perinatal injuries cause gut microbial dysbiosis in offspring
Lee, G. A., Chang, Y.-W., Yang, Y. S. H., Tseng, S., Wang, C., Lee, C., Chang, J., Wu, S., Chien, M., Chang, K., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.10.033 · Cited by 1
Early-life gut microbiota depletion leads to persistent CNS myelin impairment in adult Swiss albino mice
Dimaoui, A., Mekhlouf, Y. E., Lamtai, M., Ibouzine‐Dine, L., Marzouki, Z. E., Touil, T., Hessni, A. E., & Mesfioui, A. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01893-x · Cited by 1
Psychobiotics and the Microbiota–Gut–Brain Axis: Bridging Functional Foods with Therapeutic Potential in Neurodegenerative and Psychiatric Disorders
Megur, A., & Kumar, B. (2026) · Food Reviews International · doi:10.1080/87559129.2026.2649298 · Cited by 1
The Microbiota–Gut–Brain Axis Across the Lifespan: From Neurodevelopment to Neurodegeneration
Carnazzo, S. M., & Fanos, V. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15083065 · Cited by 1
Importance of human microbiome: an update
Wardi, M., Amin, A. B., Belghiti, I. E., Lemkhente, Z., & Belmouden, A. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2026.1787662 · Cited by 1
Research Progress on the Correlation between Butyric Acid Producing Bacteria in Intestine and Neurodegenerative Diseases
田, 格. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142347 · Cited by 1
Associations Between the Microbiome and Neurocognitive and Neuropsychiatric Function
Lundwall, R. A. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780192870414.003.0024 · Cited by 1
MYRF gene mutation leading to coronary artery anomaly combined with 46,XY sex development disorder, a case report and literature review
Ding, J., Lv, Z., Zhen, Z., Gai, Y., & Xiao, Y. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05853-9 · Cited by 1
Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregenerationPreprint
Zhao, Q. X., Fan, P., Gu, Q., Mo, X., Tan, X., Zhou, X., Yang, F., Zhou, X., & Li, Q. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.17.618899 · Cited by 1

Authors: Keogh, C. E., Kim, D. H. J., Pusceddu, M. M., Knotts, T. A., Rabasa, G., Sladek, J. A., Hsieh, M. T., Honeycutt, M., Brust-Mascher, I., Barboza, M., & Gareau, M. G.
Affiliations: University of California, Davis (US)
Corresponding author: Gareau, Mélanie G.
ORCID: Keogh, Ciara E.
Kim, Danielle H.J.
Pusceddu, Matteo M.
Knotts, Trina A.
Sladek, Jessica A.
Hsieh, Michael T.
Barboza, Mariana
Gareau, Mélanie G.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2021-01
Volume: 91
Pages: 437-450
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2020.11.001
PMC: PMC7749851
OpenAlex: W3097533391
Cited by: 137
References: 75
Citations by year: 2026: 24 · 2025: 31 · 2024: 35 · 2023: 23 · 2022: 13 · 2021: 11
FWCI: 3.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (1 R01AT009365\u201001, U24-DK092993, SCR_015361)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: myelination, microbiota-gut-brain axis, neonatal antibiotic exposure, gut dysbiosis, oligodendrocyte development, SOX10, MYRF, myelin basic protein, prefrontal cortex, cognitive impairment, anxiety-like behavior, butyrate, short-chain fatty acids, bacterial metabolites, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Brain, Mice, Inbred C57BL, Myelin Sheath, Mice, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Myelin as a regulator of development of the microbiota-gut-brain axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks