The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation
Abstract
Growing evidence suggests the involvement of the microbiota-gut-brain axis in cognitive impairment induced by sleep deprivation (SD), however how the microbiota-gut-brain axis work remains elusive. Here, we discovered that chronic SD induced intestinal dysbiosis, activated NLRP3 inflammasome in the colon and brain, destructed intestinal/blood-brain barrier, and impaired cognitive function in mice. Transplantation of "SD microbiota" could almost mimic the pathological and behavioral changes caused by chronic SD. Furthermore, all the behavioral and pathological abnormalities were practically reversed in chronic sleep-deprived NLRP3-/- mice. Regional knockdown NLRP3 expression in the gut and hippocampus, respectively. We observed that down-regulation of NLRP3 in the hippocampus inhibited neuroinflammation, and ameliorated synaptic dysfunction and cognitive impairment induced by chronic SD. More intriguingly, the down-regulation of NLRP3 in the gut protected the intestinal barrier, attenuated the levels of peripheral inflammatory factors, down-regulated the expression of NLRP3 in the brain, and improved cognitive function in chronic SD mice. Our results identified gut microbiota as a driver in chronic SD and highlighted the NLRP3 inflammasome as a key regulator within the microbiota-gut-brain axis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Chronic SD triggers gut microbiota alteration, leading to reduced mucus thickness and reduced levels of TJ proteins in mice colons, via NLRP3 inflammasome activation.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [646]
In the citing paper
“sleep deprivation (SD) induces gut dysbiosis and intestinal barrier disruption, leading to microglial activation and cognitive decline”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [646]
In the citing paper
“FMT from chronically sleep-deprived mice to control mice largely recapitulated the pathological changes observed in chronic SD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [646]
In the citing paper
“This is accompanied by impaired BBB integrity, NLRP3 activation in the brain, microglial activation, and cognitive impairment.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [646]
Citations
Cites
1 retracted
Wadhwa, M., Prabhakar, A., Anand, J. P., Ray, K., Prasad, D. N., Kumar, B., & Panjwani, U. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.004 · Cited by 82
RetractedNeuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Mechanisms and Functions of Inflammasomes
Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,579
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.014 · Cited by 2,085
Short- and long-term health consequences of sleep disruption
Medic, G., Wille, M., & Hemels, M. (2017) · Nature and Science of Sleep · doi:10.2147/nss.s134864 · Cited by 1,776
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Wood, 2018, Dementia: Peripheral inflammation could be a prodromal indicator of dementia, Nat. Rev. Neurol., 14, 127
Cited by
Sorted by citations
Items 101–106 of 106
Jiao, Y., Zhao, Y., Zhang, Z., Sun, H., Wang, Y., Bai, X., Piao, C., Lei, X., Zhang, N., & Xu, H. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1944977
Self-citationZhu, L., Wang, F., Dai, Y., Yang, X., & Wang, X. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1812091
Fan, X., Pan, K., Mao, J., Wang, X., & Hu, L. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116034
Zeng, M., Peng, M., He, C., Zhao, Y., Cheng, Z., Yu, M., Tian, H., Zhang, L., Yuan, W., Zeng, Q., et al. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70173
Ma, Y., Zhang, T., Yu, T., Chen, Q., Su, S., Lin, Y., Shi, J., Zou, Y., Li, S., Liu, S., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122434
Self-citationYang, J., Gao, Y., Han, L., Guo, Y., Zhang, Q., Miao, H., & 李天佐 (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106277
Metadata
- Authors
- Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 108
- Pages
- 98-117
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W4309880386
- Cited by
- 105
- References
- 59
- Citations by year
- 2026: 37 · 2025: 34 · 2024: 28 · 2023: 6
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- gut dysbiosis, microbiota-gut-brain axis, NLRP3 inflammasome, chronic sleep deprivation, cognitive impairment, blood-brain barrier, intestinal barrier, neuroinflammation, synaptic dysfunction, hippocampus, gut microbiota transplantation, peripheral inflammation
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Hippocampus, Intestines, Sleep Deprivation, Mice, Inflammasomes, Cognitive Dysfunction, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
