A tryptophan-rich protein diet efficiently restores sleep after food deprivation in the rat
Abstract
Sleep depends on the quantity and quality of the diet. Several studies have shown that food deprivation results in a reduction in sleep duration. It has also been demonstrated that in the newborn, the supply of certain essential amino acids improves sleep through their action on the synthesis of specific neurotransmitters. The aim of the present study was to test if the quantity and/or quality of dietary protein could improve the recovery of sleep during re-feeding after caloric deprivation. Sleep parameters were compared in rats fed ad libitum, food restricted during 4 days, or reefed isocalorically after food restriction with three dietary regimens varying in terms of the amount (14% versus 30%) or quality (milk protein or alpha-lactalbumin) of protein. The results showed that sleep recovery, in particular slow-wave sleep, was improved in rats re-fed with alpha-lactalbumin. This result confirms the close relationship between feeding and sleep and suggest that alpha-lactabumin could be used to improve sleep in adult submitted to nutritional disturbances such as food restriction, shift work, Ramadan.
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α-lactalbumin contains tryptophan which improves the quality of sleep.
“improves the quality of sleep [172, 173]”
From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [173]
Cites
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“In addition, α-lactalbumin contains an ample supply of tryptophan which increases cognitive performance under stress [172], improves the quality of sleep [172, 173], and may also speed wound healing [172], properties which could be vital for recovery from combat and contact sporting events.”
BackgroundInternational Society of Sports Nutrition position stand: protein and exercise
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Chronobiology, endocrinology, and energy‐ and food‐reward homeostasis
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- Authors
- Minet-Ringuet, J., Le Ruyet, P. M., Tomé, D., & Even, P. C.
- Affiliations
- Physiologie de la Nutrition et du Comportement Alimentaire (FR)
- Corresponding author
- Even, P.C
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 152
- Issue
- 2
- Pages
- 335-340
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1967667779
- Cited by
- 70
- References
- 2
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep recovery, food deprivation, refeeding, slow-wave sleep, alpha-lactalbumin, milk protein, dietary protein quality, essential amino acids, sleep regulation, nutritional disorders
- MeSH terms
- Animals, Body Weight, Dietary Proteins, Electroencephalography, Food Deprivation, Male, Milk Proteins, Reaction Time, Sleep Stages, Time Factors, Tryptophan, Wakefulness, Rats, Wistar, Rats
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