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Cited by 135Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchCognitive Functions and Memory

Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain

Giza, Christopher C., Griesbach, Grace S., Hovda, David A.·2005·Behavioural Brain Research
DOI 10.1016/j.bbr.2004.06.003
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Abstract

Traumatic brain injury (TBI) is most prevalent in children and young adults. The long-term effects of pediatric TBI include cognitive and behavioral impairments; however, over time, it is difficult to distinguish individual variability in intellect and behavior from sequelae of early injury. Postnatal day (PND) 19 rats underwent lateral fluid percussion (FP) injury, followed by rearing in either standard (STD) or enriched environment (EE) conditions. The hypothesis was that the traditional enhancement of cognitive functioning following EE rearing would be attenuated when this rearing is preceded by TBI at PND19. Thirty days after injury, Morris water maze (MWM) acquisition and subsequent probe trial retention were used to assess the behavioral effects of injury on experience-dependent plasticity induced by housing in EE at two different time windows. MWM acquisition demonstrated improvements following early EE rearing in both sham and injured animals; however, the degree of improvement was greater for uninjured animals. When EE rearing was delayed for 2 weeks after injury, the injury effect was absent and the effect of rearing even stronger. Memory testing in the early EE groups using a delayed probe trial showed an effect of injury and housing, with the sham EE animals benefiting the most. After the delayed EE, sham EE animals again showed more probe target hits, while FPEE animals did not, demonstrating an enduring memory deficit. These data confirm that early TBI has effects on experience-dependent plasticity resulting in long-term neurobehavioral deficits. In addition, the ability to benefit from environmental stimulation following TBI is dependent upon time after injury.

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  • The developing brain may be more susceptible to poor outcomes following TBI; studies suggest children and adolescents experience prolonged recovery rates after TBI compared to adults and poorer outcome.

    “In addition, the developing brain may be more susceptible to poor outcomes following TBI. Studies have suggested that children and adolescents experience prolonged recovery rates after TBI compared to adults [61] and poorer outcome [70].”

    From The neuropathology of sport (2014) · cites this paper as [70]

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Authors
Giza, C. C., Griesbach, G. S., & Hovda, D. A.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Giza, Christopher C.
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2005-02
Volume
157
Issue
1
Pages
11-22
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2004.06.003
OpenAlex
W2163694945
Cited by
135
References
67
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 18 · 2014: 14 · 2013: 4 · 2012: 9
FWCI
3.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (P50NS030308, NS-27544, R01NS027544, K08NS002197, R21NS048535, NS02197, NS 30308)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
traumatic brain injury, pediatric brain injury, experience-dependent plasticity, fluid percussion injury, spatial memory, memory impairment, behavioral plasticity, postnatal development, neurobehavioral deficits
MeSH terms
Adaptation, Psychological, Age Factors, Animals, Association Learning, Behavior, Animal, Brain Injuries, Disease Models, Animal, Environment, Housing, Animal, Male, Rats, Sprague-Dawley, Maze Learning, Rats

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