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Cited by 148Alzheimer's disease research and treatmentsMemory and Neural MechanismsDementia and Cognitive Impairment Research

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.

Grootendorst, Jeannette, Bour, Alexandra, Vogel, Elise, Kelche, Christian, Sullivan, Patrick M., Dodart, Jean-Cosme, Bales, Kelly, Mathis, Chantal·2005·Behavioural Brain Research
DOI 10.1016/j.bbr.2004.09.019
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Abstract

Apolipoprotein E4 (apoE4), one of the three most common human apoE (h-apoE) isoforms, is a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. The biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent effect of h-apoE on cognitive performance was studied in gene-targeted mice, which show physiological expression levels and distribution of h-apoE3 or h-apoE4. Male and female h-apoE3 and h-apoE4, apoE-deficient and C57BL/6J mice (4-5 months) were subjected to tasks evaluating spatial memory and avoidance conditioning. Female h-apoE4 mice did not detect changes in the spatial configuration of objects as opposed to female h-apoE3 mice. Female h-apoE3 mice failed to improve their performance during training in a reference memory version of the spatial water-maze task, but performed well during the probe trial 24 h after the last training trial. Memory retention performances of h-apoE4 mice were impaired during this probe trial. Both h-apoE3 and h-apoE4 mice did not improve their performance in a water-maze delayed matching to place task. Finally, h-apoE3 mice showed mild perturbations in a Y-maze active avoidance task, whereas both h-apoE mouse lines performed well in a passive avoidance task. Thus, spatial memory performances appeared particularly sensitive to h-apoE-isoform-dependent effects. Deficits occurred predominantly in female h-apoE4 mice, which support the hypothes…

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  • ApoE4 knock-in mice, particularly females, have deficits in spatial memory performance tests, compared to apoE3 mice.

    “subsequent studies demonstrate that apoE4 knock-in mice, particularly females, have deficits in spatial memory performance tests, compared to apoE3 mice (Bour et al., 2008; Grootendorst et al., 2005).”

    From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Grootendorst et al., 2005

  • Some phenotypic differences observed with apoE transgenic mouse models have been replicated with apoE knock-in mouse models.

    “Some phenotypic differences observed with apoE transgenic mouse models have been replicated with apoE knock-in mouse models (Bour et al., 2008; Grootendorst et al., 2005; Trommer et al., 2004; Wang et al., 2005).”

    From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Grootendorst et al., 2005

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Authors
Grootendorst, J., Bour, A., Vogel, E., Kelche, C., Sullivan, P. M., Dodart, J.-C., Bales, K., & Mathis, C.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Duke University (US)
  • Eli Lilly (United States) (US)
Corresponding author
Mathis, Chantal
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2005-04
Volume
159
Issue
1
Pages
1-14
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2004.09.019
OpenAlex
W1989497180
Cited by
148
References
7
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 14 · 2020: 11 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 7
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
apolipoprotein E, APOE ε4, APOE3, targeted replacement mice, spatial memory, avoidance conditioning, Alzheimer's disease risk, sex differences, memory retention, water maze, Y-maze, learning and memory
MeSH terms
Analysis of Variance, Animals, Apolipoproteins E, Avoidance Learning, Conditioning, Classical, Exploratory Behavior, Female, Genotype, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Sex Factors, Spatial Behavior, Mice, Knockout, Gene Targeting, Maze Learning, Protein Isoforms, Mice, Apolipoprotein E3, Apolipoprotein E4

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