Apolipoprotein E and cognitive performance
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There was no difference in soluble Aβ levels between apoE3/APP and apoE4/APP transgenic mice.
“Interestingly, there was no difference in soluble Aβ levels between apoE3/APP and apoE4/APP transgenic mice, suggesting that the differential effect of apoE isoform on cognition may be due to its ability to modulate functional neuronal deficits triggered by Aβ or APP.”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
In transgenic mouse models with neuronal apoE over-expression, apoE4 mice, primarily females, had impairments in learning a water maze test and in vertical exploratory activity, compared with apoE3 mice.
“In transgenic mouse models with neuronal apoE over-expression, apoE4 mice, primarily females, had impairments in learning a water maze test and in vertical exploratory activity, compared with apoE3 mice (Raber et al., 2000).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
Male apoE4 mice had significant deficits in spatial memory.
“Male apoE4 mice had significant deficits in spatial memory, whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
ApoE3 prevented Aβ or APP-induced cognitive impairment.
“whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
Compared with apoE3 transgenic mice, apoE4 transgenic mice were more severely impaired in learning and memory.
“and were more severely impaired in learning and memory (Hartman et al., 2001; Raber et al., 1998; Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
ApoE4 transgenic and apoE4-knock-in mice show age- and sex-dependent learning and memory deficits in the absence of amyloid-β accumulation, as compared to apoE3 transgenic and apoE3-knock-in mice.
“For example, both apoE4 transgenic and apoE4-KI mice show age- and sex-dependent learning and memory deficits in the absence of Aβ accumulation, as compared to apoE3 transgenic and apoE3-KI mice [68–71].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [69]
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- Authors
- Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Raber, Jacob
- Venue
- Nature
- Published
- 2000-03
- Volume
- 404
- Issue
- 6776
- Pages
- 352-354
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2089690753
- Cited by
- 237
- References
- 14
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, APOE ε4, APOE3, Alzheimer's disease, amyloid-beta, spatial memory, cognitive impairment, transgenic mice, amyloid precursor protein, genetic risk
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Cognition, Crosses, Genetic, Female, Humans, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Sex Characteristics, Space Perception, Amyloid beta-Protein Precursor, Maze Learning, Protein Isoforms, Mice, Apolipoprotein E3, Apolipoprotein E4
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