ApoE isoform-dependent changes in hippocampal synaptic function
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The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenerative disorders has focused attention on the role of these apoE isoforms in lipoprotein receptor-dependent synaptic modulation. In the present study, we used the apoE2, apoE3 and apoE4 targeted replacement (TR) mice along with recombinant human apoE isoforms to determine the role of apoE isoforms in hippocampus area CA1 synaptic function. While synaptic transmission is unaffected by apoE isoform, long-term potentiation (LTP) is significantly enhanced in apoE4 TR mice versus apoE2 TR mice. ApoE isoform-dependent differences in LTP induction require NMDA-receptor function, and apoE isoform expression alters activation of both ERK and JNK signal transduction. Acute application of specific apoE isoforms also alters LTP induction while decreasing NMDA-receptor mediated field potentials. Furthermore, acute apoE isoform application does not have the same effects on ERK and JNK activation. These findings demonstrate specific, isoform-dependent effects of human apoE isoforms on adult hippocampus synaptic plasticity and highlight mechanistic differences between chronic apoE isoform expression and acute apoE isoform exposure.
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A recent study by Korwek et al. (2009) did not find a difference in apoE protein levels in the hippocampus of mice expressing different human APOE isoforms.
“However, a recent study by Korwek et al. (2009) did not find a difference in apoE protein levels in the hippocampus of mice expressing different human APOE isoforms.”
From Differential Effects of ApoE Isoforms on Dendritic Spines<i>In Vivo</i>: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Korwek et al., 2009
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Apolipoprotein E Affects In Vitro Axonal Growth and Regeneration via the MAPK Signaling Pathway
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Retinoic Acid Enhances Apolipoprotein E Synthesis in Human Macrophages
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Extra-Hippocampal Learning Deficits in Young Apolipoprotein E4 Mice and Their Synaptic Underpinning
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“However, a recent study by Korwek et al. (2009) did not find a difference in apoE protein levels in the hippocampus of mice expressing different human APOE isoforms.”
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Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer’s Disease
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Insights into synaptic function from mouse models of human cognitive disorders
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
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- Authors
- Korwek, K. M., Trotter, J. H., LaDu, M. J., Sullivan, P. M., & Weeber, E. J.
- Affiliations
- Vanderbilt University (US)
- University of South Florida (US)
- University of Illinois Chicago (US)
- Duke Medical Center (US)
- Corresponding author
- Weeber, Edwin J
- Venue
- Molecular Neurodegeneration
- Published
- 2009-05-27
- Volume
- 4
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC2695436
- OpenAlex
- W2078287327
- Cited by
- 89
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 3 · 2012: 7
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (P01AG030128)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E isoforms, APOE ε4, APOE2, APOE3, hippocampal CA1, synaptic plasticity, long-term potentiation, NMDA receptor, ERK signaling, JNK signaling, synaptic transmission, targeted replacement mice, neurodegenerative diseases
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